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6 results on '"Mier, Verónica"'

2. Presence of Phosphorylated Tau Protein in the Skin of Alzheimer´s Disease Patients

Author

Santoyo Martha E, Martel-Gallegos Guadalupe, Zarazúa Sergio, Rodríguez-Leyva Ildefonso, Calderón–Garcidueñas Ana Laura, Chi-Ahumada Erika, Carrizales Juan, Jiménez-Capdeville María E, and Medina-Mier Verónica

Subjects
Pathology, medicine.medical_specialty, biology, medicine.diagnostic_test, business.industry, Tau protein, Protein aggregation, medicine.disease, Blot, mental disorders, Skin biopsy, biology.protein, Immunohistochemistry, Phosphorylation, Medicine, Dementia, Antibody, business
Abstract

Background: The presence of misfolded proteins in the brain is the hallmark of neurodegenerative diseases. Protein aggregates could have systemic expression and might be found in several tissues including the skin. Objective: To demonstrate the presence of phosphorylated Tau (p-Tau) in the skin cells of patients with Alzheimer´s Disease (AD). Material and methods: Antibodies against p-Tau (PHF, phosphorylated at S296 and AT8, phosphorylated at S202) were assayed in biopsied tissue from the retro-auricular area in 49. subjects: 20 with AD, 12 with nondegenerative dementia and 17 age-matched controls. Light and confocal microscopies were employed to localize Tau protein by immunohistochemistry and their presence in the skin was confirmed through Western blots. Results: The skin biopsy taken from AD patients presented significantly higher levels of p-Tau (AT8: hyperphosphorylated at Ser 202) when compared both to control subjects and patients with non-degenerative dementia (p

Published
2015

3. Parkinson disease and progressive supranuclear palsy: protein expression in skin

Author

Rodríguez‐Leyva, Ildefonso, primary, Chi‐Ahumada, Erika G., additional, Carrizales, Juan, additional, Rodríguez‐Violante, Mayela, additional, Velázquez‐Osuna, Salvador, additional, Medina‐Mier, Verónica, additional, Martel‐Gallegos, María G., additional, Zarazúa, Sergio, additional, Enríquez‐Macías, Lourdes, additional, Castro, Adriana, additional, Calderón–Garcidueñas, Ana Laura, additional, and Jiménez‐Capdeville, María E., additional

Published
2016
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