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6. Dendrimer Space Concept: A Futuristic Vision in Nanomedicine to Develop New Drugs

Author

Mignani, S., Majoral, J.-P., Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Caminade, A.-M. and Turrin, C.-O. and Majoral, and J.-P.

Subjects
[CHIM.COOR]Chemical Sciences/Coordination chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

7. A promising dual mode SPECT/CT imaging platform based on 99mTc-labeled multifunctional dendrimer-entrapped gold nanoparticles

Author

Wen, S, Zhao, L, Zhao, Q, Li, D, Liu, C, Yu, Z, Shen, M, Majoral, JP, Mignani, S, Zhao, J, and Shi, X

Abstract

© 2017 The Royal Society of Chemistry. Multifunctional 99mTc-labeled dendrimer-entrapped gold nanoparticles (99mTc-Au DENPs) were designed and synthesized. Our results show that the type of surface groups (acetyl or hydroxyl) significantly impact the biodistribution profile of the 99mTc-Au DENPs, thereby allowing for preferential SPECT/CT imaging of different organs.

Published
2017

9. A comparison between latent variable models for evaluating the quality perceived from the hospital service users

Author

Cagnone, S., Cavrini, G., and Mignani, S.

Subjects
lcsh:Statistics, lcsh:HA1-4737
Abstract

During the last years, costumer satisfaction analysis is becoming more and more important in evaluating the service quality of the sanitary system. Typically the construct ‘satisfaction’ is assumed to be a not observable variable, that is a latent variable. In this paper we illustrate and compare two different methods for analyzing latent variable models. The first one is the structural equation models with Lisrel, the second one is the generalized linear latent variable models. The comparison is performed through an application of the satisfaction analysis to a real data set referred to the patients of a hospital in Bologna. The results highlights the methodological and the applicative similarity and dissimilarity between the two methods., Statistica; Vol 64, No 4 (2004); 655-672

Published
2007

10. Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury

Author

Shakhbazau, Antos, Mishra, Manoj, Chu, Tak-Ho, Brideau, Craig, Cummins, Karen, Tsutsui, Shigeki, Shcharbin, Dzmitry, Majoral, Jean Pierre, Mignani, S., Blanchard-Desce, M., Bryszewska, M., Yong, V. Wee, Stys, Peter K., Minnen, Jan, Hotchkiss Brain Institute, University of Calgary, Institute of Biophysics and Cell Engineering, NASB, Minsk, National Academy of Sciences of Belarus (NASB), Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Centre National de la Recherche Scientifique (CNRS), Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, University of Lódź, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Université Sciences et Technologies - Bordeaux 1-Université Montesquieu - Bordeaux 4-Institut de Chimie du CNRS (INC)

Subjects
[CHIM.COOR]Chemical Sciences/Coordination chemistry
Abstract

International audience; Dendrimers and dendriplexes, highly branched synthetic macromolecules, have gained popularity as new tools for a variety of nanomedicine strategies due to their unique structure and properties. We show that fluorescent phosphorus dendrimers are well retained by bone marrow-derived macrophages and exhibit robust spectral shift in its emission in response to polarization conditions. Fluorescence properties of this marker can also assist in identifying macrophage presence and phenotype status at different time points after spinal cord injury. Potential use of a single dendrimer compound as a drug/siRNA carrier and phenotype-specific cell tracer offers new avenues for enhanced cell therapies combined with monitoring of cell fate and function in spinal cord injury.

Published
2015
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11. Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy.

Author

Li, D, Zhang, Y, Wen, S, Song, Y, Tang, Y, Zhu, X, Shen, M, Mignani, S, Majoral, J-P, Zhao, Q, Shi, X, Li, D, Zhang, Y, Wen, S, Song, Y, Tang, Y, Zhu, X, Shen, M, Mignani, S, Majoral, J-P, Zhao, Q, and Shi, X

Abstract

The advancement of biocompatible nanoplatforms with dual functionalities of diagnosis and therapeutics has been strongly demanded in biomedicine in recent years. In this work, we report the synthesis and characterization of polydopamine (pD)-coated gold nanostars (Au NSs) for computed tomography (CT) imaging and enhanced photothermal therapy (PTT) of tumors. Au NSs were firstly formed via a seed-mediated growth method and then stabilized with thiolated polyethyleneimine (PEI-SH), followed by deposition of pD on their surface. The formed pD-coated Au NSs (Au-PEI@pD NSs) were well characterized. We show that the Au-PEI@pD NSs are able to convert the absorbed near-infrared laser light into heat, and have strong X-ray attenuation properties. Due to the co-existence of Au NSs and pD, the light to heat conversion efficiency of the NSs can be significantly enhanced. These very interesting properties allow them to be used as a powerful theranostic nanoplatform for efficient CT imaging and enhanced phtotothermal therapy of cancer cells in vitro and the xenografted tumor model in vivo. Due to their easy functionalization nature enabled by the coated pD shell, the developed pD-coated Au NSs may be used as a versatile nanoplatform for targeted CT imaging and PTT of different types of cancers.

Published
2016

12. Catene di Markov Monte Carlo nei modelli di Ising

Author

Mignani, S. and Rosa, R.

Abstract

This paper deals with an application of Monte Carlo Markov Chain. This Monte Carlo sampling technique was first introduced by Metropolis et al. to provide estimates of the statistical mechanical Boltzmann averages of parameters of a system of interacting particles. To illustrate an application of this method we have chosen the square spin-flip Ising model, i.e., a regular array of sites with each site occupied by a spin, which is allowed only two orientations. On such a model we have considered estimates of internal energy, magnetization, response functions and relaxation time, at the critical temperature and for different lattice sites. The problem of the accuracy of estimates is discussed in details and it has been shown how the moving block bootstrap can be applied successfully to assess standard errors and to construe confidence intervals for the computed averages. It can been seen also that, when correlation functions have a long-time behaviour, the moving block bootstrap works better than other methods based on subseries values., Statistica; Vol 56, No 1 (1996)

Published
2013
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13. Alcune annotazioni sul gioco del totocalcio

Author

Mignani, S., Montanari, A., and Lucchi, E.

Abstract

In this paper we look for statistical regularities in football pools, a game in which many variables, not all of them random, play an important role. Studing the results of the football matches of the decade 1980-90 we succeed in fitting a multinomial model to the distribution of winning compositions and this may be read as an indicator of a sort of independence in the results of football pools which expresses itself in the invariance of the probabilities of the results 1, x, 2. This, however, does not mean that every team has the same probability of winning, losing or drawing; in fact the composition that more frequently wins is not the one realized by the highest number of permutations. A further proof of the presence of not-random components in the game of football pools is given by the low correlation between the empirical frequencies of wins and the probability of the winning columns., Statistica; Vol 52, No 1 (1992)

Published
2013
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14. Selective synthesis of trans-disubstituted-beta-lactams from N-phenylsulfenylimines

Author

Coantic, S., Mouysset, D., Mignani, S., Tabart, M., Stella, L., Chimie, biologie et radicaux libres - UMR 6517 ( CBRL ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Provence - Aix-Marseille 1-Université Paul Cézanne - Aix-Marseille 3-Université de la Méditerranée - Aix-Marseille 2, Nouguier, Colette, Chimie, biologie et radicaux libres - UMR 6517 (CBRL), and Université de la Méditerranée - Aix-Marseille 2-Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry, [ CHIM.ORGA ] Chemical Sciences/Organic chemistry, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

15. The use of N-Sulfenylimines in the beta-lactam synthon method: Staudinger reaction, oxidation of the cycloadducts and ring opening of beta-lactams

Author

Coantic, S., Mouysset, D., Mignani, S., Tabart, M., Stella, L., Chimie, biologie et radicaux libres - UMR 6517 ( CBRL ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Provence - Aix-Marseille 1-Université Paul Cézanne - Aix-Marseille 3-Université de la Méditerranée - Aix-Marseille 2, Chimie, biologie et radicaux libres - UMR 6517 (CBRL), Université de la Méditerranée - Aix-Marseille 2-Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), and Nouguier, Colette

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry, [ CHIM.ORGA ] Chemical Sciences/Organic chemistry, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

19. LIST OF CONTRIBUTORS

Author

Alazard, J.P., primary, Amin, S.G., additional, Andrus, A., additional, ApSimon, J.W., additional, Armstrong, V.W., additional, Au-Yeung, B.-W., additional, Avram, M., additional, Ayer, W.A., additional, Babin, D., additional, Backinowsky, L.V., additional, Baldwin, J.E., additional, Bally, I., additional, Balsetan, A.T., additional, Bamezai, S., additional, Bandara, B.M.R., additional, Barth, G., additional, Barton, D.H.R., additional, Beaujean, M., additional, Beeley, N.R.A., additional, Berke, C.M., additional, Besselièvre, R., additional, Betaneli, V.I., additional, Beugelmans, R., additional, Birch, A.J., additional, Bose, A.K., additional, Brambilla, R., additional, Braun-Keller, E., additional, Brown, E., additional, Brownbridge, P., additional, Caspi, E., additional, Chamberlain, K., additional, Chan, T.H., additional, Chauncy, B., additional, Chottard, J.C., additional, Clardy, J., additional, Clark, B.C., additional, Collins, J.B., additional, Coulton, S., additional, Crouse, G.D., additional, Dadoun, H., additional, Dahler, P., additional, Day, A.I., additional, De Ville, G., additional, Dinulescu, I.G., additional, Djerassi, C., additional, von E. Doering, W., additional, Drâghici, C., additional, Elian, M., additional, Factor, R.E., additional, Faulkner, D.J., additional, Fernandez, I.F., additional, Finer-Moore, J., additional, Fleming, I., additional, Florent, J.-C., additional, Fourneron, J.-D., additional, Friary, R., additional, Fuhrer, H., additional, Fukuyama, T., additional, Funke, P.T., additional, Furmanova, N.G., additional, Fürst, A., additional, Furuhata, K., additional, Gala, K., additional, Ganguly, A., additional, Georgescu, E.G., additional, Gheorghiu, M.D., additional, Girard, P., additional, Gneuss, K.D., additional, Greaves, A.M., additional, Grier, D., additional, Gruska, R., additional, Guilhem, J., additional, Hangauer, D.G., additional, Hendrickson, J.B., additional, Hillenbrand, G.F., additional, Holohan, J.J., additional, Huber, C.P., additional, Huffman, J.W., additional, Husson, H.-P., additional, Iacobucci, G.A., additional, Ireland, C., additional, Irwin, A.J., additional, Janousek, Z., additional, Jenkins, I.D., additional, Johnson, M.A., additional, Jones, B.B., additional, Julia, M., additional, Kagan, H.B., additional, Kägi, D., additional, Kalvoda, J., additional, Kapur, J.C., additional, Katritzky, A.R., additional, Kaufmann, H., additional, Kelly, L.P., additional, Khajavi, M.S., additional, Khor, T.-C., additional, Kishi, Y., additional, Kitchin, J.P., additional, Kochetkov, N.K., additional, Kreder, J., additional, Kretschmer, G., additional, Kriemler, H.-P., additional, Ksander, G.M., additional, Kuwano, H., additional, Lansbury, P.T., additional, Lester, D.J., additional, Lewis, M., additional, Ley, S.V., additional, Liepa, A.J., additional, Lindley, M., additional, Lusinchi, X., additional, Mahanty, M.K., additional, Mallion, K.B., additional, Manhas, M.S., additional, Mansuy, D., additional, Mastrocola, A.R., additional, McMurry, J.E., additional, McPhail, A.T., additional, Meerholz, C.A., additional, Merenyi, R., additional, Metlushenko, V.P., additional, Mignani, S., additional, Minkin, V.I., additional, Mohr, P., additional, Monneret, C., additional, Motherwell, W.B., additional, Mukkavilli, L., additional, Müller, G., additional, Müller, M., additional, Mulliez, E., additional, Musser, J.H., additional, Naegeli, P., additional, Nakatsuka, S.-I., additional, Namy, J.L., additional, Narula, A.S., additional, Ogura, H., additional, Olekhnovich, L.P., additional, Onan, K.D., additional, Ovchinnikov, M.V., additional, Papoula, M.T.B., additional, Paquette, L.A., additional, Parker, W.L., additional, Pârvulescu, L., additional, Patel, R.C., additional, Peel, R., additional, Pickett, J.E., additional, Piper, J.U., additional, Puar, M.S., additional, Ragault, M., additional, Ram, B., additional, Ramachandran, P.V., additional, Ramage, R., additional, Ranganathan, D., additional, Ranganathan, S., additional, Rathnum, M.L., additional, Raverty, W.D., additional, Reed, N.V., additional, Rizzardo, E., additional, Roussi, G., additional, Saeedi-Ghomi, M.H., additional, Saito, I., additional, Scheuer, P.J., additional, Schriver, G.W., additional, Schwartz, R.E., additional, Scott, A.I., additional, Sell, C., additional, Sependa, G.J., additional, Shapiro, S., additional, Sing, L.Y., additional, Smith, K.M., additional, Sondheimer, F., additional, Soulié, J., additional, Stanescu, L., additional, Stephenson, G.R., additional, Stiller, K., additional, Streitwieser, A., additional, Sugiura, M., additional, Sum, F.W., additional, Sundararaman, P., additional, Sunday, B.R., additional, Sutherland, J.K., additional, Suzuki, M., additional, Tagle, B., additional, Tamm, Ch., additional, Tho, N.-D., additional, Thomas, E.J., additional, Thompson, D.J., additional, Toczko, G.A., additional, Van Engen, D., additional, van der Veen, J.M., additional, Viehe, H.G., additional, Vincent, J.E., additional, Wasserman, H.H., additional, Watson, W.H., additional, Weiler, L., additional, Wetli, M., additional, Wiley, D.C., additional, Williamson, D.H., additional, Wolff, M.S., additional, Wong, H.N.C., additional, Wright, J.J., additional, Zabel, V., additional, and Zimmerman, H.E., additional

Published
1982
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22. An improved majorization algorithm for robust procrustes analysis

Author

Groenen, P.J F, Giaquinto, P., Kiers, H.A.L., Monari, P, Mignani, S., Montanari, A., Vichi, M., Psychometrics and Statistics, Erasmus School of Economics, and Econometrics

Subjects
Outlier, Procrustes analysis, Majorization, Focus (optics), Algorithm, Mathematics
Abstract

In this paper, we focus on algorithms for Robust Procrustes Analysis that are used to rotate a solution of coordinates towards a target solution while controlling outliers. Verboon (1994) and Verboon and Heiser (1992) showed how iterative weighted least-squares can be used to solve the problem. Kiers (1997) improved upon their algorithm by using iterative majorization. In this paper, we propose a new method called “weighted majorization” that improves on the method by Kiers (1997). A simulation study shows that compared to the method by Kiers (1997), the solutions obtained by weighted majorization are in almost all cases of better quality and are obtained significantly faster.

Published
2005

23. A Family of Indices for Teaching Evaluation: Experiences in Italian Universities

Author

Crescenzi, F, Mignani, S, Marasini, D, Quatto, P, MARASINI, DONATA, QUATTO, PIERO, Crescenzi, F, Mignani, S, Marasini, D, Quatto, P, MARASINI, DONATA, and QUATTO, PIERO

Abstract

In order to analyze the student ratings of University teaching, several indices summarize the relative frequencies of positive and negative responses in a single numerical value. Focusing on linear functions of response frequencies, the paper studies some interesting families of indices for the measurement of student satisfaction. Special attention is paid to relationships between these families and to a particular family that arises in a natural way.

Published
2014

24. Fifty Years of Business Confidence Surveys on Manufacturing Sector

Author

Crescenzi, F, Mignani, S, Martelli, B, Bruno, G, Chiodini, P, Manzi, G, Verrecchia, F, Martelli, BM, Chiodini, PM, Crescenzi, F, Mignani, S, Martelli, B, Bruno, G, Chiodini, P, Manzi, G, Verrecchia, F, Martelli, BM, and Chiodini, PM

Abstract

In this work the evolution of the Italian Business Confidence Survey on manufacturing sector is presented starting from the preliminary European project for harmonized statistics launched in the late fifties of the last century. Survey changes are described, focusing in particular on the so-called confidence indicator. The continuing increase of statistical accuracy in sampling is recalled, from the initial purposive sample and controls, up to the present state of the art. Specific attention is devoted to the role of administrative archives in the sampling plan. Emphasis is also given to the increasing use of computer simulation in assessing the validity of the estimates. The role of cyclical analysis is finally highlighted with regard to two aspects: (1) the business confidence has not a corresponding variable in the economic system—the validation can only be performed in comparison with correlated variables (e.g. IP, GDP); (2) confidence shows forecasting capability for the economic system.

Published
2014

28. A New Version of the Structural Dynamic Model with Unique Latent Scores

Author

Bock, HH, Gaul, W, Vichi, M, Arabie, P, Baier, D, Critchley, F, Decker, R, Diday, E, Greenacre, M, Lauro, C, Meulman, J, Monari, P, Nishisato, S, Ohsumi, N, Opitz, O, Ritter, G, Schader, M, Weihs, C, Mignani, S, Montanari, A, Minotti, S, Vittadini, G, MINOTTI, SIMONA CATERINA, VITTADINI, GIORGIO, Bock, HH, Gaul, W, Vichi, M, Arabie, P, Baier, D, Critchley, F, Decker, R, Diday, E, Greenacre, M, Lauro, C, Meulman, J, Monari, P, Nishisato, S, Ohsumi, N, Opitz, O, Ritter, G, Schader, M, Weihs, C, Mignani, S, Montanari, A, Minotti, S, Vittadini, G, MINOTTI, SIMONA CATERINA, and VITTADINI, GIORGIO

Abstract

The indeterminacy of the Structural Models, i.e. the arbitrariness of latent scores, due to the factorial nature of the measurement models, is, in the dynamic context, more problematic. We propose an alternative formulation of the Structural Dynamic Model, based on the Replicated Common Factor Model (Haagen e Oberhofer, 1999), where latent scores are no more indeterminate.

Published
2005

29. Selection of Structural Equation Models with the Pls.VB Programme

Author

Vichi, M, Mignani, S, Monari, P, Montanari A, Boari, Giuseppe, Cantaluppi, Gabriele, Boari, Giuseppe (ORCID:0000-0002-3208-2771), Cantaluppi, Gabriele (ORCID:0000-0001-5234-3900), Vichi, M, Mignani, S, Monari, P, Montanari A, Boari, Giuseppe, Cantaluppi, Gabriele, Boari, Giuseppe (ORCID:0000-0002-3208-2771), and Cantaluppi, Gabriele (ORCID:0000-0001-5234-3900)

Published
2005

48. ChemInform Abstract: Design, Synthesis, and Binding Affinities of Novel Non‐Peptides Mimics of Somatostatin/Sandostatin.

Author

DAMOUR, D., primary, BARREAU, M., additional, BLANCHARD, J.‐C., additional, BURGEVIN, M.‐C., additional, DOBLE, A., additional, HERMAN, F., additional, PANTEL, G., additional, JAMES‐SURCOUF, E., additional, VUILHORGNE, M., additional, MIGNANI, S., additional, POITOUT, L., additional, LE MERRER, Y., additional, and DEPEZAY, J.‐C., additional

Published
1996
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