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784 Background: Surgical and adjuvant treatment in extreme elderly ( > 80 years) patients with localized colorectal cancer is an unresolved issue. Owing to the lack of available neither clinical practice nor investigational data in this field we present our experience in this scenario. Methods: We retrospectively reviewed data regarding surgical and complementary treatment for colorectal cancer patients aged more than 80 consecutively attended by General Surgery Department in Vega Baja Hospital between 2008 and 2013. Results: A total number of 115 colorectal cancer patients were registered. 95 patients diagnosed of localized disease were selected for analysis. Colon vs rectal cancer ratio was 4:1. Median age was 83.6 years (80-94). Male sex was predominant (60 patients, 63.2%). Emergency surgery was performed in 15 patients (15.8%). Complementary treatment to surgery was advised, according to international guidelines, in 53 patients (55.8%). 10 patients (18.9%) with an advise of adjuvant treatment finally received it. More patients with rectal cancer received recommended treatment (41.7% rectal vs 12.2% colon cancer). Patients with stage III disease were more frequently finally treated according to guidelines (22.2 % stage III vs 11.8% stage II). More patients with stage II rectal cancer were advised and received treatment (recommendation: 66.7% rectal vs 36.1% colon cancer; administration: 25% rectal vs 7.7% colon cancer). Treatment was also more frequently administered to stage III rectal cancer (50% rectal vs 14.3% rectal cancer) (Table). Conclusions: Our experience in localized colorectal cancer in extreme elderly patients ( > 80 years) showed that, although advised according to guidelines, most of them did not receive adjuvant treatment to surgery. Complementary treatment administration was more common in rectal cancer patients and with more advanced disease. [Table: see text]

espanolIntroduccion: la valoracion del estado de inmunovigilancia (capacidad del organismo para evitar el desarrollo de neoplasias) en el analisis sanguineo presenta connotaciones pronosticas de interes en el cancer colorrectal. Evaluamos un posible caracter predictivo de la enfermedad en el analisis sanguineo y su cuantificacion mediante el diseno de un indice de interaccion matematico entre varios parametros sanguineos, con capacidad predictiva probabilistica de presencia de la enfermedad. Metodo: estudio casos y controles de analisis comparativo de la distribucion de parametros sanguineos, sobre 266 pacientes con cancer colorrectal y 266 pacientes sanos, durante el periodo comprendido entre 2009-2013. Resultados: los sujetos con cancer colorrectal presentaron, con respecto a los controles, diferencias estadisticamente significativas (p Conclusiones: Ante la posible existencia de un caracter predictivo de presencia de cancer colorrectal en el analisis sanguineo, mostramos que es posible su cuantificacion mediante el diseno de un indice de interaccion entre varios parametros sanguineos. El diseno y desarrollo de indices de interaccion entre parametros sanguineos constituye una linea de investigacion de interes para el desarrollo y mejora de programas de cribado de la enfermedad. EnglishIntroduction: The assessment of the state of immunosurveillance (the ability of the organism to prevent the development of neoplasias) in the blood has prognostic implications of interest in colorectal cancer. We evaluated and quantified a possible predictive character of the disease in a blood test using a mathematical interaction index of several blood parameters. The predictive capacity of the index to detect colorectal cancer was also assessed. Methods: We performed a retrospective case-control study of a comparative analysis of the distribution of blood parameters in 266 patients with colorectal cancer and 266 healthy patients during the period from 2009 to 2013. Results: Statistically significant differences (p