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328 results on '"Mihaylova, Borislava"'

2. Children’s Health in London and Luton (CHILL) cohort: a 12-month natural experimental study of the effects of the Ultra Low Emission Zone on children’s travel to school

Author

Xiao, Christina, Scales, James, Chavda, Jasmine, Dove, Rosamund E., Tsocheva, Ivelina, Wood, Helen E., Kalsi, Harpal, Sartori, Luke, Colligan, Grainne, Moon, Jessica, Lie, Esther, Petrovic, Kristian, Day, Bill, Howett, Cheryll, Keighley, Amanda, Mihaylova, Borislava, Toffolutti, Veronica, Grigg, Jonathan, Randhawa, Gurch, Sheikh, Aziz, Fletcher, Monica, Mudway, Ian, Beevers, Sean, Gauderman, W. James, Griffiths, Christopher J., van Sluijs, Esther, and Panter, Jenna

Published
2024
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3. Cross-Sectional Survey to Assess Hospital System Readiness for Hemorrhage During and After Cesarean Delivery in Africa

Author

Crowther, Marcelle, Dyer, Robert A., Bishop, David G., Bulamba, Fred, Maswime, Salome, Pearse, Rupert M, Biccard, Bruce M., Adem, Mohammed, Belachew, Tizeta, Belay, Ermiyas, Boru, Yared, Busha, Turunesh, Daniel, Selam, Dawit, Abiy, Demissie, Brook, Dersso Mengistu, Degsew, Desta, Kokeb, Desta, Kelem, Galcha, Desta, Guchima, Nuroadis, Kenna, Peniel, Kifle, Fitsum, Kifleyohanes, Tewodros, Mulye, Betelehem, Zemdkun, Bezaye, Arendse, Gwen, Bedwell, Gillian J, Biccard, Bruce M, Bishop, David G, Crowther, Marcelle, Cunnama, Lucy, Desemela, Yamkela, Duvenage, Hanel, Duys, Rowan, Dyer, Robert A, Flint, Margot, Futshane, Aphelele, Gumede, Simphiwe, Hardy, Anneli, Kabambi, Kasandji F, Kinnes, Marian, Kluyts, Hyla-Louise, Mafana, Edson, Maswime, Salome, Molaoa, Steve, Moloi, Lebogang, Mrara, Busisiwe, Mtshabe, Lwandile, Ninise, Ezile J, Pohl, Linda, Prinsloo, Rosalind V, Mokotla, Catherine F, Mdunyelwa, Rev. Mzubanzi, Baker, Tim, Bandeke, Upendo J, Biyengo, Happines, Kaliza, Aneth C, Khalid, Karima, Kitwara, Juma S, Mkumbo, Elibariki, Sunguya, Bruno, Shayo, Rafael S, Barabona, Godfrey, Amunyo, Elvis, Bulamba, Fred, Gamubaka, Richard, Hewitt-Smith, Adam, Kamwesigwe, Assen, Kawiso, Muzamiru, Khanyalano, Justine, Kidulu, James, Magala, Peter, Nakibuule, Joanitah, Naluyima, Joan, Namutebi, Hasifah, Nandutu, Rose, Nanimambi, Juliana, Okanya, David, Steven Walutsyo, John, Kiwalya, Herbert, Bhangu, Aneel, Davies, Justine, Dias, Priyanthi, Ellis, Ryan, Fadipe, Charles, Fowler, Alexander J, Hamborg, Thomas, Mihaylova, Borislava, Moore, Jolene, Pearse, Rupert M, Stephens, Timothy J, Vickery, Nicola J, and Vindrola, Cecilia

Published
2024
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6. Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis

Author

Reith, Christina, Preiss, David, Blackwell, Lisa, Emberson, Jonathan, Spata, Enti, Davies, Kelly, Halls, Heather, Harper, Charlie, Holland, Lisa, Wilson, Kate, Roddick, Alistair J, Cannon, Christopher P, Clarke, Robert, Colhoun, Helen M, Durrington, Paul N, Goto, Shinya, Hitman, Graham A, Hovingh, G Kees, Jukema, J Wouter, Koenig, Wolfgang, Marschner, Ian, Mihaylova, Borislava, Newman, Connie, Probsfield, Jeffrey L, Ridker, Paul M, Sabatine, Marc S, Sattar, Naveed, Schwartz, Gregory G, Tavazzi, Luigi, Tonkin, Andrew, Trompet, Stella, White, Harvey, Yusuf, Salim, Armitage, Jane, Keech, Anthony, Simes, John, Collins, Rory, Baigent, Colin, Barnes, Elizabeth, Fulcher, Jordan, Herrington, William G, Kirby, Adrienne, O'Connell, Rachel, Amarenco, Pierre, Arashi, Hiroyuki, Barter, Philip, Betteridge, D John, Blazing, Michael, Blauw, Gerard J, Bosch, Jackie, Bowman, Louise, Braunwald, Eugene, Bulbulia, Richard, Byington, Robert, Clearfield, Michael, Cobbe, Stuart, Dahlöf, Björn, Davis, Barry, de Lemos, James, Downs, John R, Fellström, Bengt, Flather, Marcus, Ford, Ian, Franzosi, Maria Grazia, Fuller, John, Furberg, Curt, Glynn, Robert, Goldbourt, Uri, Gordon, David, Gotto, Jr, Antonio, Grimm, Richard, Gupta, Ajay, Hawkins, C Morton, Haynes, Richard, Holdaas, Hallvard, Hopewell, Jemma, Jardine, Alan, Kastelein, John JP, Kean, Sharon, Kearney, Patricia, Kitas, George, Kjekshus, John, Knatterud, Genell, Knopp, Robert H, Koren, Michael, Krane, Vera, Landray, Martin, LaRosa, John, Latini, Roberto, Lonn, Eva, Lucci, Donata, MacFadyen, Jean, Macfarlane, Peter, MacMahon, Stephen, Maggioni, Aldo, Marchioli, Roberto, Moyé, Lemuel, Murphy, Sabina, Neil, Andrew, Nicolis, Enrico B, Packard, Chris, Parish, Sarah, Pedersen, Terje R, Peto, Richard, Pfeffer, Marc, Poulter, Neil, Pressel, Sara, Probstfield, Jeffrey, Rahman, Mahboob, Robertson, Michele, Sacks, Frank, Schmieder, Roland, Serruys, Patrick, Sever, Peter, Shaw, John, Shepherd, James, Simpson, Lara, Sleight, Peter, Smeeth, Liam, Tobert, Jonathan, Tognoni, Gianni, Varigos, John, Wanner, Christoph, Wedel, Hans, Weis, Stephen, Welch, K Michael, Wikstrand, John, Wilhelmsen, Lars, Wiviott, Stephen, Yamaguchi, Junichi, Young, Robin, and Zannad, Faiez

Published
2024
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7. Association between health insurance cost-sharing and choice of hospital tier for cardiovascular diseases in China: a prospective cohort study

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Li, Liming, Wang, Chen, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Barnard, Maxim, Bennett, Derrick, Boxall, Ruth, Chan, Kahung, Chen, Yiping, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fry, Hannah, Gilbert, Simon, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Lam, Hubert, Lin, Kuang, Liu, James, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozaricki, Alfred, Ryder, Paul, Said, Saredo, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Wang, Baihan, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Xia, Qingmei, Liu, Chao, Pei, Pei, Sun, Dianjianyi, Yu, Canqing, Chen, Naying, Liu, Duo, Tang, Zhenzhu, Chen, Ningyu, Jiang, Qilian, Lan, Jian, Li, Mingqiang, Liu, Yun, Meng, Fanwen, Meng, Jinhuai, Pan, Rong, Qin, Yulu, Wang, Ping, Wang, Sisi, Wei, Liuping, Zhou, Liyuan, Dong, Caixia, Ge, Pengfei, Ren, Xiaolan, Li, Zhongxiao, Mao, Enke, Wang, Tao, Zhang, Hui, Zhang, Xi, Chen, Jinyan, Hu, Ximin, Wang, Xiaohuan, Guo, Zhendong, Li, Huimei, Li, Yilei, Weng, Min, Wu, Shukuan, Yan, Shichun, Zou, Mingyuan, Zhou, Xue, Guo, Ziyan, Kang, Quan, Li, Yanjie, Yu, Bo, Xu, Qinai, Chang, Liang, Fan, Lei, Feng, Shixian, Zhang, Ding, Zhou, Gang, Gao, Yulian, He, Tianyou, He, Pan, Hu, Chen, Sun, Huarong, Zhang, Xukui, Chen, Biyun, Fu, Zhongxi, Huang, Yuelong, Liu, Huilin, Xu, Qiaohua, Yin, Li, Long, Huajun, Xu, Xin, Zhang, Hao, Zhang, Libo, Su, Jian, Tao, Ran, Wu, Ming, Yang, Jie, Zhou, Jinyi, Zhou, Yonglin, Hu, Yihe, Hua, Yujie, Jin, Jianrong, Liu, Fang, Liu, Jingchao, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Jun, Cheng, Liang, Du, Ranran, Gao, Ruqin, Li, Feifei, Li, Shanpeng, Liu, Yongmei, Ning, Feng, Pang, Zengchang, Sun, Xiaohui, Tian, Xiaocao, Wang, Shaojie, Zhai, Yaoming, Zhang, Hua, Hou, Wei, Lv, Silu, Wang, Junzheng, Chen, Xiaofang, Wu, Xianping, Zhang, Ningmei, Chang, Xiaoyu, Li, Jianguo, Liu, Jiaqiu, Luo, Guojin, Sun, Qiang, Zhong, Xunfu, Gong, Weiwei, Hu, Ruying, Wang, Hao, Wang, Meng, Yu, Min, Chen, Lingli, Gu, Qijun, Pan, Dongxia, Wang, Chunmei, Xie, Kaixu, Zhang, Xiaoyi, Chen, Hongyuan, Liu, Liyang, Gou, Haiyan, Wang, Xun, Ding, Jing, Zhang, Ning, Mao, Yueshi, Zhou, Shanshan, Jin, Lirong, Cheng, Xin, Lu, Yun, Chen, Li, Hao, Zilong, Xing, Xiaona, Wang, Lei, Ju, Naixin, Mao, Yiting, Li, Shuya, Du, Peng, Wang, Deren, Sun, Xiaojia, You, Shihao, Wang, Weizhi, Zhu, Yanmei, Li, Xiaojiu, Dong, Yi, Levy, Muriel, Buckell, John, Wu, Nina, Yip, Winnie, and Mihaylova, Borislava

Published
2024
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9. Investigating the impact of London’s ultra low emission zone on children’s health: children’s health in London and Luton (CHILL) protocol for a prospective parallel cohort study

Author

Tsocheva, Ivelina, Scales, James, Dove, Rosamund, Chavda, Jasmine, Kalsi, Harpal, Wood, Helen E, Colligan, Grainne, Cross, Louise, Newby, Chris, Hall, Amy, Keating, Mia, Sartori, Luke, Moon, Jessica, Thomson, Ann, Tomini, Florian, Murray, Aisling, Hamad, Wasim, Tijm, Sarah, Hirst, Alice, Vincent, Britzer Paul, Kotala, Pavani, Balkwill, Frances, Mihaylova, Borislava, Grigg, Jonathan, Quint, Jennifer K, Fletcher, Monica, Mon-Williams, Mark, Wright, John, van Sluijs, Esther, Beevers, Sean, Randhawa, Gurch, Eldridge, Sandra, Sheikh, Aziz, Gauderman, William, Kelly, Frank, Mudway, Ian S, and Griffiths, Christopher J

Published
2023
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11. Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Author

Edwards, Mark R., Forbes, Gordon, Walker, Neil, Morton, Dion G., Mythen, Monty G., Murray, Dave, Anderson, Iain, Mihaylova, Borislava, Thomson, Ann, Taylor, Matt, Hollyman, Marianne, Phillips, Rachel, Young, Keith, Kahan, Brennan C., Pearse, Rupert M., and Grocott, Michael P. W.

Published
2023
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12. Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials

Author

Reith, Christina, Baigent, Colin, Blackwell, Lisa, Emberson, Jonathan, Spata, Enti, Davies, Kelly, Halls, Heather, Holland, Lisa, Wilson, Kate, Armitage, Jane, Harper, Charlie, Preiss, David, Roddick, Alistair, Keech, Anthony, Simes, John, Collins, Rory, Barnes, Elizabeth, Fulcher, Jordan, Herrington, William G, Kirby, Adrienne, Mihaylova, Borislava, O'Connell, Rachel, Amarenco, Pierre, Barter, Philip, Betteridge (deceased), D John, Blazing, Michael, Bosch, Jackie, Bowman, Louise, Braunwald, Eugene, Cannon, Christopher P, Clearfield, Michael, Cobbe, Stuart, Colhoun, Helen M, Dahlöf, Björn, Davis, Barry, de Lemos, James, Downs, John R, Durrington, Paul N, Fellström, Bengt, Ford, Ian, Franzosi, Maria Grazia, Fuller (deceased), John, Furberg, Curt, Glynn, Robert, Gordon, David, Gotto Jr, Antonio, Grimm, Richard, Gupta, Ajay, Hawkins, C Morton, Hitman, Graham A, Holdaas (deceased), Hallvard, Jardine, Alan, Jukema, J Wouter, Kastelein, John JP, Kean, Sharon, Kjekshus, John, Knatterud (deceased), Genell, Knopp (deceased), Robert H, Koenig, Wolfgang, Koren, Michael, Krane, Vera, Landray, Martin, LaRosa, John, Latini, Roberto, Lonn, Eva, Lucci, Donata, MacFadyen, Jean, Macfarlane, Peter, MacMahon, Stephen, Maggioni, Aldo, Marchioli, Roberto, Marschner, Ian, Moyé, Lemuel, Murphy, Sabina, Neil, Andrew, Nicolis, Enrico B, Packard, Chris, Parish, Sarah, Pedersen, Terje R, Peto, Richard, Pfeffer, Marc, Poulter, Neil, Pressel, Sara, Probstfield, Jeffrey, Rahman, Mahboob, Ridker, Paul M, Robertson, Michele, Sacks, Frank, Sattar, Naveed, Schmieder, Roland, Serruys, Patrick W, Sever, Peter, Shaw (deceased), John, Shepherd (deceased), James, Simpson, Lara, Sleight (deceased), Peter, Tavazzi, Luigi, Tognoni, Gianni, Tonkin, Andrew, Trompet, Stella, Wanner, Christoph, Wedel, Hans, Weis, Stephen, Welch, K Michael, White, Harvey, Wikstrand, John, Wilhelmsen, Lars, Wiviott, Stephen, Young, Robin, Yusuf, Salim, Zannad, Faiez, Arashi, Hiroyuki, Byington, Robert, Clarke, Robert, Flather, Marcus, Goldbourt, Uri, Goto, Shinya, Hopewell, Jemma, Hovingh, Kees, Kearney, Patricia, Kitas, George, Newman, Connie, Sabatine, Marc S, Schwartz, Greg, Smeeth, Liam, Tobert, Jonathan, Varigos, John, and Yamaguchi, Junichi

Published
2022
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15. Lifetime effects and cost-effectiveness of statin therapy for older people in the United Kingdom: a modelling study.

Author

Mihaylova, Borislava, Runguo Wu, Junwen Zhou, Williams, Claire, Schlackow, Iryna, Emberson, Jonathan, Reith, Christina, Keech, Anthony, Robson, John, Parnell, Richard, Armitage, Jane, Gray, Alastair, Simes, John, and Baigent, Colin

Subjects
OLDER people, LDL cholesterol, HOSPITAL costs, HOSPITAL charges, CORONARY artery bypass, MYOCARDIAL infarction, HEART failure, STROKE units
Published
2024
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16. Quality of care for secondary cardiovascular disease prevention in 2009-2017: population-wide cohort study of antiplatelet therapy use in Scotland.

Author

Thalmann, Inna, Preiss, David, Schlackow, Iryna, Gray, Alastair, and Mihaylova, Borislava

Subjects
ARTERIOSCLEROSIS prevention, CLINICAL drug trials, CARDIOVASCULAR disease prevention, PATIENT compliance, RISK assessment, NATIONAL health services, MYOCARDIAL infarction, COMBINATION drug therapy, CARDIOVASCULAR diseases, MEDICAL quality control, RESEARCH funding, ARTERIOSCLEROSIS, TERMINATION of treatment, MULTIPLE regression analysis, PERIPHERAL vascular diseases, HOSPITAL care, RETROSPECTIVE studies, DESCRIPTIVE statistics, MULTIVARIATE analysis, LONGITUDINAL method, ODDS ratio, MEDICAL records, ACQUISITION of data, ISCHEMIC stroke, PLATELET aggregation inhibitors, SOCIODEMOGRAPHIC factors, CONFIDENCE intervals, COMPARATIVE studies, PROPORTIONAL hazards models
Abstract

Background Antiplatelet therapy (APT) can substantially reduce the risk of further vascular events in individuals with established atherosclerotic cardiovascular disease (ASCVD). However, knowledge regarding the extent and determinants of APT use is limited. Objectives Estimate the extent and identify patient groups at risk of suboptimal APT use at different stages of the treatment pathway. Methods Retrospective cohort study using linked NHS Scotland administrative data of all adults hospitalised for an acute ASCVD event (n=150 728) from 2009 to 2017. Proportions of patients initiating, adhering to, discontinuing and re-initiating APT were calculated overall and separately for myocardial infarction (MI), ischaemic stroke and peripheral arterial disease (PAD). Multivariable logistic regression and Cox proportional hazards models were used to assess the contribution of patient characteristics in initiating and discontinuing APT. Results Of patients hospitalised with ASCVD, 84% initiated APT: 94% following an MI, 83% following an ischaemic stroke and 68% following a PAD event. Characteristics associated with lower odds of initiation included female sex (22% less likely than men), age below 50 years or above 70 years (aged <50 years 26% less likely, and aged 70-79, 80-89 and ≥90 years 21%, 39% and 51% less likely, respectively, than those aged 60-69 years) and history of mental health-related hospitalisation (45% less likely). Of all APT-treated individuals, 22% discontinued treatment. Characteristics associated with discontinuation were similar to those related to non-initiation. Conclusions APT use remains suboptimal for the secondary prevention of ASCVD, particularly among women and older patients, and following ischaemic stroke and PAD hospitalisations. [ABSTRACT FROM AUTHOR]

Published
2024
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20. The case for early identification and intervention of chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Abraham, Georgi, Ademi, Zanfina, Alicic, Radica Z., de Boer, Ian, Deo, Raj, Ding, Xiaoqiang, Ebert, Natalie, Fowler, Kevin J., Fried, Linda F., Gansevoort, Ron T., Garcia-Garcia, Guillermo, Hemmelgarn, Brenda R., Lee Harding, Jessica, Hudson, Joanna Q., Iseki, Kunitoshi, Jotwani, Vasantha, Karliner, Leah S., Levey, Andrew S., Liew, Adrian, Lin, Peter J., Luk, Andrea O.Y., Martínez, Verónica, Moran, Andrew E., Nguyen, Mai, Obrador, Gregorio T., O’Donoghue, Donal, Pavkov, Meda E., Pavlinac, Jessie, Powe, Neil R., Seegmiller, Jesse C., Shen, Jenny I., Shroff, Rukshana, Solá, Laura, Taal, Maarten W., Tattersall, James, Vassalotti, Joseph A., Weir, Matthew R., Zomer, Ella, Shlipak, Michael G., Tummalapalli, Sri Lekha, Boulware, L. Ebony, Grams, Morgan E., Ix, Joachim H., Jha, Vivekanand, Kengne, Andre-Pascal, Madero, Magdalena, Mihaylova, Borislava, Tangri, Navdeep, Cheung, Michael, Jadoul, Michel, Winkelmayer, Wolfgang C., and Zoungas, Sophia

Published
2021
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21. Device-Measured Change in Physical Activity in Primary School Children During the UK COVID-19 Pandemic Lockdown: A Longitudinal Study.

Author

Scales, James, Chavda, Jasmine, Ikeda, Erika, Tsocheva, Ivelina, Dove, Rosamund E., Wood, Helen E., Kalsi, Harpal, Colligan, Grainne, Griffiths, Lewis, Day, Bill, Crichlow, Cheryll, Keighley, Amanda, Fletcher, Monica, Newby, Chris, Tomini, Florian, Balkwill, Fran, Mihaylova, Borislava, Grigg, Jonathan, Beevers, Sean, and Eldridge, Sandra

Subjects
COVID-19 pandemic, PHYSICAL activity, SCHOOL children, PRIMARY schools, STAY-at-home orders
Abstract

Background: Lockdown measures, including school closures, due to the COVID-19 pandemic have caused widespread disruption to children's lives. The aim of this study was to explore the impact of a national lockdown on children's physical activity using seasonally matched accelerometry data. Methods: Using a pre/post observational design, 179 children aged 8 to 11 years provided physical activity data measured using hip-worn triaxial accelerometers worn for 5 consecutive days prepandemic and during the January to March 2021 lockdown. Multilevel regression analyses adjusted for covariates were used to assess the impact of lockdown on time spent in sedentary and moderate to vigorous physical activity. Results: A 10.8-minute reduction in daily time spent in moderate to vigorous physical activity (standard error: 2.3 min/d, P <.001) and a 33.2-minute increase in daily sedentary activity (standard error: 5.5 min/d, P <.001) were observed during lockdown. This reflected a reduction in daily moderate to vigorous physical activity for those unable to attend school (−13.1 [2.3] min/d, P <.001) during lockdown, with no significant change for those who continued to attend school (0.4 [4.0] min/d, P <.925). Conclusion: These findings suggest that the loss of in-person schooling was the single largest impact on physical activity in this cohort of primary school children in London, Luton, and Dunstable, United Kingdom. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Association between health insurance cost-sharing and choice of hospital tier for cardiovascular diseases in China: a prospective cohort study

Author

Levy, Muriel, primary, Buckell, John, additional, Clarke, Robert, additional, Wu, Nina, additional, Pei, Pei, additional, Sun, Dianjianyi, additional, Avery, Daniel, additional, Zhang, Hua, additional, Lv, Jun, additional, Yu, Canqing, additional, Li, Liming, additional, Chen, Zhengming, additional, Yip, Winnie, additional, Chen, Yiping, additional, Mihaylova, Borislava, additional, Chen, Junshi, additional, Collins, Rory, additional, Wang, Chen, additional, Peto, Richard, additional, Walters, Robin, additional, Barnard, Maxim, additional, Bennett, Derrick, additional, Boxall, Ruth, additional, Chan, Kahung, additional, Clarke, Johnathan, additional, Du, Huaidong, additional, Mohamed, Ahmed Edris, additional, Fry, Hannah, additional, Gilbert, Simon, additional, Im, Pek Kei, additional, Iona, Andri, additional, Kakkoura, Maria, additional, Kartsonaki, Christiana, additional, Lam, Hubert, additional, Lin, Kuang, additional, Liu, James, additional, Mazidi, Mohsen, additional, Millwood, Iona, additional, Morris, Sam, additional, Nie, Qunhua, additional, Pozaricki, Alfred, additional, Ryder, Paul, additional, Said, Saredo, additional, Schmidt, Dan, additional, Stevens, Becky, additional, Turnbull, Iain, additional, Wang, Baihan, additional, Wang, Lin, additional, Wright, Neil, additional, Yang, Ling, additional, Yang, Xiaoming, additional, Yao, Pang, additional, Han, Xiao, additional, Hou, Can, additional, Xia, Qingmei, additional, Liu, Chao, additional, Chen, Naying, additional, Liu, Duo, additional, Tang, Zhenzhu, additional, Chen, Ningyu, additional, Jiang, Qilian, additional, Lan, Jian, additional, Li, Mingqiang, additional, Liu, Yun, additional, Meng, Fanwen, additional, Meng, Jinhuai, additional, Pan, Rong, additional, Qin, Yulu, additional, Wang, Ping, additional, Wang, Sisi, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Dong, Caixia, additional, Ge, Pengfei, additional, Ren, Xiaolan, additional, Li, Zhongxiao, additional, Mao, Enke, additional, Wang, Tao, additional, Zhang, Hui, additional, Zhang, Xi, additional, Chen, Jinyan, additional, Hu, Ximin, additional, Wang, Xiaohuan, additional, Guo, Zhendong, additional, Li, Huimei, additional, Li, Yilei, additional, Weng, Min, additional, Wu, Shukuan, additional, Yan, Shichun, additional, Zou, Mingyuan, additional, Zhou, Xue, additional, Guo, Ziyan, additional, Kang, Quan, additional, Li, Yanjie, additional, Yu, Bo, additional, Xu, Qinai, additional, Chang, Liang, additional, Fan, Lei, additional, Feng, Shixian, additional, Zhang, Ding, additional, Zhou, Gang, additional, Gao, Yulian, additional, He, Tianyou, additional, He, Pan, additional, Hu, Chen, additional, Sun, Huarong, additional, Zhang, Xukui, additional, Chen, Biyun, additional, Fu, Zhongxi, additional, Huang, Yuelong, additional, Liu, Huilin, additional, Xu, Qiaohua, additional, Yin, Li, additional, Long, Huajun, additional, Xu, Xin, additional, Zhang, Hao, additional, Zhang, Libo, additional, Su, Jian, additional, Tao, Ran, additional, Wu, Ming, additional, Yang, Jie, additional, Zhou, Jinyi, additional, Zhou, Yonglin, additional, Hu, Yihe, additional, Hua, Yujie, additional, Jin, Jianrong, additional, Liu, Fang, additional, Liu, Jingchao, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Jun, additional, Cheng, Liang, additional, Du, Ranran, additional, Gao, Ruqin, additional, Li, Feifei, additional, Li, Shanpeng, additional, Liu, Yongmei, additional, Ning, Feng, additional, Pang, Zengchang, additional, Sun, Xiaohui, additional, Tian, Xiaocao, additional, Wang, Shaojie, additional, Zhai, Yaoming, additional, Hou, Wei, additional, Lv, Silu, additional, Wang, Junzheng, additional, Chen, Xiaofang, additional, Wu, Xianping, additional, Zhang, Ningmei, additional, Chang, Xiaoyu, additional, Li, Jianguo, additional, Liu, Jiaqiu, additional, Luo, Guojin, additional, Sun, Qiang, additional, Zhong, Xunfu, additional, Gong, Weiwei, additional, Hu, Ruying, additional, Wang, Hao, additional, Wang, Meng, additional, Yu, Min, additional, Chen, Lingli, additional, Gu, Qijun, additional, Pan, Dongxia, additional, Wang, Chunmei, additional, Xie, Kaixu, additional, Zhang, Xiaoyi, additional, Chen, Hongyuan, additional, Liu, Liyang, additional, Gou, Haiyan, additional, Wang, Xun, additional, Ding, Jing, additional, Zhang, Ning, additional, Mao, Yueshi, additional, Zhou, Shanshan, additional, Jin, Lirong, additional, Cheng, Xin, additional, Lu, Yun, additional, Chen, Li, additional, Hao, Zilong, additional, Xing, Xiaona, additional, Wang, Lei, additional, Ju, Naixin, additional, Mao, Yiting, additional, Li, Shuya, additional, Du, Peng, additional, Wang, Deren, additional, Sun, Xiaojia, additional, You, Shihao, additional, Wang, Weizhi, additional, Zhu, Yanmei, additional, Li, Xiaojiu, additional, and Dong, Yi, additional

Published
2024
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24. Place-based household vouchers for locally supplied fruit and vegetables: The Fresh Street Pilot Cluster Randomised Controlled Trial

Author

Relton, Clare, primary, Blake, Megan, additional, Bridge, Gemma, additional, Umney, Darren, additional, Taylor, Stephanie, additional, Adams, Jean, additional, Mihaylova, Borislava, additional, Griffiths, Chris, additional, Hooper, Richard, additional, Phillips, Rachel, additional, Palmer, Louis, additional, Gamston, Annette, additional, and Williamson, Kevin, additional

Published
2024
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26. Supported online self-management versus care as usual for symptoms of fatigue, pain and urgency/incontinence in adults with inflammatory bowel disease (IBD-BOOST): study protocol for a randomised controlled trial

Author

Norton, Christine, Syred, Jonathan, Kerry, Sally, Artom, Micol, Sweeney, Louise, Hart, Ailsa, Czuber-Dochan, Wladyslawa, Taylor, Stephanie J. C., Mihaylova, Borislava, Roukas, Chris, Aziz, Qasim, Miller, Laura, Pollok, Richard, Saxena, Sonia, Stagg, Imogen, Terry, Helen, Zenasni, Zohra, Dibley, Lesley, and Moss-Morris, Rona

Published
2021
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27. 2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk

Author

Mach, François, Baigent, Colin, Catapano, Alberico L., Koskinas, Konstantinos C., Casula, Manuela, Badimon, Lina, Chapman, M. John, De Backer, Guy G., Delgado, Victoria, Ference, Brian A., Graham, Ian M., Halliday, Alison, Landmesser, Ulf, Mihaylova, Borislava, Pedersen, Terje R., Riccardi, Gabriele, Richter, Dimitrios J., Sabatine, Marc S., Taskinen, Marja-Riitta, Tokgozoglu, Lale, Wiklund, Olov, Windecker, Stephan, Aboyans, Victor, Collet, Jean-Philippe, Dean, Veronica, Fitzsimons, Donna, Gale, Chris P., Grobbee, Diederick, Halvorsen, Sigrun, Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Leclercq, Christophe, Lettino, Maddalena, Lewis, Basil S., Merkely, Bela, Mueller, Christian, Petersen, Steffen, Petronio, Anna Sonia, Roffi, Marco, Shlyakhto, Evgeny, Simpson, Iain A., Sousa-Uva, Miguel, Touyz, Rhian M., Nibouche, Djamaleddine, Zelveian, Parounak H., Siostrzonek, Peter, Najafov, Ruslan, van de Borne, Philippe, Pojskic, Belma, Postadzhiyan, Arman, Kypris, Lambros, Špinar, Jindřich, Larsen, Mogens Lytken, Eldin, Hesham Salah, Viigimaa, Margus, Strandberg, Timo E., Ferrières, Jean, Agladze, Rusudan, Laufs, Ulrich, Rallidis, Loukianos, Bajnok, László, Gudjónsson, Thorbjörn, Maher, Vincent, Henkin, Yaakov, Gulizia, Michele Massimo, Mussagaliyeva, Aisulu, Bajraktari, Gani, Kerimkulova, Alina, Latkovskis, Gustavs, Hamoui, Omar, Slapikas, Rimvydas, Visser, Laurent, Dingli, Philip, Ivanov, Victoria, Boskovic, Aneta, Nazzi, Mbarek, Visseren, Frank, Mitevska, Irena, Retterstøl, Kjetil, Jankowski, Piotr, Fontes-Carvalho, Ricardo, Gaita, Dan, Ezhov, Marat, Foscoli, Marina, Giga, Vojislav, Pella, Daniel, Fras, Zlatko, Perez de Isla, Leopoldo, Hagström, Emil, Lehmann, Roger, Abid, Leila, Ozdogan, Oner, Mitchenko, Olena, and Patel, Riyaz S.

Published
2019
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28. Cost-effectiveness of lipid lowering with statins and ezetimibe in chronic kidney disease

Author

Collins, R., Baigent, C., Landray, M.J., Bray, C., Chen, Y., Baxter, A., Young, A., Hill, M., Knott, C., Cass, A., Feldt-Rasmussen, B., Fellström, B., Grobbee, D.E., Grönhagen-Riska, C., Haas, M., Holdaas, H., Hooi, L.S., Jiang, L., Kasiske, B., Krairittichai, U., Levin, A., Massy, Z.A., Tesar, V., Walker, R., Wanner, C., Wheeler, D.C., Wiecek, A., Dasgupta, T., Herrington, W., Lewis, D., Mafham, M., Majoni, W., Reith, C., Emberson, J., Parish, S., Simpson, D., Strony, J., Musliner, T., Agodoa, L., Armitage, J., Chen, Z., Craig, J., de Zeeuw, D., Gaziano, J.M., Grimm, R., Krane, V., Neal, B., Ophascharoensuk, V., Pedersen, T., Sleight, P., Tobert, J., Tomson, C., Schlackow, Iryna, Kent, Seamus, Herrington, William, Emberson, Jonathan, Haynes, Richard, Reith, Christina, Collins, Rory, Landray, Martin J., Gray, Alastair, Baigent, Colin, and Mihaylova, Borislava

Published
2019
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29. Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

Author

Armitage, Jane, Baigent, Colin, Barnes, Elizabeth, Betteridge, D John, Blackwell, Lisa, Blazing, Michael, Bowman, Louise, Braunwald, Eugene, Byington, Robert, Cannon, Christopher, Clearfield, Michael, Colhoun, Helen, Collins, Rory, Dahlöf, Björn, Davies, Kelly, Davis, Barry, de Lemos, James, Downs, John R, Durrington, Paul, Emberson, Jonathan, Fellström, Bengt, Flather, Marcus, Ford, Ian, Franzosi, Maria Grazia, Fulcher, Jordan, Fuller, John, Furberg, Curt, Gordon, David, Goto, Shinya, Gotto, Antonio, Halls, Heather, Harper, Charlie, Hawkins, C Morton, Herrington, Will, Hitman, Graham, Holdaas, Hallvard, Holland, Lisa, Jardine, Alan, Jukema, J Wouter, Kastelein, John, Kean, Sharon, Keech, Anthony, Kirby, Adrienne, Kjekshus, John, Knatterud (deceased), Genell, Knopp (deceased), Robert, Koenig, Wolfgang, Koren, Michael, Krane, Vera, Landray, Martin J, LaRosa, John, Lonn, Eva, MacFarlane, Peter, MacMahon, Stephen, Maggioni, Aldo, Marchioli, Roberto, Marschner, Ian, Mihaylova, Borislava, Moyé, Lemuel, Murphy, Sabina, Nakamura, Haruo, Neil, Andrew, Newman, Connie, O'Connell, Rachel, Packard, Chris, Parish, Sarah, Pedersen, Terje, Peto, Richard, Pfeffer, Marc, Poulter, Neil, Preiss, David, Reith, Christina, Ridker, Paul, Robertson, Michele, Sacks, Frank, Sattar, Naveed, Schmieder, Roland, Serruys, Patrick, Sever, Peter, Shaw, John, Shear, Charles, Simes, John, Sleight, Peter, Spata, Enti, Tavazzi, Luigi, Tobert, Jonathan, Tognoni, Gianni, Tonkin, Andrew, Trompet, Stella, Varigos, John, Wanner, Christoph, Wedel, Hans, White, Harvey, Wikstrand, John, Wilhelmsen, Lars, Wilson, Kate, Young, Robin, Yusuf, Salim, and Zannad, Faiez

Published
2019
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32. An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment

Author

Beard, David, Carr, Andrew, Cook, Jonathan, Cooper, Cushla, Dean, Benjamin, Donovan, Jenny L., Gray, Alastair, Gwilym, Stephen, Judge, Andrew, Merritt, Naomi, Moser, Jane, Rees, Jonathan, Rombach, Ines, Savulescu, Julian, Tracey, Irene, Wartolowska, Karolina, Blazeby, Jane M., Barham, Paul, Brookes, Sara T., Crosby, Tom, Falk, Stephen J., Griffin, S. Michael, Hollingworth, William, Hollowood, Andrew D., Krysztopik, Richard, Lewis, Wyn, Nicklin, Jo, Streets, Christopher, Strong, Sean, Titcomb, Dan, Williams, Geraint, Birtle, Alison, Bryan, Rik, Catto, James, Chester, John, French, Ann, Hall, Emma, Harris, Chris, Johnson, Mark, Jones, Rob, Keeley, Francis, Kirkbank, Tony, Kockelbergh, Roger, Lewis, Rebecca, Newton, Michelle, Powles, Thomas, Waters, Rachel, Winterbottom, Andrew, Halliday, Alison, Becquemin, Jean-Pierre, Belli, Anna, Bosiers, Marc, Cao, Piergiorgio, Davies, Christina, Gough, Michael, Hayter, Elizabeth, Leopold, Peter, McDonald, Sumaira, Michaels, Jonathan, Mihaylova, Borislava, Peto, Richard, Robertson, Steven, Rothwell, Peter, Scott, Rachael, Thomas, Dafydd, Vermassen, Frank, Stein, Rob, Bartlett, John, Cameron, David, Campbell, Amy, Canney, Peter, Dunn, Janet, Earl, Helena, Falzon, Mary, Francis, Adele, Hall, Peter, Harmer, Victoria, Higgins, Helen, Hiller, Louise, Hughes-Davies, Luke, Hulme, Claire, Macpherson, Iain, Makris, Andreas, Marshall, Andrea, McCabe, Christopher, Morgan, Adrienne, Pinder, Sarah, Poole, Christopher, Rea, Daniel, Stallard, Nigel, Jepson, Marcus, Elliott, Daisy, Conefrey, Carmel, Wade, Julia, Rooshenas, Leila, and Wilson, Caroline

Published
2018
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33. Impact of CKD on Household Income

Author

Collins, R., Baigent, C., Landray, M.J., Bray, C., Chen, Y., Baxter, A., Young, A., Hill, M., Knott, C., Cass, A., Feldt-Rasmussen, B., Fellström, B., Grobbee, D.E., Grönhagen-Riska, C., Haas, M., Holdaas, H., Hooi, L.S., Jiang, L., Kasiske, B., Krairittichai, U., Levin, A., Massy, Z.A., Tesar, V., Walker, R., Wanner, C., Wheeler, D.C., Wiecek, A., Dasgupta, T., Herrington, W., Lewis, D., Mafham, M., Majoni, W., Reith, C., Emberson, J., Parish, S., Simpson, D., Strony, J., Musliner, T., Agodoa, L., Armitage, J., Chen, Z., Craig, J., de Zeeuw, D., Gaziano, J.M., Grimm, R., Krane, V., Neal, B., Ophascharoensuk, V., Pedersen, T., Sleight, P., Tobert, J., Tomson, C., Morton, Rachael L., Schlackow, Iryna, Gray, Alastair, Emberson, Jonathan, Herrington, William, Staplin, Natalie, Reith, Christina, Howard, Kirsten, Landray, Martin J., Cass, Alan, Baigent, Colin, and Mihaylova, Borislava

Published
2018
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38. Long-term cardiovascular risks and statin treatment impact on socioeconomic inequalities: microsimulation model

Author

Wu, Runguo, primary, Williams, Claire, additional, Zhou, Junwen, additional, Schlackow, Iryna, additional, Emberson, Jonathan, additional, Reith, Christina, additional, Keech, Anthony, additional, Robson, John, additional, Armitage, Jane, additional, Gray, Alastair, additional, Simes, John, additional, Baigent, Colin, additional, and Mihaylova, Borislava, additional

Published
2023
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39. Hospital costs in relation to body-mass index in 1·1 million women in England: a prospective cohort study

Author

Abbiss, Hayley, Abbott, Simon, Alison, Rupert, Armstrong, Miranda, Baker, Krys, Balkwill, Angela, Barnes, Isobel, Beral, Valerie, Black, Judith, Blanks, Roger, Bradbury, Kathryn, Brown, Anna, Cairns, Benjamin, Canoy, Dexter, Chadwick, Andrew, Ewart, Dave, Ewart, Sarah, Fletcher, Lee, Floud, Sarah, Gathani, Toral, Gerrard, Laura, Goodill, Adrian, Green, Jane, Guiver, Lynden, Heath, Alicia, Hogg, Darren, Hozak, Michal, Lingard, Isobel, Kan, Sau Wan, Langston, Nicky, Moser, Kath, Pirie, Kirstin, Price, Alison, Reeves, Gillian, Shaw, Keith, Sherman, Emma, Simpson, Rachel, Strange, Helena, Sweetland, Sian, Tipper, Sarah, Travis, Ruth, Trickett, Lyndsey, Webster, Anthony, Wotton, Clare, Wright, Lucy, Yang, Owen, Young, Heather, Banks, Emily, Carpenter, Lucy, Dezateux, Carol, Patnick, Julietta, Peto, Richard, Sudlow, Cathie, Kent, Seamus, Gray, Alastair, Jebb, Susan A, Cairns, Benjamin J, and Mihaylova, Borislava

Published
2017
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40. Long-term cardiovascular risks and the impact of statin treatment on socioeconomic inequalities: a microsimulation model.

Author

Wu, Runguo, Williams, Claire, Zhou, Junwen, Schlackow, Iryna, Emberson, Jonathan, Reith, Christina, Keech, Anthony, Robson, John, Armitage, Jane, Gray, Alastair, Simes, John, Baigent, Colin, Mihaylova, Borislava, Barnes, Elizabeth, Blackwell, Lisa, Collins, Rory, Davies, Kelly, Fulcher, Jordan, Halls, Heather, and Herrington, William G

Subjects
STATINS (Cardiovascular agents), CARDIOVASCULAR diseases risk factors, QUALITY-adjusted life years, LIFE expectancy, MYOCARDIAL infarction
Abstract

Background: UK cardiovascular disease (CVD) incidence and mortality have declined in recent decades but socioeconomic inequalities persist. Aim: To present a new CVD model, and project health outcomes and the impact of guideline-recommended statin treatment across quintiles of socioeconomic deprivation in the UK. Design and setting: A lifetime microsimulation model was developed using 117 896 participants in 16 statin trials, 501 854 UK Biobank (UKB) participants, and quality-of-life data from national health surveys. Method: A CVD microsimulation model was developed using risk equations for myocardial infarction, stroke, coronary revascularisation, cancer, and vascular and non-vascular death, estimated using trial data. The authors calibrated and further developed this model in the UKB cohort, including further characteristics and a diabetes risk equation, and validated the model in UKB and Whitehall II cohorts. The model was used to predict CVD incidence, life expectancy, quality-adjusted life years (QALYs), and the impact of UK guideline-recommended statin treatment across socioeconomic deprivation quintiles. Results: Age, sex, socioeconomic deprivation, smoking, hypertension, diabetes, and cardiovascular events were key CVD risk determinants. Model-predicted event rates corresponded well to observed rates across participant categories. The model projected strong gradients in remaining life expectancy, with 4–5-year (5–8 QALYs) gaps between the least and most socioeconomically deprived quintiles. Guideline-recommended statin treatment was projected to increase QALYs, with larger gains in quintiles of higher deprivation. Conclusion: The study demonstrated the potential of guideline-recommended statin treatment to reduce socioeconomic inequalities. This CVD model is a novel resource for individualised long-term projections of health outcomes of CVD treatments. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Non-randomised feasibility study testing a primary care intervention to promote engagement in an online health community for adults with troublesome asthma: protocol

Author

Karampatakis, Georgios Dimitrios, primary, Wood, Helen E, additional, Griffiths, Chris J, additional, Taylor, Stephanie J C, additional, Toffolutti, Veronica, additional, Bird, Victoria J, additional, Lea, Nathan C, additional, Ashcroft, Richard E, additional, Day, Bill, additional, Coulson, Neil S, additional, Panzarasa, Pietro, additional, Li, Xiancheng, additional, Sheikh, Aziz, additional, Relton, Clare, additional, Sastry, Nishanth, additional, Watson, Jane S, additional, Marsh, Viv, additional, Mant, Jonathan, additional, Mihaylova, Borislava, additional, Walker, Neil, additional, and De Simoni, Anna, additional

Published
2023
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42. Cost-effectiveness of Simvastatin plus Ezetimibe for Cardiovascular Prevention in CKD: Results of the Study of Heart and Renal Protection (SHARP)

Author

Collins, R., Baigent, C., Landray, M.J., Bray, C., Chen, Y., Baxter, A., Young, A., Hill, M., Knott, C., Cass, A., Feldt-Rasmussen, B., Fellström, B., Grobbee, D.E., Grönhagen-Riska, C., Haas, M., Holdaas, H., Hooi, L.S., Jiang, L., Kasiske, B., Krairittichai, U., Levin, A., Massy, Z.A., Tesar, V., Walker, R., Wanner, C., Wheeler, D.C., Wiecek, A., Dasgupta, T., Herrington, W., Lewis, D., Mafham, M., Majoni, W., Reith, C., Emberson, J., Parish, S., Simpson, D., Strony, J., Musliner, T., Agodoa, L., Armitage, J., Chen, Z., Craig, J., de Zeeuw, D., Gaziano, J.M., Grimm, R., Krane, V., Neal, B., Ophascharoensuk, V., Pedersen, T., Sleight, P., Tobert, J., Tomson, C., Mihaylova, Borislava, Schlackow, Iryna, Herrington, William, Lozano-Kühne, Jingky, Kent, Seamus, Emberson, Jonathan, Reith, Christina, Haynes, Richard, Cass, Alan, Craig, Jonathan, Gray, Alastair, Collins, Rory, Landray, Martin J., and Baigent, Colin

Published
2016
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43. Impact of Improving Community-Based Access to Malaria Diagnosis and Treatment on Household Costs

Author

Castellani, Joëlle, Nsungwa-Sabiiti, Jesca, Mihaylova, Borislava, Ajayi, IkeOluwapo O., Siribié, Mohamadou, Afonne, Chinenye, Balyeku, Andrew, Sermé, Luc, Sanou, Armande K., Sombié, Benjamin S., Tiono, Alfred B., Sirima, Sodiomon B., Kabarungi, Vanessa, Falade, Catherine O., Kyaligonza, Josephine, Evers, Silvia M. A. A., Paulus, Aggie T. G., Petzold, Max, Singlovic, Jan, and Gomes, Melba

Published
2016

45. Fluid optimisation in emergency laparotomy (FLO-ELA) trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Author

Edwards, Mark, Forbes, Gordon, Walker, Neil, Morton, Dion G., Mythen, Monty G., Murray, Dave, Anderson, Iain, Mihaylova, Borislava, Thomson, Ann, Taylor, Matt, Hollyman, Marianne, Phillips, Rachel, Young, Keith, Kahan, Brennan C., Pearse, Rupert M., and Grocott, Mike

Abstract

Introduction: postoperative morbidity and mortality in patients undergoing major emergency gastrointestinal surgery are a major burden on healthcare systems. Optimal management of perioperative intravenous fluids may reduce mortality rates and improve outcomes from surgery. Previous small trials of cardiac-output guided haemodynamic therapy algorithms in patients undergoing gastrointestinal surgery have suggested this intervention results in reduced complications and a modest reduction in mortality. However, this existing evidence is based mainly on elective (planned) surgery, with little evaluation in the emergency setting. There are fundamental clinical and pathophysiological differences between the planned and emergency surgical setting which may influence the effects of this intervention. A large definitive trial in emergency surgery is needed to confirm or refute the potential benefits observed in elective surgery and to inform widespread clinical practice.Methods: the FLO-ELA trial is a multi-centre, parallel-group, open, randomised controlled trial. 3138 patients aged 50 and over undergoing major emergency gastrointestinal surgery will be randomly allocated in a 1:1 ratio using minimisation to minimally invasive cardiac output monitoring to guide protocolised administration of intra-venous fluid, or usual care without cardiac output monitoring. The trial intervention will be carried out during surgery and for up to 6 h postoperatively. The trial is funded through an efficient design call by the National Institute for Health and Care Research Health Technology Assessment (NIHR HTA) programme and uses existing routinely collected datasets for the majority of data collection. The primary outcome is the number of days alive and out of hospital within 90 days of randomisation. Participants and those delivering the intervention will not be blinded to treatment allocation. Participant recruitment started in September 2017 with a 1-year internal pilot phase and is ongoing at the time of publication.Discussion: this will be the largest contemporary randomised trial examining the effectiveness of perioperative cardiac output-guided haemodynamic therapy in patients undergoing major emergency gastrointestinal surgery. The multi-centre design and broad inclusion criteria support the external validity of the trial. Although the clinical teams delivering the trial interventions will not be blinded, significant trial outcome measures are objective and not subject to detection bias.Trial registration: ISRCTN 14729158. Registered on 02 May 2017.

Published
2023

47. Additional file 1 of Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Author

Edwards, Mark R., Forbes, Gordon, Walker, Neil, Morton, Dion G., Mythen, Monty G., Murray, Dave, Anderson, Iain, Mihaylova, Borislava, Thomson, Ann, Taylor, Matt, Hollyman, Marianne, Phillips, Rachel, Young, Keith, Kahan, Brennan C., Pearse, Rupert M., and Grocott, Michael P. W.

Abstract

Additional file 1.

Published
2023
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48. Additional file 2 of Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Author

Edwards, Mark R., Forbes, Gordon, Walker, Neil, Morton, Dion G., Mythen, Monty G., Murray, Dave, Anderson, Iain, Mihaylova, Borislava, Thomson, Ann, Taylor, Matt, Hollyman, Marianne, Phillips, Rachel, Young, Keith, Kahan, Brennan C., Pearse, Rupert M., and Grocott, Michael P. W.

Abstract

Additional file 2. SPIRIT checklist.

Published
2023
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