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1. Influence of MUC5B gene on antisynthetase syndrome

Author

López-Mejías, Raquel, Remuzgo-Martínez, Sara, Genre, Fernanda, Pulito-Cueto, Verónica, Rozas, Sonia M. Fernández, Llorca, Javier, Fernández, David Iturbe, Cuesta, Víctor M. Mora, Ortego-Centeno, Norberto, Gómez, Nair Pérez, Mera-Varela, Antonio, Martínez-Barrio, Julia, López-Longo, Francisco Javier, Mijares, Verónica, Lera-Gómez, Leticia, Usetti, María Piedad, Laporta, Rosalía, Pérez, Virginia, Gafas, Alicia De Pablo, González, María Aránzazu Alfranca, Calvo-Alén, Jaime, Romero-Bueno, Fredeswinda, Sanchez-Pernaute, Olga, Nuno, Laura, Bonilla, Gema, Balsa, Alejandro, Hernández-González, Fernanda, Grafia, Ignacio, Prieto-González, Sergio, Narvaez, Javier, Trallero-Araguas, Ernesto, Selva-O’Callaghan, Albert, Gualillo, Oreste, Castañeda, Santos, Cavagna, Lorenzo, Cifrian, José M., and González-Gay, Miguel A.

Published
2020
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4. Brief Report: Association of HLA–DRB1*01 With IgA Vasculitis (Henoch-Schönlein)

Author

López-Mejías, Raquel, Genre, Fernanda, Pérez, Belén Sevilla, Castañeda, Santos, Ortego-Centeno, Norberto, Llorca, Javier, Ubilla, Begoña, Remuzgo-Martínez, Sara, Mijares, Verónica, Pina, Trinitario, Calvo-Río, Vanesa, Márquez, Ana, Sala-Icardo, Luis, Miranda-Filloy, José A., Conde-Jaldón, Marta, Ortiz-Fernández, Lourdes, Rubio, Esteban, Luque, Manuel León, Blanco-Madrigal, Juan M., Galíndez-Aguirregoikoa, Eva, González-Vela, Carmen M., Ocejo-Vinyals, Gonzalo J., Escribano, Francisca González, Martín, Javier, Blanco, Ricardo, and González-Gay, Miguel A.

Published
2015
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7. Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis

Author

Genre, Fernanda, primary, Rueda-Gotor, Javier, additional, Remuzgo-Martínez, Sara, additional, Pulito-Cueto, Verónica, additional, Corrales, Alfonso, additional, Mijares, Verónica, additional, Lera-Gómez, Leticia, additional, Portilla, Virginia, additional, Expósito, Rosa, additional, Mata, Cristina, additional, Blanco, Ricardo, additional, Llorca, Javier, additional, Hernández-Hernández, Vanesa, additional, Vicente, Esther, additional, Fernández-Carballido, Cristina, additional, Martínez-Vidal, María Paz, additional, Castro-Corredor, David, additional, Anino-Fernández, Joaquín, additional, Rodríguez-Lozano, Carlos, additional, Gualillo, Oreste, additional, Quevedo-Abeledo, Juan Carlos, additional, Castañeda, Santos, additional, Ferraz-Amaro, Iván, additional, López-Mejías, Raquel, additional, and González-Gay, Miguel Á., additional

Published
2020
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8. Role of vascular endotelial growth factor polymorphisms in interstitial lung disease

Author

Remuzgo Martinez, Sara, primary, Mora Cuesta, Victor Manuel, additional, Iturbe Fernández, David, additional, Fernández Rozas, Sonia María, additional, López Mejías, Raquel, additional, Genre, Fernanda, additional, Pulito Cueto, Verónica, additional, Mijares, Verónica, additional, Lera Gómez, Leticia, additional, Alonso Lecue, Pilar, additional, Usetti, María Piedad, additional, Laporta, Rosalía, additional, Pérez, Virginia, additional, De Pablo Gafas, Alicia, additional, González-Gay, Miguel Ángel, additional, and Cifrián, José Manuel, additional

Published
2019
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10. GENETIC AND FUNCTIONAL STUDY OF OMENTIN REGARDING CARDIOVASCULAR RISK IN AXIAL GENETIC AND FUNCTIONAL STUDY OF OMENTIN REGARDING CARDIOVASCULAR RISK IN AXIAL SPONDYLOARTHRITIS

Author

Genre, Fernanda, Rueda-Gotor, Javier, Remuzgo-Martínez, Sara, Pulito-Cueto, Verónica, Corrales, Alfonso, Mijares, Verónica, Lera-Gómez, Leticia, Portilla, Virginia, Expósito, Rosa, Mata, Cristina, Ferraz-Amaro, Iván, Hernández-Hernández, Vanessa, Castañeda, Santos, Vicente, Esther, Fernández-Carballido, Cristina, Martínez-Vidal, María Paz, Castro-Corredor, David, Anino-Fernández, Joaquín, Quevedo-Abeledo, Juan Carlos, Rodríguez-Lozano, Carlos, Blanco, Ricardo, Gualillo, Oreste, Martín, J., Llorca, Javier, López-Mejías, Raquel, and González-Gay, M. A.

Published
2019

11. A Genome-Wide Association Study Identifies rs116199914 As an Intergenic Variant Associated with Carotid Intima-Media Thickness in Spanish Patients with Rheumatoid Arthritis

Author

López-Mejías, Raquel, Genre, Fernanda, Remuzgo-Martínez, Sara, Carmona, David, Pulito-Cueto, Verónica, González-Juanatey, Carlos, Corrales, Alfonso, Vicente, Esther, Miranda-Filloy, J. A., Segura Tejera, Beatriz, Ramírez Huaranga, Marco A., Mijares, Verónica, Lera-Gómez, Leticia, Blanco, Ricardo, Robustillo-Villarino, Montserrat, Rodríguez-Carrio, Javier, Suárez, Ana, Alperi-López, Mercedes, Ballina García, Francisco Javier, López Longo, Francisco Javier, Narváez, Francisco Javier, Alegre, Juan José, Mera, Antonio, Perez Pampín, Eva, González, Antonio, Raya Álvarez, Enrique, López-Pedrera, Chary, Gómez Vaquero, Carmen, Balsa, Alejandro, Pascual-Salcedo, Dora, Carreira, P., González-Álvaro, Isidoro, Rodríguez Rodríguez, Luis, Fernández Gutiérrez, Benjamín, Ferraz-Amaro, Iván, Castañeda, Santos, Martín, J., Llorca, Javier, and González-Gay, M. A.

Published
2018

12. OP0304 GENETIC AND FUNCTIONAL STUDY OF OMENTIN REGARDING CARDIOVASCULAR RISK IN AXIAL SPONDYLOARTHRITIS

Author

Genre, Fernanda, primary, Rueda-Gotor, Javier, additional, Remuzgo-Martínez, Sara, additional, Pulito-Cueto, Verónica, additional, Corrales, Alfonso, additional, Mijares, Verónica, additional, Lera-Gómez, Leticia, additional, Portilla, Virginia, additional, Expósito, Rosa, additional, Mata, Cristina, additional, Ferraz-Amaro, Iván, additional, Hernández-Hernández, Vanessa, additional, Castañeda, Santos, additional, Vicente, Esther, additional, Fernández-Carballido, Cristina, additional, Martínez-Vidal, Maria Paz, additional, Castro-Corredor, David, additional, Anino-Fernández, Joaquín, additional, Quevedo-Abeledo, Juan Carlos, additional, Rodríguez-Lozano, Carlos, additional, Blanco, Ricardo, additional, Gualillo, Oreste, additional, Ibanez, Javier Martin, additional, Llorca, Javier, additional, López-Mejías, Raquel, additional, and González-Gay, Miguel A, additional

Published
2019
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13. FRI0006 PROTECTIVE ROLE OF THE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) RS2495477 POLYMORPHISM IN PATIENTS WITH RHEUMATOID ARTHRITIS AND SUBCLINICAL ATHEROSCLEROSIS

Author

Remuzgo-Martínez, Sara, primary, Genre, Fernanda, additional, Pulito-Cueto, Verónica, additional, Corrales, Alfonso, additional, Llorca, Javier, additional, Mijares, Verónica, additional, Lera-Gómez, Leticia, additional, Portilla, Virginia, additional, Ferraz-Amaro, Iván, additional, Castañeda, Santos, additional, Gualillo, Oreste, additional, Ibanez, Javier Martin, additional, Blanco, Ricardo, additional, López-Mejías, Raquel, additional, and González-Gay, Miguel A., additional

Published
2019
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14. Identification of a 3′‐Untranslated Genetic Variant of RARB Associated With Carotid Intima‐Media Thickness in Rheumatoid Arthritis: A Genome‐Wide Association Study

Author

López‐Mejías, Raquel, primary, Carmona, F. David, additional, Genre, Fernanda, additional, Remuzgo‐Martínez, Sara, additional, González‐Juanatey, Carlos, additional, Corrales, Alfonso, additional, Vicente, Esther F., additional, Pulito‐Cueto, Verónica, additional, Miranda‐Filloy, José A., additional, Ramírez Huaranga, Marco A., additional, Blanco, Ricardo, additional, Robustillo‐Villarino, Montserrat, additional, Rodríguez‐Carrio, Javier, additional, Alperi‐López, Mercedes, additional, Alegre‐Sancho, Juan J., additional, Mijares, Verónica, additional, Lera‐Gómez, Leticia, additional, Pérez‐Pampín, Eva, additional, González, Antonio, additional, Ortega‐Castro, Rafaela, additional, López‐Pedrera, Chary, additional, García Vivar, Mari L., additional, Gómez‐Arango, Catalina, additional, Raya, Enrique, additional, Narvaez, Javier, additional, Balsa, Alejandro, additional, López‐Longo, Francisco J., additional, Carreira, Patricia, additional, González‐Álvaro, Isidoro, additional, Rodríguez‐Rodríguez, Luis, additional, Fernández‐Gutiérrez, Benjamín, additional, Ferraz‐Amaro, Iván, additional, Gualillo, Oreste, additional, Castañeda, Santos, additional, Martín, Javier, additional, Llorca, Javier, additional, and González‐Gay, Miguel A., additional

Published
2019
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15. P0443 Significant sE-Selectin Levels Reduction After 6 Months of Anti-TNF-α Therapy in Non-Diabetic Patients with Moderate-to-Severe Psoriasis

Author

Armesto, Susana, Genre, Fernanda, Corrales, Alfonso, López-Mejias, Raquel, Remuzgo-Martínez, Sara, Trinitario Pina, Ubilla, Begoña, Mijares, Verónica, Rueda-Gotor, Javier, Portilla, Virginia, Dierssen-Sotos, Trinidad, Gonzalez-López, Marcos Antonio, M. Carmen González Vela, Blanco, Ricardo, Llorca, Javier, and Gonzalez-Gay, Miguel

Published
2017
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16. El tratamiento con Anti-Tnf en pacientes con psoriasis moderada-grave reduce de forma significativa la E-Selectina

Author

Armesto, Susana, Genre, Fernanda, Corrales, Alfonso, Lopez, Raquel, Remuzgo-Martínez, Sara, Trinitario Pina, Ubilla, Begoña, Mijares, Verónica, Rueda-Gotor, Javier, Portilla, Virginia, Dierssen-Sotos, Trinidad, Gonzalez-López, Marcos Antonio, M. Carmen González Vela, Blanco, Ricardo, Llorca, Javier, JL Hernandez, Marcellan, Maria, and Gonzalez-Gay, Miguel

Published
2017
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18. Protein tyrosine phosphatase non-receptor 22 and C-Src tyrosine kinase genes are down-regulated in patients with rheumatoid arthritis

Author

Remuzgo-Martínez, Sara, primary, Genre, Fernanda, additional, Castañeda, Santos, additional, Corrales, Alfonso, additional, Moreno-Fresneda, Pablo, additional, Ubilla, Begoña, additional, Mijares, Verónica, additional, Portilla, Virginia, additional, González-Vela, Jesús, additional, Pina, Trinitario, additional, Ocejo-Vinyals, Gonzalo, additional, Irure-Ventura, Juan, additional, Blanco, Ricardo, additional, Martín, Javier, additional, Llorca, Javier, additional, López-Mejías, Raquel, additional, and González-Gay, Miguel A., additional

Published
2017
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19. Systemic, non Cutaneous Repercussions, of Anti-TNF Therapy in Moderate to Severe Psoriatic Patients Without Cardiovascular Risk Factors a Prospective Study of 29 Patients

Author

Armesto, Susana, Trinitario Pina, Genre, Fernanda, López-Mejias, Raquel, Ubilla, Begoña, Mijares, Verónica, Dierssen-Sotos, Trinidad, Gonzalez-López, Marcos Antonio, M. Carmen González Vela, Blanco, Ricardo, JL Hernandez, Llorca, Javier, Marcellan, Maria, M. Drake, and Gonzalez-Gay, Miguel

Published
2016
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20. A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis

Author

López-Mejías, Raquel, primary, Carmona, F. David, additional, Castañeda, Santos, additional, Genre, Fernanda, additional, Remuzgo-Martínez, Sara, additional, Sevilla-Perez, Belén, additional, Ortego-Centeno, Norberto, additional, Llorca, Javier, additional, Ubilla, Begoña, additional, Mijares, Verónica, additional, Pina, Trinitario, additional, Miranda-Filloy, José A., additional, Navas Parejo, Antonio, additional, de Argila, Diego, additional, Aragües, Maximiliano, additional, Rubio, Esteban, additional, Luque, Manuel León, additional, Blanco-Madrigal, Juan María, additional, Galíndez-Aguirregoikoa, Eva, additional, Jayne, David, additional, Blanco, Ricardo, additional, Martín, Javier, additional, and González-Gay, Miguel A., additional

Published
2017
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21. Significant sE-Selectin levels reduction after 6 months of anti-TNF-α therapy in non-diabetic patients with moderate-to-severe psoriasis

Author

Genre, Fernanda, primary, Armesto, Susana, additional, Corrales, Alfonso, additional, López-Mejías, Raquel, additional, Remuzgo-Martínez, Sara, additional, Pina, Trinitario, additional, Ubilla, Begoña, additional, Mijares, Verónica, additional, Martín-Varillas, José Luis, additional, Rueda-Gotor, Javier, additional, Portilla, Virginia, additional, Dierssen-Sotos, Trinidad, additional, González-López, Marcos Antonio, additional, González-Vela, María del Carmen, additional, Blanco, Ricardo, additional, Llorca, Javier, additional, Hernández, José Luis, additional, and González-Gay, Miguel Ángel, additional

Published
2017
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22. Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis

Author

López-Mejías, Raquel, primary, Corrales, Alfonso, additional, Vicente, Esther, additional, Robustillo-Villarino, Montserrat, additional, González-Juanatey, Carlos, additional, Llorca, Javier, additional, Genre, Fernanda, additional, Remuzgo-Martínez, Sara, additional, Dierssen-Sotos, Trinidad, additional, Miranda-Filloy, José A., additional, Huaranga, Marco A. Ramírez, additional, Pina, Trinitario, additional, Blanco, Ricardo, additional, Alegre-Sancho, Juan J., additional, Raya, Enrique, additional, Mijares, Verónica, additional, Ubilla, Begoña, additional, Ferraz-Amaro, Iván, additional, Gómez-Vaquero, Carmen, additional, Balsa, Alejandro, additional, López-Longo, Francisco J., additional, Carreira, Patricia, additional, González-Álvaro, Isidoro, additional, Ocejo-Vinyals, J. Gonzalo, additional, Rodríguez-Rodríguez, Luis, additional, Fernández-Gutiérrez, Benjamín, additional, Castañeda, Santos, additional, Martín, Javier, additional, and González-Gay, Miguel A., additional

Published
2017
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23. Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

Author

López-Mejías, Raquel, primary, Genre, Fernanda, additional, Remuzgo-Martínez, Sara, additional, González-Juanatey, Carlos, additional, Robustillo-Villarino, Montserrat, additional, Llorca, Javier, additional, Corrales, Alfonso, additional, Vicente, Esther, additional, Miranda-Filloy, José A., additional, Magro, César, additional, Tejera-Segura, Beatriz, additional, Ramírez Huaranga, Marco A., additional, Pina, Trinitario, additional, Blanco, Ricardo, additional, Alegre-Sancho, Juan J., additional, Raya, Enrique, additional, Mijares, Verónica, additional, Ubilla, Begoña, additional, Mínguez Sánchez, María D., additional, Gómez-Vaquero, Carmen, additional, Balsa, Alejandro, additional, Pascual-Salcedo, Dora, additional, López-Longo, Francisco J., additional, Carreira, Patricia, additional, González-Álvaro, Isidoro, additional, Rodríguez-Rodríguez, Luis, additional, Fernández-Gutiérrez, Benjamín, additional, Ferraz-Amaro, Iván, additional, Castañeda, Santos, additional, Martín, Javier, additional, and González-Gay, Miguel A., additional

Published
2016
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25. Additional file 1: Table S1. of Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis)

Author

López-Mejías, Raquel, Genre, Fernanda, Remuzgo-Martínez, Sara, Pérez, Belén, Castañeda, Santos, Llorca, Javier, Ortego-Centeno, Norberto, Ubilla, Begoña, Mijares, Verónica, Trinitario Pina, Calvo-Río, Vanesa, Palmou, Natalia, Miranda-Filloy, José, Parejo, Antonio, Argila, Diego, Sánchez-Pérez, Javier, Rubio, Esteban, Luque, Manuel, Blanco-Madrigal, Juan, Galíndez-Aguirregoikoa, Eva, J. Ocejo-Vinyals, Martín, Javier, Blanco, Ricardo, and González-Gay, Miguel

Abstract

Different genetic models of inheritance for CSK polymorphisms. (DOC 28 kb)

Published
2015
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26. Additional file 2: Table S2. of Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis)

Author

López-Mejías, Raquel, Genre, Fernanda, Remuzgo-Martínez, Sara, Pérez, Belén, Castañeda, Santos, Llorca, Javier, Ortego-Centeno, Norberto, Ubilla, Begoña, Mijares, Verónica, Trinitario Pina, Calvo-Río, Vanesa, Palmou, Natalia, Miranda-Filloy, José, Parejo, Antonio, Argila, Diego, Sánchez-Pérez, Javier, Rubio, Esteban, Luque, Manuel, Blanco-Madrigal, Juan, Galíndez-Aguirregoikoa, Eva, J. Ocejo-Vinyals, Martín, Javier, Blanco, Ricardo, and González-Gay, Miguel

Abstract

CSK and PTPN22 haplotype analysis. (DOC 33 kb)

Published
2015
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27. Additional file 3: Table S3. of Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis)

Author

López-Mejías, Raquel, Genre, Fernanda, Remuzgo-Martínez, Sara, Pérez, Belén, Castañeda, Santos, Llorca, Javier, Ortego-Centeno, Norberto, Ubilla, Begoña, Mijares, Verónica, Trinitario Pina, Calvo-Río, Vanesa, Palmou, Natalia, Miranda-Filloy, José, Parejo, Antonio, Argila, Diego, Sánchez-Pérez, Javier, Rubio, Esteban, Luque, Manuel, Blanco-Madrigal, Juan, Galíndez-Aguirregoikoa, Eva, J. Ocejo-Vinyals, Martín, Javier, Blanco, Ricardo, and González-Gay, Miguel

Subjects
musculoskeletal diseases, skin and connective tissue diseases
Abstract

Genotype and allele frequencies of CSK and PTPN22 gene polymorphisms in HSP patients according to sex and the presence of joint manifestations (arthralgia or arthritis). (DOC 67 kb)

Published
2015
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29. Sclerostin serum levels in patients with systemic autoimmune diseases

Author

Fernández-Roldán, Concepción, primary, Genre, Fernanda, additional, López-Mejías, Raquel, additional, Ubilla, Begoña, additional, Mijares, Verónica, additional, Cano, Daniel Sánchez, additional, Robles, Concepción López, additional, Callejas-Rubio, José Luis, additional, Fernández, Raquel Ríos, additional, Ruiz, Manuela Expósito, additional, González-Gay, Miguel Á, additional, and Centeno, Norberto Ortego, additional

Published
2016
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30. Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy

Author

Hernández, José L., primary, López-Mejías, Raquel, additional, Blanco, Ricardo, additional, Pina, Trinitario, additional, Ruiz, Sheila, additional, Sierra, Isabel, additional, Ubilla, Begoña, additional, Mijares, Verónica, additional, González-López, Marcos A., additional, Armesto, Susana, additional, Corrales, Alfonso, additional, Pons, Enar, additional, Fuentevilla, Patricia, additional, González-Vela, Carmen, additional, and González-Gay, Miguel Á., additional

Published
2016
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31. Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients

Author

López-Mejías, Raquel, primary, Genre, Fernanda, additional, Remuzgo-Martínez, Sara, additional, Robustillo-Villarino, Montserrat, additional, García-Bermúdez, Mercedes, additional, Llorca, Javier, additional, Corrales, Alfonso, additional, González-Juanatey, Carlos, additional, Ubilla, Begoña, additional, Miranda-Filloy, José A., additional, Mijares, Verónica, additional, Pina, Trinitario, additional, Blanco, Ricardo, additional, Alegre-Sancho, Juan J., additional, Ramírez Huaranga, Marco A., additional, Mínguez Sánchez, María D., additional, Tejera Segura, Beatriz, additional, Ferraz-Amaro, Iván, additional, Vicente, Esther, additional, Carmona, F. David, additional, Castañeda, Santos, additional, Martín, Javier, additional, and González-Gay, Miguel A., additional

Published
2015
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32. Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis)

Author

López-Mejías, Raquel, primary, Genre, Fernanda, additional, Remuzgo-Martínez, Sara, additional, Pérez, Belén Sevilla, additional, Castañeda, Santos, additional, Llorca, Javier, additional, Ortego-Centeno, Norberto, additional, Ubilla, Begoña, additional, Mijares, Verónica, additional, Pina, Trinitario, additional, Calvo-Río, Vanesa, additional, Palmou, Natalia, additional, Miranda-Filloy, José A., additional, Parejo, Antonio Navas, additional, Argila, Diego, additional, Sánchez-Pérez, Javier, additional, Rubio, Esteban, additional, Luque, Manuel León, additional, Blanco-Madrigal, Juan María, additional, Galíndez-Aguirregoikoa, Eva, additional, Ocejo-Vinyals, J. Gonzalo, additional, Martín, Javier, additional, Blanco, Ricardo, additional, and González-Gay, Miguel A., additional

Published
2015
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33. Association of HLA-B*41:02 with Henoch-Schönlein Purpura (IgA Vasculitis) in Spanish individuals irrespective of the HLA-DRB1 status

Author

López-Mejías, Raquel, primary, Genre, Fernanda, additional, Pérez, Belén Sevilla, additional, Castañeda, Santos, additional, Ortego-Centeno, Norberto, additional, Llorca, Javier, additional, Ubilla, Begoña, additional, Remuzgo-Martínez, Sara, additional, Mijares, Verónica, additional, Pina, Trinitario, additional, Calvo-Río, Vanesa, additional, Márquez, Ana, additional, Miranda-Filloy, José A, additional, Parejo, Antonio Navas, additional, Conde-Jaldón, Marta, additional, Ortiz-Fernández, Lourdes, additional, Argila, Diego, additional, Aragües, Maximiliano, additional, Rubio, Esteban, additional, León Luque, Manuel, additional, Blanco-Madrigal, Juan María, additional, Galíndez-Aguirregoikoa, Eva, additional, Escribano, Francisca González, additional, Ocejo-Vinyals, J Gonzalo, additional, Martín, Javier, additional, Blanco, Ricardo, additional, and González-Gay, Miguel A, additional

Published
2015
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37. Role of PTPN22and CSKgene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis)

Author

López-Mejías, Raquel, Genre, Fernanda, Remuzgo-Martínez, Sara, Pérez, Belén, Castañeda, Santos, Llorca, Javier, Ortego-Centeno, Norberto, Ubilla, Begoña, Mijares, Verónica, Pina, Trinitario, Calvo-Río, Vanesa, Palmou, Natalia, Miranda-Filloy, José, Parejo, Antonio, Argila, Diego, Sánchez-Pérez, Javier, Rubio, Esteban, Luque, Manuel, Blanco-Madrigal, Juan, Galíndez-Aguirregoikoa, Eva, Ocejo-Vinyals, J., Martín, Javier, Blanco, Ricardo, and González-Gay, Miguel

Abstract

To determine whether the PTPN22 (protein tyrosine phosphatase nonreceptor 22)/CSK (c-src tyrosine kinase) pathway is implicated in the susceptibility and clinical heterogeneity of Henoch-Schönlein purpura (HSP) in the largest series of Caucasian HSP patients ever assessed for genetic studies. A set of 329 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al. classification criteria and 515 sex and ethnically matched controls were recruited in this study. Two well-known CSK(CSKrs34933034 and CSKrs1378942) and two functional PTPN22(PTPN22rs2476601 (R620W) and PTPN22rs33996649 (R263Q)) polymorphisms, previously associated with autoimmunity, were genotyped with TaqMan single nucleotide polymorphism (SNP) genotyping assays. No significant differences in the genotype and allele frequencies between HSP patients and controls were observed when the CSKrs34933034, CSKrs1378942, PTPN22rs2476601 (R620W) and PTPN22rs33996649 (R263Q) polymorphisms were analyzed independently. In keeping with this observation, no significant differences were found when we assessed these polymorphisms combined conforming haplotypes. In addition, there were no differences in the allele or genotype frequencies when HSP patients were stratified according the age at disease onset, sex, presence of arthralgia/arthritis, nephritis or gastrointestinal manifestations. Our results do not support association between PTPN22/CSKand HSP.

Published
2015
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38. Association of the Aromatase Gene Alleles With BMD: Epidemiological and Functional Evidence.

Author

Riancho, José A., Sañudo, Carolina, Valero, Carmen, Pipaón, Carlos, Olmos, José M., Mijares, Verónica, Fernández-Luna, José L., and Zarrabeitia, Maria T.

Abstract

The article presents epidemiological and functional evidence linking aromatase gene allele and bone mineral density (BMD). The study analyzed the relationship between several single nucleotide polymorphism (SNPs) in the aromatase region and hip BMD in 1163 postmenopausal women. The results revealed that polymorphisms in a 12-kb region proximal to the start of translation site of the aromatase gene are associated with BMD in a large sample of postmenopausal women.

Published
2009
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39. Influence of IL17A gene on the pathogenesis of immunoglobulin-A vasculitis.

Author

López-Mejías R, Genre F, Remuzgo-Martínez S, Pulito-Cueto V, Sevilla-Pérez B, Llorca J, Ortego-Centeno N, Mijares V, Lera-Gómez L, Leonardo MT, Peñalba A, Cabero MJ, Martín-Penagos L, Miranda-Filloy JA, Navas Parejo A, Sánchez Pérez J, de Argila D, Rubio E, León Luque M, Blanco-Madrigal JM, Galíndez-Agirregoikoa E, Martín J, Blanco R, Castañeda S, and González-Gay MA

Subjects
Case-Control Studies, Gene Regulatory Networks, Haplotypes, Humans, Polymorphism, Single Nucleotide, Vasculitis pathology, Genetic Predisposition to Disease, Immunoglobulin A, Interleukin-17 genetics, Vasculitis genetics
Abstract

Objectives: Cytokines signaling pathway genes represent a key component of the genetic network implicated in the pathogenesis of immunoglobulin-A vasculitis (IgAV), an inflammatory vascular pathology. Interleukin (IL)17A is described as a genetic risk locus for some autoimmune diseases, such as giant cell arteritis and spondyloarthritis. Accordingly, we aimed to determine the potential influence of IL17A on the pathogenesis of IgAV., Methods: Five IL17A tag polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909), which cover the major variability of this gene, were genotyped in 360 Caucasian patients with IgAV and 1,003 sex and ethnically matched healthy controls using TaqMan probes., Results: No statistically significant differences between patients with IgAV and healthy controls were observed when each IL17A genetic variant was analysed independently. Similarly, no statistically significant differences between patients with IgAV and healthy controls were found when the five IL17A polymorphisms were evaluated combined conforming haplotypes. In addition, there were no statistically significant differences in genotype, allele and haplotype frequencies of IL17A when patients with IgAV were stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations., Conclusions: Our results do not support an influence of IL17A on the pathogenesis of IgAV.

Published
2020

40. Implication of osteoprotegerin and sclerostin in axial spondyloarthritis cardiovascular disease: study of 163 Spanish patients.

Author

Genre F, Rueda-Gotor J, Remuzgo-Martínez S, Corrales A, Ubilla B, Mijares V, Fernández-Díaz C, Portilla V, Blanco R, Hernández JL, Llorca J, López-Mejías R, and González-Gay MA

Subjects
Adaptor Proteins, Signal Transducing, Adult, Aged, Carotid Intima-Media Thickness, Female, Genetic Markers, Humans, Male, Middle Aged, Bone Morphogenetic Proteins blood, Cardiovascular Diseases etiology, Osteoprotegerin blood, Spondylarthritis complications
Abstract

Objectives: Due to the high incidence of cardiovascular disease in axial spondyloarthritis (axSpA), the search of potential biomarkers that may help to identify patients with high cardiovascular risk is of main importance. Therefore, in this study we assessed the implication of osteoprotegerin (OPG) and sclerostin (SCL), two biomarkers associated with cardiovascular disease and bone metabolism, in the clinical spectrum and atherosclerotic disease of patients with axSpA., Methods: OPG and SCL serum levels were determined in 163 axSpA Spanish patients (119 ankylosing spondylitis and 44 non-radiographic axSpA) and 63 healthy controls by enzyme-linked immunosorbent assay. Carotid ultrasound was performed in axSpA patients to determine the presence of subclinical atherosclerosis (by the identification of abnormally increased carotid intima-media thickness [cIMT] and presence of plaques)., Results: Patients displayed higher OPG but lower SCL levels than controls (p=0.02 and 0.001, respectively). Association of these molecules with some metabolic syndrome features was seen. In this regard, OPG negatively correlated with body mass index (p=0.04) whereas SCL levels were higher in hypertensive patients (p=0.01) and in men (p=0.002). However, serum OPG and SCL were not significantly correlated with cIMT values or presence of plaques when data were adjusted by age at the time of the study, sex, classic cardiovascular risk factors and anti-TNF therapy., Conclusions: Our results suggest an association of OPG and SCL in axSpA with some metabolic syndrome features that are associated with an increased risk of CV disease.

Published
2018

41. Interleukin 1 beta (IL1ß) rs16944 genetic variant as a genetic marker of severe renal manifestations and renal sequelae in Henoch-Schönlein purpura.

Author

López-Mejías R, Genre F, Remuzgo-Martínez S, Sevilla Pérez B, Castañeda S, Llorca J, Ortego-Centeno N, Ubilla B, Mijares V, Pina T, Calvo-Río V, Miranda-Filloy JA, Navas Parejo A, Argila D, Sánchez-Pérez J, Rubio E, Luque ML, Blanco-Madrigal JM, Galíndez-Aguirregoikoa E, Martín J, Blanco R, and González-Gay MA

Subjects
Adolescent, Child, Child, Preschool, Female, Genetic Markers genetics, Genotype, Humans, IgA Vasculitis complications, Male, IgA Vasculitis genetics, Interleukin-1beta genetics, Kidney Diseases etiology, Polymorphism, Single Nucleotide
Abstract

Objectives: Data from a small series suggested that the Interleukin 1 beta (IL1ß) rs16944 polymorphism may be associated with severe renal involvement and persistent renal damage (renal sequelae) in Henoch-Schönlein purpura (HSP). To confirm this association, we assessed the largest cohort of Caucasian HSP patients ever considered for genetic studies., Methods: 338 Spanish HSP patients and 635 sex and ethnically matched controls were recruited in this study. All patients were required to have had at least 6 months' follow-up. Patients and controls were genotyped for IL1β rs16944 by TaqMan genotyping assay., Results: No differences between IL1β rs16944 genotype or allele frequencies were found either in the case/control study or when HSP patients were stratified according to the age at disease onset, presence of nephritis or gastrointestinal manifestations. Nevertheless, 4 (25%) of the 16 HSP patients who developed severe renal manifestations carried the TT genotype versus 29 (9%) of 322 who did not develop this complication (p=0.01, OR=5.48, 95% CI: 1.01-28.10). Accordingly, patients carrying the mutant T allele had an increased risk of developing severe nephropathy (p=0.016, OR=2.35, 95% CI: 1.09-5.07). Additionally, a significant increase of the TT genotype was observed in patients with persistent renal damage when compared with those patients without this complication (25% versus 8.6%, respectively; p=0.0035, OR=4.90, 95% CI: 1.26- 18.51). Moreover, renal sequelae were more common in patients carrying the mutant T allele (p=0.0076, OR=2.20, 95% CI: 1.17-4.14)., Conclusions: Our results support that the IL1ß rs16944 polymorphism may be a potential marker of severe renal manifestations and renal sequelae in HSP.

Published
2016

42. HLA-DRB1 association with Henoch-Schonlein purpura.

Author

López-Mejías R, Genre F, Pérez BS, Castañeda S, Ortego-Centeno N, Llorca J, Ubilla B, Remuzgo-Martínez S, Mijares V, Pina T, Calvo-Río V, Márquez A, Sala-Icardo L, Miranda-Filloy JA, Conde-Jaldón M, Ortiz-Fernández L, Rubio E, León Luque M, Blanco-Madrigal JM, Galíndez-Aguirregoikoa E, González-Vela MC, Ocejo-Vinyals JG, González Escribano F, Martín J, Blanco R, and González-Gay MA

Abstract

Objective: Henoch-Schönlein purpura (HSP) is the most common vasculitis in children but it is not exceptional in adults. Increased familial occurrence supports a genetic predisposition for HSP. In this context, an association with the human leukocyte antigen-HLA-DRB1*01 phenotype has been suggested in Caucasian individuals with HSP. However, data on the potential association of HSP with HLA-DRB1*01 were based on small case series. To further investigate this issue, we performed HLA-DRB1 genotyping of the largest series of HSP patients ever assessed for genetic studies in Caucasians. Methods: 342 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al classification criteria, and 303 sex and ethnically matched controls were assessed. HLA-DRB1 alleles were determined using a PCR-Sequence-Specific-Oligonucleotide Probe (PCR-SSOP) method. Results: A statistically significant increase of HLA-DRB1*01 in HSP patients when compared with controls was found (43% vs 7%, respectively; p<0.001; odds ratio-OR=2.03 [1.43-2.87]). It was due to the increased frequency of HLA-DRB1*0103 phenotype in HSP (14% vs 2%; p<0.001; OR=8.27 [3.46-23.9]). These results remained statistically significant after adjusting for Bonferroni correction. In contrast, a statistically significant decreased frequency of the HLA-DRB1*0301 phenotype was observed in patients compared to controls (5.6% vs 18.1%, respectively; p<0.001, OR=0.26 [0.14-0.47]), even after adjustment for Bonferroni correction. No HLA-DRB1 association with specific features of the disease was found. Conclusion: Our study confirms an association of HSP with HLA-DRB1*01 in Caucasians. Also, a protective effect against the development of HSP appears to exist in Caucasians carrying the HLA-DRB1*03 phenotype. This article is protected by copyright. All rights reserved., (Copyright © 2014 American College of Rheumatology.)

Published
2015
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