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Your search keyword '"Mikami, Hayato"' showing total 13 results
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13 results on '"Mikami, Hayato"'

1. Novel Choline-Deficient and 0.1%-Methionine-Added High-Fat Diet Induces Burned-Out Metabolic-Dysfunction-Associated Steatohepatitis with Inflammation by Rapid Immune Cell Infiltration on Male Mice.

Author

Sakaguchi, Takatoshi, Nagahama, Yasuharu, Hamada, Nanako, Singh, Shailendra Kumar, Mikami, Hayato, Maeda, Kazuhiko, and Akira, Shizuo

Abstract

Background: Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a progressive liver disorder that possesses metabolic dysfunction and shows steatohepatitis. Although the number of patients is globally increasing and many clinical studies have developed medicine for MASLD, most of the studies have failed due to low efficacy. One reason for this failure is the lack of appropriate animal disease models that reflect human MASLD to evaluate the potency of candidate drugs. Methods: We developed a novel choline-deficient and 0.11%-methionine-added high-fat diet (CDAHFD)-based (MASH) diet that can induce murine metabolic-dysfunction-associated steatohepatitis (MASH) without severe body weight loss. We performed kinetic analyses post-feeding and proposed an appropriate timing of MASH pathogenesis by quantitatively analyzing steatosis, inflammation, and fibrosis. Results: This MASH diet induced liver fibrosis earlier than the conventional CDAHFD model. In brief, lipid accumulation, inflammation, and fibrosis started after 1 week from feeding. Lipid accumulation increased until 8 weeks and declined thereafter; on the other hand, liver fibrosis showed continuous progression. Additionally, immune cells, especially myeloid cells, specifically accumulated and induced inflammation in the initiation stage of MASH. Conclusions: The novel MASH diet promotes the dynamics of lipid deposition and fibrosis in the liver, similar to human MASH pathophysiology. Furthermore, immune-cell-derived inflammation possibly contributes to the initiation of MASH pathogenesis. We propose this model can be the new pre-clinical MASH model to discover the drugs against human MASH by evaluating the interaction between parenchymal and non-parenchymal cells. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Three Dimensional Magnetohydrodynamical Simulations of Core Collapse Supernova

Author

Mikami, Hayato, Sato, Yuji, Matsumoto, Tomoaki, and Hanawa, Tomoyuki

Subjects
Astrophysics
Abstract

We show three-dimensional magnetohydrodynamical simulations of core collapse supernova in which the progenitor has magnetic fields inclined to the rotation axis. The simulations employed a simple empirical equation of state in which the pressure of degenerate gas is approximated by piecewise polytropes for simplicity. Neither energy loss due to neutrino is taken into account for simplicity. The simulations start from the stage of dynamical collapse of an iron core. The dynamical collapse halts at $ t $ = 189 ms by the pressure of high density gas and a proto-neutron star (PNS) forms. The evolution of PNS was followed about 40 milli-seconds in typical models. When the initial rotation is mildly fast and the initial magnetic fields are mildly strong, bipolar jets are launched from an upper atmosphere ($ r \sim 60 {\rm km} $) of the PNS. The jets are accelerated to $ \sim 3 \times 10 ^4 $ km s$^{-1}$, which is comparable to the escape velocity at the foot point. The jets are parallel to the initial rotation axis. Before the launch of the jets, magnetic fields are twisted by rotation of the PNS. The twisted magnetic fields form torus-shape multi-layers in which the azimuthal component changes alternately. The formation of magnetic multi-layers is due to the initial condition in which the magnetic fields are inclined with respect to the rotation axis. The energy of the jet depends only weakly on the initial magnetic field assumed. When the initial magnetic fields are weaker, the time lag is longer between the PNS formation and jet ejection. It is also shown that the time lag is related to the Alfv\'en transit time. Although the nearly spherical prompt shock propagates outward in our simulations, it is ..., Comment: 41 pages, 24 figures, 4 tables, accepted for publication in ApJ. The high resolution version is available at http://www.astro.phys.s.chiba-u.ac.jp/~mikami/research/

Published
2008
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6. Development of video tests for elementary school physical education to assess pupil’s ability to think and judge: Utilization of simultaneously reproduced four-split screen videos

Author

Osedo, Kazuki, Sakata, Kohei, and Mikami, Hayato

Subjects
video tests, physical education
Abstract

This study is a follow-up report of a study by Osedo et al. (2018), wherein a video test in which pupils “think and judge” based on the knowledge gained in physical education classes was developed. In this study, we developed a new video test that simultaneously reproduces video images with two technical differences on a four-split screen. We then administered a survey to third grade students to examine whether there were any differences in their viewpoints when observing the video. The results from an analysis of the data suggest that if a teacher wants his or her students to “think and judge” based on the observation of physical exercise from several viewpoints, a four-split screen video acts as a teaching material that requires more comprehensive “thinking and judging” as compared to Osedo et al.’s (2018) test. However, because of the increase in the number of video images, students may have developed dispersed observation viewpoints; therefore, a further examination of developmentally appropriate utilization methods is necessary., 本研究は，日本学術振興会科研費の助成（16K01619）を受けたものです。

Published
2019

7. Modulation of circulating endothelial progenitor cells by erythropoiesis-stimulating agents in patients with chronic kidney disease stage G5 and 5D

Author

Naito, Takashi, primary, Sanaka, Tsutomu, additional, Mikami, Hayato, additional, Soga, Asuka, additional, Yamatani, Kotoko, additional, Segawa, Kaori, additional, Kawashima, Moe, additional, Yoshikura, Tetsuya, additional, Niwayama, Jun, additional, Nishimura, Hideki, additional, Ogawa, Tetsuya, additional, Ando, Akitoshi, additional, Teramoto, Akira, additional, and Nitta, Kosaku, additional

Published
2016
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Author

Osedo, Kazuki, Sakata, Kohei, Mikami, Hayato, Osedo, Kazuki, Sakata, Kohei, and Mikami, Hayato

Abstract

This study is a follow-up report of a study by Osedo et al. (2018), wherein a video test in which pupils “think and judge” based on the knowledge gained in physical education classes was developed. In this study, we developed a new video test that simultaneously reproduces video images with two technical differences on a four-split screen. We then administered a survey to third grade students to examine whether there were any differences in their viewpoints when observing the video. The results from an analysis of the data suggest that if a teacher wants his or her students to “think and judge” based on the observation of physical exercise from several viewpoints, a four-split screen video acts as a teaching material that requires more comprehensive “thinking and judging” as compared to Osedo et al.’s (2018) test. However, because of the increase in the number of video images, students may have developed dispersed observation viewpoints; therefore, a further examination of developmentally appropriate utilization methods is necessary.

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