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2. Wireless power transfer in magnetic resonance imaging at a higher-order mode of a birdcage coil

Author

Burmistrov, Oleg I., Mikhailov, Nikita V., Dashkevich, Dmitriy S., Seregin, Pavel S., and Olekhno, Nikita A.

Subjects
Physics - Applied Physics, Physics - Medical Physics
Abstract

Magnetic resonance imaging (MRI) is a crucial tool for medical visualization. In many cases, performing a scanning procedure requires the use of additional equipment, which can be powered by wires as well as via wireless power transfer (WPT) or wireless energy harvesting. In this Letter, we propose a novel scheme for WPT that uses a higher-order mode of the MRI scanner's birdcage coil for energy transmission. In contrast to the existing WPT solutions, our approach does not require additional transmitting coils. Compared to the energy harvesting, the proposed method allows supplying significantly more power. We perform numerical simulations demonstrating that one can use the fundamental mode of the birdcage coil to perform a scanning procedure while transmitting the energy to the receiver at a higher-order mode without any interference with the scanning signal or violation of safety constraints, as guaranteed by the mode structure of the birdcage. Also, we evaluate the specific absorption rate along with the energy transfer efficiency and verify our numerical model by a direct comparison with an experimental setup featuring a birdcage coil of a 1.5T MRI scanner., Comment: 6 pages, 5 figures + Supplementary Material 10 pages, 7 figures

Published
2023

3. Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Author

Lampinen, Riikka, Belaya, Irina, Saveleva, Liudmila, Liddell, Jeffrey R., Rait, Dzhessi, Huuskonen, Mikko T., Giniatullina, Raisa, Sorvari, Annika, Soppela, Liisi, Mikhailov, Nikita, Boccuni, Isabella, Giniatullin, Rashid, Cruz-Haces, Marcela, Konovalova, Julia, Koskuvi, Marja, Domanskyi, Andrii, Hämäläinen, Riikka H., Goldsteins, Gundars, Koistinaho, Jari, Malm, Tarja, Chew, Sweelin, Rilla, Kirsi, White, Anthony R., Marsh-Armstrong, Nicholas, and Kanninen, Katja M.

Published
2022
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4. Microglial amyloid beta clearance is driven by PIEZO1 channels

Author

Jäntti, Henna, Sitnikova, Valeriia, Ishchenko, Yevheniia, Shakirzyanova, Anastasia, Giudice, Luca, Ugidos, Irene F., Gómez-Budia, Mireia, Korvenlaita, Nea, Ohtonen, Sohvi, Belaya, Irina, Fazaludeen, Feroze, Mikhailov, Nikita, Gotkiewicz, Maria, Ketola, Kirsi, Lehtonen, Šárka, Koistinaho, Jari, Kanninen, Katja M., Hernández, Damian, Pébay, Alice, Giugno, Rosalba, Korhonen, Paula, Giniatullin, Rashid, and Malm, Tarja

Published
2022
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11. Microglial amyloid beta clearance is driven by PIEZO1 channels

Author

Konttinen, Henna, primary, Sitnikova, Valeria, additional, Ishchenko, Yevheniia, additional, Shakirzyanova, Anastasia, additional, Giudice, Luca, additional, Ugidos, Irene F, additional, Gomez Budia, Mireia, additional, Korvenlaita, Nea, additional, Ohtonen, Sohvi, additional, Belaya, Irina, additional, Fazaludeen, Feroze, additional, Mikhailov, Nikita, additional, Gotkiewicz, Maria, additional, Ketola, Kirsi, additional, Lehtonen, Sarka, additional, Koistinaho, Jari, additional, Kanninen, Katja, additional, Hernandez, Damian, additional, Pebay, Alice, additional, Giugno, Rosalba, additional, Korhonen, Paula, additional, Giniatullin, Rashid, additional, and Malm, Tarja, additional

Published
2022
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12. Additional file 1 of Microglial amyloid beta clearance is driven by PIEZO1 channels

Author

Jäntti, Henna, Sitnikova, Valeriia, Ishchenko, Yevheniia, Shakirzyanova, Anastasia, Giudice, Luca, Ugidos, Irene F., Gómez-Budia, Mireia, Korvenlaita, Nea, Ohtonen, Sohvi, Belaya, Irina, Fazaludeen, Feroze, Mikhailov, Nikita, Gotkiewicz, Maria, Ketola, Kirsi, Lehtonen, Šárka, Koistinaho, Jari, Kanninen, Katja M., Hernández, Damian, Pébay, Alice, Giugno, Rosalba, Korhonen, Paula, Giniatullin, Rashid, and Malm, Tarja

Abstract

Additional file 1: Fig. S1. PIEZO1 and PIEZO2 expression in human and mouse RNA‑seq dataset and staining controls for hiMGL immunostaining. Fig. S2. Activation of PIEZO1 orchestrates immune response of human iMGLs. Fig. S3. No differences in PIEZO1 expression in bulk brain tissue between WT and 5xFAD mice. Fig. S4. PIEZO1, microglia, astrocyte and Aβ plaque stainings in 5xFAD hippocampi. Fig. S5. PIEZO1 gene expression in published AD‑related RNA datasets by our analysis. Fig. S6. Characterization of MAD1 and MAD8 iPSC lines. Fig. S7. A diagram visualizing author contribution. Fig. S8. A graphical abstract summarizing the main finding of the paper. Table S1. A correlation data for Piezo1 and the DAM signature genes in microglial subpopulations in Keren-Shaul et al. 2017 dataset [41] (GSE98969). Table S2. A correlation data for Piezo1and the DAM signature genes in microglial subpopulations in Zhou et al. 2021 dataset [42] (GSE140511). Table S3. Differentially expressed genes (DEGs) specific for m1‑subcluster in snRNA Grubman etal. 2019 dataset [40] (GSE138852).

Published
2022
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13. Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Author

Lampinen, Riikka, Belaya, Irina, Saveleva, Liudmila, Liddell, Jeffrey R., Rait, Dzhessi, Huuskonen, Mikko T., Giniatullina, Raisa, Sorvari, Annika, Soppela, Liisi, Mikhailov, Nikita, Boccuni, Isabella, Giniatullin, Rashid, Cruz-Haces, Marcela, Konovalova, Julia, Koskuvi, Marja, Domanskyi, Andrii, Hämäläinen, Riikka H., Goldsteins, Gundars, Koistinaho, Jari, Malm, Tarja, Chew, Sweelin, Rilla, Kirsi, White, Anthony R., Marsh-Armstrong, Nicholas, Kanninen, Katja M., Institute of Biotechnology, Biosciences, and Neuroscience Center

Subjects
EXPRESSION, Neurons, MITOCHONDRIAL DYSFUNCTION, Amyloid beta-Peptides, Mitophagy, Alzheimer's disease, PARKIN, Mitochondria, MODEL, Mice, Alzheimer Disease, Astrocytes, S100A4, 1182 Biochemistry, cell and molecular biology, Animals, AUTOPHAGY, Transmitophagy, ACCUMULATION
Abstract

Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in neurodegeneration but it is unknown whether and how transmitophagy is altered in Alzheimer's disease (AD). Here we report that the internalization of neuronal mitochondria is significantly increased in astrocytes isolated from AD mouse brains. We also demonstrate that the degradation of neuronal mitochondria by astrocytes is increased in AD mice at the age of 6 months onwards. Furthermore, we demonstrate for the first time a similar phenomenon between human neurons and AD astrocytes, and in murine hippocampi in vivo. The results suggest the involvement of S100a4 in impaired mitochondrial transfer between neurons and AD astrocytes together with significant increases in the mitophagy regulator and reactive oxygen species in aged AD astrocytes. These findings demonstrate altered neuronsupporting functions of AD astrocytes and provide a starting point for studying the molecular mechanisms of transmitophagy in AD.

Published
2021

15. Alzheimer's disease alters astrocytic functions related to neuronal support and transcellular internalization of mitochondria

Author

Lampinen, Riikka, primary, Belaya, Irina, additional, Saveleva, Liudmila, additional, Liddell, Jeffrey R, additional, Rait, Dzhessi, additional, Huuskonen, Mikko T, additional, Giniatullina, Raisa, additional, Sorvari, Annika, additional, Soppela, Liisi, additional, Mikhailov, Nikita, additional, Boccuni, Isabella, additional, Giniatullin, Rashid, additional, Cruz-Haces, Marcela, additional, Konovalova, Julia, additional, Koskuvi, Marja, additional, Rauramaa, Tuomas, additional, Domanskyi, Andrii, additional, Hamalainen, Riikka H, additional, Goldsteins, Gundars, additional, Koistinaho, Jari, additional, Malm, Tarja, additional, Chew, Sweelin, additional, Rilla, Kirsi, additional, White, Anthony R, additional, Marsh-Armstrong, Nicholas, additional, and Kanninen, Katja M, additional

Published
2021
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16. The role of cholinergic and mechanosensitive signalling and the meningeal lymphatic system in peripheral trigeminal nociception

Author

Mikhailov, Nikita, A.I. Virtanen -instituutti, A.I. Virtanen Institute for Molecular Sciences, Terveystieteiden tiedekunta, A.I. Virtanen -instituutti, Faculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences, Terveystieteiden tiedekunta, and Faculty of Health Sciences

Subjects
kipu, Receptors, Nicotinic, Calcitonin Gene-Related Peptide, hiiret, Brain, Pain, Lymphatic System, syöttösolut, Meninges, Carbachol, Trigeminal Nerve, Nicotine, Acetylcholine, nikotiini, Receptors, Muscarinic, kipuaisti, Animals, Mast Cells, Rats, asetyylikoliini, Nociception, Migraine Disorders, eläimet, migreeni, aivot, Mice, rotat (suku)
Published
2020

17. Endoscopic endonasal removal of nasal cavity chondrosarcoma extending to the base of the skull: a case report

Author

Mikhailov, Nikita I., primary, Zaitsev, Anton M., additional, Rerberg, Andrew G., additional, Kisarev, Sergei A., additional, Khokhrikov, Gennadei I., additional, Lazarev, Artem E., additional, Kirsanova, Olga N., additional, Kobyletskaya, Tatyana M., additional, Bezbabicheva, Tatiana S., additional, Krivobokova, Angelina V., additional, Shegay, Peter V., additional, and Kaprin, Andrey D., additional

Published
2021
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18. Modeling a Nociceptive Neuro-Immune Synapse Activated by ATP and 5-HT in Meninges: Novel Clues on Transduction of Chemical Signals Into Persistent or Rhythmic Neuronal Firing

Author

Suleimanova, Alina, primary, Talanov, Max, additional, Gafurov, Oleg, additional, Gafarov, Fail’, additional, Koroleva, Ksenia, additional, Virenque, Anaïs, additional, Noe, Francesco M., additional, Mikhailov, Nikita, additional, Nistri, Andrea, additional, and Giniatullin, Rashid, additional

Published
2020
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20. Additional file 1 of Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

Author

Sweelin Chew, Lampinen, Riikka, Saveleva, Liudmila, Korhonen, Paula, Mikhailov, Nikita, Grubman, Alexandra, Polo, Jose M., Wilson, Trevor, Komppula, Mika, Rönkkö, Teemu, Gu, Cheng, Mackay-Sim, Alan, Malm, Tarja, White, Anthony R., Jalava, Pasi, and Kanninen, Katja M.

Subjects
complex mixtures
Abstract

Additional file 1: Table S1. Cell Line Information. Table S2. Chemical composition of PMs used in this study. Table S3. Taqman assays used in this study. Figure S1. Initial dose response assessment of PM10–2.5 and PM2.5–1.

Published
2020
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23. Endoscopic transsphenoidal approach in treatment of germinomas of the chiasmosellar region

Author

Kutin, Maxim, additional, Fomichev, Dmitry, additional, Shkarubo, Alexey, additional, Chernov, Ilia, additional, Sharipov, Oleg, additional, Andreev, Dmitry, additional, Ismailov, Denilbek, additional, Mikhailov, Nikita, additional, Kobyakov, Grigoriy, additional, Trunin, Yuriy, additional, Astafyeva, Ludmila, additional, Abdilatipov, Abdishukur, additional, Poddubsky, Artem, additional, and Kalinin, Pavel, additional

Published
2019
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26. Endocrine Abstracts

Author

Astafyeva, Ludmila, primary, Kalinin, Pavel, additional, Mikhailov, Nikita, additional, Trunin, Yuriy, additional, and Kobyakov, Grigiriy, additional

Published
2018
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27. The acromegalia diagnosis and treatment. Russian literature review

Author

Kostin Aleksandr Eduardovich, Mikhailov Nikita Igorevich, Chernov Ilya Valerievich, Isamilov Danilbek Beksultanovich, and Andreev Dmitry Nikolaevich

Subjects
акромегалия, аденома гипофиза, соматотропинома
Abstract

в данной статье рассмотрена проблема лечения акромегалии. В работе представлены современные представления о хирургическом и нехирургическом лечении соматотропином. Приведены отличительные особенности клинической картины акромегалии. Выделены методы, направленные на уточнение диагноза акромегалии. Раскрыты способы лечения исследуемого заболевания.

Published
2016
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29. Диагностика и лечение акромегалии. Обзор отечественной литературы

Author

Костин Александр Эдуардович, ФГАУ «Научно-исследовательский институт нейрохирургии им. академика Н.Н. Бурденко» Минздрава России, Kostin Aleksandr Eduardovich, FSAI "N.N. Burdenko Scientific Research Institute of Neurological Surgery" of the Ministry of Health of the Russian Federation, Михайлов Никита Игоревич, Mikhailov Nikita Igorevich, Чернов Илья Валерьевич, Chernov Ilya Valerievich, Исмаилов Данилбек Бексултанович, Isamilov Danilbek Beksultanovich, Андреев Дмитрий Николаевич, Andreev Dmitry Nikolaevich, Костин Александр Эдуардович, ФГАУ «Научно-исследовательский институт нейрохирургии им. академика Н.Н. Бурденко» Минздрава России, Kostin Aleksandr Eduardovich, FSAI "N.N. Burdenko Scientific Research Institute of Neurological Surgery" of the Ministry of Health of the Russian Federation, Михайлов Никита Игоревич, Mikhailov Nikita Igorevich, Чернов Илья Валерьевич, Chernov Ilya Valerievich, Исмаилов Данилбек Бексултанович, Isamilov Danilbek Beksultanovich, Андреев Дмитрий Николаевич, and Andreev Dmitry Nikolaevich

Abstract

в данной статье рассмотрена проблема лечения акромегалии. В работе представлены современные представления о хирургическом и нехирургическом лечении соматотропином. Приведены отличительные особенности клинической картины акромегалии. Выделены методы, направленные на уточнение диагноза акромегалии. Раскрыты способы лечения исследуемого заболевания.

Published
2016

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