1. Immunomodulating Properties of Humic Acids Extracted from Oligotrophic Sphagnum magellanicum Peat.
- Author
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Trofimova ES, Zykova MV, Danilets MG, Ligacheva AA, Sherstoboev EY, Tsupko AV, Mikhalyov DA, and Belousov MV
- Subjects
- Animals, Interleukin-12 metabolism, Interleukin-1beta metabolism, Macrophages, Peritoneal metabolism, Mice, Inbred C57BL, Sphagnopsida chemistry, Tumor Necrosis Factor-alpha metabolism, Mice, Humic Substances, Soil
- Abstract
Humic acids extracted with sodium pyrophosphate from Oligotrophic Sphagnum magellanicum peat reduce mitogen-stimulated production of anti-inflammatory cytokine IL-10 by mouse peritoneal macrophages and do not affect the secretion of IL-4 by lymphocytes. The studied humic acid sample stimulates the production of proinflammatory cytokines IL-12, TNFα, IL-1β, and IFNγ by immunocompetent mouse cells and human mononuclear cells. Course administration of humic acids to mice enhances the humoral immunity, increasing the number of antibody-forming cells in the spleen and the titer of antibodies in the blood serum after immunization with sheep red blood cells.
- Published
- 2021
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