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The development of transport infrastructure is becoming a strategic priority for Russian fuel and energy complex development in aspect of increasing its competitive ability on the world stage. The transport industry is not only the leading consumer of fuel and energy products, it is the most important condition for an effective functioning of fuel and energy complex, participate at all stages of manufacture, starting from mining and ending with the delivery of fuel and energy products to the consumer. The research includes the state of national fuel and energy complex over the past decade, current trends and forecast of development based on power function. The research also includes the role of certain types of transport in the functioning of the fuel and energy complex. The export component analysis of national fuel and energy complex development was done with condition of sanctions restrictions on oil, gas and coal supply, and reorientation of logistic flows to the Asia-Pacific countries.

In the current system of contract bidding, there are a number of problems, one of which is the imperfection of the evaluation criteria by which applicants are selected. The article presents a methodology for assessing the organizational and technological reliability of a construction organization and its competitive offers for tenders for construction and installation works. It is proposed to use the indicator of its organizational and technological reliability as a criterion for evaluating a construction organization that claims to fulfill a construction order. To determine the reliability of a construction company, information about the intensity of development of capital investments is used. This indicator allows you to assess how much the bidder can ensure the maximum return on the construction equipment and workers used, reduce the cost of construction using modern construction materials and resource-saving technologies. Each construction and installation organization will have its own intensity of development of capital investments. It depends on the qualification of employees, the availability and use of a fleet of construction machines and mechanisms, construction production technologies, construction organization methods, etc. As an indicator that characterizes the relative change in the actual development of capital investments from the standard or calculated value, the capital investment development index is used. Using retrospective data on the speed of capital investment development for similar objects or using variant design of the construction process, curves of accumulated probabilities of capital investment development indices are constructed, which are used to determine the organizational and technological reliability of the contract bidder. The proposed assessment of the reliability of a construction organization allows the customer (investor) to choose a reliable partner – contractor that best meets their requirements.

When choosing a construction company, it is important for the investor to assess its organizational and technological reliability, which affects the duration and cost of construction. It is proposed to use as a source of information about the reliability of the data on the development of capital investments by the construction organization for a fixed period of time. The purpose of the study – to offer a mechanism for assessing the organizational and technological reliability of the construction company in the construction of the Foundation. On the basis of the method of variant design all possible alternatives of simple technological processes in the construction of pile foundations were considered. Using the method of statistical testing of simulation models on each process flow, the most probable duration and cost of design work were determined. All the options for the development of capital investments were reduced to a statistical series, on the basis of which the curve of accumulated probabilities was constructed. On the curve of accumulated probabilities it is possible to determine the probability of building foundations at the right time with the required value of the index of development of capital investments. Variant design of the construction process allows to develop simulation models of construction of any foundations, on the basis of which the curves of the accumulated probabilities of the indices of development of capital investments for each type of foundations are formed. These curves serve as the basis for the investor in determining the organizational and technological reliability of construction organizations.

The article discusses the relevance and necessity of assessing the impact of the duration of construction on the economic efficiency of investments. Using a mathematical expression, the profit received by the investor during the life cycle of the direct investment process is described. The peculiarity of investment projects involving the creation of capital investment (real estate), is the period of time during which profit is impossible. This period of time is equal to the duration of construction, including installation of technological equipment and commissioning. An analytical description of the degree of influence of the duration of construction on the indicators of economic efficiency of the investment project (profitability and profitability of property) is proposed. On the basis of the learned expressions, a numerical experiment was performed and graphs were constructed. The results of the research prove the possibility of analytical description of the degree of influence of the duration of construction on the quantitative indicators describing the investment project (profitability (Bank interest), profitability of the created property). It seems that the described approach allows to carry out forecasts which reliability surpasses the results obtained, for example, by means of expert estimations. The proposed mathematical apparatus is much simpler than the methods of probability theory and fuzzy set theory.

The recovery period after traumatic brain injury (TBI) is often complicated by secondary damage that may last for days or even months after trauma. Two proteins, Hsp70 and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), were recently described as modulating post-traumatic processes, and in this study, we test them as targets for combination therapy using an inhibitor of GAPDH aggregation (derivative of hydrocortisone RX624) and an inducer of Hsp70 synthesis (the pyrrolylazine derivative PQ-29). The protective effect of the combination on C6 rat glioblastoma cells treated with the cerebrospinal fluid of traumatized animals resulted in an increase in the cell index and in a reduced level of apoptosis. Using a rat weight drop model of TBI, we found that the combined use of both drugs prevented memory impairment and motor deficits, as well as a reduction of neurons and accumulation of GAPDH aggregates in brain tissue. In conclusion, we developed and tested a new approach to the treatment of TBI based on influencing distinct molecular mechanisms in brain cells. [ABSTRACT FROM AUTHOR]

Derivatives of fused 1,2,4-triazines containing heterocyclic and metallocene fragments were obtained by one-pot oxidative cyclization of heterocyclic hydrazones in the presence of hypervalent iodine(III) reagents. For 1,2,4-triazolo[4,3- a ]azines, the ability to activate HSF1 was investigated. The obtained compounds were shown to increase the degree of HSF1 activation. It was shown that the 1,2,4-triazines can be used to induce Hsp70 expression and decrease the extent of mutant HTT aggregate formation. [ABSTRACT FROM AUTHOR]