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402 results on '"Mikkelsen, Ellen M"'

1. Ambient air pollution and rate of spontaneous abortion

Author

Wesselink, Amelia K., Kirwa, Kipruto, Hystad, Perry, Kaufman, Joel D., Szpiro, Adam A., Willis, Mary D., Savitz, David A., Levy, Jonathan I., Rothman, Kenneth J., Mikkelsen, Ellen M., Laursen, Anne Sofie Dam, Hatch, Elizabeth E., and Wise, Lauren A.

Published
2024
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2. Per- and Polyfluoroalkyl Substances and Anti-Mullerian Hormone Concentrations in Two Preconception Cohort Studies

Author

Wise, Lauren A., Wang, Tanran R., Mikkelsen, Ellen M., Wesselink, Amelia K., Calafat, Antonia M., Wegienka, Ganesa, Geller, Ruth J., Coleman, Chad M., Willis, Mary D., Marsh, Erica E., Schildroth, Samantha, Botelho, Julianne C., Messerlian-Lambert, Geralyn, and Hatch, Elizabeth E.

Subjects
Hormones, Menstruation, Environmental issues, Health
Abstract

Introduction Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent synthetic chemicals found in consumer products, firefighting foam, and contaminated food and water. (1) Routes of exposure include ingestion, inhalation, and [...]

Published
2023
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10. Ambient air pollution and rate of spontaneous abortion

Author

Wesselink, Amelia K., primary, Kirwa, Kipruto, additional, Hystad, Perry, additional, Kaufman, Joel D., additional, Szpiro, Adam A., additional, Willis, Mary D., additional, Savitz, David A., additional, Levy, Jonathan I., additional, Rothman, Kenneth J., additional, Mikkelsen, Ellen M., additional, Laursen, Anne Sofie Dam, additional, Hatch, Elizabeth E., additional, and Wise, Lauren A., additional

Published
2023
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16. Mental disorders, participation, and trajectories in the Danish colorectal cancer programme:a population-based cohort study

Author

Thomsen, Mette Kielsholm, Jørgensen, Marie Dahl, Pedersen, Lars, Erichsen, Rune, Sørensen, Henrik Toft, and Mikkelsen, Ellen M.

Abstract

Background: People with mental disorders exhibit increased mortality due to colorectal cancer, despite having a similar incidence to the general population. We aimed to evaluate the extent to which people with mental disorders participate in organised colorectal cancer screening. Methods: We conducted a population-based cohort study of all Danish residents aged 50–74 years who were invited to undergo biennial faecal immunochemical testing between March 1, 2014, and Sept 30, 2018. We used national registry data from all first-time invitees. The primary endpoint was participation within 90 days of invitation. We calculated the proportion who participated and assessed their screening results and adherence to and completeness of follow-up colonoscopy according to their history of mental disorders, classified as none, mild or moderate, or severe. We computed crude and adjusted participation differences in percentage points and participation ratios using the pseudo-observations method. Findings: Of 2 036 704 people who were invited, we included 2 036 352 in the final cohort, of whom 1 008 045 (49·5%) were men and 1 028 307 (50·5%) were women, with a mean age of 60·7 years (SD 8·3, range 49–78). Data on ethnicity were not collected. Compared with people with no mental disorders, the adjusted analysis showed lower participation among people with mild or moderate mental disorders (men: participation difference –4·4 percentage points [95% CI –4·7 to –4·1]; women: –3·8 percentage points [–4·1 to –3·6]) and severe mental disorders (men: participation difference –13·8 percentage points [–14·3 to –13·3]; women: –15·4 percentage points [–15·8 to –14·9]). People with mental disorders had a higher proportion of positive faecal immunochemical test results, lower adherence to colonoscopy, and more incomplete colonoscopies than people without mental disorders. Interpretation: People with mental disorders were less likely to participate in colorectal cancer screening than those without these disorders. Patients with mental disorders could benefit from support or encouragement from their general practitioner or mental health-care facility to participate in cancer screening. Potential interventions should consider type of mental disorder, as needs might differ. Funding: Danish Cancer Society, Danish Health Foundation.

Published
2023

21. Effect of a FIT-Based Colorectal Cancer Screening Program on Mortality Estimated by the Regression Discontinuity Design.

Author

Thomsen, Mette K, Nicolaisen, Sia K, Pedersen, Lars, Lash, Timothy L, Erichsen, Rune, Sørensen, Henrik Toft, and Mikkelsen, Ellen M

Subjects
FECAL analysis, IMMUNOCHEMISTRY, HEMOGLOBINS, CONFIDENCE intervals, COLONOSCOPY, MORTALITY, EARLY detection of cancer, COLORECTAL cancer, HUMAN services programs, COMPARATIVE studies, RESEARCH funding, MEDICAL referrals, LONGITUDINAL method
Abstract

The fecal immunochemical test (FIT) has been implemented in colorectal cancer (CRC) screening programs, but effect evaluations are lacking. We evaluated the effect of a positive FIT on all-cause and CRC mortality using the regression discontinuity design. The Danish CRC screening program invites all residents 50–74 years old, using a 20-μg hemoglobin/g feces cutoff for colonoscopy referral. In this cohort study, we followed all first-time screening participants from 2014–2019 until 2020. We estimated the local effect of screening results, of just above the cutoff vs. just below, as hazard ratios (HRs) between models fitted at each side of the cutoff. We conducted the analysis within a narrow hemoglobin range (≥17 and <23, n  = 16,428) and a wider range (≥14 and <26, n  = 35,353). Those screened just above the cutoff had lower all-cause mortality compared with below (HR = 0.87, 95% confidence interval: 0.69; 1.10), estimated from the narrow range. The CRC mortality analysis had few outcomes. In the wider range, those with a FIT just above the cutoff had a lower hazard of CRC mortality compared with just below the cutoff (HR = 0.49, 95% confidence interval: 0.17; 1.41). A FIT result just above the cutoff, leading to referral to colonoscopy, pointed towards reduced all-cause and CRC mortality compared with just below the cutoff. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Perceived stress and semen quality

Author

Lund, Katrine H., primary, Laursen, Anne Sofie D., additional, Grønborg, Therese K., additional, Toft, Gunnar, additional, Jacobsen, Bjarke H., additional, Wang, Tanran R., additional, Wesselink, Amelia K., additional, Hatch, Elizabeth E., additional, Sommer, Greg J., additional, Eisenberg, Michael L., additional, Rothman, Kenneth J., additional, Sørensen, Henrik T., additional, Wise, Lauren A., additional, and Mikkelsen, Ellen M., additional

Published
2022
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36. Mental disorders, participation, and trajectories in the Danish colorectal cancer programme: a population-based cohort study

Author

Thomsen, Mette Kielsholm, Jørgensen, Marie Dahl, Pedersen, Lars, Erichsen, Rune, Sørensen, Henrik Toft, and Mikkelsen, Ellen M

Abstract

People with mental disorders exhibit increased mortality due to colorectal cancer, despite having a similar incidence to the general population. We aimed to evaluate the extent to which people with mental disorders participate in organised colorectal cancer screening.

Published
2023
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41. Perceived stress and semen quality.

Author

Lund, Katrine H., Laursen, Anne Sofie D., Grønborg, Therese K., Toft, Gunnar, Jacobsen, Bjarke H., Wang, Tanran R., Wesselink, Amelia K., Hatch, Elizabeth E., Sommer, Greg J., Eisenberg, Michael L., Rothman, Kenneth J., Sørensen, Henrik T., Wise, Lauren A., and Mikkelsen, Ellen M.

Subjects
SEMEN analysis, PERCEIVED Stress Scale, GENERALIZED estimating equations, MEDICAL history taking, SPERM count
Abstract

Background: Psychological stress is prevalent among reproductive‐aged men. Assessment of semen quality for epidemiological studies is challenging as data collection is expensive and cumbersome, and studies evaluating the effect of perceived stress on semen quality are inconsistent. Objective: To examine the association between perceived stress and semen quality. Material and methods: We analyzed baseline data on 644 men (1,159 semen samples) from two prospective preconception cohort studies during 2015–2021: 592 in Pregnancy Study Online (PRESTO) and 52 in SnartForaeldre.dk (SF). At study entry, men aged ≥21 years (PRESTO) and ≥18 years (SF) trying to conceive without fertility treatment completed a questionnaire on reproductive and medical history, socio‐demographics, lifestyle, and the 10‐item version of the Perceived Stress Scale (PSS; interquartile range [IQR] of scores: 0–40). After enrollment (median weeks: 2.1, IQR: 1.3–3.7), men were invited to perform in‐home semen testing, twice with 7–10 days between tests, using the Trak Male Fertility Testing System. Semen quality was characterized by semen volume, sperm concentration, and total sperm count. We fit generalized estimating equation linear regression models to estimate the percent difference in mean log‐transformed semen parameters by four PSS groups (<10, 10–14, 15–19, ≥20), adjusting for potential confounders. Results: The median PSS score and IQR was 15 (10–19), and 136 men (21.1%) had a PSS score ≥20. Comparing men with PSS scores ≥20 with <10, the adjusted percent difference was −2.7 (95% CI: −9.8; 5.0) for semen volume, 6.8 (95% CI: ‐10.9; 28.1) for sperm concentration, and 4.3 (95% CI: −13.8; 26.2) for total sperm count. Conclusion: Our findings indicate that perceived stress is not materially associated with semen volume, sperm concentration, or total sperm count. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Dietary folate intake and fecundability in two preconception cohorts

Author

Cueto, Heidi T, primary, Jacobsen, Bjarke H, additional, Laursen, Anne Sofie Dam, additional, Riis, Anders H, additional, Hatch, Elizabeth E, additional, Wise, Lauren A, additional, Trolle, Ellen, additional, Sørensen, Henrik Toft, additional, Rothman, Kenneth J, additional, Wesselink, Amelia K, additional, Willis, Sydney, additional, Johannesen, Benjamin R, additional, and Mikkelsen, Ellen M, additional

Published
2022
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44. A Prospective Cohort Study of COVID-19 Vaccination, SARS-CoV-2 Infection, and Fertility

Author

Wesselink, Amelia K, primary, Hatch, Elizabeth E, additional, Rothman, Kenneth J, additional, Wang, Tanran R, additional, Willis, Mary D, additional, Yland, Jennifer, additional, Crowe, Holly M, additional, Geller, Ruth J, additional, Willis, Sydney K, additional, Perkins, Rebecca B, additional, Regan, Annette K, additional, Levinson, Jessica, additional, Mikkelsen, Ellen M, additional, and Wise, Lauren A, additional

Published
2022
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45. Air pollution and fecundability: Results from a Danish preconception cohort study

Author

Wesselink, Amelia K., primary, Wang, Tanran R., additional, Ketzel, Matthias, additional, Mikkelsen, Ellen M., additional, Brandt, Jørgen, additional, Khan, Jibran, additional, Hertel, Ole, additional, Laursen, Anne Sofie D., additional, Johannesen, Benjamin R., additional, Willis, Mary D., additional, Levy, Jonathan I., additional, Rothman, Kenneth J., additional, Sørensen, Henrik T., additional, Wise, Lauren A., additional, and Hatch, Elizabeth E., additional

Published
2021
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48. Air pollution and fecundability in two preconception cohort studies

Author

Hatch, Elizabeth E., primary, Wesselink, Amelia K., additional, Quraishi, Sabah M., additional, Kirwa, Kipruto, additional, Ketzel, Matthias, additional, Mikkelsen, Ellen M., additional, Willis, Mary D., additional, Hystad, Perry, additional, Kaufman, Joel D., additional, and Wise, Lauren A., additional

Published
2021
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49. Prospective Cohort Study of COVID-19 Vaccination, SARS-CoV-2 Infection, and Fertility.

Author

Wesselink, Amelia K, Hatch, Elizabeth E, Rothman, Kenneth J, Wang, Tanran R, Willis, Mary D, Yland, Jennifer, Crowe, Holly M, Geller, Ruth J, Willis, Sydney K, Perkins, Rebecca B, Regan, Annette K, Levinson, Jessica, Mikkelsen, Ellen M, and Wise, Lauren A

Subjects
RISK factors in infertility, COVID-19, CONFIDENCE intervals, COVID-19 vaccines, SELF-evaluation, REGRESSION analysis, RISK assessment, FERTILITY, QUESTIONNAIRES, DESCRIPTIVE statistics, ATTITUDES toward pregnancy, STATISTICAL models, SEXUAL partners, LONGITUDINAL method
Abstract

Some reproductive-aged individuals remain unvaccinated against coronavirus disease 2019 (COVID-19) because of concerns about potential adverse effects on fertility. Using data from an internet-based preconception cohort study, we examined the associations of COVID-19 vaccination and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with fertility among couples trying to conceive spontaneously. We enrolled 2,126 self-identified female participants aged 21–45 year residing in the United States or Canada during December 2020–September 2021 and followed them through November 2021. Participants completed questionnaires every 8 weeks on sociodemographics, lifestyle, medical factors, and partner information. We fit proportional probabilities regression models to estimate associations between self-reported COVID-19 vaccination and SARS-CoV-2 infection in both partners with fecundability (i.e. the per-cycle probability of conception), adjusting for potential confounders. COVID-19 vaccination was not appreciably associated with fecundability in either partner (female fecundability ratio (FR) = 1.08, 95% confidence interval (CI): 0.95, 1.23; male FR = 0.95, 95% CI: 0.83, 1.10). Female SARS-CoV-2 infection was not strongly associated with fecundability (FR = 1.07, 95% CI: 0.87, 1.31). Male infection was associated with a transient reduction in fecundability (for infection within 60 days, FR = 0.82, 95% CI: 0.47, 1.45; for infection after 60 days, FR = 1.16, 95% CI: 0.92, 1.47). These findings indicate that male SARS-CoV-2 infection may be associated with a short-term decline in fertility and that COVID-19 vaccination does not impair fertility in either partner. [ABSTRACT FROM AUTHOR]

Published
2022
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