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1. Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts

Author

Ackerlund, Cecilia, Adams, Hadie, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubović, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maegele, Marc, Majdan, Marek, Manara, Alex, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McFadyen, Charles, McMahon, Catherine, Melegh, Béla, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Oresic, Matej, Ortolano, Fabrizio, Otesile, Olubukola, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rehorčíková, Veronika, Helmrich, Isabel Retel, Rhodes, Jonathan, Richter, Sophie, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Singh, Ranjit D., Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Te Ao, Braden, Tenovuo, Olli, Theadom, Alice, Thibaut, Aurore, Thomas, Matt, Tibboel, Dick, Timmers, Marjolijn, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, van der Jagt, Mathieu, van der Naalt, Joukje, Van der Steen, Gregory, van Dijck, Jeroen T.J.M., van Erp, Inge A., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, van Veen, Ernest, van Wijk, Roel, Vyvere, Thijs Vande, Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Peter, Whitehouse, Daniel, Wiegers, Eveline, Williams, Guy, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso, Adeoye, Opeolu, Badjatia, Neeraj, Barber, Jason, Bergin, Michael, Boase, Kim, Bodien, Yelena, Chesnut, Randall, Corrigan, John, Crawford, Karen, Diaz-Arrastia, Ramon, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, Venkata, Ferguson, Adam R., Foreman, Brandon, Gaudette, Etienne, Giacino, Joseph, Gonzalez, Luis, Gopinath, Shankar, Grandhi, Ramesh, Gullapalli, Rao, Hemphill, Claude, Hotz, Gillian, Huie, Russell, Jha, Ruchira, Keene, Dirk C., Kitagawa, Ryan, Korley, Frederick, Kramer, Joel, Kreitzer, Natalie, Levin, Harvey, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Martin, Alastair, McAllister, Thomas, McCrea, Michael, Merchant, Randall, Mukherjee, Pratik, Nelson, Lindsay, Ngwenya, Laura B., Noel, Florence, Nolan, Amber, Okonkwo, David, Palacios, Eva, Perl, Daniel, Puccio, Ava, Rabinowitz, Miri, Robertson, Claudia, Ben Rodgers, Richard, Rosenthal, Eric, Sander, Angelle, Sandsmark, Danielle, Schneider, Andrea, Schnyer, David, Seabury, Seth, Sherer, Mark, Sugar, Gabriella, Temkin, Nancy, Toga, Arthur, Torres-Espin, Abel, Valadka, Alex, Vassar, Mary, Wang, Kevin, Wang, Vincent, Yue, John K., Yuh, Esther, Zafonte, Ross, Kals, Mart, Wilson, Lindsay, Levey, Daniel F., Parodi, Livia, Steyerberg, Ewout W., Richardson, Sylvia, He, Feng, Sun, Xiaoying, Jain, Sonia, Palotie, Aarno, Ripatti, Samuli, Rosand, Jonathan, Manley, Geoff T., Maas, Andrew I.R., Stein, Murray B., and Menon, David K.

Published
2024
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2. Traumatic brain injury: progress and challenges in prevention, clinical care, and research.

Author

Maas, Andrew, Menon, David, Manley, Geoffrey, Abrams, Mathew, Åkerlund, Cecilia, Andelic, Nada, Aries, Marcel, Bashford, Tom, Bell, Michael, Bodien, Yelena, Brett, Benjamin, Büki, András, Chesnut, Randall, Citerio, Giuseppe, Clark, David, Clasby, Betony, Cooper, D, Czeiter, Endre, Czosnyka, Marek, Dams-OConnor, Kristen, De Keyser, Véronique, Diaz-Arrastia, Ramon, Ercole, Ari, van Essen, Thomas, Falvey, Éanna, Nelson, David, Nelson, Lindsay, Newcombe, Virginia, Okonkwo, David, Orešič, Matej, Peul, Wilco, Pisică, Dana, Polinder, Suzanne, Ponsford, Jennie, Puybasset, Louis, Raj, Rahul, Robba, Chiara, Røe, Cecilie, Rosand, Jonathan, Schueler, Peter, Sharp, David, Smielewski, Peter, Stein, Murray, von Steinbüchel, Nicole, Stewart, William, Steyerberg, Ewout, Stocchetti, Nino, Temkin, Nancy, Tenovuo, Olli, Theadom, Alice, Thomas, Ilias, Espin, Abel, Turgeon, Alexis, Unterberg, Andreas, Van Praag, Dominique, van Veen, Ernest, Verheyden, Jan, Vyvere, Thijs, Wang, Kevin, Wiegers, Eveline, Williams, W, Wilson, Lindsay, Wisniewski, Stephen, Younsi, Alexander, Figaji, Anthony, Fitzgerald, Melinda, Foreman, Brandon, Gantner, Dashiell, Gao, Guoyi, Giacino, Joseph, Gravesteijn, Benjamin, Guiza, Fabian, Gupta, Deepak, Gurnell, Mark, Haagsma, Juanita, Hammond, Flora, Hawryluk, Gregory, Hutchinson, Peter, van der Jagt, Mathieu, Jain, Sonia, Jain, Swati, Jiang, Ji-Yao, Kent, Hope, Kolias, Angelos, Kompanje, Erwin, Lecky, Fiona, Lingsma, Hester, Maegele, Marc, Majdan, Marek, Markowitz, Amy, McCrea, Michael, Meyfroidt, Geert, Mikolić, Ana, Mondello, Stefania, Yuh, Esther, Zeiler, Frederick, Zeldovich, Marina, Zemek, Roger, Ferguson, Adam, and Mukherjee, Pratik

Subjects
Humans, Brain Injuries, Traumatic, Cost of Illness, Violence, Sports
Abstract

Traumatic brain injury (TBI) has the highest incidence of all common neurological disorders, and poses a substantial public health burden. TBI is increasingly documented not only as an acute condition but also as a chronic disease with long-term consequences, including an increased risk of late-onset neurodegeneration. The first Lancet Neurology Commission on TBI, published in 2017, called for a concerted effort to tackle the global health problem posed by TBI. Since then, funding agencies have supported research both in high-income countries (HICs) and in low-income and middle-income countries (LMICs). In November 2020, the World Health Assembly, the decision-making body of WHO, passed resolution WHA73.10 for global actions on epilepsy and other neurological disorders, and WHO launched the Decade for Action on Road Safety plan in 2021. New knowledge has been generated by large observational studies, including those conducted under the umbrella of the International Traumatic Brain Injury Research (InTBIR) initiative, established as a collaboration of funding agencies in 2011. InTBIR has also provided a huge stimulus to collaborative research in TBI and has facilitated participation of global partners. The return on investment has been high, but many needs of patients with TBI remain unaddressed. This update to the 2017 Commission presents advances and discusses persisting and new challenges in prevention, clinical care, and research. In LMICs, the occurrence of TBI is driven by road traffic incidents, often involving vulnerable road users such as motorcyclists and pedestrians. In HICs, most TBI is caused by falls, particularly in older people (aged ≥65 years), who often have comorbidities. Risk factors such as frailty and alcohol misuse provide opportunities for targeted prevention actions. Little evidence exists to inform treatment of older patients, who have been commonly excluded from past clinical trials—consequently, appropriate evidence is urgently required. Although increasing age is associated with worse outcomes from TBI, age should not dictate limitations in therapy. However, patients injured by low-energy falls (who are mostly older people) are about 50% less likely to receive critical care or emergency interventions, compared with those injured by high-energy mechanisms, such as road traffic incidents. Mild TBI, defined as a Glasgow Coma sum score of 13–15, comprises most of the TBI cases (over 90%) presenting to hospital. Around 50% of adult patients with mild TBI presenting to hospital do not recover to pre-TBI levels of health by 6 months after their injury. Fewer than 10% of patients discharged after presenting to an emergency department for TBI in Europe currently receive follow-up. Structured follow-up after mild TBI should be considered good practice, and urgent research is needed to identify which patients with mild TBI are at risk for incomplete recovery. The selection of patients for CT is an important triage decision in mild TBI since it allows early identification of lesions that can trigger hospital admission or life-saving surgery. Current decision making for deciding on CT is inefficient, with 90–95% of scanned patients showing no intracranial injury but being subjected to radiation risks. InTBIR studies have shown that measurement of blood-based biomarkers adds value to previously proposed clinical decision rules, holding the potential to improve efficiency while reducing radiation exposure. Increased concentrations of biomarkers in the blood of patients with a normal presentation CT scan suggest structural brain damage, which is seen on MR scanning in up to 30% of patients with mild TBI. Advanced MRI, including diffusion tensor imaging and volumetric analyses, can identify additional injuries not detectable by visual inspection of standard clinical MR images. Thus, the absence of CT abnormalities does not exclude structural damage—an observation relevant to litigation procedures, to management of mild TBI, and when CT scans are insufficient to explain the severity of the clinical condition. Although blood-based protein biomarkers have been shown to have important roles in the evaluation of TBI, most available assays are for research use only. To date, there is only one vendor of such assays with regulatory clearance in Europe and the USA with an indication to rule out the need for CT imaging for patients with suspected TBI. Regulatory clearance is provided for a combination of biomarkers, although evidence is accumulating that a single biomarker can perform as well as a combination. Additional biomarkers and more clinical-use platforms are on the horizon, but cross-platform harmonisation of results is needed. Health-care efficiency would benefit from diversity in providers. In the intensive care setting, automated analysis of blood pressure and intracranial pressure with calculation of derived parameters can help individualise management of TBI. Interest in the identification of subgroups of patients who might benefit more from some specific therapeutic approaches than others represents a welcome shift towards precision medicine. Comparative-effectiveness research to identify best practice has delivered on expectations for providing evidence in support of best practices, both in adult and paediatric patients with TBI. Progress has also been made in improving outcome assessment after TBI. Key instruments have been translated into up to 20 languages and linguistically validated, and are now internationally available for clinical and research use. TBI affects multiple domains of functioning, and outcomes are affected by personal characteristics and life-course events, consistent with a multifactorial bio-psycho-socio-ecological model of TBI, as presented in the US National Academies of Sciences, Engineering, and Medicine (NASEM) 2022 report. Multidimensional assessment is desirable and might be best based on measurement of global functional impairment. More work is required to develop and implement recommendations for multidimensional assessment. Prediction of outcome is relevant to patients and their families, and can facilitate the benchmarking of quality of care. InTBIR studies have identified new building blocks (eg, blood biomarkers and quantitative CT analysis) to refine existing prognostic models. Further improvement in prognostication could come from MRI, genetics, and the integration of dynamic changes in patient status after presentation. Neurotrauma researchers traditionally seek translation of their research findings through publications, clinical guidelines, and industry collaborations. However, to effectively impact clinical care and outcome, interactions are also needed with research funders, regulators, and policy makers, and partnership with patient organisations. Such interactions are increasingly taking place, with exemplars including interactions with the All Party Parliamentary Group on Acquired Brain Injury in the UK, the production of the NASEM report in the USA, and interactions with the US Food and Drug Administration. More interactions should be encouraged, and future discussions with regulators should include debates around consent from patients with acute mental incapacity and data sharing. Data sharing is strongly advocated by funding agencies. From January 2023, the US National Institutes of Health will require upload of research data into public repositories, but the EU requires data controllers to safeguard data security and privacy regulation. The tension between open data-sharing and adherence to privacy regulation could be resolved by cross-dataset analyses on federated platforms, with the data remaining at their original safe location. Tools already exist for conventional statistical analyses on federated platforms, however federated machine learning requires further development. Support for further development of federated platforms, and neuroinformatics more generally, should be a priority. This update to the 2017 Commission presents new insights and challenges across a range of topics around TBI: epidemiology and prevention (section 1); system of care (section 2); clinical management (section 3); characterisation of TBI (section 4); outcome assessment (section 5); prognosis (Section 6); and new directions for acquiring and implementing evidence (section 7). Table 1 summarises key messages from this Commission and proposes recommendations for the way forward to advance research and clinical management of TBI.

Published
2022

3. Association of early blood-based biomarkers and six-month functional outcomes in conventional severity categories of traumatic brain injury: capturing the continuous spectrum of injury

Author

Ackerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubović, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Nair, Nandesh, Negru, Ancuta, Nelson, David, Nieboer, Daan, Nyirádi, József, Oresic, Matej, Ortolano, Fabrizio, Otesile, Olubukola, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Helmrich, Isabel Retel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosand, Jonathan, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Singh, Ranjit D., Sewalt, Charlie, Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Thibaut, Aurore, Tibboel, Dick, Timmers, Marjolijn, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, van der Jagt, Mathieu, van der Naalt, Joukje, Van der Steen, Gregory, van Dijck, Jeroen T.J.M., van Erp, Inge A., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, van Veen, Ernest, van Wijk, Roel P.J., Vyvere, Thijs Vande, Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Peter, Wang, Kevin K.W., Wiegers, Eveline, Williams, Guy, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Zelinkova, Veronika, Ziverte, Agate, Zoerle, Tommaso, Wilson, Lindsay, Newcombe, Virginia F.J., Whitehouse, Daniel P., Mondello, Stefania, Maas, Andrew I.R., and Menon, David K.

Published
2024
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4. One-year employment outcome prediction after traumatic brain injury: A CENTER-TBI study

Author

Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I.R., Castaño-León, Ana M., Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Martino, Costanza, Maréchal, Hugues, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Olubukola, Otesile, Oresic, Matej, Ortolano, Fabrizio, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Helmrich, Isabel Retel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Singh, Ranjit D., Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Thibaut, Aurore, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolein, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Vallance, Shirley, Valeinis, Egils, Vámos, Zoltán, van der Jagt, Mathieu, Van der Steen, Gregory, van der Naalt, Joukje, van Dijck, Jeroen T.J.M., van Erp, Inge A.M., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, van Veen, Ernest, Vyvere, Thijs Vande, van Wijk, Roel P.J., Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K.W., Whitehouse, Daniel, Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Zelinkova, Veronika, Ziverte, Agate, Zoerle, Tommaso, Van Deynse, Helena, Cools, Wilfried, De Deken, Viktor-Jan, Hubloue, Ives, Tisseghem, Ellen, and Putman, Koen

Published
2024
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5. Clinical descriptors of disease trajectories in patients with traumatic brain injury in the intensive care unit (CENTER-TBI): a multicentre observational cohort study

Author

Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Carbayo Lozano, Guillermo, Carbonara, Marco, Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, DahyotFizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, den Boogert, Hugo, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, GuyLoup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Jiyao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, LarsOwe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I.R., CastañoLeón, Ana M., Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Martino, Costanza, Maréchal, Hugues, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Olubukola, Otesile, Oresic, Matej, Ortolano, Fabrizio, Palotie, Aarno, Parizel, Paul M., Payen, JeanFrançois, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Retel Helmrich, Isabel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, SanchezPorras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Singh, Ranjit D., Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolein, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Vallance, Shirley, Valeinis, Egils, Vámos, Zoltán, van der Jagt, Mathieu, Van der Steen, Gregory, van der Naalt, Joukje, van Dijck, Jeroen T.J.M., van Erp, Inge A.M., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, van Veen, Ernest, Vande Vyvere, Thijs, van Wijk, Roel P.J., Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K.W., Whitehouse, Daniel, Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Zelinkova, Veronika, Ziverte, Agate, Zoerle, Tommaso, Åkerlund, Cecilia A I, Holst, Anders, Bhattacharyay, Shubhayu, Steyerberg, Ewout, Menon, David K, and Nelson, David W

Published
2024
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6. Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study

Author

A˚ kerlund, Cecilia, George, Pradeep, Lanyon, Linda, Muraleedharan, Visakh, Nelson, David, Amrein, Krisztina, Ezer, Erzsébet, Kovács, Noémi, Melegh, Béla, Nyirádi, József, Tamás, Viktória, Vámos, Zoltán, Sorinola, Abayomi, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Frisvold, Shirin, Antoni, Anna, Schwendenwein, Elisabeth, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Beretta, Luigi, Calvi, Maria Rosa, Bartels, Ronald, den Boogert, Hugo, Barzó, Pál, Beauvais, Romuald, Perera, Natascha, Beer, Ronny, Helbok, Raimund, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Degos, Vincent, Galanaud, Damien, Perlbarg, Vincent, Berardino, Maurizio, Cavallo, Simona, Blaabjerg, Morten, Rosenlund, Christina, Schou, Rico Frederik, Bragge, Peter, Brazinova, Alexandra, Majdan, Marek, Taylor, Mark Steven, Zelinkova, Veronika, Brinck, Vibeke, Jarrett, Mike, Brooker, Joanne, Donoghue, Emma, Synnot, Anneliese, Brorsson, Camilla, Koskinen, Lars-Owe, Sundström, Nina, Buki, Andras, Czeiter, Endre, Bullinger, Monika, Cabeleira, Manuel, Czosnyka, Marek, Dixit, Abhishek, Ercole, Ari, Koraropoulos, Evgenios, Menon, David, Newcombe, Virginia, Richter, Sophie, Smielewski, Peter, Stamatakis, Emmanuel, Williams, Guy, Winzeck, Stefan, Zeiler, Frederick A., Caccioppola, Alessio, Calappi, Emiliana, Carbonara, Marco, Ortolano, Fabrizio, Zoerle, Tommaso, Stocchetti, Nino, Cameron, Peter, Gantner, Dashiell, Murray, Lynnette, Trapani, Tony, Vallance, Shirley, Lozano, Guillermo Carbayo, Pomposo, Inigo, Castaño-León, Ana M., Gomez, Pedro A., Lagares, Alfonso, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Vargiolu, Alessia, Ceyisakar, Iris, Gravesteijn, Benjamin, Haagsma, Juanita A., Huijben, Jilske, Lingsma, Hester, Nieboer, Daan, Mikolic, Ana, Polinder, Suzanne, Sewalt, Charlie, Steyerberg, Ewout W., Velt, Kimberley, Voormolen, Daphne, Wiegers, Eveline, Peul, Wilco, van Dijck, Jeroen T.J.M., van Essen, Thomas A., van Wijk, Roel P.J., Clusmann, Hans, Coburn, Mark, Kowark, Ana, Rossaint, Rolf, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Cˇovid, Amra, von Steinbüchel, Nicole, Curry, Nicola, Stanworth, Simon, Dahyot-Fizelier, Claire, Dark, Paul, Johnson, Faye, Dawes, Helen, Esser, Patrick, van Heugten, Caroline, De Keyser, Véronique, Maas, Andrew I.R., Menovsky, Tomas, Van der Steen, Gregory, Corte, Francesco Della, Grossi, Francesca, Depreitere, Bart, Đilvesi, Đula, Golubovic, Jagoš, Karan, Mladen, Vulekovic, Petar, Dreier, Jens, Vajkoczy, Peter, Wolf, Stefan, Dulière, Guy-Loup, Maréchal, Hugues, Fabricius, Martin, Kondziella, Daniel, Feigin, Valery L., Jones, Kelly, Ao, Braden Te, Theadom, Alice, Foks, Kelly, Haitsma, Iain, Volovici, Victor, Furmanov, Alex, Rosenthal, Guy, Gagliardo, Pablo, Gao, Guoyi, Jiang, Ji-yao, Ghuysen, Alexandre, Giga, Lelde, Valeinis, Egils, Ziverte, Agate, Glocker, Ben, Rueckert, Daniel, Gratz, Johannes, Gruen, Russell L., Gupta, Deepak, Roe, Cecilie, Helseth, Eirik, Roise, Olav, Horton, Lindsay, Wilson, Lindsay, Hutchinson, Peter J., Kolias, Angelos G., Jacobs, Bram, van der Naalt, Joukje, Jankowski, Stefan, Kompanje, Erwin, Timmers, Marjolein, Laureys, Steven, Ledoux, Didier, Misset, Benoit, Lecky, Fiona, Olubukola, Otesile, Lefering, Rolf, Schäfer, Nadine, Legrand, Valerie, Lejeune, Aurelie, Vega, Emmanuel, Mattern, Julia, Levi, Leon, Lightfoot, Roger, Maegele, Marc, Manara, Alex, Thomas, Matt, Manley, Geoffrey, Martino, Costanza, Sakowitz, Oliver, Sanchez-Porras, Renan, Younsi, Alexander, McMahon, Catherine, Negru, Ancuta, Oresic, Matej, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Persona, Paolo, Piippo-Karjalainen, Anna, Pirinen, Matti, Ples, Horia, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rhodes, Jonathan, Richardson, Sylvia, Ripatti, Samuli, Rocka, Saulius, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rossi, Sandra, Rusnák, Martin, Sahuquillo, Juan, Sandor, Janos, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Skandsen, Toril, Stevens, Robert, Stewart, William, Takala, Riikka, Tamosuitis, Tomas, Tenovuo, Olli, Tibboel, Dick, Tolias, Christos, Tudora, Cristina Maria, van der Jagt, Mathieu, Van Hecke, Wim, Van Praag, Dominique, Vyvere, Thijs Vande, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Wang, Kevin K.W., Yang, Zhihui, Ylén, Peter, van der Vlegel, Marjolein, Mikolić, Ana, Lee Hee, Quentin, Kaplan, Z.L. Rana, Retel Helmrich, Isabel R.A., van Veen, Ernest, Steinbuechel, Nicole v., Plass, Anne Marie, and Zeldovich, Marina

Published
2022
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8. Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort study

Author

Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubović, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I.R., Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Nair, Nandesh, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Oresic, Matej, Ortolano, Fabrizio, Otesile, Olubukola, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rehorčíková, Veronika, Helmrich, Isabel Retel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosand, Jonathan, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Kowark, Ana, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolijn, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, Van der Jagt, Mathieu, van der Naalt, Joukje, Van der Steen, Gregory, van Dijck, Jeroen T.J.M., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, Van Veen, Ernest, van Wijk, Roel, Vyvere, Thijs Vande, Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K.W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso, van Erp, Inge A.M., Lingsma, Hester F., Pisică, Dana, Yue, John K., Singh, Ranjit D., Kolias, Angelos, Peppel, Lianne D., Heijenbrok-Kal, Majanka, Ribbers, Gerard M., Menon, David K., Hutchinson, Peter J.A., Manley, Geoffrey T., de Ruiter, Godard C.W., and Peul, Wilco C.

Published
2023
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9. Surgery versus conservative treatment for traumatic acute subdural haematoma: a prospective, multicentre, observational, comparative effectiveness study

Author

Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Carbayo Lozano, Guillermo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubović, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Nair, Nandesh, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Oresic, Matej, Ortolano, Fabrizio, Otesile, Olubukola, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Piippo-Karjalainen, Anna, Pirinen, Matti, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rehorčíková, Veronika, Retel Helmrich, Isabel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosand, Jonathan, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Kowark, Ana, Stevens, Robert, Stewart, William, Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Te Ao, Braden, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolijn, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, Van der Jagt, Mathieu, van der Naalt, Joukje, Van der Steen, Gregory, van Dijck, Jeroen T.J.M., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, Van Veen, Ernest, van Wijk, Roel, Vande Vyvere, Thijs, Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K.W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso, van Essen, Thomas A, Lingsma, Hester F, Pisică, Dana, Singh, Ranjit D, Volovici, Victor, den Boogert, Hugo F, Younsi, Alexander, Peppel, Lianne D, Heijenbrok-Kal, Majanka H, Ribbers, Gerard M, Walchenbach, Robert, Menon, David K, Hutchinson, Peter, Depreitere, Bart, Steyerberg, Ewout W, Maas, Andrew I R, de Ruiter, Godard C W, and Peul, Wilco C

Published
2022
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10. A genome-wide association study of outcome from traumatic brain injury

Author

Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark, Coles, Jonathan P., Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, DahyotFizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Corte, Francesco Della, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, GuyLoup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J.A., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Jiyao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, LarsOwe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I.R., CastañoLeón, Ana M., Maegele, Marc, Majdan, Marek, Manara, Alex, Martino, Costanza, Maréchal, Hugues, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David K., Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia F.J., Nieboer, Daan, Nyirádi, József, Olubukola, Otesile, Oresic, Matej, Ortolano, Fabrizio, Palotie, Aarno, Parizel, Paul M., Payen, JeanFrançois, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Helmrich, Isabel Retel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosenfeld, Jeffrey V., Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, SanchezPorras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolein, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Vallance, Shirley, Valeinis, Egils, Vámos, Zoltán, van der Jagt, Mathieu, van der Steen, Gregory, van der Naalt, Joukje, van Dijck, Jeroen T.J.M., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, van Veen, Ernest, Vyvere, Thijs Vande, van Wijk, Roel P.J., Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K.W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Zelinkova, Veronika, Ziverte, Agate, Zoerle, Tommaso, Izzy, Saef, Radmanesh, Farid, Frantzén, Janek, Katila, Ari, Maanpää, Henna-Rikka, Tallus, Jussi, Adeoye, Opeolu, Badjatia, Neeraj, Boase, Kim, Barber, Jason, Bodien, Yelena, Chesnut, Randall, Corrigan, John D., Crawford, Karen, Diaz-Arrastia, Ramon, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, Ramana, Ferguson, Adam R., Foreman, Brandon, Gardner, Raquel, Gaudette, Etienne, Giacino, Joseph, Goldman, Dana, Gonzalez, Luis, Gopinath, Shankar, Gullapalli, Rao, Hemphill, Claude, Hotz, Gillian, Jain, Sonia, Keene, Dirk, Korley, Frederick K., Kramer, Joel, Kreitzer, Natalie, Levin, Harvey, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Manley, Geoffrey T., Martin, Alastair, McAllister, Thomas, McCrea, Michael, Merchant, Randall, Mukherjee, Pratik, Nelson, Lindsay, Ngwenya, Laura B, Noel, Florence, Nolan, Amber, Okonkwo, David, Palacios, Eva, Perl, Daniel, Puccio, Ava, Rabinowitz, Miri, Robertson, Claudia, Rosand, Jonathan, Sander, Angelle, Satris, Gabriella, Schnyer, David, Seabury, Seth, Sherer, Mark, Stein, Murray, Taylor, Sabrina, Temkin, Nancy, Toga, Arthur, Valadka, Alex, Vassar, Mary, Yue, John K., Yuh, Esther, Zafonte, Ross, Kals, Mart, Kunzmann, Kevin, Parodi, Livia, Anderson, Christopher D., Puccio, Ava M., Okonkwo, David O., Stein, Murray B., and Manley, Geoff T.

Published
2022
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11. Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation

Author

Ackerlund, Cecilia, Adams, Hadie, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Carbayo Lozano, Guillermo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Covic, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, den Boogert, Hugo, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maegele, Marc, Majdan, Marek, Manara, Alex, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McFadyen, Charles, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Oresic, Matej, Ortolano, Fabrizio, Otesile, Olubukola, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rehorčíková, Veronika, Retel Helmrich, Isabel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Singh, Ranjit D., Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Te Ao, Braden, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolijn, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, van der Jagt, Mathieu, van der Naalt, Joukje, Van der Steen, Gregory, van Dijck, Jeroen T.J.M., van Erp, Inge A., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, van Veen, Ernest, van Wijk, Roel, Vande Vyvere, Thijs, Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Peter, Wang, Kevin K.W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso, Adeoye, Opeolu, Badjatia, Neeraj, Barber, Jason, Bergin, Michael, Boase, Kim, Bodien, Yelena, Chesnut, Randall, Corrigan, John, Crawford, Karen, Diaz-Arrastia, Ramon, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, Venkata, Ferguson, Adam R, Foreman, Brandon, Gaudette, Etienne, Giacino, Joseph, Gonzalez, Luis, Gopinath, Shankar, Grandhi, Ramesh, Gullapalli, Rao, Hemphill, Claude, Hotz, Gillian, Huie, Russell, Jha, Ruchira, Keene, C. Dirk, Kitagawa, Ryan, Korley, Frederick, Kramer, Joel, Kreitzer, Natalie, Levin, Harvey, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Martin, Alastair, McAllister, Thomas, McCrea, Michael, Merchant, Randall, Mukherjee, Pratik, Nelson, Lindsay, Ngwenya, Laura B., Noel, Florence, Nolan, Amber, Okonkwo, David, Palacios, Eva, Perl, Daniel, Puccio, Ava, Rabinowitz, Miri, Robertson, Claudia, Rodgers, Richard Ben, Rosand, Jonathan, Rosenthal, Eric, Sander, Angelle, Sandsmark, Danielle, Sugar, Gabriella, Schneider, Andrea, Schnyer, David, Seabury, Seth, Sherer, Mark, Stein, Murray, Temkin, Nancy, Toga, Arthur, Torres-Espin, Abel, Valadka, Alex, Vassar, Mary, Wang, Kevin, Wang, Vincent, Yue, John K., Yuh, Esther, Zafonte, Ross, Galimberti, Stefania, Graziano, Francesca, Maas, Andrew I R, Isernia, Giulia, Lecky, Fiona, Jain, Sonia, Sun, Xiaoying, Gardner, Raquel C, Taylor, Sabrina R, Markowitz, Amy J, Manley, Geoffrey T, Valsecchi, Maria Grazia, Bellelli, Giuseppe, and Citerio, Giuseppe

Published
2022
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12. Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury

Author

Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Ceyisakar, Iris, Clusmann, Hans, Coburn, Mark, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Koraropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I.R., Castaño-León, Ana M., Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Martino, Costanza, Maréchal, Hugues, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Olubukola, Otesile, Oresic, Matej, Ortolano, Fabrizio, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Synnot, Anneliese, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolein, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Vallance, Shirley, Valeinis, Egils, Vámos, Zoltán, van der Jagt, Mathieu, Van der Steen, Gregory, van der Naalt, Joukje, van Dijck, Jeroen T.J.M., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, Vyvere, Thijs Vande, van Wijk, Roel P.J., Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K.W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Zelinkova, Veronika, Ziverte, Agate, Zoerle, Tommaso, Van Praag, Dominique L.G., Wouters, Kristien, and Van Den Eede, Filip

Published
2022
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14. Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study

Author

Brooker, Joanne, Bragge, Peter, Rosenfeld, Jeffrey, Cooper, Jamie D., Helbok, Raimund, Beer, Ronny, Schoechl, Herbert, Rusnák, Martin, Schwendenwein, Elisabeth, Antoni, Anna, De Keyser, Véronique, Menovsky, Tomas, Van Praag, Dominique, Maas, Andrew I.R., Van der Steen, Gregory, Parizel, Paul M., Vande Vyvere, Thijs, Depreitere, Bart, Van Hecke, Wim, Verheyden, Jan, Misset, Benoit, Ledoux, Didier, Laureys, Steven, Ghuysen, Alexandre, Maréchal, Hugues, Dulière, Guy-Loup, Gao, Guoyi, Jiang, Ji-yao, Kondziella, Daniel, Fabricius, Martin, Schou, Rico Frederik, Blaabjerg, Morten, Rosenlund, Christina, Piippo-Karjalainen, Anna, Raj, Rahul, Pirinen, Matti, Ripatti, Samuli, Palotie, Aarno, Ylén, Peter, Posti, Jussi P., Tenovuo, Olli, Takala, Riikka, Payen, Jean-François, Vega, Emmanuel, Lejeune, Aurelie, Audibert, Gérard, Degos, Vincent, Benali, Habib, Galanaud, Damien, Perlbarg, Vincent, Puybasset, Louis, Azouvi, Philippe, Legrand, Valerie, Dahyot-Fizelier, Claire, Rossaint, Rolf, Coburn, Mark Steven, Kowark, Ana, Clusmann, Hans, Dreier, Jens, Wolf, Stefan, Vajkoczy, Peter, Maegele, Marc, Gratz, Johannes, Schäfer, Nadine, Lefering, Rolf, Covic, Amra, von Steinbüchel, Nicole, Schmidt, Silke, Bullinger, Monika, Younsi, Alexander, Unterberg, Andreas, Mattern, Julia, Sakowitz, Oliver, Sanchez-Porras, Renan, Perera, Natascha, Beauvais, Romuald, Sandor, Janos, Czeiter, Endre, Buki, Andras, Ezer, Erzsébet, Vámos, Zoltán, Melegh, Béla, Tamás, Viktória, Sorinola, Abayomi, Kovács, Noémi, Nyirádi, József, Amrein, Krisztina, Barzó, Pál, Gupta, Deepak, Levi, Leon, Rosenthal, Guy, Furmanov, Alex, Martino, Costanza, Beretta, Luigi, Calvi, Maria Rosa, Azzolini, Maria Luisa, Stocchetti, Nino, Calappi, Emiliana, Zoerle, Tommaso, Ortolano, Fabrizio, Carbonara, Marco, Caccioppola, Alessio, Citerio, Giuseppe, Vargiolu, Alessia, Chieregato, Arturo, Chevallard, Giorgio, Della Corte, Francesco, Grossi, Francesca, Rossi, Sandra, Persona, Paolo, Berardino, Maurizio, Cavallo, Simona, Rambadagalla, Malinka, Ziverte, Agate, Giga, Lelde, Valeinis, Egils, Vilcinis, Rimantas, Tamosuitis, Tomas, Rocka, Saulius, Ragauskas, Arminas, van der Naalt, Joukje, Jacobs, Bram, Steyerberg, Ewout W., Bartels, Ronald, den Boogert, Hugo, Kompanje, Erwin, Timmers, Marjolijn, Foks, Kelly, Haitsma, Iain, Volovici, Victor, van der Jagt, Mathieu, Haagsma, Juanita A., Mikolic, Ana, Lingsma, Hester, Velt, Kimberley, Huijben, Jilske, Voormolen, Daphne, Nieboer, Daan, Wiegers, Eveline, Sewalt, Charlie, Gravesteijn, Benjamin, Polinder, Suzanne, Tibboel, Dick, van Wijk, Roel, van Dijck, Jeroen T.J.M., van Essen, Thomas A., Peul, Wilco, Schoonman, Guus, Jones, Kelly, Feigin, Valery L., Te Ao, Braden, Theadom, Alice, Helseth, Eirik, Roe, Cecilie, Roise, Olav, Andelic, Nada, Frisvold, Shirin, Andreassen, Lasse, Anke, Audny, Vik, Anne, Skandsen, Toril, Ples, Horia, Tudora, Cristina Maria, Negru, Ancuta, Vulekovic, Peter, Đilvesi, Đula, Karan, Mladen, Golubovic, Jagoš, Rehorcíková, Veronika, Taylor, Mark Steven, Brazinova, Alexandra, Majdan, Marek, Sahuquillo, Juan, Radoi, Andreea, Carbayo Lozano, Guillermo, Pomposo, Inigo, Lagares, Alfonso, Gomez, Pedro A., Castaño-León, Ana M., Gagliardo, Pablo, Oresic, Matej, Bellander, Bo-Michael, Lanyon, Linda, George, Pradeep, Muraleedharan, Visakh, Nelson, David, Ackerlund, Cecilia, Koskinen, Lars-Owe, Sundström, Nina, Brorsson, Camilla, Belli, Antonio, Manara, Alex, Thomas, Matt, Czosnyka, Marek, Smielewski, Peter, Cabeleira, Manuel, Coles, Jonathan, Richardson, Sylvia, Zeiler, Frederick A., Stamatakis, Emmanuel, Williams, Guy, Menon, David, Ercole, Ari, Dixit, Abhishek, Newcombe, Virginia, Richter, Sophie, McFadyen, Charles, Hutchinson, Peter J., Kolias, Angelos G., Adams, Hadie, Correia, Marta, Rhodes, Jonathan, Stewart, William, McMahon, Catherine, Rueckert, Daniel, Glocker, Ben, Tolias, Christos, Dawes, Helen, Esser, Patrick, van Heugten, Caroline, Curry, Nicola, Stanworth, Simon, Lecky, Fiona, Otesile, Olubukola, Johnson, Faye, Dark, Paul, Jankowski, Stefan, Lightfoot, Roger, Wilson, Lindsay, Horton, Lindsay, Stevens, Robert, Rosand, Jonathan, Manley, Geoffrey, Jarrett, Mike, Brinck, Vibeke, Wang, Kevin K.W., Yang, Zhihui, Vespa, Paul M., Gruen, Russell L., Cameron, Peter, Donoghue, Emma, Gantner, Dashiell, Gruen, Russel, Murray, Lynette, Rosenfeld, Jeffrey V., Varma, Dinesh, Trapani, Tony, Vallance, Shirley, MacIsaac, Cristopher, Jordan, Andrea, Wiegers, Eveline Janine Anna, Lingsma, Hester Floor, Huijben, Jilske Antonia, Cooper, David James, Maas, Andrew Ian Ramsay, Menon, David Krishna, Moore, Elizabeth Madeleine, Dippel, Diederik Willem, and Steyerberg, Ewout Willem

Published
2021
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15. Tracheal intubation in traumatic brain injury: a multicentre prospective observational study

Author

Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Ceyisakar, Iris, Clusmann, Hans, Coburn, Mark, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Koraropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I.R., Castaño-León, Ana M., Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Martino, Costanza, Maréchal, Hugues, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Olubukola, Otesile, Oresic, Matej, Ortolano, Fabrizio, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Synnot, Anneliese, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolein, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Vajkoczy, Peter, Vallance, Shirley, Valeinis, Egils, Vámos, Zoltán, van der Jagt, Mathieu, Van der Steen, Gregory, van der Naalt, Joukje, van Dijck, Jeroen T.J.M., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, Vyvere, Thijs Vande, van Wijk, Roel P.J., Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K.W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Zelinkova, Veronika, Ziverte, Agate, Zoerle, Tommaso, Gravesteijn, Benjamin Yael, Sewalt, Charlie Aletta, Menon, David Krishna, Maas, Andrew, Klimek, Markus, and Lingsma, Hester Floor

Published
2020
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18. Prognostic models for global functional outcome and post-concussion symptoms following mild traumatic brain injury : a collaborative european neurotrauma effectiveness research in traumatic brain injury (CENTER-TBI) study

Author

Mikolić, Ana, Steyerberg, Ewout W., Polinder, Suzanne, Wilson, Lindsay, Zeldovich, Marina, von Steinbuechel, Nicole, Newcombe, Virginia F.J., Menon, David K., van der Naalt, Joukje, Lingsma, Hester F., Maas, Andrew I.R., van Klaveren, David, Mikolić, Ana, Steyerberg, Ewout W., Polinder, Suzanne, Wilson, Lindsay, Zeldovich, Marina, von Steinbuechel, Nicole, Newcombe, Virginia F.J., Menon, David K., van der Naalt, Joukje, Lingsma, Hester F., Maas, Andrew I.R., and van Klaveren, David

Abstract

After mild traumatic brain injury (mTBI), a substantial proportion of individuals do not fully recover on the Glasgow Outcome Scale Extended (GOSE) or experience persistent post-concussion symptoms (PPCS). We aimed to develop prognostic models for the GOSE and PPCS at 6 months after mTBI and to assess the prognostic value of different categories of predictors (clinical variables; questionnaires; computed tomography [CT]; blood biomarkers). From the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, we included participants aged 16 or older with Glasgow Coma Score (GCS) 13-15. We used ordinal logistic regression to model the relationship between predictors and the GOSE, and linear regression to model the relationship between predictors and the Rivermead Post-concussion Symptoms Questionnaire (RPQ) total score. First, we studied a pre-specified Core model. Next, we extended the Core model with other clinical and sociodemographic variables available at presentation (Clinical model). The Clinical model was then extended with variables assessed before discharge from hospital: early post-concussion symptoms, CT variables, biomarkers, or all three categories (extended models). In a subset of patients mostly discharged home from the emergency department, the Clinical model was extended with 2-3-week post-concussion and mental health symptoms. Predictors were selected based on Akaike's Information Criterion. Performance of ordinal models was expressed as a concordance index (C) and performance of linear models as proportion of variance explained (R2). Bootstrap validation was used to correct for optimism. We included 2376 mTBI patients with 6-month GOSE and 1605 patients with 6-month RPQ. The Core and Clinical models for GOSE showed moderate discrimination (C = 0.68 95% confidence interval 0.68 to 0.70 and C = 0.70[0.69 to 0.71], respectively) and injury severity was the strongest predictor. The extended models had better

Published
2023
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19. Prognostic Models for Global Functional Outcome and Post-Concussion Symptoms Following Mild Traumatic Brain Injury:A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study

Author

Mikolić, Ana, Steyerberg, Ewout W., Polinder, Suzanne, Wilson, Lindsay, Zeldovich, Marina, von Steinbuechel, Nicole, Newcombe, Virginia F.J., Menon, David K., van der Naalt, Joukje, Lingsma, Hester F., Maas, Andrew I.R., van Klaveren, David, Mikolić, Ana, Steyerberg, Ewout W., Polinder, Suzanne, Wilson, Lindsay, Zeldovich, Marina, von Steinbuechel, Nicole, Newcombe, Virginia F.J., Menon, David K., van der Naalt, Joukje, Lingsma, Hester F., Maas, Andrew I.R., and van Klaveren, David

Abstract

After mild traumatic brain injury (mTBI), a substantial proportion of individuals do not fully recover on the Glasgow Outcome Scale Extended (GOSE) or experience persistent post-concussion symptoms (PPCS). We aimed to develop prognostic models for the GOSE and PPCS at 6 months after mTBI and to assess the prognostic value of different categories of predictors (clinical variables; questionnaires; computed tomography [CT]; blood biomarkers). From the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, we included participants aged 16 or older with Glasgow Coma Score (GCS) 13-15. We used ordinal logistic regression to model the relationship between predictors and the GOSE, and linear regression to model the relationship between predictors and the Rivermead Post-concussion Symptoms Questionnaire (RPQ) total score. First, we studied a pre-specified Core model. Next, we extended the Core model with other clinical and sociodemographic variables available at presentation (Clinical model). The Clinical model was then extended with variables assessed before discharge from hospital: early post-concussion symptoms, CT variables, biomarkers, or all three categories (extended models). In a subset of patients mostly discharged home from the emergency department, the Clinical model was extended with 2-3-week post-concussion and mental health symptoms. Predictors were selected based on Akaike's Information Criterion. Performance of ordinal models was expressed as a concordance index (C) and performance of linear models as proportion of variance explained (R2). Bootstrap validation was used to correct for optimism. We included 2376 mTBI patients with 6-month GOSE and 1605 patients with 6-month RPQ. The Core and Clinical models for GOSE showed moderate discrimination (C = 0.68 95% confidence interval 0.68 to 0.70 and C = 0.70[0.69 to 0.71], respectively) and injury severity was the strongest predictor. The extended models had bett

Published
2023

20. Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study

Author

van der Vlegel, Marjolein, primary, Mikolić, Ana, additional, Lee Hee, Quentin, additional, Kaplan, Z.L. Rana, additional, Retel Helmrich, Isabel R.A., additional, van Veen, Ernest, additional, Andelic, Nada, additional, Steinbuechel, Nicole v., additional, Plass, Anne Marie, additional, Zeldovich, Marina, additional, Wilson, Lindsay, additional, Maas, Andrew I.R., additional, Haagsma, Juanita A., additional, Polinder, Suzanne, additional, A˚ kerlund, Cecilia, additional, George, Pradeep, additional, Lanyon, Linda, additional, Muraleedharan, Visakh, additional, Nelson, David, additional, Amrein, Krisztina, additional, Ezer, Erzsébet, additional, Kovács, Noémi, additional, Melegh, Béla, additional, Nyirádi, József, additional, Tamás, Viktória, additional, Vámos, Zoltán, additional, Sorinola, Abayomi, additional, Andreassen, Lasse, additional, Anke, Audny, additional, Frisvold, Shirin, additional, Antoni, Anna, additional, Schwendenwein, Elisabeth, additional, Audibert, Gérard, additional, Azouvi, Philippe, additional, Azzolini, Maria Luisa, additional, Beretta, Luigi, additional, Calvi, Maria Rosa, additional, Bartels, Ronald, additional, den Boogert, Hugo, additional, Barzó, Pál, additional, Beauvais, Romuald, additional, Perera, Natascha, additional, Beer, Ronny, additional, Helbok, Raimund, additional, Bellander, Bo-Michael, additional, Belli, Antonio, additional, Benali, Habib, additional, Degos, Vincent, additional, Galanaud, Damien, additional, Perlbarg, Vincent, additional, Berardino, Maurizio, additional, Cavallo, Simona, additional, Blaabjerg, Morten, additional, Rosenlund, Christina, additional, Schou, Rico Frederik, additional, Bragge, Peter, additional, Brazinova, Alexandra, additional, Majdan, Marek, additional, Taylor, Mark Steven, additional, Zelinkova, Veronika, additional, Brinck, Vibeke, additional, Jarrett, Mike, additional, Brooker, Joanne, additional, Donoghue, Emma, additional, Synnot, Anneliese, additional, Brorsson, Camilla, additional, Koskinen, Lars-Owe, additional, Sundström, Nina, additional, Buki, Andras, additional, Czeiter, Endre, additional, Bullinger, Monika, additional, Cabeleira, Manuel, additional, Czosnyka, Marek, additional, Dixit, Abhishek, additional, Ercole, Ari, additional, Koraropoulos, Evgenios, additional, Menon, David, additional, Newcombe, Virginia, additional, Richter, Sophie, additional, Smielewski, Peter, additional, Stamatakis, Emmanuel, additional, Williams, Guy, additional, Winzeck, Stefan, additional, Zeiler, Frederick A., additional, Caccioppola, Alessio, additional, Calappi, Emiliana, additional, Carbonara, Marco, additional, Ortolano, Fabrizio, additional, Zoerle, Tommaso, additional, Stocchetti, Nino, additional, Cameron, Peter, additional, Gantner, Dashiell, additional, Murray, Lynnette, additional, Trapani, Tony, additional, Vallance, Shirley, additional, Lozano, Guillermo Carbayo, additional, Pomposo, Inigo, additional, Castaño-León, Ana M., additional, Gomez, Pedro A., additional, Lagares, Alfonso, additional, Chevallard, Giorgio, additional, Chieregato, Arturo, additional, Citerio, Giuseppe, additional, Vargiolu, Alessia, additional, Ceyisakar, Iris, additional, Gravesteijn, Benjamin, additional, Huijben, Jilske, additional, Lingsma, Hester, additional, Nieboer, Daan, additional, Mikolic, Ana, additional, Sewalt, Charlie, additional, Steyerberg, Ewout W., additional, Velt, Kimberley, additional, Voormolen, Daphne, additional, Wiegers, Eveline, additional, Peul, Wilco, additional, van Dijck, Jeroen T.J.M., additional, van Essen, Thomas A., additional, van Wijk, Roel P.J., additional, Clusmann, Hans, additional, Coburn, Mark, additional, Kowark, Ana, additional, Rossaint, Rolf, additional, Coles, Jonathan, additional, Cooper, Jamie D., additional, Correia, Marta, additional, Cˇovid, Amra, additional, von Steinbüchel, Nicole, additional, Curry, Nicola, additional, Stanworth, Simon, additional, Dahyot-Fizelier, Claire, additional, Dark, Paul, additional, Johnson, Faye, additional, Dawes, Helen, additional, Esser, Patrick, additional, van Heugten, Caroline, additional, De Keyser, Véronique, additional, Menovsky, Tomas, additional, Van der Steen, Gregory, additional, Corte, Francesco Della, additional, Grossi, Francesca, additional, Depreitere, Bart, additional, Đilvesi, Đula, additional, Golubovic, Jagoš, additional, Karan, Mladen, additional, Vulekovic, Petar, additional, Dreier, Jens, additional, Vajkoczy, Peter, additional, Wolf, Stefan, additional, Dulière, Guy-Loup, additional, Maréchal, Hugues, additional, Fabricius, Martin, additional, Kondziella, Daniel, additional, Feigin, Valery L., additional, Jones, Kelly, additional, Ao, Braden Te, additional, Theadom, Alice, additional, Foks, Kelly, additional, Haitsma, Iain, additional, Volovici, Victor, additional, Furmanov, Alex, additional, Rosenthal, Guy, additional, Gagliardo, Pablo, additional, Gao, Guoyi, additional, Jiang, Ji-yao, additional, Ghuysen, Alexandre, additional, Giga, Lelde, additional, Valeinis, Egils, additional, Ziverte, Agate, additional, Glocker, Ben, additional, Rueckert, Daniel, additional, Gratz, Johannes, additional, Gruen, Russell L., additional, Gupta, Deepak, additional, Roe, Cecilie, additional, Helseth, Eirik, additional, Roise, Olav, additional, Horton, Lindsay, additional, Hutchinson, Peter J., additional, Kolias, Angelos G., additional, Jacobs, Bram, additional, van der Naalt, Joukje, additional, Jankowski, Stefan, additional, Kompanje, Erwin, additional, Timmers, Marjolein, additional, Laureys, Steven, additional, Ledoux, Didier, additional, Misset, Benoit, additional, Lecky, Fiona, additional, Olubukola, Otesile, additional, Lefering, Rolf, additional, Schäfer, Nadine, additional, Legrand, Valerie, additional, Lejeune, Aurelie, additional, Vega, Emmanuel, additional, Mattern, Julia, additional, Levi, Leon, additional, Lightfoot, Roger, additional, Maegele, Marc, additional, Manara, Alex, additional, Thomas, Matt, additional, Manley, Geoffrey, additional, Martino, Costanza, additional, Sakowitz, Oliver, additional, Sanchez-Porras, Renan, additional, Younsi, Alexander, additional, McMahon, Catherine, additional, Negru, Ancuta, additional, Oresic, Matej, additional, Palotie, Aarno, additional, Parizel, Paul M., additional, Payen, Jean-François, additional, Persona, Paolo, additional, Piippo-Karjalainen, Anna, additional, Pirinen, Matti, additional, Ples, Horia, additional, Posti, Jussi P., additional, Puybasset, Louis, additional, Radoi, Andreea, additional, Ragauskas, Arminas, additional, Raj, Rahul, additional, Rambadagalla, Malinka, additional, Rhodes, Jonathan, additional, Richardson, Sylvia, additional, Ripatti, Samuli, additional, Rocka, Saulius, additional, Rosand, Jonathan, additional, Rosenfeld, Jeffrey V., additional, Rossi, Sandra, additional, Rusnák, Martin, additional, Sahuquillo, Juan, additional, Sandor, Janos, additional, Schmidt, Silke, additional, Schoechl, Herbert, additional, Schoonman, Guus, additional, Skandsen, Toril, additional, Stevens, Robert, additional, Stewart, William, additional, Takala, Riikka, additional, Tamosuitis, Tomas, additional, Tenovuo, Olli, additional, Tibboel, Dick, additional, Tolias, Christos, additional, Tudora, Cristina Maria, additional, van der Jagt, Mathieu, additional, Van Hecke, Wim, additional, Van Praag, Dominique, additional, Vyvere, Thijs Vande, additional, Verheyden, Jan, additional, Vespa, Paul M., additional, Vik, Anne, additional, Vilcinis, Rimantas, additional, Wang, Kevin K.W., additional, Yang, Zhihui, additional, and Ylén, Peter, additional

Published
2022
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21. Health care utilization and outcomes in older adults after Traumatic Brain Injury : a CENTER-TBI study

Author

van der Vlegel, Marjolein, Mikolić, Ana, Lee Hee, Quentin, Kaplan, Z. L. Rana, Retel Helmrich, Isabel R. A., van Veen, Ernest, Andelic, Nada, Steinbuechel, Nicole V., Plass, Anne Marie, Zeldovich, Marina, Wilson, Lindsay, Maas, Andrew I. R., Haagsma, Juanita A., Polinder, Suzanne, van der Vlegel, Marjolein, Mikolić, Ana, Lee Hee, Quentin, Kaplan, Z. L. Rana, Retel Helmrich, Isabel R. A., van Veen, Ernest, Andelic, Nada, Steinbuechel, Nicole V., Plass, Anne Marie, Zeldovich, Marina, Wilson, Lindsay, Maas, Andrew I. R., Haagsma, Juanita A., and Polinder, Suzanne

Abstract

INTRODUCTION: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI. METHODS: We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury. RESULTS: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms. CONCLUSION: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.

Published
2022
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22. Does poor methodological quality of prediction modeling studies translate to poor model performance?:An illustration in traumatic brain injury

Author

Helmrich, Isabel R A Retel, Mikolić, Ana, Kent, David M, Lingsma, Hester F, Wynants, Laure, Steyerberg, Ewout W, van Klaveren, David, Helmrich, Isabel R A Retel, Mikolić, Ana, Kent, David M, Lingsma, Hester F, Wynants, Laure, Steyerberg, Ewout W, and van Klaveren, David

Abstract

BACKGROUND: Prediction modeling studies often have methodological limitations, which may compromise model performance in new patients and settings. We aimed to examine the relation between methodological quality of model development studies and their performance at external validation.METHODS: We systematically searched for externally validated multivariable prediction models that predict functional outcome following moderate or severe traumatic brain injury. Risk of bias and applicability of development studies was assessed with the Prediction model Risk Of Bias Assessment Tool (PROBAST). Each model was rated for its presentation with sufficient detail to be used in practice. Model performance was described in terms of discrimination (AUC), and calibration. Delta AUC (dAUC) was calculated to quantify the percentage change in discrimination between development and validation for all models. Generalized estimation equations (GEE) were used to examine the relation between methodological quality and dAUC while controlling for clustering.RESULTS: We included 54 publications, presenting ten development studies of 18 prediction models, and 52 external validation studies, including 245 unique validations. Two development studies (four models) were found to have low risk of bias (RoB). The other eight publications (14 models) showed high or unclear RoB. The median dAUC was positive in low RoB models (dAUC 8%, [IQR - 4% to 21%]) and negative in high RoB models (dAUC - 18%, [IQR - 43% to 2%]). The GEE showed a larger average negative change in discrimination for high RoB models (- 32% (95% CI: - 48 to - 15) and unclear RoB models (- 13% (95% CI: - 16 to - 10)) compared to that seen in low RoB models.CONCLUSION: Lower methodological quality at model development associates with poorer model performance at external validation. Our findings emphasize the importance of adherence to methodological principles and reporting guidelines in prediction modeling st

Published
2022

23. Health care utilization and outcomes in older adults after Traumatic Brain Injury:A CENTER-TBI study

Author

van der Vlegel, Marjolein, Mikolić, Ana, Lee Hee, Quentin, Kaplan, Z. L.Rana, Retel Helmrich, Isabel R.A., van Veen, Ernest, Andelic, Nada, Steinbuechel, Nicole v., Plass, Anne Marie, Zeldovich, Marina, Wilson, Lindsay, Maas, Andrew I.R., Haagsma, Juanita A., Polinder, Suzanne, van der Vlegel, Marjolein, Mikolić, Ana, Lee Hee, Quentin, Kaplan, Z. L.Rana, Retel Helmrich, Isabel R.A., van Veen, Ernest, Andelic, Nada, Steinbuechel, Nicole v., Plass, Anne Marie, Zeldovich, Marina, Wilson, Lindsay, Maas, Andrew I.R., Haagsma, Juanita A., and Polinder, Suzanne

Abstract

Introduction: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI. Methods: We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury. Results: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms. Conclusion: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.

Published
2022

24. Traumatic brain injury: progress and challenges in prevention, clinical care, and research

Author

Maas, A, Menon, D, Manley, G, Abrams, M, Åkerlund, C, Andelic, N, Aries, M, Bashford, T, Bell, M, Bodien, Y, Brett, B, Büki, A, Chesnut, R, Citerio, G, Clark, D, Clasby, B, Cooper, D, Czeiter, E, Czosnyka, M, Dams-O'Connor, K, De Keyser, V, Diaz-Arrastia, R, Ercole, A, van Essen, T, Falvey, É, Ferguson, A, Figaji, A, Fitzgerald, M, Foreman, B, Gantner, D, Gao, G, Giacino, J, Gravesteijn, B, Guiza, F, Gupta, D, Gurnell, M, Haagsma, J, Hammond, F, Hawryluk, G, Hutchinson, P, van der Jagt, M, Jain, S, Jiang, J, Kent, H, Kolias, A, Kompanje, E, Lecky, F, Lingsma, H, Maegele, M, Majdan, M, Markowitz, A, Mccrea, M, Meyfroidt, G, Mikolić, A, Mondello, S, Mukherjee, P, Nelson, D, Nelson, L, Newcombe, V, Okonkwo, D, Orešič, M, Peul, W, Pisică, D, Polinder, S, Ponsford, J, Puybasset, L, Raj, R, Robba, C, Røe, C, Rosand, J, Schueler, P, Sharp, D, Smielewski, P, Stein, M, von Steinbüchel, N, Stewart, W, Steyerberg, E, Stocchetti, N, Temkin, N, Tenovuo, O, Theadom, A, Thomas, I, Espin, A, Turgeon, A, Unterberg, A, Van Praag, D, van Veen, E, Verheyden, J, Vyvere, T, Wang, K, Wiegers, E, Williams, W, Wilson, L, Wisniewski, S, Younsi, A, Yue, J, Yuh, E, Zeiler, F, Zeldovich, M, Zemek, R, Maas, Andrew I R, Menon, David K, Manley, Geoffrey T, Abrams, Mathew, Åkerlund, Cecilia, Andelic, Nada, Aries, Marcel, Bashford, Tom, Bell, Michael J, Bodien, Yelena G, Brett, Benjamin L, Büki, András, Chesnut, Randall M, Citerio, Giuseppe, Clark, David, Clasby, Betony, Cooper, D Jamie, Czeiter, Endre, Czosnyka, Marek, Dams-O'Connor, Kristen, De Keyser, Véronique, Diaz-Arrastia, Ramon, Ercole, Ari, van Essen, Thomas A, Falvey, Éanna, Ferguson, Adam R, Figaji, Anthony, Fitzgerald, Melinda, Foreman, Brandon, Gantner, Dashiell, Gao, Guoyi, Giacino, Joseph, Gravesteijn, Benjamin, Guiza, Fabian, Gupta, Deepak, Gurnell, Mark, Haagsma, Juanita A, Hammond, Flora M, Hawryluk, Gregory, Hutchinson, Peter, van der Jagt, Mathieu, Jain, Sonia, Jain, Swati, Jiang, Ji-yao, Kent, Hope, Kolias, Angelos, Kompanje, Erwin J O, Lecky, Fiona, Lingsma, Hester F, Maegele, Marc, Majdan, Marek, Markowitz, Amy, McCrea, Michael, Meyfroidt, Geert, Mikolić, Ana, Mondello, Stefania, Mukherjee, Pratik, Nelson, David, Nelson, Lindsay D, Newcombe, Virginia, Okonkwo, David, Orešič, Matej, Peul, Wilco, Pisică, Dana, Polinder, Suzanne, Ponsford, Jennie, Puybasset, Louis, Raj, Rahul, Robba, Chiara, Røe, Cecilie, Rosand, Jonathan, Schueler, Peter, Sharp, David J, Smielewski, Peter, Stein, Murray B, von Steinbüchel, Nicole, Stewart, William, Steyerberg, Ewout W, Stocchetti, Nino, Temkin, Nancy, Tenovuo, Olli, Theadom, Alice, Thomas, Ilias, Espin, Abel Torres, Turgeon, Alexis F, Unterberg, Andreas, Van Praag, Dominique, van Veen, Ernest, Verheyden, Jan, Vyvere, Thijs Vande, Wang, Kevin K W, Wiegers, Eveline J A, Williams, W Huw, Wilson, Lindsay, Wisniewski, Stephen R, Younsi, Alexander, Yue, John, Yuh, Esther L, Zeiler, Frederick A, Zeldovich, Marina, Zemek, Roger, Maas, A, Menon, D, Manley, G, Abrams, M, Åkerlund, C, Andelic, N, Aries, M, Bashford, T, Bell, M, Bodien, Y, Brett, B, Büki, A, Chesnut, R, Citerio, G, Clark, D, Clasby, B, Cooper, D, Czeiter, E, Czosnyka, M, Dams-O'Connor, K, De Keyser, V, Diaz-Arrastia, R, Ercole, A, van Essen, T, Falvey, É, Ferguson, A, Figaji, A, Fitzgerald, M, Foreman, B, Gantner, D, Gao, G, Giacino, J, Gravesteijn, B, Guiza, F, Gupta, D, Gurnell, M, Haagsma, J, Hammond, F, Hawryluk, G, Hutchinson, P, van der Jagt, M, Jain, S, Jiang, J, Kent, H, Kolias, A, Kompanje, E, Lecky, F, Lingsma, H, Maegele, M, Majdan, M, Markowitz, A, Mccrea, M, Meyfroidt, G, Mikolić, A, Mondello, S, Mukherjee, P, Nelson, D, Nelson, L, Newcombe, V, Okonkwo, D, Orešič, M, Peul, W, Pisică, D, Polinder, S, Ponsford, J, Puybasset, L, Raj, R, Robba, C, Røe, C, Rosand, J, Schueler, P, Sharp, D, Smielewski, P, Stein, M, von Steinbüchel, N, Stewart, W, Steyerberg, E, Stocchetti, N, Temkin, N, Tenovuo, O, Theadom, A, Thomas, I, Espin, A, Turgeon, A, Unterberg, A, Van Praag, D, van Veen, E, Verheyden, J, Vyvere, T, Wang, K, Wiegers, E, Williams, W, Wilson, L, Wisniewski, S, Younsi, A, Yue, J, Yuh, E, Zeiler, F, Zeldovich, M, Zemek, R, Maas, Andrew I R, Menon, David K, Manley, Geoffrey T, Abrams, Mathew, Åkerlund, Cecilia, Andelic, Nada, Aries, Marcel, Bashford, Tom, Bell, Michael J, Bodien, Yelena G, Brett, Benjamin L, Büki, András, Chesnut, Randall M, Citerio, Giuseppe, Clark, David, Clasby, Betony, Cooper, D Jamie, Czeiter, Endre, Czosnyka, Marek, Dams-O'Connor, Kristen, De Keyser, Véronique, Diaz-Arrastia, Ramon, Ercole, Ari, van Essen, Thomas A, Falvey, Éanna, Ferguson, Adam R, Figaji, Anthony, Fitzgerald, Melinda, Foreman, Brandon, Gantner, Dashiell, Gao, Guoyi, Giacino, Joseph, Gravesteijn, Benjamin, Guiza, Fabian, Gupta, Deepak, Gurnell, Mark, Haagsma, Juanita A, Hammond, Flora M, Hawryluk, Gregory, Hutchinson, Peter, van der Jagt, Mathieu, Jain, Sonia, Jain, Swati, Jiang, Ji-yao, Kent, Hope, Kolias, Angelos, Kompanje, Erwin J O, Lecky, Fiona, Lingsma, Hester F, Maegele, Marc, Majdan, Marek, Markowitz, Amy, McCrea, Michael, Meyfroidt, Geert, Mikolić, Ana, Mondello, Stefania, Mukherjee, Pratik, Nelson, David, Nelson, Lindsay D, Newcombe, Virginia, Okonkwo, David, Orešič, Matej, Peul, Wilco, Pisică, Dana, Polinder, Suzanne, Ponsford, Jennie, Puybasset, Louis, Raj, Rahul, Robba, Chiara, Røe, Cecilie, Rosand, Jonathan, Schueler, Peter, Sharp, David J, Smielewski, Peter, Stein, Murray B, von Steinbüchel, Nicole, Stewart, William, Steyerberg, Ewout W, Stocchetti, Nino, Temkin, Nancy, Tenovuo, Olli, Theadom, Alice, Thomas, Ilias, Espin, Abel Torres, Turgeon, Alexis F, Unterberg, Andreas, Van Praag, Dominique, van Veen, Ernest, Verheyden, Jan, Vyvere, Thijs Vande, Wang, Kevin K W, Wiegers, Eveline J A, Williams, W Huw, Wilson, Lindsay, Wisniewski, Stephen R, Younsi, Alexander, Yue, John, Yuh, Esther L, Zeiler, Frederick A, Zeldovich, Marina, and Zemek, Roger

Published
2022

25. Health care utilization and outcomes in older adults after Traumatic Brain Injury: a CENTER-TBI study

Author

van der Vlegel, M, Mikolić, A, Hee, Q, Kaplan, Z, Helmrich, I, van Veen, E, Andelic, N, Steinbuechel, N, Plass, A, Zeldovich, M, Wilson, L, Maas, A, Haagsma, J, Polinder, S, Åkerlund, C, George, P, Lanyon, L, Muraleedharan, V, Nelson, D, Amrein, K, Ezer, E, Kovács, N, Melegh, B, Nyirádi, J, Tamás, V, Vámos, Z, Sorinola, A, Andreassen, L, Anke, A, Frisvold, S, Antoni, A, Schwendenwein, E, Audibert, G, Azouvi, P, Azzolini, M, Beretta, L, Calvi, M, Bartels, R, Boogert, H, Barzó, P, Beauvais, R, Perera, N, Beer, R, Helbok, R, Bellander, B, Belli, A, Benali, H, Degos, V, Galanaud, D, Perlbarg, V, Berardino, M, Cavallo, S, Blaabjerg, M, Rosenlund, C, Schou, R, Bragge, P, Brazinova, A, Majdan, M, Taylor, M, Zelinkova, V, Brinck, V, Jarrett, M, Brooker, J, Donoghue, E, Synnot, A, Brorsson, C, Koskinen, L, Sundström, N, Buki, A, Czeiter, E, Bullinger, M, Cabeleira, M, Czosnyka, M, Dixit, A, Ercole, A, Koraropoulos, E, Menon, D, Newcombe, V, Richter, S, Smielewski, P, Stamatakis, E, Williams, G, Winzeck, S, Zeiler, F, Caccioppola, A, Calappi, E, Carbonara, M, Ortolano, F, Zoerle, T, Stocchetti, N, Cameron, P, Gantner, D, Murray, L, Trapani, T, Vallance, S, Lozano, G, Pomposo, I, Castaño-León, A, Gomez, P, Lagares, A, Chevallard, G, Chieregato, A, Citerio, G, Vargiolu, A, Ceyisakar, I, Gravesteijn, B, Huijben, J, Lingsma, H, Nieboer, D, Mikolic, A, Sewalt, C, Steyerberg, E, Velt, K, Voormolen, D, Wiegers, E, Peul, W, van Dijck, J, van Essen, T, van Wijk, R, Clusmann, H, Coburn, M, Kowark, A, Rossaint, R, Coles, J, Cooper, J, Correia, M, Čovid, A, von Steinbüchel, N, Curry, N, Stanworth, S, Dahyot-Fizelier, C, Dark, P, Johnson, F, Dawes, H, Esser, P, van Heugten, C, De Keyser, V, Menovsky, T, Van der Steen, G, Corte, F, Grossi, F, Depreitere, B, Đilvesi, Đ, Golubovic, J, Karan, M, Vulekovic, P, Dreier, J, Vajkoczy, P, Wolf, S, Dulière, G, Maréchal, H, Fabricius, M, Kondziella, D, Feigin, V, Jones, K, Ao, B, Theadom, A, Foks, K, Haitsma, I, Volovici, V, Furmanov, A, Rosenthal, G, Gagliardo, P, Gao, G, Jiang, J, Ghuysen, A, Giga, L, Valeinis, E, Ziverte, A, Glocker, B, Rueckert, D, Gratz, J, Gruen, R, Gupta, D, Roe, C, Helseth, E, Roise, O, Horton, L, Hutchinson, P, Kolias, A, Jacobs, B, van der Naalt, J, Jankowski, S, Kompanje, E, Timmers, M, Laureys, S, Ledoux, D, Misset, B, Lecky, F, Olubukola, O, Lefering, R, Schäfer, N, Legrand, V, Lejeune, A, Vega, E, Mattern, J, Levi, L, Lightfoot, R, Maegele, M, Manara, A, Thomas, M, Manley, G, Martino, C, Sakowitz, O, Sanchez-Porras, R, Younsi, A, Mcmahon, C, Negru, A, Oresic, M, Palotie, A, Parizel, P, Payen, J, Persona, P, Piippo-Karjalainen, A, Pirinen, M, Ples, H, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rhodes, J, Richardson, S, Ripatti, S, Rocka, S, Rosand, J, Rosenfeld, J, Rossi, S, Rusnák, M, Sahuquillo, J, Sandor, J, Schmidt, S, Schoechl, H, Schoonman, G, Skandsen, T, Stevens, R, Stewart, W, Takala, R, Tamosuitis, T, Tenovuo, O, Tibboel, D, Tolias, C, Tudora, C, van der Jagt, M, Van Hecke, W, Van Praag, D, Vyvere, T, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Wang, K, Yang, Z, Ylén, P, van der Vlegel, Marjolein, Mikolić, Ana, Hee, Quentin Lee, Kaplan, Z. L. Rana, Helmrich, Isabel R. A. Retel, van Veen, Ernest, Andelic, Nada, Steinbuechel, Nicole v., Plass, Anne Marie, Zeldovich, Marina, Wilson, Lindsay, Maas, Andrew I. R., Haagsma, Juanita A., Polinder, Suzanne, Åkerlund, Cecilia, George, Pradeep, Lanyon, Linda, Muraleedharan, Visakh, Nelson, David, Amrein, Krisztina, Ezer, Erzsébet, Kovács, Noémi, Melegh, Béla, Nyirádi, József, Tamás, Viktória, Vámos, Zoltán, Sorinola, Abayomi, Andreassen, Lasse, Anke, Audny, Frisvold, Shirin, Antoni, Anna, Schwendenwein, Elisabeth, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Beretta, Luigi, Calvi, Maria Rosa, Bartels, Ronald, Boogert, Hugo den, Barzó, Pál, Beauvais, Romuald, Perera, Natascha, Beer, Ronny, Helbok, Raimund, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Degos, Vincent, Galanaud, Damien, Perlbarg, Vincent, Berardino, Maurizio, Cavallo, Simona, Blaabjerg, Morten, Rosenlund, Christina, Schou, Rico Frederik, Bragge, Peter, Brazinova, Alexandra, Majdan, Marek, Taylor, Mark Steven, Zelinkova, Veronika, Brinck, Vibeke, Jarrett, Mike, Brooker, Joanne, Donoghue, Emma, Synnot, Anneliese, Brorsson, Camilla, Koskinen, Lars-Owe, Sundström, Nina, Buki, Andras, Czeiter, Endre, Bullinger, Monika, Cabeleira, Manuel, Czosnyka, Marek, Dixit, Abhishek, Ercole, Ari, Koraropoulos, Evgenios, Menon, David, Newcombe, Virginia, Richter, Sophie, Smielewski, Peter, Stamatakis, Emmanuel, Williams, Guy, Winzeck, Stefan, Zeiler, Frederick A., Caccioppola, Alessio, Calappi, Emiliana, Carbonara, Marco, Ortolano, Fabrizio, Zoerle, Tommaso, Stocchetti, Nino, Cameron, Peter, Gantner, Dashiell, Murray, Lynnette, Trapani, Tony, Vallance, Shirley, Lozano, Guillermo Carbayo, Pomposo, Inigo, Castaño-León, Ana M., Gomez, Pedro A., Lagares, Alfonso, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Vargiolu, Alessia, Ceyisakar, Iris, Gravesteijn, Benjamin, Huijben, Jilske, Lingsma, Hester, Nieboer, Daan, Mikolic, Ana, Sewalt, Charlie, Steyerberg, Ewout W., Velt, Kimberley, Voormolen, Daphne, Wiegers, Eveline, Peul, Wilco, van Dijck, Jeroen T. J. M., van Essen, Thomas A., van Wijk, Roel P. J., Clusmann, Hans, Coburn, Mark, Kowark, Ana, Rossaint, Rolf, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čovid, Amra, von Steinbüchel, Nicole, Curry, Nicola, Stanworth, Simon, Dahyot-Fizelier, Claire, Dark, Paul, Johnson, Faye, Dawes, Helen, Esser, Patrick, van Heugten, Caroline, De Keyser, Véronique, Menovsky, Tomas, Van der Steen, Gregory, Corte, Francesco Della, Grossi, Francesca, Depreitere, Bart, Đilvesi, Đula, Golubovic, Jagoš, Karan, Mladen, Vulekovic, Petar, Dreier, Jens, Vajkoczy, Peter, Wolf, Stefan, Dulière, Guy-Loup, Maréchal, Hugues, Fabricius, Martin, Kondziella, Daniel, Feigin, Valery L., Jones, Kelly, Ao, Braden Te, Theadom, Alice, Foks, Kelly, Haitsma, Iain, Volovici, Victor, Furmanov, Alex, Rosenthal, Guy, Gagliardo, Pablo, Gao, Guoyi, Jiang, Ji-yao, Ghuysen, Alexandre, Giga, Lelde, Valeinis, Egils, Ziverte, Agate, Glocker, Ben, Rueckert, Daniel, Gratz, Johannes, Gruen, Russell L., Gupta, Deepak, Roe, Cecilie, Helseth, Eirik, Roise, Olav, Horton, Lindsay, Hutchinson, Peter J., Kolias, Angelos G., Jacobs, Bram, van der Naalt, Joukje, Jankowski, Stefan, Kompanje, Erwin, Timmers, Marjolein, Laureys, Steven, Ledoux, Didier, Misset, Benoit, Lecky, Fiona, Olubukola, Otesile, Lefering, Rolf, Schäfer, Nadine, Legrand, Valerie, Lejeune, Aurelie, Vega, Emmanuel, Mattern, Julia, Levi, Leon, Lightfoot, Roger, Maegele, Marc, Manara, Alex, Thomas, Matt, Manley, Geoffrey, Martino, Costanza, Sakowitz, Oliver, Sanchez-Porras, Renan, Younsi, Alexander, McMahon, Catherine, Negru, Ancuta, Oresic, Matej, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Persona, Paolo, Piippo-Karjalainen, Anna, Pirinen, Matti, Ples, Horia, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rhodes, Jonathan, Richardson, Sylvia, Ripatti, Samuli, Rocka, Saulius, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rossi, Sandra, Rusnák, Martin, Sahuquillo, Juan, Sandor, Janos, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Skandsen, Toril, Stevens, Robert, Stewart, William, Takala, Riikka, Tamosuitis, Tomas, Tenovuo, Olli, Tibboel, Dick, Tolias, Christos, Tudora, Cristina Maria, van der Jagt, Mathieu, Van Hecke, Wim, Van Praag, Dominique, Vyvere, Thijs Vande, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Wang, Kevin K. W., Yang, Zhihui, Ylén, Peter, van der Vlegel, M, Mikolić, A, Hee, Q, Kaplan, Z, Helmrich, I, van Veen, E, Andelic, N, Steinbuechel, N, Plass, A, Zeldovich, M, Wilson, L, Maas, A, Haagsma, J, Polinder, S, Åkerlund, C, George, P, Lanyon, L, Muraleedharan, V, Nelson, D, Amrein, K, Ezer, E, Kovács, N, Melegh, B, Nyirádi, J, Tamás, V, Vámos, Z, Sorinola, A, Andreassen, L, Anke, A, Frisvold, S, Antoni, A, Schwendenwein, E, Audibert, G, Azouvi, P, Azzolini, M, Beretta, L, Calvi, M, Bartels, R, Boogert, H, Barzó, P, Beauvais, R, Perera, N, Beer, R, Helbok, R, Bellander, B, Belli, A, Benali, H, Degos, V, Galanaud, D, Perlbarg, V, Berardino, M, Cavallo, S, Blaabjerg, M, Rosenlund, C, Schou, R, Bragge, P, Brazinova, A, Majdan, M, Taylor, M, Zelinkova, V, Brinck, V, Jarrett, M, Brooker, J, Donoghue, E, Synnot, A, Brorsson, C, Koskinen, L, Sundström, N, Buki, A, Czeiter, E, Bullinger, M, Cabeleira, M, Czosnyka, M, Dixit, A, Ercole, A, Koraropoulos, E, Menon, D, Newcombe, V, Richter, S, Smielewski, P, Stamatakis, E, Williams, G, Winzeck, S, Zeiler, F, Caccioppola, A, Calappi, E, Carbonara, M, Ortolano, F, Zoerle, T, Stocchetti, N, Cameron, P, Gantner, D, Murray, L, Trapani, T, Vallance, S, Lozano, G, Pomposo, I, Castaño-León, A, Gomez, P, Lagares, A, Chevallard, G, Chieregato, A, Citerio, G, Vargiolu, A, Ceyisakar, I, Gravesteijn, B, Huijben, J, Lingsma, H, Nieboer, D, Mikolic, A, Sewalt, C, Steyerberg, E, Velt, K, Voormolen, D, Wiegers, E, Peul, W, van Dijck, J, van Essen, T, van Wijk, R, Clusmann, H, Coburn, M, Kowark, A, Rossaint, R, Coles, J, Cooper, J, Correia, M, Čovid, A, von Steinbüchel, N, Curry, N, Stanworth, S, Dahyot-Fizelier, C, Dark, P, Johnson, F, Dawes, H, Esser, P, van Heugten, C, De Keyser, V, Menovsky, T, Van der Steen, G, Corte, F, Grossi, F, Depreitere, B, Đilvesi, Đ, Golubovic, J, Karan, M, Vulekovic, P, Dreier, J, Vajkoczy, P, Wolf, S, Dulière, G, Maréchal, H, Fabricius, M, Kondziella, D, Feigin, V, Jones, K, Ao, B, Theadom, A, Foks, K, Haitsma, I, Volovici, V, Furmanov, A, Rosenthal, G, Gagliardo, P, Gao, G, Jiang, J, Ghuysen, A, Giga, L, Valeinis, E, Ziverte, A, Glocker, B, Rueckert, D, Gratz, J, Gruen, R, Gupta, D, Roe, C, Helseth, E, Roise, O, Horton, L, Hutchinson, P, Kolias, A, Jacobs, B, van der Naalt, J, Jankowski, S, Kompanje, E, Timmers, M, Laureys, S, Ledoux, D, Misset, B, Lecky, F, Olubukola, O, Lefering, R, Schäfer, N, Legrand, V, Lejeune, A, Vega, E, Mattern, J, Levi, L, Lightfoot, R, Maegele, M, Manara, A, Thomas, M, Manley, G, Martino, C, Sakowitz, O, Sanchez-Porras, R, Younsi, A, Mcmahon, C, Negru, A, Oresic, M, Palotie, A, Parizel, P, Payen, J, Persona, P, Piippo-Karjalainen, A, Pirinen, M, Ples, H, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rhodes, J, Richardson, S, Ripatti, S, Rocka, S, Rosand, J, Rosenfeld, J, Rossi, S, Rusnák, M, Sahuquillo, J, Sandor, J, Schmidt, S, Schoechl, H, Schoonman, G, Skandsen, T, Stevens, R, Stewart, W, Takala, R, Tamosuitis, T, Tenovuo, O, Tibboel, D, Tolias, C, Tudora, C, van der Jagt, M, Van Hecke, W, Van Praag, D, Vyvere, T, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Wang, K, Yang, Z, Ylén, P, van der Vlegel, Marjolein, Mikolić, Ana, Hee, Quentin Lee, Kaplan, Z. L. Rana, Helmrich, Isabel R. A. Retel, van Veen, Ernest, Andelic, Nada, Steinbuechel, Nicole v., Plass, Anne Marie, Zeldovich, Marina, Wilson, Lindsay, Maas, Andrew I. R., Haagsma, Juanita A., Polinder, Suzanne, Åkerlund, Cecilia, George, Pradeep, Lanyon, Linda, Muraleedharan, Visakh, Nelson, David, Amrein, Krisztina, Ezer, Erzsébet, Kovács, Noémi, Melegh, Béla, Nyirádi, József, Tamás, Viktória, Vámos, Zoltán, Sorinola, Abayomi, Andreassen, Lasse, Anke, Audny, Frisvold, Shirin, Antoni, Anna, Schwendenwein, Elisabeth, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Beretta, Luigi, Calvi, Maria Rosa, Bartels, Ronald, Boogert, Hugo den, Barzó, Pál, Beauvais, Romuald, Perera, Natascha, Beer, Ronny, Helbok, Raimund, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Degos, Vincent, Galanaud, Damien, Perlbarg, Vincent, Berardino, Maurizio, Cavallo, Simona, Blaabjerg, Morten, Rosenlund, Christina, Schou, Rico Frederik, Bragge, Peter, Brazinova, Alexandra, Majdan, Marek, Taylor, Mark Steven, Zelinkova, Veronika, Brinck, Vibeke, Jarrett, Mike, Brooker, Joanne, Donoghue, Emma, Synnot, Anneliese, Brorsson, Camilla, Koskinen, Lars-Owe, Sundström, Nina, Buki, Andras, Czeiter, Endre, Bullinger, Monika, Cabeleira, Manuel, Czosnyka, Marek, Dixit, Abhishek, Ercole, Ari, Koraropoulos, Evgenios, Menon, David, Newcombe, Virginia, Richter, Sophie, Smielewski, Peter, Stamatakis, Emmanuel, Williams, Guy, Winzeck, Stefan, Zeiler, Frederick A., Caccioppola, Alessio, Calappi, Emiliana, Carbonara, Marco, Ortolano, Fabrizio, Zoerle, Tommaso, Stocchetti, Nino, Cameron, Peter, Gantner, Dashiell, Murray, Lynnette, Trapani, Tony, Vallance, Shirley, Lozano, Guillermo Carbayo, Pomposo, Inigo, Castaño-León, Ana M., Gomez, Pedro A., Lagares, Alfonso, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Vargiolu, Alessia, Ceyisakar, Iris, Gravesteijn, Benjamin, Huijben, Jilske, Lingsma, Hester, Nieboer, Daan, Mikolic, Ana, Sewalt, Charlie, Steyerberg, Ewout W., Velt, Kimberley, Voormolen, Daphne, Wiegers, Eveline, Peul, Wilco, van Dijck, Jeroen T. J. M., van Essen, Thomas A., van Wijk, Roel P. J., Clusmann, Hans, Coburn, Mark, Kowark, Ana, Rossaint, Rolf, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čovid, Amra, von Steinbüchel, Nicole, Curry, Nicola, Stanworth, Simon, Dahyot-Fizelier, Claire, Dark, Paul, Johnson, Faye, Dawes, Helen, Esser, Patrick, van Heugten, Caroline, De Keyser, Véronique, Menovsky, Tomas, Van der Steen, Gregory, Corte, Francesco Della, Grossi, Francesca, Depreitere, Bart, Đilvesi, Đula, Golubovic, Jagoš, Karan, Mladen, Vulekovic, Petar, Dreier, Jens, Vajkoczy, Peter, Wolf, Stefan, Dulière, Guy-Loup, Maréchal, Hugues, Fabricius, Martin, Kondziella, Daniel, Feigin, Valery L., Jones, Kelly, Ao, Braden Te, Theadom, Alice, Foks, Kelly, Haitsma, Iain, Volovici, Victor, Furmanov, Alex, Rosenthal, Guy, Gagliardo, Pablo, Gao, Guoyi, Jiang, Ji-yao, Ghuysen, Alexandre, Giga, Lelde, Valeinis, Egils, Ziverte, Agate, Glocker, Ben, Rueckert, Daniel, Gratz, Johannes, Gruen, Russell L., Gupta, Deepak, Roe, Cecilie, Helseth, Eirik, Roise, Olav, Horton, Lindsay, Hutchinson, Peter J., Kolias, Angelos G., Jacobs, Bram, van der Naalt, Joukje, Jankowski, Stefan, Kompanje, Erwin, Timmers, Marjolein, Laureys, Steven, Ledoux, Didier, Misset, Benoit, Lecky, Fiona, Olubukola, Otesile, Lefering, Rolf, Schäfer, Nadine, Legrand, Valerie, Lejeune, Aurelie, Vega, Emmanuel, Mattern, Julia, Levi, Leon, Lightfoot, Roger, Maegele, Marc, Manara, Alex, Thomas, Matt, Manley, Geoffrey, Martino, Costanza, Sakowitz, Oliver, Sanchez-Porras, Renan, Younsi, Alexander, McMahon, Catherine, Negru, Ancuta, Oresic, Matej, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Persona, Paolo, Piippo-Karjalainen, Anna, Pirinen, Matti, Ples, Horia, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rhodes, Jonathan, Richardson, Sylvia, Ripatti, Samuli, Rocka, Saulius, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rossi, Sandra, Rusnák, Martin, Sahuquillo, Juan, Sandor, Janos, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Skandsen, Toril, Stevens, Robert, Stewart, William, Takala, Riikka, Tamosuitis, Tomas, Tenovuo, Olli, Tibboel, Dick, Tolias, Christos, Tudora, Cristina Maria, van der Jagt, Mathieu, Van Hecke, Wim, Van Praag, Dominique, Vyvere, Thijs Vande, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Wang, Kevin K. W., Yang, Zhihui, and Ylén, Peter

Abstract

Introduction: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI. Methods: We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury. Results: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms. Conclusion: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.

Published
2022

26. Additional file 1 of Does poor methodological quality of prediction modeling studies translate to poor model performance? An illustration in traumatic brain injury

Author

Helmrich, Isabel R. A. Retel, Mikolić, Ana, Kent, David M., Lingsma, Hester F., Wynants, Laure, Steyerberg, Ewout W., and van Klaveren, David

Abstract

Additional file 1: Supplementary Table 1: Inclusion criteria of systematic search (Adapted from Dijkland et al., (2020)). Supplementary Table 2: Search strategy (Dijkland et al., 2019). Supplementary Table 3: Prediction model Risk Of Bias Assessment Tool (PROBAST) items and guidelines for reviewers. Supplementary Table 4: Relatedness rubric. Supplementary Table 5: Data extraction of 10 model development studies describing 18 prediction models. Supplementary Table 6: Methodological quality of model development studies for outcome following moderate and severe traumatic brain injury in terms of Applicability and Risk of Bias assessed with a short form based on the PROBAST. Supplementary Table 7: Data extraction of validation studies of 18 prediction models for outcome following moderate and severe traumatic brain injury. Supplementary Table 8: Median AUC and IQR at development and validation for each model.

Published
2022
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27. Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury : External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study

Author

Mikolić, Ana, Polinder, Suzanne, Steyerberg, Ewout W., Retel Helmrich, Isabel R. A., Giacino, Joseph T., Maas, Andrew I. R., van der Naalt, Joukje, Voormolen, Daphne C., von Steinbüchel, Nicole, Wilson, Lindsay, Lingsma, Hester F., van Klaveren, David, Mikolić, Ana, Polinder, Suzanne, Steyerberg, Ewout W., Retel Helmrich, Isabel R. A., Giacino, Joseph T., Maas, Andrew I. R., van der Naalt, Joukje, Voormolen, Daphne C., von Steinbüchel, Nicole, Wilson, Lindsay, Lingsma, Hester F., and van Klaveren, David

Abstract

The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score of 13-15. Prognostic models that were developed to predict functional outcome and persistent post-concussive symptoms (PPCS) after mild TBI have rarely been externally validated. We aimed to externally validate models predicting 3-12-month Glasgow Outcome Scale Extended (GOSE) or PPCS in adults with mild TBI. We analyzed data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) project, which included 2862 adults with mild TBI, with 6-month GOSE available for 2374 and Rivermead Post-Concussion Symptoms Questionnaire (RPQ) results available for 1605 participants. Model performance was evaluated based on calibration (graphically and characterized by slope and intercept) and discrimination (C-index). We validated five published models for 6-month GOSE and three for 6-month PPCS scores. The models used different cutoffs for outcome and some included symptoms measured 2 weeks post-injury. Discriminative ability varied substantially (C-index between 0.58 and 0.79). The models developed in the Corticosteroid Randomisation After Significant Head Injury (CRASH) trial for prediction of GOSE <5 discriminated best (C-index 0.78 and 0.79), but were poorly calibrated. The best performing models for PPCS included 2-week symptoms (C-index 0.75 and 0.76). In conclusion, none of the prognostic models for early prediction of GOSE and PPCS has both good calibration and discrimination in persons with mild TBI. In future studies, prognostic models should be tailored to the population with mild TBI, predicting relevant end-points based on readily available predictors.

Published
2021
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28. Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury

Author

Mikolić, Ana, van Klaveren, David, Oude Groeniger, Joost, Wiegers, Eveline J. A., Lingsma, Hester F., Zeldovich, Marina, von Steinbüchel, Nicole, Maas, Andrew I. R., Roeters van Lennep, Jeanine E., Polinder, Suzanne, Mikolić, Ana, van Klaveren, David, Oude Groeniger, Joost, Wiegers, Eveline J. A., Lingsma, Hester F., Zeldovich, Marina, von Steinbüchel, Nicole, Maas, Andrew I. R., Roeters van Lennep, Jeanine E., and Polinder, Suzanne

Abstract

Traumatic brain injury (TBI) is a significant cause of disability, but little is known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, and the broad range of care pathways, treatment characteristics, and outcomes following mild and moderate/severe TBI. We performed mixed-effects regression analyses in the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, stratified for injury severity and age, and adjusted for baseline characteristics. Outcomes were various care pathway and treatment variables, and 6-month measures of functional outcome, health-related quality of life (HRQoL), post-concussion symptoms (PCS), and mental health symptoms. The study included 2862 adults (36% women) with mild (mTBI; Glasgow Coma Scale [GCS] score 13–15), and 1333 adults (26% women) with moderate/severe TBI (GCS score 3–12). Women were less likely to be admitted to the intensive care unit (ICU; odds ratios [OR] 0.6, 95% confidence interval [CI]: 0.4-0.8) following mTBI. Following moderate/severe TBI, women had a shorter median hospital stay (OR 0.7, 95% CI: 0.5-1.0). Following mTBI, women had poorer outcomes; lower Glasgow Outcome Scale Extended (GOSE; OR 1.4, 95% CI: 1.2-1.6), lower generic and disease-specific HRQoL, and more severe PCS, depression, and anxiety. Among them, women under age 45 and above age 65 years showed worse 6-month outcomes compared with men of the same age. Following moderate/severe TBI, there was no difference in GOSE (OR 0.9, 95% CI: 0.7-1.2), but women reported more severe PCS (OR 1.7, 95% CI: 1.1-2.6). Men and women differ in care pathways and outcomes following TBI. Women generally report worse 6-month outcomes, but the size of differences depend on TBI severity and age. Future studies should examine factors that explain these differences.

Published
2021
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31. Prepoznavanje emocija i osjetljivost na gađenje u funkciji menstrualnog ciklusa

Author

Mikolić, Ana

Subjects
menstrualni ciklus, ranjivost na zaraze, osjetljivost na gađenje, patogeni, prepoznavanje facijalnih ekspresija
Abstract

U lutealnoj fazi menstrualnog ciklusa pod utjecajem progesterona dolazi do snižavanja imunoloških odgovora, što olakšava prihvat zametka i očuvanje trudnoće, no istovremeno dovodi do povećane podložnosti zarazama. Cilj ovog istraživanja bio je provjeriti dolazi li u lutealnoj fazi do izraženijih profilaktičkih kompenzacijskih ponašanja koje mogu smanjiti vjerojatnost zaraze. Ispitivana ponašanja bila su procjene gadljivosti i opasnosti različitih prizora, neutralnih i onih povezanih sa zarazom i kontaminacijom te brzina i točnost prepoznavanja facijalne ekspresije gađenja i ostalih bazičnih emocija. Ispitan je i doprinos percipirane ranjivosti na zaraze. Analizirani su podaci N=40 sudionica, prikupljeni u dva navrata, tijekom njihove rane folikularne i lutealne faze ciklusa. Hipoteza o postojanju profilaktičkih ponašanja nije potvrđena te nisu pronađene razlike u osjetljivosti na gađenje niti u procjeni opasnosti prizora povezanih sa zarazom i kontaminacijom. Facijalna ekspresija gađenja prepoznavala se jednako brzo i točno u obje faze menstrualnog ciklusa. No, potvrdilo se da se u ranoj folikularnoj fazi ciklusa bazične emocije točnije prepoznaju nego u lutealnoj fazi.

Published
2014

32. Očekivanje rodne diskriminacije u razvoju profesionalne karijere studenata i studentica završnih godina studija

Author

Jelić, Margareta, Bubalo, Iva, Mikolić, Ana, Radoš, Lara, Sušanj, Zoran, Miletić, Irena, Kalebić Maglica, Barbara, and Lopižić, Josip

Subjects
rodna diskriminacija, razvoj karijere, rodni identitet, rodne uloge
Abstract

Rodna diskriminacija obuhvaća nejednaku raspodjelu moći, resursa i privilegija, u pravilu u korist muškaraca. Unatoč mnogim društvenim promjenama i postojanju jasnih antidiskriminacijskih zakona te onih o rodnoj ravnopravnosti, u Hrvatskoj je rodna diskriminacija još uvijek u velikoj mjeri prisutna u području zapošljavanja i rada. Stoga je cilj ovog istraživanja bio ispitati očekivanje rodne diskriminacije u razvoju profesionalne karijere kod studenata i studentica završnih godina studija. Također, zanimalo nas je ovisi li to očekivanje kod studentica o njihovim stavovima prema rodnim ulogama i rodnom identitetu. Istraživanje je provedeno putem interneta, a sudjelovalo je 400 studenata/ica Sveučilišta u Zagrebu. Primijenjeni instrumenti bili su Upitnik sociodemografskih podataka, Upitnik očekivanja rodne diskriminacije u profesionalnoj karijeri, Upitnik faktora koji utječu na zapošljavanje, Upitnik faktora razvoja profesionalne karijere, Skala stavova prema rodnim ulogama i Upitnik osobnih karakteristika. Pokazalo se da studentice završnih godina studija imaju izraženija očekivanja rodne diskriminacije u zapošljavanju i razvoju karijere nego studenti. Također, spol se procjenjivao manje važnim za zapošljavanje i razvoj karijere u odnosu na druge faktore (znanja i vještine, sposobnosti i dr.), ali su ga studentice procjenjivale važnijim i za svoje zapošljavanje i za razvoj svoje karijere u odnosu na studente. Očekivanje rodne diskriminacije kod studentica nije se razlikovalo ovisno o tome pohađaju li dominantno muški ili dominantno ženski fakultet, kao niti ovisno o njihovim stavovima prema rodnim ulogama. No, studentice koje su manje maskuline, a pritom i manje feminine, imale su viša očekivanja rodne diskriminacije od androginih i maskulinih studentica. Dobiveni rezultati proširili su postojeće spoznaje o rodnoj diskriminaciji u Hrvatskoj na uzorak studenata/ica koji tek započinju svoju profesionalnu karijeru. Praktične implikacije odnose se poduzimanje dodatnih napora za postizanje rodne ravnopravnosti, veće društveno osvještavanje o ovoj problematici te poticanje samopoštovanja i asertivnosti mladih osoba.

Published
2013

33. Čija je emocionalna podrška važna za psihičko zdravlje studenata?

Author

Mikolić, Ana, Putarek, Vanja, Radojević, Ivana, Kuterovac Jagodić, Gordana, and Erceg Jugović, Inja, Huić, Aleksandra

Subjects
emocionalna podrška, romantični odnos, psihičke smetnje, zadovoljstvo životom, rodne razlike
Abstract

Studenti su zbog mnoštva promjena osobito ranjiva skupina za pojavu psihičkih poteškoća. Djelovanje stresnih događaja na studente ovisi o njihovom psihičkom zdravlju i socijalnim odnosima u koje su uključeni. Istraživanja na odrasloj populaciji pokazala su da postoje razlike između muškaraca i žena u socijalnim odnosima, te razlike u psihičkom zdravlju ovisno o uključenosti u romantičnu vezu. Cilj ovog istraživanja bio je ispitati postoje li kod studenata rodne razlike i razlike ovisno o partnerskom statusu u percipiranoj kvaliteti emocionalne podrške, psihičkim smetnjama i zadovoljstvu životom. Razlike u percipiranoj kvaliteti emocionalne podrške ispitivane su ovisno o izvoru podrške. Psihičke smetnje koje smo proučavali bile su depresivnost, anksioznost i stres. Istraživanje je provedeno online i sudjelovalo je 340 studenata. Primijenjeni mjerni instrumenti su Upitnik sociodemografskih podataka, Skala emocionalne podrške, DASS-21 i globalna mjera za određivanje zadovoljstva životom. Pokazalo se da studentice procjenjuju da dobivaju kvalitetniju emocionalnu podršku nego studenti te kvalitetnijom procjenjuju emocionalnu podršku od članova obitelji i prijatelja. Razlike u procjeni emocionalne podrške od partnera/ice te u psihičkim smetnjama i zadovoljstvu životom nisu pronađene. Usporedbom studenata/ica koji su u romantičnoj vezi i koji nisu, pokazalo se da su pojedinci u romantičnoj vezi zadovoljniji životom i manje depresivni, dok razlike u anksioznosti i stresu nisu pronađene. Studenti/ice koji nisu u romantičnoj vezi izvještavaju o jednakoj kvaliteti opće emocionalne podrške kao i pojedinci koji su u romantičnoj vezi, a podršku od prijatelja procjenjuju kvalitetnijom, što pokazuje da su samci usmjereniji na prijateljske odnose. Istraživanje je proširilo razumijevanje djelovanja različitih izvora emocionalne podrške ovisno o rodu pojedinca te potvrdilo važnost romantičnog odnosa i na studentskoj populaciji.

Published
2013

34. Osamljenost žena rane i srednje odrasle dobi : zaštitno značenje emocionalne podrške partnera, prijatelja i obitelji

Author

Mikolić, Ana and Putarek, Vanja

Subjects
osamljenost, emocionalna podrška, izvori podrške, žene, rana i srednja odrasla dob
Abstract

Osamljenost je univerzalan doživljaj koji se javlja kada očekivanja o socijalnim odnosima i potreba za pripadanjem nisu ispunjeni. Kronična osamljenost ima ozbiljne negativne posljedice za čovjekovo psihofizičko zdravlje. Stoga je važno odrediti kojim se zaštitnim čimbenicima kronična osamljenost može smanjiti ili spriječiti. Jedan od mogućih zaštitnih čimbenika je socijalna podrška. Osobito korisnom pokazuje se jedna od njezinih dimenzija, emocionalna podrška. Zaštitno djelovanje podrške od psihičkih smetnji razlikuje se ovisno o izvoru podrške i dobi pojedinca. Stoga je cilj ovog istraživanja bio ispitati razlike između žena rane i srednje odrasle dobi u emocionalnoj podršci od obitelji, prijatelja/ica i partnera te osamljenosti, kao i odnos između emocionalne podrške od ovih izvora i osamljenosti. Istraživanje je provedeno online i u njemu je sudjelovalo 340 žena. Podatci su prikupljeni Ljestvicom emocionalne podrške i Ljestvicom osamljenosti UCLA (verzija 3). Pokazalo se da nema razlike između žene rane i srednje odrasle dobi u osamljenosti, kvaliteti emocionalne podrške od obitelji i prijatelja/ica. Žene srednje odrasle dobi emocionalnu podršku od partnera percipiraju manje kvalitetnom od žena rane odrasle dobi. Podrška od obitelji i partnera doprinose nižoj razini osamljenosti nezavisno od podrške od drugih izvora. Rezultati istraživanja doprinose razumijevanju važnosti podrške iz različitih izvora za psihičko funkcioniranje žena.

Published
2013

35. Prediction of global functional outcome and post-concussive symptoms after mild Traumatic Brain Injury: external validation of prognostic models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study

Author

Mikolic, Ana, Polinder, Suzanne, Steyerberg, Ewout W, Retel Helmrich, Isabel, Giacino, Joseph T., Maas, Andrew I.R., van der Naalt, Joukje, Voormolen, Daphne, von Steinbüchel, Nicole, Wilson, Lindsay, Lingsma, Hester F, van Klaveren, David, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Frisvold, Shirin, Helseth, Eirik, Røe, Cecilie, Røise, Olav, Skandsen, Toril, Vik, Anne, Åkerlund, Cecilia, Amrein, Krisztina, Antoni, Anna, Audibert, Gerard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzo, Pal, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, CENTER-TBI Study Participants, Ragauskas, Arminas, Rocka, Saulius, Tamosuitis, Tomas, Vilcinis, Rimantas, Mary Ann Liebert, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, HUS Neurocenter, Neurokirurgian yksikkö, Helsinki Institute for Information Technology, Statistical and population genetics, Department of Mathematics and Statistics, Biostatistics Helsinki, Clinicum, Helsinki University Hospital Area, Department of Public Health, Doctoral Programme in Clinical Research, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, University Management, Ročka, Saulius, Tamošuitis, Tomas, Mikolic, A, Polinder, S, Steyerberg, E, Retel Helmrich, I, Giacino, J, Maas, A, Van Der Naalt, J, Voormolen, D, Von Steinbuchel, N, Wilson, L, Lingsma, H, Van Klaveren, D, Citerio, G, Public Health, Mikolić, Ana, Polinder, Suzanne, Steyerberg, Ewout W, Retel Helmrich, Isabel R A, Giacino, Joseph T, Maas, Andrew I R, van der Naalt, Joukje, Voormolen, Daphne C, von Steinbüchel, Nicole, Wilson, Lindsay, Lingsma, Hester F, van Klaveren, David (Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study Participants and Investigators), Beretta, Luigi, Molecular Neuroscience and Ageing Research (MOLAR), Section Neuropsychology, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, and RS: FPN NPPP I

Subjects
Male, DISORDER, 030506 rehabilitation, Neurologi, Glasgow Outcome Scale, GUIDELINES, 3124 Neurology and psychiatry, 0302 clinical medicine, Epidemiology, Medicine, EPIDEMIOLOGY, prognostic model, Longitudinal Studies, Prospective Studies, Aged, 80 and over, education.field_of_study, Post-Concussion Syndrome, Head injury, Glasgow outcome scale extended, external validation, mild traumatic brain injury, post-concussive symptoms, Rivermead post-concussion symptoms questionnaire, Middle Aged, RECOVERY, Prognosis, 3. Good health, PREVALENCE, Neurology, Female, 0305 other medical science, Glasgow Outcome Scale Extended, Adult, medicine.medical_specialty, Adolescent, Traumatic brain injury, Population, BIOMARKERS, QUESTIONNAIRE, 03 medical and health sciences, Young Adult, Humans, Glasgow Coma Scale, education, Prognostic models, Brain Concussion, Aged, business.industry, 3112 Neurosciences, HEAD-INJURY, post-concussive symptom, Models, Theoretical, CARE, medicine.disease, PREVENTION, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Physical therapy, Quality of Life, RISK-FACTORS, Neurology (clinical), Human medicine, business, 030217 neurology & neurosurgery
Abstract

The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score of 13-15. Prognostic models that were developed to predict functional outcome and persistent post-concussive symptoms (PPCS) after mild TBI have rarely been externally validated. We aimed to externally validate models predicting 3-12-month Glasgow Outcome Scale Extended (GOSE) or PPCS in adults with mild TBI. We analyzed data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) project, which included 2862 adults with mild TBI, with 6-month GOSE available for 2374 and Rivermead Post-Concussion Symptoms Questionnaire (RPQ) results available for 1605 participants. Model performance was evaluated based on calibration (graphically and characterized by slope and intercept) and discrimination (C-index). We validated five published models for 6-month GOSE and three for 6-month PPCS scores. The models used different cutoffs for outcome and some included symptoms measured 2 weeks post-injury. Discriminative ability varied substantially (C-index between 0.58 and 0.79). The models developed in the Corticosteroid Randomisation After Significant Head Injury (CRASH) trial for prediction of GOSE, Funding Agencies:Hannelore Kohl Stiftung (Germany) OneMind (USA) Integra LifeSciences Corporation (USA) Neurotrauma Sciences (USA)

Published
2020
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36. Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury

Author

Marek Majdan, Marina Zeldovich, Thomas Van Essen, Daniel Kondziella, Juan Sahuquillo, Oliver Sakowitz, Ana M Castaño-Leon, Matti Pirinen, Thijs Vande Vyvere, Giuseppe Citerio, Ana Mikolic, Jussi Posti, Renán Sánchez-Porras, Andreea Rădoi, Peter Hutchinson, Sandra Rossi, Pedro Gomez, Virginia Newcombe, William Stewart, Jonathan Coles, Frederick Zeiler, Aarno Palotie, Paul Dark, Arminas Ragauskas, Mikolic, A, Van Klaveren, D, Groeniger, J, Wiegers, E, Lingsma, H, Zeldovich, M, Von Steinbuchel, N, Maas, A, Roeters Van Lennep, J, Polinder, S, Citerio, G, Sociology, Public Health, Internal Medicine, Ragauskas, Arminas, Ročka, Saulius, Tamošuitis, Tomas, Vilcinis, Rimantas, CTR-TBI Participants, Rocka, Saulius, Tamosuitis, Tomas, Mary Ann Liebert, Section Neuropsychology, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: FPN NPPP I, Mikolić, Ana, van Klaveren, David, Oude Groeniger, Joost, Wiegers, Eveline J A, Lingsma, Hester F, Zeldovich, Marina, von Steinbüchel, Nicole, Maas, Andrew I R, Roeters van Lennep, Jeanine E, Polinder, Suzanne (CENTER-TBI Participants and Investigators), Beretta, Luigi, Centre of Excellence in Complex Disease Genetics, Research Programs Unit, Aarno Palotie / Principal Investigator, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, HUS Neurocenter, Neurokirurgian yksikkö, Helsinki Institute for Information Technology, Statistical and population genetics, Department of Mathematics and Statistics, Biostatistics Helsinki, Clinicum, Helsinki University Hospital Area, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, and Molecular Neuroscience and Ageing Research (MOLAR)

Subjects
Male, sex differences, 030506 rehabilitation, Neurologi, VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803, Glasgow Outcome Scale, outcomes, 3124 Neurology and psychiatry, CONCUSSION SYMPTOMS QUESTIONNAIRE, law.invention, 0302 clinical medicine, Quality of life, QUALITY-OF-LIFE, law, Brain Injuries, Traumatic, Prospective Studies, Depression (differential diagnoses), treatment, traumatic brain injury, Head injury, Age Factors, Middle Aged, Prognosis, DEPRESSION, Intensive care unit, PREVALENCE, 3. Good health, Intensive Care Units, Treatment Outcome, VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803, Neurology, outcome, Female, care pathway, SEX, HEALTH, 0305 other medical science, Adult, medicine.medical_specialty, Traumatic brain injury, sex difference, INTIMATE-PARTNER-VIOLENCE, Young Adult, 03 medical and health sciences, Sex Factors, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Humans, Disabled Persons, Healthcare Disparities, Aged, GENDER-DIFFERENCES, business.industry, CENTER CARE, 3112 Neurosciences, HEAD-INJURY, Glasgow Coma Scale, Odds ratio, Length of Stay, MILD, medicine.disease, Quality of Life, Human medicine, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Traumatic brain injury (TBI) is a significant cause of disability, but little is known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, and the broad range of care pathways, treatment characteristics, and outcomes following mild and moderate/severe TBI. We performed mixed-effects regression analyses in the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, stratified for injury severity and age, and adjusted for baseline characteristics. Outcomes were various care pathway and treatment variables, and 6-month measures of functional outcome, health-related quality of life (HRQoL), post-concussion symptoms (PCS), and mental health symptoms. The study included 2862 adults (36% women) with mild (mTBI; Glasgow Coma Scale [GCS] score 13–15), and 1333 adults (26% women) with moderate/severe TBI (GCS score 3–12). Women were less likely to be admitted to the intensive care unit (ICU; odds ratios [OR] 0.6, 95% confidence interval [CI]: 0.4-0.8) following mTBI. Following moderate/severe TBI, women had a shorter median hospital stay (OR 0.7, 95% CI: 0.5-1.0). Following mTBI, women had poorer outcomes; lower Glasgow Outcome Scale Extended (GOSE; OR 1.4, 95% CI: 1.2-1.6), lower generic and disease-specific HRQoL, and more severe PCS, depression, and anxiety. Among them, women under age 45 and above age 65 years showed worse 6-month outcomes compared with men of the same age. Following moderate/severe TBI, there was no difference in GOSE (OR 0.9, 95% CI: 0.7-1.2), but women reported more severe PCS (OR 1.7, 95% CI: 1.1-2.6). Men and women differ in care pathways and outcomes following TBI. Women generally report worse 6-month outcomes, but the size of differences depend on TBI severity and age. Future studies should examine factors that explain these differences Ana Mikolic´ et al., 2020; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

Published
2020
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37. Prognostic models for depression and post-traumatic stress disorder symptoms following traumatic brain injury: a CENTER-TBI study.

Author

Mikolić A, van Klaveren D, Jost M, Maas AI, Shi S, Silverberg ND, Wilson L, Lingsma HF, and Steyerberg EW

Subjects
Humans, Male, Female, Adult, Prognosis, Middle Aged, Depressive Disorder, Major epidemiology, Depressive Disorder, Major diagnosis, Depressive Disorder, Major psychology, Depressive Disorder, Major etiology, Depression epidemiology, Depression diagnosis, Depression etiology, Depression psychology, Young Adult, Brain Injuries, Traumatic psychology, Brain Injuries, Traumatic diagnosis, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic diagnosis, Stress Disorders, Post-Traumatic psychology, Stress Disorders, Post-Traumatic etiology
Abstract

Background: Traumatic brain injury (TBI) is associated with an increased risk of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). We aimed to identify predictors and develop models for the prediction of depression and PTSD symptoms at 6 months post-TBI., Methods: We analysed data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury study. We used linear regression to model the relationship between predictors and depression (Patient Health Questionnaire-9) and PTSD symptoms (PTSD Checklist for Diagnostic and Statistical Manual for Mental Health Disorders Fifth Edition). Predictors were selected based on Akaike's Information Criterion. Additionally, we fitted logistic models for the endpoints 'probable MDD' and 'probable PTSD'. We also examined the incremental prognostic value of 2-3 weeks of symptoms., Results: We included 2163 adults (76% Glasgow Coma Scale=13-15). Depending on the scoring criteria, 7-18% screened positive for probable MDD and about 10% for probable PTSD. For both outcomes, the selected models included psychiatric history, employment status, sex, injury cause, alcohol intoxication and total injury severity; and for depression symptoms also preinjury health and education. The performance of the models was modest (proportion of explained variance=R 2 8% and 7% for depression and PTSD, respectively). Symptoms assessed at 2-3 weeks had a large incremental prognostic value (delta R 2 =0.25, 95% CI 0.24 to 0.26 for depression symptoms; delta R 2 =0.30, 95% CI 0.29 to 0.31 for PTSD)., Conclusion: Preinjury characteristics, such as psychiatric history and unemployment, and injury characteristics, such as violent injury cause, can increase the risk of mental health problems after TBI. The identification of patients at risk should be guided by early screening of mental health., Competing Interests: Competing interests: AMikolić reports the University of British Columbia Institute of Mental Health Marshall Fellows Program Postdoctoral fellowship. NDS reports grants from the Canadian Institutes of Health Research, Canadian Foundation for Innovation, Ontario Brain Institute, Weston Brain Institute, Heart and Stroke Foundation of Canada, MITACS, VGH+UBC Hospital Foundation and WorkSafeBC; clinical consulting fees from the National Hockey League and Major League Soccer, and speakers fees from NYU Langone, WorkSafeBC, Yukon Workers’ Safety and Compensation Board, International Academy of Independent Medical Examiners and Canadian Concussion Network. AMaas declares personal fees from NeuroTrauma Sciences and Novartis and participation on the DSMB of PresSura Neuro. LW reports consulting fees for Neurotrauma Sciences, Novartis and Mass General Brigham. ES reports royalties for text book with Springer: Clinical Prediction Models., (© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. Published by BMJ.)

Published
2025
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38. Priority Clinical Actions for Outpatient Management of Nonhospitalized Traumatic Brain Injury.

Author

Silverberg ND, Lee K, Mikolić A, Bayley MT, Brody DL, Ely EW, Giacino JT, Halabi C, Hammond FM, Ignacio DA, Mosti C, van der Naalt J, Pappadis MR, Tenovuo O, Wang VY, Verduzco-Gutierrez M, and Manley GT

Abstract

Outpatient care following nonhospitalized traumatic brain injury (TBI) is variable, and often sparse. The National Academies of Sciences, Engineering, and Medicine's 2022 report on Traumatic Brain Injury: A Roadmap for Accelerating Progress highlighted the need to improve the consistency and quality of TBI care in the community. In response, the present study aimed to identify existing evidence-based guidance and specific clinical actions over the days to months following nonhospitalized TBI that should be prioritized for implementation in primary care. In systematic literature searches, 17 clinical practice guidelines met our eligibility criteria and an additional expert consensus statement was considered highly relevant. We extracted 73 topics covered by one or more existing clinical practice guidelines. After removing redundant and out-of-scope topics, those deemed essential (not requiring prioritization), 42 topics were subjected to a prioritization exercise. Experts from the author group ( n = 14), people with lived experience ( n = 112), and clinicians in the community ( n = 99) selected and ranked topics they considered most important. There were areas of agreement (e.g., early education was ranked highly by all groups) and discordance (e.g., people with lived experience perceived diagnostic tests/investigations as more important than the other groups). We synthesized the prioritization survey results into a top-10 list of the highest priority clinical actions. This list will inform implementation efforts aimed at improving post-acute care for nonhospitalized TBI.

Published
2025
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39. Outcomes after Traumatic Brain Injury with and Without Computed Tomography.

Author

Mikolić A, Shi S, Panenka W, Brubacher JR, Scheuermeyer FX, Nelson LD, and Silverberg ND

Abstract

Our recent improved understanding of traumatic brain injury (TBI) comes largely from cohort studies of TBI patients with indication for computed tomography (CT). Using CT head as an inclusion criterion may overestimate poor outcomes after TBI with Glasgow Coma Scale (GCS) 13-15. We aimed to compare outcomes after TBI in adults who had a head CT scan (with negative findings) versus those who had no CT when presenting to an emergency department. This was a secondary analysis of a trial that recruited adults with GCS = 13-15 after TBI in Vancouver, Canada. We included 493 participants (18-69 years, 54% female), after removing n = 19 with traumatic abnormalities on CT (intracranial and/or skull fracture). Outcomes were Glasgow Outcome Scale Extended (GOSE), Rivermead Post-Concussion Symptoms Questionnaire (RPQ), Patient Health Questionnaire (PHQ)-9, and generalized anxiety disorder (GAD)-7 at 6 months post-injury. Over half (55%) of participants received a CT. At 6 months, 55% of participants with CT and 49% without CT had functional limitations on GOSE; 32% with CT and 33% without CT reported severe post-concussion symptoms (RPQ ≥16); 26% (with CT) and 28% (without CT) screened positive for depression (PHQ-9 ≥ 10), and 25% (with CT) and 28% (without CT) screened positive for anxiety (GAD-7 ≥ 8). In regression adjusted for personal variables, participants with CT had somewhat higher odds of worse functioning (ordinal GOSE; 1.4, 95% CI 1.0-2.0) but similar odds of severe post-concussion symptoms (1.1, 95% CI: 0.7-1.7), and depression (1.1, 95% CI: 0.7-1.7) and anxiety (1.0, 95% CI: 0.6-1.5) symptoms. Adults with and without head CT have mostly comparable outcomes from TBI with GCS = 13-15. Requiring CT by clinical indication for study entry may not create problematic selection bias for outcome research.

Published
2024
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