1. ASCs and their role in obesity and metabolic diseases.
- Author
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Milan, Gabriella, Conci, Scilla, Sanna, Marta, Favaretto, Francesca, Bettini, Silvia, and Vettor, Roberto
- Subjects
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OBESITY , *METABOLIC disorders , *DRUG target , *CELL communication , *HOMEOSTASIS - Abstract
We describe adipose stromal/stem cells (ASCs) in the structural/functional context of the adipose tissue (AT) stem niche (adiponiche), including cell–cell interactions and the microenvironment, and emphasize findings obtained in humans and in lineage-tracing models. ASCs have distinctive markers, 'colors', and anatomical 'locations' which influence their functions. Each adiponiche component can become impaired, thereby contributing to the pathological AT alterations seen in obesity and metabolic diseases. We discuss adiposopathy with a focus on adiponiche dysfunction, and underline the mechanisms that control AT expansion and energy balance. Better understanding of adiponiche regulation and ASC features could help to identify therapeutic targets that favor weight loss and counteract weight regain, and also contribute to innovative strategies for regenerative medicine. ASCs have been analyzed in the structural/functional context of the adiponiche. The adiponiche consists of multiple cell types, the microenvironment, and their interactions that control ASC homeostasis. ASCs possess specific markers distinct characteristics that are associated with their anatomical 'location', and probably their 'color'. ASCs localize near to blood vessels and probably consist of many distinct subpopulations. Each adiponiche component can became dysregulated and can play a role in obesity and metabolic disease. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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