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2. Cytokine receptor IL27RA is an NF-κB–responsive gene involved in CD38 upregulation in multiple myeloma

Author

Brownlie, Rebecca J., Kennedy, Ruth, Wilson, Erica B., Milanovic, Maja, Taylor, Claire F., Wang, Dapeng, Davies, John R., Owston, Heather, Adams, Emma J., Stephenson, Sophie, Caeser, Rebecca, Gewurz, Benjamin E., Giannoudis, Peter V., Scuoppo, Claudio, McGonagle, Dennis, Hodson, Daniel J., Tooze, Reuben M., Doody, Gina M., Cook, Gordon, Westhead, David R., and Klein, Ulf

Published
2023
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3. Role of Arthrospira Platensis in Preventing and Treating High-Fat Diet-Induced Hypercholesterolemia in Adult Rats

Author

Cacciola, Nunzio Antonio, primary, De Cicco, Paola, additional, Milanović, Maja, additional, Milovanović, Ivan, additional, Mišan, Aleksandra, additional, Kojić, Danijela, additional, Simeunović, Jelica, additional, Blagojević, Dajana, additional, Popović, Tamara, additional, Arsić, Aleksandra, additional, Pilija, Vladimir, additional, Mandić, Anamarija, additional, Borrelli, Francesca, additional, and Milić, Nataša, additional

Published
2024
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9. Is there a difference in the phthalate exposure between adults with metabolic disorders and healthy ones?

Author

Stepanović Kristina, Vuković Bojan, Milanović Maja, Milošević Nataša, Bosić-Živanović Dragana, Stojadinović Aleksandra, Tomić-Naglić Dragana, Lepić Sanja, Milić Nataša, and Medić-Stojanoska Milica

Subjects
endocrine system diseases, phthalic acid, monoethyl phthalate, risk assessment, serbia, Medicine (General), R5-920
Abstract

Background/Aim. Phthalates are recognized as endocrine-disrupting compounds and are extensively present in a variety of everyday products. Chronic exposure to phthalates is suspected to be associated with a range of health disorders. The aim of the study was to examine the abundance of phthalate metabolites in the urine samples among adults in the Autonomous Province of Vojvodina, Serbia, and to determine the prevalence of phthalate metabolites in healthy individuals and those with metabolic disorders such as obesity and newly diagnosed type 2 diabetes mellitus (T2DM). Methods. For the study purpose, the first morning urine sample of 308 participants was screened for the presence of 10 phthalate metabolites: mono-ethyl phthalate (MEP), mono-(2-ethylhexyl) phthalate (MEHP), mono-n-butyl phthalate (MBP), mono-iso-allyl phthalate (MiAP), mono-n-allyl phthalate (MnAP), mono-cyclohexyl phthalate (MCHP), mono-benzyl phthalate (MBzP), mono-n-octyl phthalate (MOP), mono-n-propyl phthalate (MPP) and mono-methyl phthalate (MMP). Results. At least one phthalate metabolite was detected in the first morning urine sample in 50.32% of the examined population. The most frequently detected phthalate metabolites were MEP and MEHP. Out of all phthalate-positive participants, 38.3% of them had one, 10.7% had two, while 1.3% of participants had three phthalate metabolites in the first morning urine sample. A significant difference (p < 0.05) between groups was observed on MEP and MMP frequency, while border-line significant difference (p < 0.1) between groups was observed on MEHP and MCHP frequency. Conclusion. In the Vojvodina region, both healthy adults and those with metabolic disorders such as obesity and newly diagnosed T2DM are predominantly exposed to di-ethyl phthalate and di-(2-ethylhexyl)phthalate since MEP and MEHP were the most frequently detected phthalate metabolites. Further re-search is required in order to provide more details of the phthalates influence on the adverse health effects.

Published
2022
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10. Stress among international medical students during COVID-19 pandemic: A cross-sectional study

Author

Milanović Maja, Mijatović Emilia, Đokić Milena, Stanisavljević Tamara, Đokić Ana, Milić Nikola, Ćirković Anđa, and Rajović Nina

Subjects
medical students, international, covid-19, stress, Medicine
Abstract

Introduction: The aim of this study was to investigate the prevalence of stress among international medical students and factors associated with higher levels of student's stress during the COVID-19 epidemic in Serbia. Material and methods: The cross-sectional study was conducted using a five-section online questionnaire during January, 2021 among international medical students attending the Faculty of Medicine University of Belgrade, Studies in English in Serbia, using snowball sampling method. Results: A total of 52 international medical students with a mean age of 21.0 ± 2.2 years, 58% female, were enrolled. Stress level was rated higher than usual in 65% of students. The predictors of higher level of stress were: not being prepared for full online courses (p = 0.058), worry about own health (p = 0.04), worry about the health of loved ones (p = 0.058), concern about finances (p = 0.004) and exams/future study plans (p = 0.033), lack of energy (p = 0.012), strong emotions or mood swings (p = 0.004) and inability to get needed things from stores (p = 0.054). Fear or worry about the health of their loved ones, concern about money, as well as concern about exams or future study plans were independent predictors of the respondents' higher level of stress in multivariate analysis. Conclusion: The COVID-19 pandemic has led to an increase in the level of stress among the international medical students in Serbia. A higher level of stress was associated with fear about health of loved ones, concern about finances and exams/future study plans.

Published
2022
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12. Polyphenol rich horseradish root extracts and juice: In vitro antitumor activity and mechanism of action

Author

Petrović Vidosava, Četojević-Simin Dragana, Milanović Maja, Vulić Jelena, and Milić Nataša

Subjects
horseradish, phenols, antineoplastic agents, in vitro techniques, cell, death, apoptosis, Medicine (General), R5-920
Abstract

Background/Aim. Plant polyphenols are well known to show antimutagenic, anticarcinogenic, antiviral and antioxidative activity. The aim of this study was to investigate bio-active potential of Armoracia rusticana root juice and extracts: their polyphenol content, as well as in vitro antitumor activity and cell-death mechanism. Methods. Liquid-liquid extraction of polar and non-polar compounds was used and poly-phenolic compounds were identified and quantified by high performance liquid chomatography (HPLC) analysis. Anti-proliferative activity was examined in vitro on human cervix carcinoma (HeLa), breast adenocarcinoma (MCF7, MDA-MB-231), colon adenocarcinoma (HT-29), lung adenocarcinoma (A549), prostate adenocarcinoma (PC-3), melanocyte carcinoma (Hs 294T), hepatocyte carcinoma (Hep G2), as well as rat hepatocyte carcinoma (H-4-II-E), and normal human fetal lung (MRC-5) cell line using sulforhodamine B assay. The mechanism of cell-death in cell line was determined using Cell Death Detection ELISAPLUS kit. Results. Dichloromethane extracts had the highest content of cate-chin, p-hydroxybenzoic, syringic and gallic acid (pulp, E1), and epicatechin (juice, E3). The results showed strong and non-selective antiproliferative activity of chloroform and di-chloromethane extracts and root juice – highest being to-wards liver, breast and lung tissue cells. IC50 values of ex-tracts and juice had low range of concentrations (IC50 = 3.49–26.5 μg/mL) and high range of dilutions (IC50 = 418–1,590). High and unfavorable potential of horseradish juice and chloroform juice extract (E4) to induce necrotic cell death was detected. Conclusion. Strong and non-selective in vitro antiproliferative activity of chloroform and dichloromethane extracts and root juice of horseradish was detected, with necrosis as a main mechanism of induced cell death. In order to utilize horseradish root bioactive potential further investigations that will pinpoint active components with more favourable apoptosis/necrosis inducing properties are needed.

Published
2021
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14. Onion Polyphenols as Multi-Target-Directed Ligands in MASLD: A Preliminary Molecular Docking Study.

Author

Paravati, Maria Rosaria, Procopio, Anna Caterina, Milanović, Maja, Scarlata, Giuseppe Guido Maria, Milošević, Nataša, Ružić, Maja, Milić, Nataša, and Abenavoli, Ludovico

Abstract

A sedentary lifestyle associated with unregulated diets rich in high-calorie foods have contributed to the great prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) latterly, with up to 60% in the high-risk population and 25% in the general population. The absence of specific pharmacological strategies for this syndrome represents one of the major problems in the management of MASLD patients. Lifestyle interventions and adherence to a healthy diet are the main cornerstones of current therapies. The identification of nutraceuticals useful in the treatment of MASLD appears to be one of the most promising strategies for the development of new effective and safe treatments for this disease. The onion, one of the most widely studied foods in the field of nutraceuticals, serves as an inexhaustible reservoir of potent compounds with various beneficial effects. The following preliminary study analyzes, mediating in silico studies, the iteration of a library of typical onion compounds with 3-hydroxy-3-methylglutaryl-coenzyme A reductase, liver receptors X α and β, as well as peroxisome proliferator-activated receptors α and γ. In this study, for the first time promising smart molecules from the onion that could have a beneficial action in MASLD patients were identified. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Plasma Amino Acids in NAFLD Patients With Obesity Are Associated With Steatosis and Fibrosis; Results From the MAST4HEALTH Study

Author

Amanatidou, Athina I., primary, Mikropoulou, Eleni V, additional, Amerikanou, Charalampia, additional, Milanović, Maja, additional, Stojanoski, Stefan, additional, Bjelan, Mladen, additional, Cesarini, Lucia, additional, Campolo, Jonica, additional, Thanopoulou, Anastasia, additional, Banerjee, Rajarshi, additional, Kurth, Mary Jo, additional, Milić, Nataša, additional, Medic-Stojanoska, Milica, additional, Trivella, Maria Giovanna, additional, Gastaldelli, Amalia, additional, Halabalaki, Maria, additional, Kaliora, Andriana C., additional, and Dedoussis, George V, additional

Published
2023
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19. Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma

Author

Du, Jing, Neuenschwander, Martin, Yu, Yong, Däbritz, J.Henry M., Neuendorff, Nina-Rosa, Schleich, Kolja, Bittner, Aitomi, Milanovic, Maja, Beuster, Gregor, Radetzki, Silke, Specker, Edgar, Reimann, Maurice, Rosenbauer, Frank, Mathas, Stephan, Lohneis, Philipp, Hummel, Michael, Dörken, Bernd, von Kries, Jens Peter, Lee, Soyoung, and Schmitt, Clemens A.

Published
2017
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23. Seasonal variations of bisphenol A in the Danube River by the municipality of Novi Sad, Serbia

Author

Milanović Maja, Suđi Jan, Grujić-Letić Nevena, Radonić Jelena, Turk-Sekulić Maja, Vojinović-Miloradov Mirjana, and Milić Nataša

Subjects
bisphenol A, the Danube river, endocrine disrupter, GC-MS, surface water, Chemistry, QD1-999
Abstract

Seasonal variations of bisphenol A (BPA) were investigated in the Danube along the Novi Sad bank, Serbia using solid-phase extraction followed by gas chromatographic mass spectrometric method. The obtained results confirmed the presence of BPA above the limit of quantification (6 ng/L) in 22 out of 32 water samples at all eight sampling sites. Тhe BPA concentration varied from 1) for autumn, spring and summer. The high potential risk which is attributed to the elevated summer concentrations is probably the result of the increased human activates and weather conditions. [Projekat Ministarstva nauke Republike Srbije, br. III46009]

Published
2016
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25. Challenges in the Analytical Preparation of a Biological Matrix in Analyses of Endocrine-Disrupting Bisphenols.

Author

Milić, Nataša, Milanović, Maja, Drljača, Jovana, Sudji, Jan, and Milošević, Nataša

Subjects
*HAIR analysis, *SALIVA, *LIQUID chromatography-mass spectrometry, *COMPOSITION of breast milk, *BISPHENOLS, *BISPHENOL A, *ENDOCRINE disruptors, *BIOCOMPLEXITY
Abstract

Endocrine-disrupting chemicals (EDCs) are xenobiotics presented in a variety of everyday products that may disrupt the normal activity of hormones. Exposure to bisphenol A as EDC at trace and ultra-trace levels is associated with adverse health effects, and children are recognized as the most vulnerable group to EDCs exposure. In this review, a summary is presented of up-to-date sample preparation methods and instrumental techniques applied for the detection and quantification of bisphenol A and its structural analogues in various biological matrices. Biological matrices such as blood, cell-free blood products, urine, saliva, breast milk, cordial blood, amniotic and semen fluids, as well as sweat and hair, are very complex; therefore, the detection and later quantification of bisphenols at low levels present a real analytical challenge. The most popular analytical approaches include gas and liquid chromatography coupled with mass spectrometry, and their enhanced reliability and sensitivity finally allow the separation and detection of bisphenols in biological samples, even as ultra-traces. Liquid/liquid extraction (LLE) and solid-phase extraction (SPE) are still the most common methods for their extraction from biological matrices. However, many modern and environmentally safe microextraction techniques are currently under development. The complexity of biological matrices and low concentrations of analytes are the main issues for the limited identification, as well as understanding the adverse health effects caused by chronical and ubiquitous exposure to bisphenols and its analogues. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Industrial emerging chemicals in the environment

Author

Vojinović-Miloradov Mirjana B., Turk-Sekulić Maja M., Radonić Jelena R., Milić Nataša B., Grujić-Letić Nevena N., Mihajlović Ivana J., and Milanović Maja Lj.

Subjects
industrial emerging contaminants, Industrial wastewater, Danube, Novi Sad, Chemical technology, TP1-1185
Abstract

In the recent time, considerable interest has grown concerning the presence of the emerging industrial chemicals, EmIC. They are contaminants that have possible pathway to enter to the environment and they are dominantly released by industrial and anthropogenic activities. EmIC are applied in different fields using as industrial chemicals (new and recently recognized), global organic contaminants (flame retardant chemicals), pharmaceuticals (for both human and animal uses), endocrine-modulating compounds, biological metabolites, personal care products, household chemicals, nanomaterial (energy storage products, lubricants), anticorrosive and agriculture chemicals and others that are applied to a wide variety of everyday items such as clothing, upholstery, electronics and automobile interiors. NORMAN (Network of reference laboratories for monitoring of emerging environmental pollutants) has established an open, dynamic, list of emerging substances and pollutants. EmIC have been recently detected in the environment due to their long-term presence, pseudo-persistence and increased use. Improvements in sophisticated analytical methods and time integrative passive sampling have enabled the identification and quantification of EmIC, in very low concentrations (ppb, ppt and lower), which likely have been present in all environmental mediums for decades. Passive technology is an innovative technique for the time-integrated measurement of emerging contaminants in water, sediment, soil and air. Passive samplers are simple handling cost-effective tool that could be used in environmental monitoring programmes. These devices are now being considered as a part of an emerging strategy for monitoring a range of emerging industrial chemicals and priority pollutants in the aquatic environment. EmIC are substances that are not included in the routine monitoring programmes and whose fate, behaviour and (eco)toxicological effects are still not well understood. Emerging pollutants have no regulatory standards based on peer-reviewed science. EmIC might jeopardize aquatic environment. The first screening analyses of emerging industrial and priority organic contaminants in the Danube surface water, in the vicinity of Novi Sad, have been done and approximately more than 140 compounds have been registered. The new sampling campaign, screening and target analyses are in progress. [Projekat Ministarstva nauke Republike Srbije, br. III46009]

Published
2014
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27. SARS-CoV-2 Omicron Variant in Croatia—Rapid Detection of the First Case and Cross-Border Spread

Author

Ferenčak, Ivana, primary, Obrovac, Mihaela, additional, Žmak, Ljiljana, additional, Kuzle, Josipa, additional, Petrović, Goranka, additional, Vilibić-Čavlek, Tatjana, additional, Jurić, Dragan, additional, Jurić, Anita, additional, Hruškar, Željka, additional, Capak, Krunoslav, additional, Stevanović, Vladimir, additional, Milanović, Maja, additional, Govedarica, Marija, additional, Vujošević, Danijela, additional, and Tabain, Irena, additional

Published
2022
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28. Bipartite graphs

Author

Milanović, Maja, Mostarac, Nina, Slamić, Ivana, and Tonić, Vera

Abstract

Tema ovog završnog rada su bipartitni grafovi. U prvom dijelu rada opisujemo osnovne pojmove iz teorije grafova koji su nam potrebni da bi razumjeli pojam bipartitnog grafa. Zatim, slijedi poglavlje o prepoznavanju bipartitnih grafova, u kojem su prikazani određeni tipovi bipartitnih grafova i njihova matrična karakterizacija. Iskazat ćemo neke teoreme, korolare te propozicije koje nam pobliže objašnjavaju svojstva bipartitnih grafova. U četvrtom poglavlju navodimo metrička svojstva bipartitnih grafova. Neki od bitnijih pojmova su radijus, dijametar i centar bipartitnog grafa. U zadnjem dijelu rada, obradit ćemo sparivanja na bipartitnim grafovima. Definirat ćemo osnovne pojmove bitne za sparivanje grafova te iskazati i dokazati Hallov teorem, kao i Teorem o braku. Za kraj, opisat ćemo mađarski algoritam, koji nam pomaže pronaći savršeno sparivanje u bipartitnom grafu s jednakobrojnim dijelovima particije, te odrediti postoji li takvo sparivanje uopće.

Published
2021

31. Conductometric study of sodium dodecyl sulfate - nonionic surfactant (Triton X-100, Tween 20, Tween 60, Tween 80 or Tween 85) mixed micelles in aqueous solution

Author

Ćirin Dejan M., Poša Mihalj M., Krstonošić Veljko S., and Milanović Maja Lj.

Subjects
conductometric study, mixed micelles, cmc, anionic surfactant, SDS, nonionic surfactants, Triton X-100, Tween 20, Tween 60, Tween 80, Tween 85, Chemical technology, TP1-1185
Abstract

The present study is concerned with the determination of the critical micelle concentration (cmc) of mixed micelles of sodium dodecyl sulfate with one of five nonionic surfactants (Triton X-100, Tween 20, Tween 60, Tween 80 or Tween 85) from conductance measurements. Based on the calculated values of the β parameters we have noticed that SDS-nonionic surfactants mostly showed strong synergistic effect. It was found that nonionic surfactants with mainly longer and more hydrophobic tail show stronger interactions with hydrophobic part of SDS, thus expressing stronger synergism. In SDS-Tween 80 binary system the strongest synergistic effect was noticed. SDS-Tween 85 micellar system showed antagonistic effect, most probably because the presence of the double bond in its three hydrophobic tails (three C18 tails) makes it sterically rigid.

Published
2012
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32. The effect of fermentation temperature on the functional dairy product quality

Author

Kanurić Katarina G., Hrnjez Dajana V., Ranogajec Marjan I., Milanović Spasenija D., Iličić Mirela D., Vukić Vladimir R., and Milanović Maja Lj.

Subjects
milk, kombucha, probiotics, fermented dairy product, functional food, Technology (General), T1-995
Abstract

The aim of this study was to examine the possibility of fermented dairy beverage production by the application of kombucha cultivated on thyme tea in combination with a probiotic starter and to evaluate the quality of the new functional product. Fermented dairy beverages are produced from milk with 1.6% milk fat at three fermentation temperatures: 37°C, 40ºC and 43ºC.Chemical quality, rheological properties and products of added starter cultures metabolism were determined in the fermented dairy beverages after production and after10 days of storage. Produced fermented dairy beverages have reduced milk fat content and good textural characteristics. Besides the highly valuable milk components, they contain numerous compounds which have pronounced therapeutic properties. These products could be used as functional food in the diet of different populations for health improvement.

Published
2011
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34. Civil disobedience

Author

Milanović, Maja, Preložnjak, Barbara, Petričušić, Antonija, and Horvat Vuković, Ana

Abstract

Živimo u društvu ovisnom o pravilima. Pravila nas obvezuju i upućuju na određeno ponašanje koje je propisala država. Postavlja se pitanje kako se onda pobuniti protiv tih pravila bez da „odbacimo“ sustav pravila. U ovom slučaju javlja se ideja građanskog neposluha kao svjesnog kršenja pravila uz svjesno prihvaćanje kazne i posljedica. Neposlušnici ne krše zakon zbog vlastitih interesa već zbog osjećaja pravde. Prihvaćanjem sankcija pokazuju koliko im je stalo do ideje za koju se zalažu, a istovremeno pokazuju svoju vjernost sustavu. Povijesno gledano, građanski neposluh javljao se kao reakcija na kršenje i nepoštivanje temeljnih ljudskih prava. U modernim demokratskim sustavima pojam građanskog neposluha manifestira se kao reakcija na vladine odluke koje nisu u skladu s mišljenjem i stavovima manjina.

Published
2021

35. Curcumin Efficacy in a Serum/glucose Deprivation-induced Neuronal PC12 Injury Model

Author

Kanoni, Stavroula, Kumar, Satish, Amerikanou, Charalampia, Kurth, Mary Jo, Stathopoulou, Maria, Bourgeois, Stephane, Masson, Christine, Kannt, Aimo, Cesarini, Lucia, Kontoe, Maria-Spyridoula, Milanović, Maja, Roig, Francisco, Beribaka, Mirjana, Campolo, Jonica, Jiménez-Hernández, Nuria, Milošević, Nataša, Llorens, Carlos, Smyrnioudis, Ilias, Francino, M. Pilar, Milić, Nataša, Kaliora, Andriana, Trivella, Maria Giovanna, Ruddock, Mark, Medić-Stojanoska, Milica, Gastaldelli, Amalia, Lamont, John, Deloukas, Panos, Dedoussis, George, Visvikis-Siest, Sophie, Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Birjand University of Medical Sciences [Birjand, Iran] (BUMS), Sabanci University [Istanbul], Mashhad University of Medical Sciences, and Albert Einstein College of Medicine [New York]

Subjects
0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Curcumin, Antioxidant, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Apoptosis, Inflammation, Pharmacology, medicine.disease_cause, PC12 Cells, Article, Lipid peroxidation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Humans, Viability assay, chemistry.chemical_classification, Reactive oxygen species, nutritional and metabolic diseases, General Medicine, Rats, 3. Good health, Oxidative Stress, Glucose, 030104 developmental biology, chemistry, medicine.symptom, 030217 neurology & neurosurgery, Oxidative stress
Abstract

Background: Glucose/serum deprivation (GSD), has been used for understanding molecular mechanisms of neuronal damage during ischemia. It has been suggested that curcumin may improve neurodegenerative diseases. Aim: In this study, the protective effects of curcumin and its underlying mechanisms were investigated in PC12 cells upon GSD-induced stress. Methods: PC12 cells were cultured in DMEM overnight and then incubated in GSD condition for either 6 or 12h. GSD-treated cells were pretreated with various concentrations of curcumin (10, 20, and 40 μM) for 5h. The cell viability, apoptosis, reactive oxygen species (ROS) level, oxidative stress, expression of apoptosis-related genes, and IL-6 were determined. Results: Curcumin increased cell viability and caused an anti-apoptotic effect in PC12 cells exposed for 12h to GSD . Curcumin also increased antioxidant enzyme expression, suppressed lipid peroxidation, and decreased interleukin-6 secretion in PC12 cells subjected to GSD. In addition, pretreatment with curcumin down-regulated pro-apoptotic (Bax), and up-regulated antiapoptotic (Bcl2) mediators. Conclusion: Curcumin mitigates many of the adverse effects of ischemia, and therefore, should be considered as an adjunct therapy in ischemic patients.

Published
2021

36. Nutrigenetic Interactions Might Modulate the Antioxidant and Anti-Inflammatory Status in Mastiha-Supplemented Patients With NAFLD

Author

Kanoni, Stavroula, primary, Kumar, Satish, additional, Amerikanou, Charalampia, additional, Kurth, Mary Jo, additional, Stathopoulou, Maria G., additional, Bourgeois, Stephane, additional, Masson, Christine, additional, Kannt, Aimo, additional, Cesarini, Lucia, additional, Kontoe, Maria-Spyridoula, additional, Milanović, Maja, additional, Roig, Francisco J., additional, Beribaka, Mirjana, additional, Campolo, Jonica, additional, Jiménez-Hernández, Nuria, additional, Milošević, Nataša, additional, Llorens, Carlos, additional, Smyrnioudis, Ilias, additional, Francino, M. Pilar, additional, Milić, Nataša, additional, Kaliora, Andriana C., additional, Trivella, Maria Giovanna, additional, Ruddock, Mark W., additional, Medić-Stojanoska, Milica, additional, Gastaldelli, Amalia, additional, Lamont, John, additional, Deloukas, Panos, additional, Dedoussis, George V., additional, and Visvikis-Siest, Sophie, additional

Published
2021
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42. NOVI LEKOVI – ZNAČAJ SLUČAJNOG OTKRIĆA.

Author

Đurić, Larisa, Milanović, Maja, Milošević, Nataša, and Milić, Nataša

Abstract

Copyright of Medical Journal / Medicinski Časopis is the property of Serbian Medical Society, Section Kragujevac and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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43. Uticaj anjonskog i nejonskog tenzida na fizičko-hemijske osobine vodenih rastvora makromolekula

Author

Milanović, Maja, Krstonosic, Veljko, Dokić, Ljubica, Dapčević Hadnađev, Tamara, Milić, Nataša, Poša, Mihalj, and Dapčević, Hadnađev Tamara

Subjects
Surface-Active Agents, polisorbati, površinski aktivne materije, natrijum dodecil sulfat, polimeri, makromolekularne supstance, Polymers, Macromolecular Substances, Polysorbates, Sodium Dodecyl Sulfate
Abstract

Razvoj savremenih sistema za ciljanu aplikaciju farmakološki aktivne supstance zasniva se na postojanju interakcija između funkcionalnih grupa makromolekula i površinski aktivne materije što omogućava kontrolisano oslobađanje, smanjenu toksičnost i bolji režim doziranja leka. Prisustvo tenzida, kako se jos površinski aktivne materije nazivaju, u niskim koncentracijima može značajno da izmeni konformaciju makromolekula i viskozitet sistema, i samim tim proširi mogućnosti primene modifikovanjem svojstava. Stoga je poznavanje fizičko-hemijskih osobina vodenih rastvora makromolekul-površinski aktivna materija neophodno radi dobijanja adekvatnog finalnog proizvoda unapređenih osobina uz primenu optimalnih koncentracija pomoćnih supstanci. U radu su prikazani rezultati ispitivanja uticaja natrijum lauril sulfata, predstavnika anjonskih tenzida, odnosno polioksietilen (20) sorbitan monooleata, kao široko korišćenog nejonskog tenzida na fizičko-hemijske osobine vodenih rastvora makromolekula karbomera 940 i ksantan gume. U cilju potpunog razumevanja ovih sistema, čiste komponente su prvo analizirane infracrvenom spektroskopijom primenom Fourierove tranformacije. Ponašanje karbomera 940 odnosno ksantan gume u prisustvu tenzida, ispitano je kombinacijom različitih tehnika (viskozimetrije, konduktometrije, tenziometrije, spektroskopije, spektrofluorimetrije, skenirajuće elektronske mikroskopije) koje pružaju uporedive rezultate. Određene vrednosti interakcionih parametara, potvrdjuju hipotezu o postojanju međudejstva između karbomera 940/ksantan gume i ispitivanih tenzida i ukazuju da povećanje koncentracije makromolekula u rastvoru uslovljava širenje opsega interakcije. Tenzidom indukovane promene konformacije ksantan gume odnosno karbomera 940 potvrđene su i na mikroskopskom nivou. Takođe, rezultati uticaja ispitivanih tenzida na osobine vodenih rastvora smeša karbomera 940 i ksantan gume dobijeni su istim tehnikama. Međudejstvom dva različita polimera bez dodatne sinteze na jeftin i brz način mogu se postići željene karakteristike sistema. Na osnovu eksperimentalnih rezultata definisani su matematički modeli primenom metodologije odzivnih površina i višestruke linearne regresije, čija je validnost statistički potvrđena te se mogu primeniti u optimizaciji i predviđanju fizičko-hemijskih osobina vodenih rastvora analiziranih binarnih sistema., The possible interactions between polymers and surfactants are of great interest in the development of drug delivery systems, where they improve therapeutic efficiency by the controlled release and reduced toxicity. The addition of even a small amount of surfactant could change the physico-chemical properties of polymer dispersions in terms of viscosity and stability of the system and, consequently, enlarge possibilities for their application. Therefore, understanding the physico-chemical properties of polymer-surfactant aqueous solutions are necessary in order to optimize the formulation of these compounds and consequently to get product with acceptable properties and desired effect. In this thesis the physico-chemical changes of carbomer 940 and xanthan gum influenced by different surfactants were investigated. Widely used anionic surfactant sodium dodecyl sulfate, and nonionic polyoxyethylene (20) sorbitan monooleate were used. In order to completely understand the mechanism of interaction the pure polymers and surfactants were tested by Fourier transform infrared spectrometer. The behaviour of carbomer 940 as well as xanthan gum in the presence of examined surfactants were analysed by the combination of different techniques such as viscometry, conductometry, tensiometry, spectrophotometry, fluorimetry and scanning electron microscopy. The obtained results confirmed the existence of interactions between carbomer 940 / xanthan gum and tested surfactants. Furthermore, the interaction parameters were determined and the polymer saturation points for both surfactants increased with the increase in carbomer 940 and xanthan gum content, respectively. Additionally, the surfactant induced microstructural changes of carbomer 940 as well as xanthan gum were confirmed. Moreover, the physico-chemical properties of the mixture of carbomer 940 and xanthan gum influenced by the addition of anionic and nonionic surfactant were examined by the same techniques. Without additional synthesis the desired characteristics of the system could be achieved by optimizing the interaction between two different polymers. The obtained results were analysed by response surface methodology and multiple linear regression analysis. The defined mathematical models could be used to optimize and predict physico-chemical properties of aqueous solutions of the tested binary systems.

Published
2016

44. Procjena metoda za proračun požarne otpornosti čeličnog nosača

Author

Milanović, Maja, Rogić, Ivana, and Šitum, Ana

Subjects
požarna otpornost, čelični nosač, Round Robin studija, pojednostavljene metode proračuna na požar, napredne metode proračuna na požar
Abstract

Požarno inženjerstvo, kao relativno nova znanstvena disciplina, zahtjeva ozbiljno usavršavanje s obzirom na poguban utjecaj požara na ljudske živote i imovinu. Ovaj rad izrađen je u sklopu znanstvenog istraživanja u svrhu poboljšanja metoda za proračun požarne otpornosti elemenata čeličnih konstrukcija. Prema dosadašnjem iskustvu, procjena požarne otpornosti čeličnih elemenata prema europskim normama je, uglavnom, konzervativna. S druge strane, napredne metode su izuzetno neujednačene, što je razumljivo s obzirom na činjenicu da postoji mnoštvo naprednih kompjuterskih programa, a opće znanje i unificiranost kriterija je neusklađeno. Kako bi se pojednostavljene normirane metode mogle unaprijediti potrebno ih je testirati na rezultate laboratorijskih ispitivanja. Puno je jednostavnije, i jeftinije, jednostavne metode unaprijediti korištenjem numeričkih simulacija koje moraju biti kalibrirane u odnosu na rezultate ispitivanja. U ovom radu opisan je prvi korak, te je prikazana usporedba rezultata dobivenih primjenom različitih metoda i rezultata laboratorijskih ispitivanja. Obrađene su pojednostavljene i napredne metode proračuna požarne otpornosti čeličnog nosača. Unutar pojednostavljenih (normiranih) metoda objašnjen je ručni proračun i proračun u programskom paketu Elefir-EN. Za proračun naprednom metodom odabran je sofisticirani programski paket ANSYS. Nadalje, predstavljena je međunarodna Round Robin studija u kojoj je 11 sudionika, od kojih je jedan bio i Građevinski fakultet Sveučilišta u Zagrebu, neovisno provelo proračun (procjenu) požarne otpornosti čeličnog nosača na temelju jednakih ulaznih podataka. Nosač istih karakteristika ispitan je u uvjetima standardnog ISO požara u Tehničkom istraživačkom centar u Švedskoj, koji je bio inicijator Round Robin studije. Prikazana je usporedba rezultata svih sudionika studije, te je dana kompletna analiza koja je bila doprinos Sveučilišta u Zagrebu (Građevinskog fakulteta) ovom međunarodnom istraživanju. Nakon razrade i diskusije rezultata zaključeno je, suprotno očekivanju, da europske norme značajno precjenjuju požarnu otpornost ovog 'trivijalnog' problema. S druge strane, napredne metode zbog svoje složenosti i neusklađenosti razine znanja i kriterija otkazivanja, daju izuzetno neujednačene procjene. Preporučuje se daljnja istraživanja proširiti na nova laboratorijska ispitivanja iz čega će proizaći pravila za modeliranje naprednim metodama i usuglašeni kriteriji otkazivanja. Tek potom, na kalibriranim numeričkim metodama može se ostvariti poboljšanje jednostavnih metoda proračuna koje će osigurati zahtijevanu razinu pouzdanosti na europskoj razini.

Published
2015

45. Analiza i dimenzioniranje čelične konstrukcije višekatne zgrade

Author

Milanović, Maja

Subjects
višekatna čelična zgrada, analiza i dimenzioniranje, statička analiza, dinamička analiza
Abstract

Proveden je proračun čelične konstrukcije višekatne zgrade prema europskim normama. Tlocrtne dimenzije konstrukcije su 40, 0 m x 40, 0 m. Visina konstrukcije je 42, 0 m, visina prve etaže je 6, 0 m, a ostale visine etaža su 4, 0 m. Konstrukcija je proračunata s proračunskim vrijednostima unutarnjih sila dobivenih statičkom analizom II. reda, te dinamičkom analizom I. reda. Učinci drugog reda kod statičke analize uzeti su u obzir nelinearnom analizom modela u programskom paketu Autodesk Robot koja uzima u obzir P- Delta učinke. Kod dinamičke analize učinci drugog reda nisu uzeti u obzir jer su koeficijenti senzibilnosti manji od 0, 1 kako je propisano prema EN 1998-1. Prvotna ideja da zgrada bude izvedena kao okvirna konstrukcija u oba smjera, zadržala se do kraja proračuna. Značajne uzdužne sile u stupovima zahtijevale su promjene profila, a osim toga mijenjali su se profili stupova u svrhu mogućnosti izvedbe detalja. Unatoč promjenama, statički sustav zgrade ostao je jednak onome na početku proračuna. Za dimenzioniranje nosača i stupova bila je mjerodavna statička analiza. Kod seizmičke analize uzeti su u obzir dodatni uvjeti propisani u EN 1998-1, ali potresno opterećenje nije nadmašilo djelovanje koje su proizvela statička opterećenja. Nakon dimenzioniranja napravljena je tablica iskoristivosti elemenata iz koje je zaključeno da ekonomizacija profila neće biti provedena. Kako je riječ o građevini s upetim priključcima, posebna pozornost obratila se i na izvedbu detalja. Tako su priključci stupova kvadratnog profila i nosača I profila izvedeni pomoću vanjskih dijafragmi zavarenih na stupove. Ta vrsta priključka sve se više koristi, a posebno je pogodna za primjenu u seizmički aktivnim područjima. Proračun ostalih priključaka proveden je u programskom paketu Autodesk Robot Structural Analysis Professional 2014.

Published
2015

46. TEMELJNE ODREDNICE POREZA NA DOHODAK UZ ANALIZU UTJECAJA ZAKONSKIH IZMJENA NA OPOREZIVANJE DOHOTKA OD NESAMOSTALNOG RADA IZ RADNOG ODNOSA (PLAĆE)

Author

Perić, Renata, Topić, Ivana, Milanović, Maja, Romić, Danijela, Vajda Halak, Željka, and Belaj, Ivan

Subjects
porez na dohodak, dohodak od nesamostalnog rada, oporezivanje plaće, osnovni osobni odbitak, porezni razredi
Abstract

U poreznom sustavu Republike Hrvatske porez na dohodak definira se kao izravni (neposredni) porez namijenjen oporezivanju ukupnog dohotka fizičkih osoba koji je ostvaren u određenom poreznom razdoblju, a kao jedan od izvora dohotka koji se oporezuje istim je i dohodak od nesamostalnog rada. Dohodak od nesamostalnog rada iz radnog odnosa kroz plaće, za fizičke osobe koje ostvaruju oporezivi dio dohotka (porezni obveznici), obilježava progresivnost poreznih stopa koja se vezuje uz ostvarenje vertikalne pravednosti. Stupanjem na snagu izmjena i dopuna Zakona o porezu na dohodak te Pravilnika o porezu na dohodak uvedene su novine u načinu oporezivanja plaće te će iste biti detaljnije razrađene u radu prikazom temeljnih odrednica poreza na dohodak i analizom ukupnog poreznog opterećenja plaće s naglaskom na izmjene u pogledu visine osnovnog osobnog odbitka te veličinu poreznih razreda.

Published
2015

47. Physicochemical and textural properties of kombucha fermented dairy products

Author

Milanović Maja, Milanović Spasenija, Vukić Vladimir, Ranogajec Marjan, Hrnjez Dajana, Iličić Mirela, and Kanurić Katarina

Subjects
Acid content, Kombucha, Chemistry, Fermented milk product, kombucha, textural properties, physicochemical properties, food and beverages, Applied Microbiology and Biotechnology, law.invention, Probiotic, Starter, law, Genetics, Fermented milk products, Fermentation, Camellia sinensis, Food science, Agronomy and Crop Science, Molecular Biology, Black tea, Biotechnology
Abstract

The possibility of kombucha application cultivated on two different tea types in combination with probiotics for milk fermentation at different temperatures, as well as the physicochemical and textural properties of manufactured fermented milk products were investigated. Combination of probiotic starter culture and kombucha inoculums, cultivated on Camellia sinensis (black tea) and Thymus serphyllum (thyme tea) were used for milk fermentation. Obtained results showed that kombucha inoculums cultivated on different tea types could be used for fermented milk products in combination with probiotic starter culture. Different temperatures of milk fermentation had no significant effect on chemical characteristics of kombucha fermented dairy products. As the results of factorial ANOVA test revealed the significant influence of the interaction of factors Temperature*Tea type on L–lactic acid content. Tea type had singificant influence on textural characteristics of fermented dairy products, especially after storage. After 10 day of storage, all textural characteristics except firmness had highly significant diferences depending on the tea type used for kombucha inoculum cultivation. Significant effect on textural characteristics showed interaction of factors Tea Type*Day of storage. Key words: Fermented milk product, kombucha, textural properties, physicochemical properties.

Published
2014

50. Utjecaj gnojidbe dušikom na morfološka i fenološka svojstva nekih kultivara predivog lana

Author

Milanović, Maja

Subjects
predivi lan, kultivari, gnojidba dušikom, morfološka i fenološka svojstva
Abstract

U radu se iznose rezultati morfoloških i fenoloških svojstva predivog lana pet inozemnih kultivara (Viking, Viola, Venica, Agatha i Electra) gnojenih s četiri količine dušika (0 ; 30 ; 60 i 90 kg ha¯¹) primjenjenih u različito vrijeme. Pokus s predivim lanom izveden je tijekom 2007. godine u Zagrebu na pokušalištu Maksimir na eutrično smeđem antropogeniziranom tlu i bio je postavljen prema metodi slučajnog bloknog rasporeda u četiri ponavljanja. Na osnovi dobivenih rezultata jednogodišnjeg istraživanja morfoloških i fenoloških svojstva predivog lana utvrđeno je da postoje signifikantne razlike između istraživanih kultivara i između primijenjenih količina dušika. Prema dobivenim rezultatima istraživanih svojstava u gnojidbi predivog lana nije potrebno dodavati više od 30 kg ha¯¹ dušika. Kultivar Viola ostvario je najviše vrijednosti istraživanih svojstava.

Published
2013

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