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9 results on '"Mildner, Finn"'

3. Whole stromal fibroblast signature is linked to specific chemokine and immune infiltration patterns and to improved survival in NSCLC

Author

Koeck, Stefan, primary, Amann, Arno, additional, Kern, Johan, additional, Zwierzina, Marit, additional, Lorenz, Edith, additional, Sopper, Sieghart, additional, Zwierzina, Heinz, additional, Mildner, Finn, additional, Sykora, Martina, additional, Sprung, Susanne, additional, Hackl, Hubert, additional, Augustin, Florian, additional, Maier, Hubert T., additional, Pircher, Andreas, additional, Pall, Georg, additional, Wolf, Dominik, additional, and Gamerith, Gabriele, additional

Published
2023
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4. Abstract 6668: Immune infiltrate co-occurrence and neoantigen similarity are prognostic factors in early stage NSCLC

Author

Sykora, Martina M., primary, Pugh, Jason, additional, Li, Bailiang, additional, Mildner, Finn O., additional, Hackl, Hubert, additional, Amann, Arno, additional, Nocera, Fabienne I., additional, Pyke, Rachel M., additional, McDaniel, Lee, additional, Abbott, Charles W., additional, Boyle, Sean M., additional, Chen, Richard O., additional, Wolf, Dominik, additional, Sopper, Sieghart, additional, and Gamerith, Gabriele, additional

Published
2023
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6. Association of baseline soluble immune checkpoints with the risk of relapse in PR3-ANCA vasculitis following induction of remission

Author

Gamerith, Gabriele, primary, Mildner, Finn, additional, Merkel, Peter A, additional, Harris, Kristina, additional, Cooney, Laura, additional, Lim, Noha, additional, Spiera, Robert, additional, Seo, Philip, additional, Langford, Carol A, additional, Hoffman, Gary S, additional, St Clair, E William, additional, Fervenza, Fernando C, additional, Monach, Paul, additional, Ytterberg, Steven R, additional, Geetha, Duvuru, additional, Amann, Arno, additional, Wolf, Dominik, additional, Specks, Ulrich, additional, Stone, John H, additional, and Kronbichler, Andreas, additional

Published
2022
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8. Molecular Characteristics of Radon Associated Lung Cancer Highlights MET Alterations

Author

Gamerith, Gabriele, Kloppenburg, Marcel, Mildner, Finn, Amann, Arno, Merkelbach-Bruse, Sabine, Heydt, Carina, Siemanowski, Janna, Buettner, Reinhard, Fiegl, Michael, Manzl, Claudia, Pall, Georg, Gamerith, Gabriele, Kloppenburg, Marcel, Mildner, Finn, Amann, Arno, Merkelbach-Bruse, Sabine, Heydt, Carina, Siemanowski, Janna, Buettner, Reinhard, Fiegl, Michael, Manzl, Claudia, and Pall, Georg

Abstract

Simple Summary Lung cancer (LC) is the leading cause of cancer death worldwide. After smoking, one of the most prominent risk factors for LC development is radon (Rn) exposure. In our study we analysed and compared the genetic landscape of LC patients from a Rn exposed village with local matched non-exposed patients. Within the concordant genetic landscape, an increase in genetic MET proto-oncogene, receptor tyrosine kinase (MET) alteration in the Rn-exposed cohort was monitored, underlining the importance of routine MET testing and potential to enable a more effective treatment for this specific subgroup. Effective targeted treatment strategies resulted from molecular profiling of lung cancer with distinct prevalent mutation profiles in smokers and non-smokers. Although Rn is the second most important risk factor, data for Rn-dependent driver events are limited. Therefore, a Rn-exposed cohort of lung cancer patients was screened for oncogenic drivers and their survival and genetic profiles were compared with data of the average regional population. Genetic alterations were analysed in 20 Rn-exposed and 22 histologically matched non-Rn exposed LC patients using targeted Next generation sequencing (NGS) and Fluorescence In Situ Hybridization (FISH). Sufficient material and sample quality could be obtained in 14/27 non-exposed versus 17/22 Rn-exposed LC samples. Survival was analysed in comparison to a histologically and stage-matched regional non-exposed lung cancer cohort (n = 51) for hypothesis generating. Median overall survivals were 83.02 months in the Rn-exposed and 38.7 months in the non-exposed lung cancer cohort (p = 0.22). Genetic alterations of both patient cohorts were in high concordance, except for an increase in MET alterations and a decrease in TP53 mutations in the Rn-exposed patients in this small hypothesis generating study.

Published
2022

9. Association of baseline soluble immune checkpoints with the risk of relapse in PR3-ANCA vasculitis following induction of remission.

Author

Gamerith, Gabriele, Mildner, Finn, Merkel, Peter A., Harris, Kristina, Cooney, Laura, Lim, Noha, Spiera, Robert, Seo, Philip, Langford, Carol A., Hoffman, Gary S., St Clair, E. William, Fervenza, Fernando C., Monach, Paul, Ytterberg, Steven R., Geetha, Duvuru, Amann, Arno, Wolf, Dominik, Specks, Ulrich, Stone, John H., and Kronbichler, Andreas

Published
2023
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