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334 results on '"Millar, B.C."'

8. Fungal endocarditis in neonates and children

Author

Millar, B.C., Jugo, J., and Moore, J.E.

Subjects
Children -- Diseases, Endocarditis -- Causes of -- Risk factors -- Diagnosis -- Drug therapy, Mycoses -- Causes of -- Risk factors -- Diagnosis -- Drug therapy, Health
Abstract

Abstract. Fungal endocarditis in the neonate and pediatric population is associated with a high degree of morbidity and mortality, with diagnosis in the majority of cases made postmortem. The aim [...]

Published
2005

9. Comparison of API20C with molecular identification of Candida spp isolated from bloodstream infections. (Short Report)

Author

Xu, J., Millar, B.C., Moore, J.E., McClurg, R., Walker, M.J., Evans, J., Hedderwick, S., and McMullan, R.

Subjects
Hematology -- Research, Candida -- Genetic aspects -- Identification and classification -- Research, Health, Identification and classification, Genetic aspects, Research
Abstract

A study was carried out to compare the API20C technology with polymerase chain reaction amplification and direct sequencing of the short internal transcribed spacer region 2 (ITS2) for the identification [...]

Published
2002

16. Regulation of protein synthesis and degradation in adult ventricular cardiomyocytes

Author

Schluter, K.-D., Millar, B.C., McDermott, B.J., and Piper, H.M.

Subjects
Cardiomyopathy, Hypertrophic -- Research, Heart cells -- Research, Human cell culture -- Innovations, Biological sciences
Abstract

The use of cultured, isolated adult ventricular cardiomyocytes in studies of myocardial protein metabolism was introduced in the 1980s. Such studies have led to better knowledge of myocardial hypertrophy-induced abnormalities in cardiomyocyte protein synthesis. Thus, it has been discovered that alpha-1-adrenoceptor stimulation, neuropeptide Y and mechanical stretch play a role in the regulation of protein synthesis in cardiomyocytes.

Published
1995

26. Misidentification of a genomovar of Burkholderia cepacia by recA restriction fragment length polymorphism. (Short Report)

Author

Moore, J.E., Millar, B.C., Xu, J., Crowe, M., Redmond, A.O.B., and Elborn, J.S.

Subjects
Opportunistic infections -- Diagnosis -- Complications and side effects, Cystic fibrosis -- Complications and side effects -- Diagnosis, Diagnostic errors -- Analysis, Health
Abstract

An 8 year old girl with cystic fibrosis presented with a pulmonary exacerbation from which Burkholderia cepacia was cultured. Subsequent polymerase chain reaction restriction fragment length polymorphism analysis of the [...]

Published
2002

34. In vitro antimicrobial activity of ceftolozane/tazobactam against Pseudomonas aeruginosaand other non-fermenting Gram-negative bacteria in adults with cystic fibrosis

Author

Gramegna, A., Millar, B.C., Blasi, F., Elborn, J.S., Downey, D.G., and Moore, J.E.

Abstract

•Ceftolozane/tazobactam (C/T) is a new cephalosporin/β-lactamase inhibitor antimicrobial combination.•C/T has activity towards non-fermenting Gram-negative bacteria.•C/T has good in vitro activity against cystic fibrosis clinical Pseudomonas aeruginosacompared with other antimicrobials.•C/T has no activity against Burkholderia cenocepaciaor Achromobacter xylosoxidans.

Published
2018
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41. Molecular biology methods for detection and identification of cryptosporidium species in feces, water, and shellfish

Author

Lowery, C.J., Xiao, L., Ryan, U.M., Dooley, J.S.G., Millar, B.C., Moore, J.E., Lowery, C.J., Xiao, L., Ryan, U.M., Dooley, J.S.G., Millar, B.C., and Moore, J.E.

Abstract

Techniques based on nucleic acid amplification have proven to be essential for the detection and epidemiological tracking of members of the genus Cryptosporidium. This gastrointestinal protozoan parasite cannot be routinely cultivated and it has an extremely low infectious dose, possibly below 100 oocysts. As Cryptosporidium is an important pathogen, particularly in immuno-compromised hosts, there is a pressing need to employ sensitive and discriminatory systems to monitor the organism. A number of fairly standard target genes have been assessed as detection targets, including 18S rRNA, microsatellites, and heat-shock (stress) proteins. As our knowledge of the biology of the organism increases, and as the full genome information becomes available, the choice of target may change. Genes encoding parasite-specific surface proteins (gp60, TRAP-C2, COWP) have already been examined. Much of the effort expended in molecular diagnostics of Cryptosporidium has been directed toward developing robust nucleic acid extraction methods. These are vital in order to recover amplifiable DNA from environments where small numbers of oocysts, often fewer than 100, may exist. Methodology based on adaptation of commercial kits has been developed and successfully employed to recover amplifiable DNA directly from water, food (particularly seafood), and fecal samples.

Published
2005

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