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AbstractAim To evaluate the acceptability of two co-designed mobile applications Mit Sygehus [a knowledge-based solution] and Genoptræn.dk [a self-training solution] to support a cross-sectoral, person-centred and empowering stroke rehabilitation.Setting The applications were implemented and tested throughout two stroke rehabilitation trajectories in Southern Denmark, comprising two acute, two sub-acute and two municipal stroke rehabilitation settings.Methods, participants and analysis A process evaluation focusing on acceptability was conducted. Individual and dyadic interviews were performed with ten stroke survivors (three women and seven men, aged 50–84) with moderate stroke and seven significant others (five women and two men, aged 50–78) post-rehabilitation. A constructivist Grounded Theory analysis was used to explore what, why, when, and how the apps worked or did not work throughout the stroke rehabilitation trajectory and if adaptions were needed.Results Participants found that Mit Sygehus provided adequate and sufficient knowledge and was easy to use, however, acceptability of Mit Sygehus declined throughout the rehabilitation process. Also, knowledge on ‘return-to-work’ and ‘re-gaining driver’s license/permission to drive’ needed to be developed. The content in Genoptræn.dk was perceived as acceptable, through content being person-centred, motivating and meaningful. Genoptræn.dk furthermore, supported the transfer between rehabilitation settings, provided a sense of progress throughout the rehabilitation process, facilitated positive habits regarding self-training, and relieved the burden on significant others. Genoptræn.dk was perceived most acceptable in the sub-acute rehabilitation setting and declined when rehabilitation continued in the municipal setting.Conclusion Stroke survivors and their significant others found Mit Sygehus and Genoptræn.dk acceptable to support cross-sectoral, person-centred and empowering stroke rehabilitation, however acceptability declined throughout the rehabilitation process. Further investigations are required to determine how cognitive rehabilitation can play a greater role in app-supported stroke rehabilitation and how the need for more long-term follow-up can be supported.

Abstract Aim To investigate and describe the process of using experience-based co-design (EBCD) to develop mobile/tablet applications to support a person-centred and empowering stroke rehabilitation. Setting Two cross-sectoral stroke rehabilitation settings in Denmark comprising six rehabilitation units. Participants Stroke survivors (n = 23), significant others (n = 18), occupational therapists (n = 12), physiotherapists (n = 9), representative of a patient organization (n = 1), application developers (n = 3) and researchers (n = 2). Method A structured, facilitated EBCD approach comprising six stages was used to co-design a service that aimed to address the priorities and needs of all relevant end-users. Data were collected by interviews, participant observations, notes on “flip sheets” and written feedback on the content in the apps and on the instruction pages. Data were analyzed descriptively and with a constructivist grounded theory analysis. Results The content in the application solutions “Mit Sygehus” and “Genoptræn.dk” were co-designed to support the needs identified by all end-users. Relevant evidence-based knowledge, person-centred exercises and guidelines using video recordings were the most important among the developed content in the applications to support person-centred and empowering stroke rehabilitation. Furthermore, easy, and seamless communication were considered important. Conclusions EBCD facilitated the development of content in the applications to support a person-centred and empowering stroke rehabilitation. Participants experienced that their contribution was considered important and valued.

Objective: To identify and describe occupational and physiotherapy rehabilitation modalities used to support an interdisciplinary rehabilitation in adults (aged 16 + years) with concussion. Methods: A scoping review methodology was used. Included studies were categorized according to Wade’s elements of rehabilitation and the Danish White Paper definition of rehabilitation. Results: Ten studies were included in this review, addressing: “assessment” (n = 9), “goal-setting” (n = 4), “training” (n = 10), and “social participation and discharge support” (n = 4). Interventions were delivered mainly by physiotherapists or an interdisciplinary team. In two studies occupational therapists were part of the interdisciplinary team. Randomized controlled trials more often addressed several of the rehabilitation elements using interdisciplinary intervention delivery. No studies specifically aimed their intervention at patients with acute or subacute concussion. Conclusion: The therapeutic modalities identified were: (i) manual and sensory motor interventions; (ii) physical exercises; and (iii) management of, or coping with, symptoms. More research is needed on how to better support social participation and discharge or return to work in the rehabilitation process. In addition, interventions delivered in the acute phases of concussion need further exploration. LAY ABSTRACT Individuals with prolonged or persisting symptoms from a concussion often struggle to participate in activities of daily living, and their quality of life and work ability is affected. Interdisciplinary rehabilitation is recommended, and it is recognized that occupational and physiotherapy is important to support the interdisciplinary rehabilitation and promote recovery. However, this scoping review found that occupational therapists were seldom part of the interdisciplinary rehabilitation team. Furthermore, the physiotherapy and occupational rehabilitation modalities used consisted of manual or sensory motor interventions, physical exercise interventions, and management and coping. Only a few studies included social participation and discharge support as a part of the rehabilitation. No studies specifically aimed their intervention at preventing prolonged symptoms in patients with acute or subacute concussion. There is a need for more research into how to better support social participation and discharge in the rehabilitation process. Also, interventions delivered in the acute phases of concussion need further exploration.

Objective: To describe and review evidence of mobile/tablet and web-based applications to support the rehabilitation process after stroke. The secondary aim was to describe participants’ stroke severity, and use of applications in relation to, respectively, the setting and phase of the rehabilitation process. Methods: A scoping review methodology was used to identify studies, through databases such as Pub-Med, CINAHL, Embase and AMED. In addition, grey literature was searched. The studies were categorized according to Wade’s model of rehabilitation. Results: The literature search resulted in 12,065 records. Forty-six studies were included, in which applications were used to support: assessment (n = 16); training (n = 25); discharge from hospital (n = 2); and 2 studies were targeted at supporting discharge/education/information and training. One study targeted assessment, discharge support and goal-setting. No studies were related to the element “participation” using Wade’s model of rehabilitation. Of the 46 studies, 33 studies included participants with mild to moderate stroke, and 4 studies included participants with severe stroke. In 9 studies the stroke severity was not reported. Twenty three studies included participants with chronic stroke, 16 acute and/or subacute stroke, and 5 included participants with acute and/or subacute and/or chronic stroke. In 2 studies, stroke onset was not reported. Applications were used in a rehabilitation setting (n = 21), home setting (n = 17), and both settings (n = 3). In 5 studies the setting was not reported. Conclusion: Most studies of applications developed to support the rehabilitation process after stroke have been explorative. They primarily include participants with mild or moderate stroke and focus on a limited aspect of the rehabilitation process, e.g. assessment or training. Future applications to support stroke rehabilitation should accommodate stroke survivors’ and significant others’ need for solutions, irrespective of stroke severity and throughout the entire rehabilitation process. LAY ABSTRACT Studies have shown that the integration of applications (apps) can support the rehabilitation process after stroke. However, this scoping review found that most existing app solutions have limited usability, providing only 1 aspect of support in the rehabilitation process, such as clinical assessment or a narrow focus on exercises. Furthermore, currently available app solutions mainly target stroke survivors with mild stroke. Stroke survivors and significant others express a need for more comprehensive solutions to support the entire crosssectorial rehabilitation process. Therefore, there is a need for development of app solutions that support a greater part of the stroke rehabilitation process regardless of stroke severity.

AimThe aim of this study was to explore the current and potential use of information and communication technology (ICT) to enhance coherent person-centred rehabilitation after stroke, from the perspectives of physiotherapists and occupational therapists.MethodFive occupational therapists and four physiotherapists from different phases of the Danish stroke rehabilitation process were included and two focus group interviews were carried out. A grounded theory approach was used throughout the study and a constant comparative method was used in the analysis.ResultsThree subcategories were identified from the analysis of interviews with participants: 1) ICT and apps as meaningful and supportive in the rehabilitation process, 2) ICT as a tool in communication and documentation and 3) Barriers to the integration of ICT and apps in the rehabilitation process. From these categories one core category emerged: The potential of a personalized app solution to facilitate coherent person-centred rehabilitation.ConclusionICT was perceived as important to integrate in stroke rehabilitation both for assessment, training and to compensate for remaining deficits. The development of a personalized app solution could accommodate stroke survivors' and significant others' need for insight into and overview over the rehabilitation process as well as access to relevant information, which would thereby empower them. Furthermore, a personalized app solution could also facilitate follow-up after discharge and was perceived to ease the communication and documentation within and between sectors, as well as communication with both stroke survivors and significant others.

Spectro-ptychography offers improved spatial resolution and additional phase spectral information relative to that provided by scanning transmission X-ray microscopes. However, carrying out ptychography at the lower range of soft X-ray energies (e.g. below 200 eV to 600 eV) on samples with weakly scattering signals can be challenging. Here, results of soft X-ray spectro-ptychography at energies as low as 180 eV are presented, and its capabilities are illustrated with results from permalloy nanorods (Fe 2p), carbon nanotubes (C 1s) and boron nitride bamboo nanostructures (B 1s, N 1s). The optimization of low-energy X-ray spectro-ptychography is described and important challenges associated with measurement approaches, reconstruction algorithms and their effects on the reconstructed images are discussed. A method for evaluating the increase in radiation dose when using overlapping sampling is presented., (open access.)

Magnetic skyrmions are topological spin textures that hold great promise as nanoscale information carriers in non-volatile memory and logic devices. While room-temperature magnetic skyrmions and their current-induced motion were recently demonstrated, the stray field resulting from their finite magnetisation and their topological charge limit their minimum size and reliable motion. Antiferromagnetic skyrmions allow to lift these limitations owing to their vanishing magnetisation and net zero topological charge, promising ultra-small and ultra-fast skyrmions. Here, we report on the observation of isolated skyrmions in compensated synthetic antiferromagnets at zero field and room temperature using X-ray magnetic microscopy. Micromagnetic simulations and an analytical model confirm the chiral antiferromagnetic nature of these skyrmions and allow the identification of the physical mechanisms controlling their size and stability. Finally, we demonstrate the nucleation of synthetic antiferromagnetic skyrmions via local current injection and ultra-fast laser excitation., (© 2022. The Author(s).)

Magnetite nanoparticles (MNPs) with 12, 34 and 53 nm sizes have been measured by AC-magnetometry at 50 kHz and 57 mT maximum applied field. The MNPs form chains under the AC-field, and the dynamics of the formation can be studied by measuring hysteresis cycles at different times. The measurement time has been varied from 5 ms to 10 s and for different initial temperatures of 5, 25 and 50 °C. The chain formation, identified by the increase of susceptibility and remanence with the measurement time, appears only for 34 nm particles. It has been observed that saturation, remanence and susceptibility at low (high) fields increase (decrease) with time. For the other two samples, these magnitudes are independent of time. At low fields, the heating efficiency is higher at 5 °C than at 50 °C, whereas it shows an opposite behaviour at higher fields; the origin of this behaviour is discussed in the article. Additionally, the relaxation times, τ N and τ B , have been calculated by considering the influence of the applied field. Chain formation requires translation and rotation of MNPs; therefore, the Brownian mechanism plays a fundamental role. It is found that magnetic reversal for 12 nm MNPs is mainly due to Néel relaxation. However, in the case of 34 nm MNPs, both mechanisms, Néel and Brownian relaxation, can be present depending on the amplitude of the field; for μ 0 H < 22 mT, the physical rotation of the particle is the dominant mechanism; on the other hand, for μ 0 H > 22 mT, both mechanisms are present within the size distribution. This highlights the importance of taking the field intensity into account to calculate relaxation times when analysing the relaxation mechanisms of magnetic colloids subjected to AC fields., Competing Interests: The authors declare no competing financial or non-financial interest., (This journal is © The Royal Society of Chemistry.)

Magnetically induced catalysis can be promoted taking advantage of optimal heating properties from the magnetic nanoparticles to be employed. However, when unprotected, these heating agents that are usually air-sensitive, get sintered under the harsh catalytic conditions. In this context, we present, to the best of our knowledge, the first example of air-stable magnetic nanoparticles that: 1) show excellent performance as heating agents in the CO 2 methanation catalyzed by Ni/SiRAlOx, with CH 4 yields above 95 %, and 2) do not sinter under reaction conditions. To attain both characteristics we demonstrate, first the exchange-coupled magnetic approach as an alternative and effective way to tune the magnetic response and heating efficiency, and second, the chemical stability of cuboctahedron-shaped core-shell hard CoFe 2 O 4 -soft Fe 3 O 4 nanoparticles., (© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Heating magnetic nanoparticles with high frequency magnetic fields is a topic of interest for biological applications (magnetic hyperthermia) as well as for heterogeneous catalysis. This study shows why FeC NPs of similar structures and static magnetic properties display radically different heating power (SAR from 0 to 2 kW g-1). By combining results from Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS) and static and time-dependent high-frequency magnetic measurements, we propose a model describing the heating mechanism in FeC nanoparticles. Using, for the first time, time-dependent high-frequency hysteresis loop measurements, it is shown that in the samples displaying the larger heating powers, the hysteresis is strongly time dependent. More precisely, the hysteresis area increases by a factor 10 on a timescale of a few tens of seconds. This effect is directly related to the ability of the nanoparticles to form chains under magnetic excitation, which depends on the presence or not of strong dipolar couplings. These differences are due to different ligand concentrations on the surface of the particles. As a result, this study allows the design of a scalable synthesis of nanomaterials displaying a controllable and reproducible SAR.

In order to understand the properties involved in the heating performance of magnetic nanoparticles during hyperthermia treatments, a systematic study of different γ-Fe₂O₃ and Fe₃O₄ nanoparticles has been done. High-frequency hysteresis loops at 50 kHz carried out on particles with sizes ranging from 6 to 350 nm show susceptibility χ increases from 9 to 40 for large particles and it is almost field independent for the smaller ones. This suggests that the applied field induces chain ordering in large particles but not in the smaller ones due to the competition between thermal and dipolar energy. The specific absorption rate (SAR) calculated from hysteresis losses at 60 mT and 50 kHz ranges from 30 to 360 W/g Fe , depending on particle size, and the highest values correspond to particles ordered in chains. This enhanced heating efficiency is not a consequence of the intrinsic properties like saturation magnetization or anisotropy field but to the spatial arrangement of the particles., Competing Interests: The authors declare no conflict of interest.

The present manuscript reports the use of hybrid magneto-plasmonic nanoparticles (HMPNPs) based on iron oxide nanoparticles and Au nanorods as colloidal nanoheaters. The individual synthesis of the magnetic and plasmonic components allowed optimizing their features for heating performance separately, before they were hybridized. Besides, a detailed characterization and finite element simulations were carried out to explain the interaction effects observed between the phases of the HMPNPs. The study also analyzed the heating power of these nanostructures when they were excited with infrared light and AC magnetic fields, and compared this with the heating power of their plasmonic and magnetic components. In the latter case, the AC magnetization curves revealed that the magnetic dipolar interactions increase the amount of heat released by the hybrid nanostructures.