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29 results on '"Miller, Danforth P."'

12. Electrical conductivity of supercooled aqueous mixtures of trehalose with sodium chloride

Author

Miller, Danforth P., Conrad, Paul B., Fucito, Silvana, Corti, Horacio R., and Pablo, Juan J. de

Subjects
Carbohydrates -- Electric properties, Viscosity -- Analysis, Electrical conductivity -- Analysis, Chemicals, plastics and rubber industries
Abstract

The viscosity and electrical conductivity of aqueous solutions of trehalose and other saccharides containing 1:1 electrolytes are measured. A decrease in the molar conductivity of each electrolytes with increasing viscosity is less than the predicted by Walden's rule is observed.

Published
2000

13. Viscosity and glass transition temperatures of aqueous mixtures of trehalose with borax and sodium chloride

Author

Miller, Danforth P., de Pablo, Juan J., and Corti, Horacio R.

Subjects
Borax -- Observations, Transition temperature -- Research, Chemicals, plastics and rubber industries
Abstract

A study of the glass transition temperature and viscosity of aqueous trehalose and its mixtures with borax and sodium chloride is presented with measurements taken over a wide range of concentration.

Published
1999

18. Idealhalers Versus Realhalers: Is It Possible to Bypass Deposition in the Upper Respiratory Tract?

Author

Weers, Jeffry G., primary, Son, Yoen-Ju, additional, Glusker, Mark, additional, Haynes, Alfred, additional, Huang, Daniel, additional, Kadrichu, Nani, additional, Le, John, additional, Li, Xue, additional, Malcolmson, Richard, additional, Miller, Danforth P., additional, Tarara, Thomas E., additional, Ung, Keith, additional, and Clark, Andy, additional

Published
2019
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29. Stabilization and Preservation of Lactobacillus acidophilusin Saccharide Matrices

Author

Conrad, Paul B., Miller, Danforth P., Cielenski, Peter R., and de Pablo, Juan J.

Abstract

Lyophilization and vacuum- or spray-drying are some of the most useful techniques for preserving foods, agricultural products, and pharmaceuticals. Biological materials, however, can be irreversibly damaged during these treatments. Therefore, it is essential to design protective agents to preserve protein activity and cell viability. In this paper we examine the use of α,α-trehalose–borate systems as protectants for Lactobacillus acidophilusduring freeze- and vacuum-drying. Trehalose was found to be an effective protectant for freeze-dried and vacuum-dried samples, and it is equivalent to a protective formulation which is in current industrial use. It is known from our previous work on enzymes that the presence of borate can dramatically enhance the protective ability of trehalose. In this work, the addition of trehalose–borate to bacterial concentrate greatly improves the recovery of viable cells after storage. This improvement was seen in freeze-dried samples stored at 37°C as well as for vacuum-dried samples held at room temperature. A tailored buffering strategy was tested to counteract the high pH resulting from the addition of borate to the mixture. Use of citric or lactic acids in combination with ammonium hydroxide gave a protectant solution with high pH (resulting in effective crosslinking between trehalose and borate) but a dry product with reduced pH upon rehydration (conducive to cell survival). These results raise exciting possibilities for protection of more labile prokaryotic species as well as simple eukaryotes.

Published
2000
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