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3. Spotlight Column

Author

Baquet-Simpson, Alena M., Craig, Kelly Jean Thomas, MacKenzie, Shannon M., Miller, Hillary V., Yang, Hannah, Foreman, Robin P., Martinez, Kerry A., McNutt, Sherrie L., Verbrugge, Dorothea J., and Sharp, Jamie S.

Published
2022
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5. Notes

Author

Miller, Hillary

Published
2016

6. Index

Author

Miller, Hillary

Published
2016

19. Cover

Author

Miller, Hillary

Published
2016

22. Fmo induction as a tool to screen for pro-longevity drugs

Author

Huang, Shijiao, Cox, Rebecca L., Tuckowski, Angela, Beydoun, Safa, Bhat, Ajay, Howington, Marshall B., Sarker, Marjana, Miller, Hillary, Ruwe, Ethan, Wang, Emily, Li, Xinna, Gardea, Emily A., DeNicola, Destiny, Peterson, William, Carrier, Jeffrey M., Miller, Richard A., Sutphin, George L., and Leiser, Scott F.

Published
2024
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29. Maladaptive behaviors in individuals with Angelman syndrome

Author

Sadhwani, Anjali, Willen, Jennifer M, LaVallee, Nicole, Stepanians, Miganush, Miller, Hillary, Peters, Sarika U, Barbieri‐Welge, Rene L, Horowitz, Lucia T, Noll, Lisa M, Hundley, Rachel J, Bird, Lynne M, and Tan, Wen‐Hann

Subjects
Paediatrics, Biomedical and Clinical Sciences, Basic Behavioral and Social Science, Clinical Research, Behavioral and Social Science, Mental Health, Pediatric Research Initiative, Pediatric, Clinical Trials and Supportive Activities, Adolescent, Adult, Alleles, Angelman Syndrome, Child, Child, Preschool, Disease Susceptibility, Female, Genetic Predisposition to Disease, Genotype, Humans, Infant, Male, Parenting, Quality of Life, Severity of Illness Index, Stereotyped Behavior, Stress, Psychological, Young Adult, behavior rating scale, behavioral symptoms, developmental disabilities, problem behavior, Genetics, Clinical Sciences, Clinical sciences
Abstract

Maladaptive behaviors are challenging and a source of stress for caregivers of individuals with Angelman Syndrome (AS). There is limited information on how these maladaptive behaviors vary over time among individuals with AS due to different genetic etiologies. In this study, caregivers of 301 individuals with AS were asked questions about their child's behavior and completed the Aberrant Behavior Checklist-Community version (ABC-C). Developmental functioning was evaluated with either the Bayley Scales of Infant Development, Third Edition (Bayley-III) or the Mullen Scales of Early Learning (MSEL). Family functioning was assessed using the parent-completed Parenting Stress Index (PSI) and the Family Quality of Life questionnaire (FQoL). Approximately 70% of participants had AS due to a deletion on the maternally-inherited copy of chromosome 15q11q13. Results revealed that at baseline, individuals with AS had low scores in the domains of lethargy (mean: 2.6-4.2 depending on genotype) and stereotypy (mean: 2.3-4.2 depending on genotype). Higher cognitive functioning was associated with increased irritability (r = 0.32, p

Published
2019

30. Same Question, Different World: Replicating an Open Access Research Impact Study

Author

Arendt, Julie, Peacemaker, Bettina, and Miller, Hillary

Abstract

To examine changes in the open access landscape over time, this study partially replicated Kristin Antelman's 2004 study of open access citation advantage. Results indicated open access articles still have a citation advantage. For three of the four disciplines examined, the most common sites hosting freely available articles were independent sites, such as academic social networks or article sharing sites. For the same three disciplines, more than 70% of the open access copies were publishers' PDFs. The major difference from Antelman's is the increase in the number of freely available articles that appear to be in violation of publisher policies.

Published
2019

31. Television as Theatre Text in the Austere Academy: A Curricular Exploration

Author

Miller, Hillary

Abstract

The theatre classroom is necessarily a space in dialogue with myths about the marginalisation of theatre as an art and theatre audiences as a public. It is precisely "because" theatre is a marginalised discipline that curricula should incorporate the processes by which the labour of theatre artists changes value and joins the mainstream; playwrights employed in television offer a relevant study of just that. How do we revise undergraduate curricula in order to substantially address this intermediality in a way that is legible for students? And where do television and theatre meet in existing theatre courses and objectives?

Published
2019
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35. A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

Author

McCormick, Mark A, Delaney, Joe R, Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Shemorry, Anna, Sim, Sylvia, Chou, Annie Chia-Zong, Ahmed, Umema, Carr, Daniel, Murakami, Christopher J, Schleit, Jennifer, Sutphin, George L, Wasko, Brian M, Bennett, Christopher F, Wang, Adrienne M, Olsen, Brady, Beyer, Richard P, Bammler, Theodor K, Prunkard, Donna, Johnson, Simon C, Pennypacker, Juniper K, An, Elroy, Anies, Arieanna, Castanza, Anthony S, Choi, Eunice, Dang, Nick, Enerio, Shiena, Fletcher, Marissa, Fox, Lindsay, Goswami, Sarani, Higgins, Sean A, Holmberg, Molly A, Hu, Di, Hui, Jessica, Jelic, Monika, Jeong, Ki-Soo, Johnston, Elijah, Kerr, Emily O, Kim, Jin, Kim, Diana, Kirkland, Katie, Klum, Shannon, Kotireddy, Soumya, Liao, Eric, Lim, Michael, Lin, Michael S, Lo, Winston C, Lockshon, Dan, Miller, Hillary A, Moller, Richard M, Muller, Brian, Oakes, Jonathan, Pak, Diana N, Peng, Zhao Jun, Pham, Kim M, Pollard, Tom G, Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Robison, Brett, Rodriguez, Ariana A, Ros, Bopharoth, Sage, Michael, Singh, Manpreet K, Smith, Erica D, Snead, Katie, Solanky, Amrita, Spector, Benjamin L, Steffen, Kristan K, Tchao, Bie Nga, Ting, Marc K, Wende, Helen Vander, Wang, Dennis, Welton, K Linnea, Westman, Eric A, Brem, Rachel B, Liu, Xin-guang, Suh, Yousin, Zhou, Zhongjun, Kaeberlein, Matt, and Kennedy, Brian K

Subjects
Genetics, Nutrition, Biotechnology, Aging, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Animals, Basic-Leucine Zipper Transcription Factors, Caenorhabditis elegans, Caloric Restriction, DNA Damage, Gene Deletion, Gene Expression Regulation, Genome, Longevity, Nuclear Pore Complex Proteins, RNA, Transfer, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, TOR Serine-Threonine Kinases, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism
Abstract

Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We performed a systematic analysis of yeast RLS in a set of 4,698 viable single-gene deletion strains. Multiple functional gene clusters were identified, and full genome-to-genome comparison demonstrated a significant conservation in longevity pathways between yeast and C. elegans. Among the mechanisms of aging identified, deletion of tRNA exporter LOS1 robustly extended lifespan. Dietary restriction (DR) and inhibition of mechanistic Target of Rapamycin (mTOR) exclude Los1 from the nucleus in a Rad53-dependent manner. Moreover, lifespan extension from deletion of LOS1 is nonadditive with DR or mTOR inhibition, and results in Gcn4 transcription factor activation. Thus, the DNA damage response and mTOR converge on Los1-mediated nuclear tRNA export to regulate Gcn4 activity and aging.

Published
2015

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