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BACKGROUND: The subcutaneous ICD (S-ICD) is developed to overcome lead-related complications and systemic infections, inherent to transvenous ICD (TV-ICD) therapy. The PRAETORIAN trial demonstrated that the S-ICD is non-inferior to the TV-ICD with regard to the combined primary endpoint of inappropriate shocks and complications. This prespecified secondary analysis evaluates all complications in the PRAETORIAN trial. METHODS: The PRAETORIAN trial is an international, multicenter, randomised trial in which 849 patients with an indication for ICD therapy were randomised to receive an SICD (N = 426) or TV-ICD (N = 423) and followed for a median of 49 months. Endpoints were device-related complications, lead-related complications, systemic infections and the need for invasive interventions. RESULTS: Thirty-six device-related complications occurred in 31 patients in the S-ICD group of which bleedings were the most frequent. In the TV-ICD group 49 complications occurred in 44 patients of which lead-dysfunction was most frequent (HR 0.69; P =0.11). In both groups half of all complications were within 30 days after implantation. Lead-related complications and systemic infections occurred significantly less in the S-ICD group compared to the TV-ICD group (P

Interatrial block (IAB) is an electrocardiographic pattern describing the conduction delay between the right and left atria. IAB is classified into 3 degrees of block that correspond to decreasing conduction in the region of Bachmann's bundle. Although initially considered benign in nature, specific subsets of IAB have been associated with atrial arrhythmias, elevated thromboembolic stroke risk, cognitive impairment, and mortality. As the pathophysiologic relationships between IAB and stroke are reinforced, investigation has now turned to the potential benefit of early detection, atrial imaging, cardiovascular risk factor modification, antiarrhythmic pharmacotherapy, and stroke prevention with oral anticoagulation. This review provides a contemporary overview of the epidemiology, pathophysiology, diagnosis, and management of IAB, with a focus on future directions. (C) 2022 by the American College of Cardiology Foundation.

STUDY OBJECTIVES Patients with Huntington's disease (HD) show a high prevalence of sleep disorders that typically occur prior to the onset of motoric symptoms and neurodegeneration. Our understanding of the pathophysiological alterations in premanifest HD is limited, hindering the ability to measure disease modification in response to treatment. We used a full-length knock-in HD model to determine early changes in the electroencephalogram (EEG) and sleep that may predict the onset and progression of the disease. METHODS A 10-month longitudinal study was designed to determine the effect of the HD mutation on the EEG and sleep/wake changes in heterozygous (HET) and homozygous (HOM) zQ175 mice and wild-type (WT) littermates from 8 to 48 w of age. Mice were instrumented with tethered headmounts to record EEG/electromyography signals. Telemeters were implanted to continuously measure locomotor activity (LMA) and body temperature (Tb). Sleep deprivation (SDep) was performed at 8, 12, 16, 24, 32, and 48 w of age. RESULTS The HD mutation disrupted the EEG field potential from 8-12 w in an age- and mutant huntington dose-dependent manner, prior to changes in sleep/wake states, LMA, and Tb. Prominent effects of the HD mutation on the EEG included a progressive reduction in low frequency power, a slowing of rapid eye movement peak theta frequency, and the emergence of state-dependent beta/gamma oscillations. There was no effect of genotype on the relative increase in nonrapid eye movement delta power or sleep time in response to SDep. CONCLUSIONS The expression of the Huntington's disease (HD) mutation results in complex EEG alterations that occur prior to deficits in behavioral measures and are one of the earliest phenotypes uncovered in this mouse model. Despite these EEG changes, homeostatic responses to sleep loss were preserved in HET and HOM zQ175 mice. Greater insight into the localization and response of these EEG alterations to novel therapies may enable early intervention and improve outcomes for patients with HD.

In this article, I discuss how transnormativity can be disrupted by not exaggerating the physical aspects of medical transition and by engaging in conversations around consequential sources of tension within gender and sexual minority communities, namely linguistic understandings of trans and gendered racism within white, gay, cisgender communities toward trans communities of color. This study is based on qualitative interviews with six trans YouTubers; these interviews were complemented by analyses of these YouTubers' videos and select comments on these videos. With this exploratory study, I aim to provide nuance to existing lesbian, gay, bisexual, and trans (LGBT) YouTube literature through highlighting the experiences of nonbinary trans vloggers and trans vloggers of color, regardless of medical transition status, as well as contribute a transfeminist analysis to ongoing conversations around transnormativity within sociology, cultural and media studies, and queer and trans theory.

Behavioral skills training (BST) has been employed within many different populations for the reduction of problem behaviors and acquisition of new skills; however, these changes have not always maintained over time. This study evaluated the effects of a booster training for re-establishing the classroom management proficiencies that teachers had acquired previously, but had declined over a 12-month period. The single-subject experimental results showed the booster training to be effective in re-establishing teacher performance of skills as measured by both analogue role-play and in situ postassessments within the classroom. These findings suggest that a booster training utilizing BST may be an important strategy for maintaining skill performance over time.

BACKGROUND/AIMS: Patients with chronic kidney disease (CKD) have increased risk for Clostridium difficile infection (CDI) and for subsequent mortality. We determined the effect of CKD on response to treatment for CDI. METHODS: This is a post hoc analysis of two randomized controlled phase 3 trials that enrolled patients with CDI. Patients received either fidaxomicin 200 mg b.i.d. or vancomycin 125 mg q.i.d. for 10 days. Univariate and multivariate analyses compared end points by treatment received and CKD stage. RESULTS: At baseline, 27, 21, and 9% of the patients had stage 2 (60-89 ml/min/1.73 m(2)), stage 3 (30-59), and stage 4 or higher (

The victim impact statement (VIS) is a written account of the physical, psychological, and economic harms experienced by a victim as a result of crime. This paper describes a qualitative study conducted in Ontario, Canada with 15 hospital-based sexual assault care and treatment centre social workers (SWs) who had supported victims through the process of producing a VIS for criminal court. It was found that while SWs' formal knowledge of VIS legislation and legal practice was often poor, they were mindful of its implementation in the courts and concerned with assisting women in avoiding inciting ire in judges through the use of inappropriate or inadmissible VIS commentary. The practice of many SWs was guided by a firm belief in the intrinsic expressive function of the VIS, which contrasted with most victims' motivation to complete a VIS due to its perceived instrumental value. The authors conclude with recommendations for future research.

This article presents the art therapist's engagement in responsive art making as an effective approach in working with an adolescent survivor of developmental trauma. Through a case study illustrat...

Important in the homeostasis of normal tissues, apoptosis can be altered to favor cell survival within tumors. High expression of survivin, an inhibitor of apoptosis, and absence of caspase 8, a pro-apoptotic enzyme, independently correlate with poor outcomes in several tumor types. Favorable histology Wilms tumor has a remarkably high cure rate; as a result, the focus of therapy is now aimed at reducing treatment-related morbidity. With the goal of safely reducing therapy in select subgroups of patients, the authors investigated whether the levels of apoptotic factors in tumors could predict the risk for recurrence. Tumor apoptotic factor levels were surveyed in a case-control study from the National Wilms Tumor Study 5 (NWTS-5) and measured via quantitative real-time RT-PCR. Survivin and caspase 8 levels were surveyed in 92 primary tumor specimens and SMAC, Bid, and CD95 were surveyed in 24 specimens. All four pro-apoptotic factors studied (caspase 8, SMAC, Bid, and CD95) were analyzed individually and in relation to survivin expression. Although survivin mRNA was present at markedly greater levels than in normal kidney, none of the factors assayed independently or as a ratio was associated with stage of disease or risk for tumor recurrence in this group of tumors.

This comprehensive volume about posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) is timely given the considerable attention in the literature subsequent to the recent war...

“Stories have to be told or they die, and when they die, we can't remember who we are or why we're here” (Kidd, 2003, p. 107). Storytelling has been used to entertain, to teach, and to provide a wa...

The recent censuses in Eastern Europe and the former Soviet Union have resulted in an enormous quantity of resources that are freely available on the Internet. These resources include not only census data, but also other census-related materials such as methodologies and questionnaires that are equally valuable to researchers of the region. Accessing these materials online is convenient and free, but at the same time worrisome from a research standpoint in that much of this material may vanish from the Internet. Since this material has largely not yet appeared in published format, librarians and researchers may consider saving an archival copy for research purposes.

Alpha-synuclein is a small, highly conserved protein in vertebrates that has been linked to several neurodegenerative diseases. The avian song control system is one of the model systems in which the protein was independently discovered. Alpha-synuclein is dynamically regulated in the song system during song learning, a process in which sex steroids play a central role. We compared alpha-synuclein mRNA expression in the brains of 12 adult male chipping sparrows (Spizella passerina) treated with either testosterone or blank s.c. implants. We saw pronounced upregulation of alpha-synuclein mRNA in, as well as an increase in the volume of, the song control nucleus area X in response to exogenous testosterone. To our knowledge this is the first report of steroid regulation of synuclein gene expression in any model system.

Eric Aoki, Media Reviews Editor Dragonfly Stories is an anthology of personal narratives from the GLBTQ community, their friends, and allies. According to editors Joyce Cascio, Catherine Brown, and...

The aim was to investigate whether the Thr715Pro P-selectin polymorphism is associated with soluble P-selectin (sP-selectin) levels in individuals from different ethnic groups. Plasma sP-selectin and Thr715Pro (A/C) P-selectin gene polymorphism were measured in 237 white (106 females), 177 black African origin (92 females) and 201 South Asian (94 females) individuals living in England. All were free from coronary heart disease (CHD), stroke and other cardiovascular disease, diabetes, drug therapy for hypertension or high lipids, hormone replacement therapy or oral contraceptive pill. The Thr715Pro C allele was rare in blacks (0.8%) and intermediate in South Asians (3.0%) compared to whites (11.2%; p

A study was undertaken in spring 1991 in the South Florida market among communication professionals to learn what characteristics were determinant of interest in graduate programs. Discriminant analysis was performed to determine what factors caused one to opt for a formal degree program for enrollment in a formal degree program was not economic based, but perceived benefit to the company. It was also found that more minorities wanted a formal education from a degree program. Of note, the needs of advertising and public relations professionals were similar, lending credence to the need for an integrated program.

The in vitro and in vivo electrochemical behavior of commercially pure titanium (cp Ti) was characterized using a specialized osseous implant in conjunction with electrochemical impedance spectroscopy (EIS) measurement techniques. Studies performed in vitro were used to verify the operation of the transducer and develop methods of deconvoluting EIS data. This method was subsequently used to describe an electrochemical equivalent circuit model of the surface oxide and electrical doublelayer capacitance of cp Ti in the endogenous electrolyte found in the medullary compartment of a baboon tibia. Kinetic profiles of the double-layer capacitance and the polarization resistance were constructed from multiple in vitro and in vivo EIS measurements performed over 60 min at 0 V (reference Ag/AgCI) conditioning potential. The profiles demonstrated that the growth of surface oxides was biphasic, with rapid decrease in the doublelayer capacitance occurring within 20 min and reaching steady-state conditions at approximately 40 min. These data suggested that a passive, stable biofilm formed on the cp Ti surface in vivo and in vitro. © 1993 John Wiley & Sons, Inc.

The multifocused faculty selection model is designed to assist the faculty search committee in two ways. First, this model organizes the stages for obtaining information about the applicant's abilities related to faculty performance. Second, the model provides a consistent method for faculty selection as the membership of the department's search committee changes. The applicant selection techniques used in this model include descriptive interviewing, computer assisted data, and the teaching demonstration.

Market segmentation is an important topic to higher education researchers and administrators. The authors explored the relative importance that prospective students attach to various benefirts offered by a medium-sized private university with moderately selective admissions criteria. The purposes of the study were to test, and provide data to illustrate, the efficacy of one approach to college benefit segmentation analysis.