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34 results on '"Milosavljević, Vedran"'

14. Synthesis and structural characterization of antimicrobial binuclear copper(II) coordination compounds bridged by hydroxy- and/or thiodipropionic acid

Author

Buchtelova, Hana, Skubalova, Zuzana, Strmiska, Vladislav, Michalek, Petr, Kociova, Silvia, Smerkova, Kristyna, Kruszynski, Rafal, Bienko, Alina, Kaj, Michalina, Lewinska, Agnieszka, Bienko, Dariusz, Malik-Gajewska, Magdalena, Milosavljevic, Vedran, Kopel, Pavel, Heger, Zbynek, and Adam, Vojtech

Published
2019
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21. Corrigendum to “Development and characterisation of furcellaran-gelatin films containing SeNPs and AgNPs that have antimicrobial activity” [Food Hydrocolloids 83 (2018) 9–16]

Author

Jamróz, Ewelina, primary, Kopel, Pavel, additional, Juszczak, Lesław, additional, Kawecka, Agnieszka, additional, Bytesnikova, Zuzana, additional, Milosavljević, Vedran, additional, Kucharek, Mateusz, additional, Makarewicz, Małgorzata, additional, and Adam, Vojtech, additional

Published
2022
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29. Biogenic amines modified carbon quantum dots as antibacterial agent

Author

Gagić, Milica, Kočiová, Silvia, Richtera, Lukáš, Šmerková, Kristýna, and Milosavljević, Vedran

Subjects
resistance, antibacterial, biogenic amines, pathogenic bacteria, carbon quantum dots
Abstract

An alternative to conventional way is needed to treat multiple drug resistant bacteria. In this work, four different amine modified carbon quantum dots (CQDs) were obtained by microwave irradiation treatment. The four different biogenic amines (spermidine, putrescine, cadaverine, and histamine) as capping agent and citric acid as a carbon precursor were used. Prepared CQDs were evaluated for their antibacterial activity against three common pathogenic bacteria (Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus), and the growth curves were modeled. The CQDs showed a strong broad-spectrum antibacterial activity. The bactericidal activity was linked to their specific surface chemistry and caused bacterial death, which was due to the electrostatic interactions between protonated CQDs and the lipids of the bacterial cell membrane. The biocompatibility of CQDs was tested in HBL100 and HEK293 cell lines and low or absence of toxicity was indicated.

Published
2019

30. Isolation of histamine using -Fe2O3 nanoparticles

Author

Gagić, Milica, Kopel, Pavel, Milosavljević, Vedran, Cernei, Natalia Vladimirovna, Zítka, Ondřej, Švec, Pavel, Jamroz, Ewelina, and Adam, Vojtěch

Subjects
food safety, rapid method, biogenic amines, nanoparticles, fish poisoning
Abstract

Histamine, biologically active amine, is normally present in the body and it is involved in a local regulation of physiological processes. It occurs in food as a product of microbial decarboxylation of the amino acid histidine, and the ingestion of foods that contain high levels of histamine can lead to poisoning. Hence, the presence of this biogenic amine is considered as an indicator of food spoilage. Many different methods are available to detect the presence of histamine in food samples. The aim of this study was to design a fast and low-cost method for histamine identification employing magnetic isolation and subsequent reaction of desorbed histamine with ninhydrin for final ion exchange chromatography quantification.

Published
2019

31. Novel Vancomycin-Peptide Conjugate as Potent Antibacterial Agent against Vancomycin-Resistant Staphylococcus aureus

Author

Jelínková, Pavlína, Šplíchal, Zbyněk, Jimenez Jimenez, Ana Maria, Haddad, Yazan Abdulmajeed Eyadh, Mazumdar, Aninda, Sur, Vishma Pratap, Milosavljević, Vedran, Kopel, Pavel, Buchtelová, Hana, Guráň, Roman, Zítka, Ondřej, Richtera, Lukáš, Hegerová, Dagmar, Heger, Zbyněk, Moulick, Amitava, and Adam, Vojtěch

Subjects
antibacterial, Staphylococcus aureus, antibiotic resistance, Vancomycin, peptide
Abstract

Background: Increase in vancomycin (Van)-resistant bacterial strains including vancomycin-resistant Staphylococcus aureus (VRSA) and lack of new effective antibiotics have become a formidable health problem. Materials and methods: We designed a new conjugate composed of Van and a peptide Hecate (Hec; Van/Hec), and its potential antimicrobial activity was evaluated. Results: Results from disk diffusion test, time-kill assay, determination of minimum inhibitory concentration (MIC), microscopy, and comet assay showed strong antimicrobial effects of Van/Hec against wild-type, methicillin-resistant Staphylococcus aureus (MRSA) and VRSA. Microscopy revealed that the exposure to Van/Hec results in disruption of bacterial cell integrity in all tested strains, which was not observed in case of Van or Hec alone. Conclusion: Overall, we showed that the preparation of conjugates from antibiotics and biologically active peptides could help us to overcome the limitation of the use of antibiotic in the treatment of infections caused by multidrug-resistant bacteria.

Published
2018

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