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4. Evaluation of Expression and Prognostic Significance of FUNDC1 Protein in Non-small Cell Lung Cancer Based on TCGA Database and Clinicopathology

Author

WANG Yuxiu, Chen Yu, GONG Daohui, CAO Liuzhao, XU Wenjing, XU Xingxiang, and MIN Lingfeng

Subjects
mitochondrial receptors, fun14 domain-containing protein 1, nsclc, clinicopathological characteristics, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Objective To evaluate the expression of FUNDC1 and its clinical significance in non-small cell lung cancer. Methods We used TCGA database to analyze the difference of mitochondrial receptors (DRP1, BNIP3, FUNDC1, NIX, RHEB, LC3, OPA1 and MFN1) expression between normal and NSCLC tissues, as well as its effect on the prognosis of NSCLC patients. Immunohistochemistry was used to detect FUNDC1 expression. The correlations between FUNDC1 expression and clinicopathological characteristics, prognosis were evaluated by SPSS 22.0 statistical software. Results FUNDC1 expression was increased in NSCLC tissues, compared with normal tissues. FUNDC1 expression was related to the degree of differentiation and lymph node metastasis, but not to gender, age, pathological type, distant metastasis or TNM classification. The Cox regression analysis showed that FUNDC1 protein expression, lymph node metastasis, differentiation degree were independent prognostic factors of NSCLC. Increased FUNDC1 expression was related to decreased OS and PFS (P < 0.01). Conclusion The up-regulation of FUNDC1 expression can affect the prognosis of patients with NSCLC. It may be a new potential target for treating with NSCLC.

Published
2022
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6. Gold brocade coated CoFe PBA with enhanced peroxidase-like activity for a chemiluminescent imaging immunoassay.

Author

Li, Ling, Chen, Qingwen, Shi, Feng, Wu, Jiayu, Min, Lingfeng, Li, Juan, and Yang, Zhanjun

Subjects
ENZYME inactivation, PRUSSIAN blue, GOLD coatings, SYNTHETIC enzymes, IMMUNOASSAY
Abstract

Traditional chemiluminescence (CL) imaging immunoassays usually rely on natural enzymes as catalytic probes, which has hampered their extensive application due to the susceptibility to inactivation of natural enzymes. In response, a gold brocade coated CoFe Prussian blue analogue (CoFe PBA@Au brocade) with enhanced peroxidase-like activity was synthesized and utilized as a powerful label probe for constructing a highly sensitive CL imaging immunosensor targeting disease biomarkers with excellent performance. This research offers a universal strategy for enhancing the sensitivity of CL imaging immunoassays and further expands the application of PBA nanozymes. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Expert Consensus on the Diagnosis and Treatment of NRG1/2 Gene Fusion Solid Tumors

Author

Xu, Chunwei, additional, Wang, Qian, additional, Wang, Dong, additional, Wang, Wenxian, additional, Fang, Wenfeng, additional, Li, Ziming, additional, Liu, Aijun, additional, Yu, Jinpu, additional, Zhong, Wenzhao, additional, Wang, Zhijie, additional, Zhang, Yongchang, additional, Liu, Jingjing, additional, Zhang, Shirong, additional, Cai, Xiuyu, additional, Liu, Anwen, additional, Li, Wen, additional, Zhan, Ping, additional, Liu, Hongbing, additional, Lv, Tangfeng, additional, Miao, Liyun, additional, Min, Lingfeng, additional, Chen, Yu, additional, Yuan, Jingping, additional, Wang, Feng, additional, Jiang, Zhansheng, additional, Lin, Gen, additional, Huang, Long, additional, Pu, Xingxiang, additional, Lin, Rongbo, additional, Liu, Weifeng, additional, Rao, Chuangzhou, additional, Lv, Dongqing, additional, Yu, Zongyang, additional, Li, Xiaoyan, additional, Tang, Chuanhao, additional, Zhou, Chengzhi, additional, Zhang, Junping, additional, Xue, Junli, additional, Guo, Hui, additional, Chu, Qian, additional, Meng, Rui, additional, Wu, Jingxun, additional, Zhang, Rui, additional, Zhou, Jin, additional, Zhu, Zhengfei, additional, Li, Yongheng, additional, Qiu, Hong, additional, Xia, Fan, additional, Lu, Yuanyuan, additional, Chen, Xiaofeng, additional, Ge, Rui, additional, Dai, Enyong, additional, Han, Yu, additional, Pan, Weiwei, additional, Pang, Fei, additional, He, Qingqing, additional, Huang, Jintao, additional, Wang, Kai, additional, Wu, Fan, additional, Xu, Bingwei, additional, Wang, Liping, additional, Zhu, Youcai, additional, Lin, Li, additional, Xie, Yanru, additional, Lin, Xinqing, additional, Cai, Jing, additional, Xu, Ling, additional, Li, Jisheng, additional, Jiao, Xiaodong, additional, Li, Kainan, additional, Wei, Jia, additional, Feng, Huijing, additional, Wang, Lin, additional, Du, Yingying, additional, Yao, Wang, additional, Shi, Xuefei, additional, Niu, Xiaomin, additional, Yuan, Dongmei, additional, Yao, Yanwen, additional, Huang, Jianhui, additional, Feng, Yue, additional, Zhang, Yinbin, additional, Sun, Pingli, additional, Wang, Hong, additional, Ye, Mingxiang, additional, Wang, Zhaofeng, additional, Hao, Yue, additional, Wang, Zhen, additional, Wan, Bin, additional, Lv, Donglai, additional, Yang, Shengjie, additional, Kang, Jin, additional, Zhang, Jiatao, additional, Zhang, Chao, additional, Ou, Juanjuan, additional, Shi, Lin, additional, Wang, Yina, additional, Li, Bihui, additional, Zhang, Zhang, additional, Li, Zhongwu, additional, Liu, Zhefeng, additional, Yang, Nong, additional, Wu, Lin, additional, Wang, Huijuan, additional, Jin, Gu, additional, Wang, Guansong, additional, Wang, Jiandong, additional, Fang, Meiyu, additional, Fang, Yong, additional, Li, Yuan, additional, Wang, Xiaojia, additional, Zhang, Yiping, additional, Zhu, Xixu, additional, Shen, Yi, additional, Ma, Shenglin, additional, Wang, Biyun, additional, Si, Lu, additional, Song, Yong, additional, Lu, Yuanzhi, additional, Chen, Jing, additional, and Song, Zhengbo, additional

Published
2024
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9. A Survival Prediction Model of Pulmonary Sarcomatoid Carcinoma Based on SEER Database

Author

LIU Ying, XIE Bin, WANG Meng, LI Yiran, YAN Wenjin, XU Xingxiang, and MIN Lingfeng

Subjects
pulmonary sarcomatoid carcinoma, prognostic factors, predictive model, seer database, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Objective To analyze the factors affecting the prognosis of patients with pulmonary sarcomatoid carcinoma (PSC) and construct a nomogram prediction model for the prognosis of PSC patients. Methods Based on the SEER database, 1671 patients diagnosed as PSC from 1988 to 2015 were collected and divided into modeling group and validation group according to the ratio of 7:3. Univariate and multivariate Cox regression analysis were performed in the modeling group to explore independent risk factors affecting the prognosis and construct a nomogram survival prediction model. The consistency index and calibration curve were used for verification in the modeling group and the test module respectively. Results Age, gender, histological type, TNM stage, tumor diameter > 50mm, surgery, radiotherapy and chemotherapy were independent factors that affected the prognosis of PSC patients. The nomogram prediction model was constructed and verified based on independent factors. The C indexes of the modeling group and the test model were 0.790 (95%CI: 0.776-0.804) and 0.781 (95%CI: 0.759-0.803), respectively. The calibration curves of the modeling group and the test model indicated that the predicted survival rate was basically the same as the actual survival rate. Conclusion The nomogram prediction model constructed based on the results of multivariate analysis can predict the prognosis of PSC patients, and has high accuracy and consistency.

Published
2021
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10. Prognosis Analysis of Non-small Cell Lung Cancer with Diameter over 7.0 cm Based on SEER Database

Author

FENG Tingting, CHEN Zhongzhong, YAN Wenjin, WANG Yuxiu, ZHANG Jun, XU Xingxiang, CHEN Yong, YANG Junjun, and MIN Lingfeng

Subjects
tumor size, nsclc, surgery, seer database, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Objective To analyze the mortality risk and evaluate the curative effects of surgery and non-surgery on NSCLC with diameter > 7.0 cm. Methods We collected the data of NSCLC patients with diameter > 7.0 cm from 2010 to 2015 from the SEER database. The 1, 2, 3-year survival rates were analyzed by life table method. Overall survival curve was estimated by Kaplan-Meier method. Univariate and multivariate Cox regression models were used to analyze the independent prognostic factors. Results The 1, 2, 3-year survival rates were 51.8%, 33.0% and 25.0%, respectively. In univariate and multivariate analyses, tumor size, N stage and treatment were the independent prognostic factors (P < 0.001). Conclusion Surgery is benefited for the prognosis of stage N0-N1 NSCLC patients with diameter > 7.0 cm. And for stage N2 NSCLC patients with diameter 7.0-9.0 cm, surgical treatment has advantages in improving the prognosis. Surgical and non-surgical patients with tumor diameter ≥9.0 cm or lymph node N3 stage have no statistically significant differences in prognosis. In addition, palliative treatment does not improve the prognosis of patients.

Published
2021
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11. An Au bipyramids@CuZn MOF core–shell nanozyme enables universal SERS and a colorimetric dual-model bioassay.

Author

Wang, Mengdi, Shi, Feng, Li, Jiayin, Min, Lingfeng, Yang, Zhanjun, and Li, Juan

Subjects
SERS spectroscopy
Abstract

In this study, a new type of gold nano-bipyramids@CuZn bimetallic organic framework (AuNBPs@CuZn MOF) nanozyme with high peroxidase (POD)-like activity and surface enhanced Raman scattering (SERS) activity was constructed with a special core–shell structure, which can catalyze the oxidation of TMB (colourless and Raman-inactive) into ox-TMB (blue and Raman-active). An AuNBPs@CuZn MOF-enabling universal SERS and colorimetric dual-model bioassay was thus developed for biomolecules with excellent performance, and has promising application prospects in the biosensing fields. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Expert consensus on the diagnosis and treatment of RET gene fusion non‐small cell lung cancer in China

Author

Pu, Xingxiang, primary, Xu, Chunwei, additional, Wang, Qian, additional, Wang, Wenxian, additional, Wu, Fang, additional, Cai, Xiuyu, additional, Song, Zhengbo, additional, Yu, Jinpu, additional, Zhong, Wenzhao, additional, Wang, Zhijie, additional, Zhang, Yongchang, additional, Liu, Jingjing, additional, Zhang, Shirong, additional, Liu, Anwen, additional, Li, Wen, additional, Zhan, Ping, additional, Liu, Hongbing, additional, Lv, Tangfeng, additional, Miao, Liyun, additional, Min, Lingfeng, additional, Lin, Gen, additional, Huang, Long, additional, Yuan, Jingping, additional, Jiang, Zhansheng, additional, Rao, Chuangzhou, additional, Lv, Dongqing, additional, Yu, Zongyang, additional, Li, Xiaoyan, additional, Tang, Chuanhao, additional, Zhou, Chengzhi, additional, Zhang, Junping, additional, Guo, Hui, additional, Chu, Qian, additional, Meng, Rui, additional, Liu, Xuewen, additional, Wu, Jingxun, additional, Zhou, Jin, additional, Zhu, Zhengfei, additional, Pan, Weiwei, additional, Pang, Fei, additional, Huang, Jintao, additional, Wang, Kai, additional, Wu, Fan, additional, Shen, Tingting, additional, Zou, Shirui, additional, Xu, Bingwei, additional, Wang, Liping, additional, Zhu, Youcai, additional, Lin, Xinqing, additional, Cai, Jing, additional, Xu, Ling, additional, Li, Jisheng, additional, Jiao, Xiaodong, additional, Li, Kainan, additional, Feng, Huijing, additional, Wang, Lin, additional, Du, Yingying, additional, Yao, Wang, additional, Shi, Xuefei, additional, Niu, Xiaomin, additional, Yuan, Dongmei, additional, Yao, Yanwen, additional, Kang, Jing, additional, Zhang, Jiatao, additional, Zhang, Chao, additional, Fu, Jianfei, additional, Huang, Jianhui, additional, Zhang, Yinbin, additional, Sun, Pingli, additional, Wang, Hong, additional, Ye, Mingxiang, additional, Wang, Dong, additional, Wang, Zhaofeng, additional, Hao, Yue, additional, Wang, Zhen, additional, Wan, Bing, additional, Lv, Donglai, additional, Lan, Gang, additional, Yang, Shengjie, additional, Shi, Lin, additional, Wang, Yina, additional, Li, Bihui, additional, Zhang, Zhang, additional, Li, Zhongwu, additional, Li, Yuan, additional, Liu, Zhefeng, additional, Yang, Nong, additional, Wang, Huijuan, additional, Huang, Wenbin, additional, Hong, Zhuan, additional, Wang, Guansong, additional, Wang, Jiandong, additional, Fang, Meiyu, additional, Fang, Yong, additional, Zhu, Xixu, additional, Shen, Yi, additional, Zhang, Yiping, additional, Ma, Shenglin, additional, Song, Yong, additional, Lu, Yuanzhi, additional, Fang, Wenfeng, additional, Li, Ziming, additional, and Wu, Lin, additional

Published
2023
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14. Chinese expert consensus on the diagnosis and treatment of malignant pleural mesothelioma

Author

Wang, Qian, primary, Xu, Chunwei, additional, Wang, Wenxian, additional, Zhang, Yongchang, additional, Li, Ziming, additional, Song, Zhengbo, additional, Wang, Jiandong, additional, Yu, Jinpu, additional, Liu, Jingjing, additional, Zhang, Shirong, additional, Cai, Xiuyu, additional, Li, Wen, additional, Zhan, Ping, additional, Liu, Hongbing, additional, Lv, Tangfeng, additional, Miao, Liyun, additional, Min, Lingfeng, additional, Li, Jiancheng, additional, Liu, Baogang, additional, Yuan, Jingping, additional, Jiang, Zhansheng, additional, Lin, Gen, additional, Chen, Xiaohui, additional, Pu, Xingxiang, additional, Rao, Chuangzhou, additional, Lv, Dongqing, additional, Yu, Zongyang, additional, Li, Xiaoyan, additional, Tang, Chuanhao, additional, Zhou, Chengzhi, additional, Zhang, Junping, additional, Guo, Hui, additional, Chu, Qian, additional, Meng, Rui, additional, Liu, Xuewen, additional, Wu, Jingxun, additional, Hu, Xiao, additional, Zhou, Jin, additional, Zhu, Zhengfei, additional, Chen, Xiaofeng, additional, Pan, Weiwei, additional, Pang, Fei, additional, Zhang, Wenpan, additional, Jian, Qijie, additional, Wang, Kai, additional, Wang, Liping, additional, Zhu, Youcai, additional, Yang, Guocai, additional, Lin, Xinqing, additional, Cai, Jing, additional, Feng, Huijing, additional, Wang, Lin, additional, Du, Yingying, additional, Yao, Wang, additional, Shi, Xuefei, additional, Niu, Xiaomin, additional, Yuan, Dongmei, additional, Yao, Yanwen, additional, Huang, Jianhui, additional, Wang, Xiaomin, additional, Zhang, Yinbin, additional, Sun, Pingli, additional, Wang, Hong, additional, Ye, Mingxiang, additional, Wang, Dong, additional, Wang, Zhaofeng, additional, Hao, Yue, additional, Wang, Zhen, additional, Wan, Bing, additional, Lv, Donglai, additional, Yu, Jianwei, additional, Kang, Jin, additional, Zhang, Jiatao, additional, Zhang, Chao, additional, Wu, Lixin, additional, Shi, Lin, additional, Ye, Leiguang, additional, Wang, Gaoming, additional, Wang, Yina, additional, Gao, Feng, additional, Huang, Jianfei, additional, Wang, Guifang, additional, Wei, Jianguo, additional, Huang, Long, additional, Li, Bihui, additional, Zhang, Zhang, additional, Li, Zhongwu, additional, Liu, Yueping, additional, Li, Yuan, additional, Liu, Zhefeng, additional, Yang, Nong, additional, Wu, Lin, additional, Wang, Qiming, additional, Huang, Wenbin, additional, Hong, Zhuan, additional, Wang, Guansong, additional, Qu, Fengli, additional, Fang, Meiyu, additional, Fang, Yong, additional, Zhu, Xixu, additional, Du, Kaiqi, additional, Ji, Jiansong, additional, Shen, Yi, additional, Chen, Jing, additional, Zhang, Yiping, additional, Ma, Shenglin, additional, Lu, Yuanzhi, additional, Song, Yong, additional, Liu, Anwen, additional, Zhong, Wenzhao, additional, and Fang, Wenfeng, additional

Published
2023
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17. Effects of awake prone position vs. usual care on acute hypoxemic respiratory failure in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials

Author

Peng, Qing, primary, Yang, Sheng, additional, Zhang, Yu, additional, Zhao, Wenjie, additional, Hu, Man, additional, Meng, Bo, additional, Ni, Huanhuan, additional, Min, Lingfeng, additional, Yu, Jiangquan, additional, Wang, Yongxiang, additional, and Zhang, Liang, additional

Published
2023
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20. Chinese expert consensus on the diagnosis and treatment of thymic epithelial tumors

Author

Xu, Chunwei, primary, Zhang, Yongchang, additional, Wang, Wenxian, additional, Wang, Qian, additional, Li, Ziming, additional, Song, Zhengbo, additional, Wang, Jiandong, additional, Yu, Jinpu, additional, Liu, Jingjing, additional, Zhang, Shirong, additional, Cai, Xiuyu, additional, Wu, Ming, additional, Zhan, Ping, additional, Liu, Hongbing, additional, Lv, Tangfeng, additional, Miao, Liyun, additional, Min, Lingfeng, additional, Li, Jiancheng, additional, Liu, Baogang, additional, Yuan, Jingping, additional, Jiang, Zhansheng, additional, Lin, Gen, additional, Chen, Xiaohui, additional, Pu, Xingxiang, additional, Rao, Chuangzhou, additional, Lv, Dongqing, additional, Yu, Zongyang, additional, Li, Xiaoyan, additional, Tang, Chuanhao, additional, Zhou, Chengzhi, additional, Zhang, Junping, additional, Guo, Hui, additional, Chu, Qian, additional, Meng, Rui, additional, Liu, Xuewen, additional, Wu, Jingxun, additional, Hu, Xiao, additional, Fang, Min, additional, Zhou, Jin, additional, Zhu, Zhengfei, additional, Chen, Xiaofeng, additional, Pan, Weiwei, additional, Pang, Fei, additional, Zhou, Yuxiang, additional, Jian, Qijie, additional, Wang, Kai, additional, Wang, Liping, additional, Zhu, Youcai, additional, Yang, Guocai, additional, Lin, Xinqing, additional, Cai, Jing, additional, Liang, Lijun, additional, Feng, Huijing, additional, Wang, Lin, additional, Du, Yingying, additional, Yao, Wang, additional, Shi, Xuefei, additional, Niu, Xiaomin, additional, Yuan, Dongmei, additional, Yao, Yanwen, additional, Huang, Jianhui, additional, Zhang, Yinbin, additional, Sun, Pingli, additional, Wang, Hong, additional, Ye, Mingxiang, additional, Wang, Dong, additional, Wang, Zhaofeng, additional, Hao, Yue, additional, Wang, Zhen, additional, Wan, Bing, additional, Lv, Donglai, additional, Yu, Genhua, additional, Li, Anna, additional, Kang, Jin, additional, Zhang, Jiatao, additional, Zhang, Chao, additional, Chen, Huafei, additional, Shi, Lin, additional, Ye, Leiguang, additional, Wang, Gaoming, additional, Wang, Yina, additional, Gao, Feng, additional, Zhou, Wei, additional, Hu, Chunxiu, additional, Wei, Jianguo, additional, Li, Bihui, additional, Li, Zhongwu, additional, Li, Yuan, additional, Liu, Zhefeng, additional, Yang, Nong, additional, Wu, Lin, additional, Wang, Qiming, additional, Huang, Wenbin, additional, Hong, Zhuan, additional, Wang, Guansong, additional, Fang, Meiyu, additional, Fang, Yong, additional, Zhu, Xixu, additional, Du, Kaiqi, additional, Ji, Jiansong, additional, Shen, Yi, additional, Zhang, Yiping, additional, Ma, Shenglin, additional, Song, Yong, additional, Lu, Yuanzhi, additional, Liu, Anwen, additional, Fang, Wenfeng, additional, and Zhong, Wenzhao, additional

Published
2023
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21. Associative analysis of multi-omics data indicates that acetylation modification is widely involved in cigarette smoke-induced chronic obstructive pulmonary disease

Author

Gao, Junyin, primary, Liu, Hongjun, additional, Wang, Xiaolin, additional, Wang, Liping, additional, Gu, Jianjun, additional, Wang, Yuxiu, additional, Yang, Zhiguang, additional, Liu, Yunpeng, additional, Yang, Jingjing, additional, Cai, Zhibin, additional, Shu, Yusheng, additional, and Min, Lingfeng, additional

Published
2023
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23. Effects of prone position versus usual care on acute hypoxaemic respiratory failure in patients with COVID‑19: a systematic review and meta-analysis of randomized controlled trials

Author

Peng, Qing, primary, Yang, Sheng, additional, Zhang, Yu, additional, Zhao, Wenjie, additional, Hu, Man, additional, Meng, Bo, additional, Ni, Huanhuan, additional, Min, Lingfeng, additional, Yu, Jiangquan, additional, Wang, Yongxiang, additional, and Zhang, Liang, additional

Published
2022
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24. Chinese expert consensus on the diagnosis and treatment of HER2 ‐altered non–small cell lung cancer

Author

Zhang, Shirong, primary, Wang, Wenxian, additional, Xu, Chunwei, additional, Zhang, Yongchang, additional, Cai, Xiuyu, additional, Wang, Qian, additional, Song, Zhengbo, additional, Li, Ziming, additional, Yu, Jinpu, additional, Zhong, Wenzhao, additional, Wang, Zhijie, additional, Liu, Jingjing, additional, Liu, Anwen, additional, Li, Wen, additional, Zhan, Ping, additional, Liu, Hongbing, additional, Lv, Tangfeng, additional, Miao, Liyun, additional, Min, Lingfeng, additional, Lin, Gen, additional, Huang, Long, additional, Yuan, Jingping, additional, Jiang, Zhansheng, additional, Pu, Xingxiang, additional, Rao, Chuangzhou, additional, Lv, Dongqing, additional, Yu, Zongyang, additional, Li, Xiaoyan, additional, Tang, Chuanhao, additional, Zhou, Chengzhi, additional, Zhang, Junping, additional, Guo, Hui, additional, Chu, Qian, additional, Meng, Rui, additional, Liu, Xuewen, additional, Wu, Jingxun, additional, Zhou, Jin, additional, Zhu, Zhengfei, additional, Pan, Weiwei, additional, Dong, Xiaowei, additional, Pang, Fei, additional, Wang, Kai, additional, Yao, Chao, additional, Lin, Guomin, additional, Li, Site, additional, Yang, Zhi, additional, Luo, Jiancheng, additional, Jia, Hongtao, additional, Nie, Xiuqing, additional, Wang, Liping, additional, Zhu, Youcai, additional, Hu, Xiao, additional, Xie, Yanru, additional, Lin, Xinqing, additional, Cai, Jing, additional, Xia, Yang, additional, Feng, Huijing, additional, Wang, Lin, additional, Du, Yingying, additional, Yao, Wang, additional, Shi, Xuefei, additional, Niu, Xiaomin, additional, Yuan, Dongmei, additional, Yao, Yanwen, additional, Kang, Jing, additional, Zhang, Jiatao, additional, Zhang, Chao, additional, Gao, Wenbin, additional, Huang, Jianhui, additional, Zhang, Yinbin, additional, Sun, Pingli, additional, Wang, Hong, additional, Ye, Mingxiang, additional, Wang, Dong, additional, Wang, Zhaofeng, additional, Wan, Bing, additional, Lv, Donglai, additional, Yu, Genhua, additional, Shi, Lin, additional, Xia, Yuanli, additional, Gao, Feng, additional, Zhang, Xiaochen, additional, Xu, Tao, additional, Zhou, Wei, additional, Wang, Haixia, additional, Liu, Zhefeng, additional, Yang, Nong, additional, Wu, Lin, additional, Wang, Qiming, additional, Wang, Guansong, additional, Hong, Zhuan, additional, Wang, Jiandong, additional, Fang, Meiyu, additional, Fang, Yong, additional, Zhang, Yiping, additional, Song, Yong, additional, Ma, Shenglin, additional, Fang, Wenfeng, additional, and Lu, Yuanzhi, additional

Published
2022
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25. Chinese expert consensus on the multidisciplinary management of pneumonitis associated with immune checkpoint inhibitor

Author

Wang, Wenxian, primary, Wang, Qian, additional, Xu, Chunwei, additional, Li, Ziming, additional, Song, Zhengbo, additional, Zhang, Yongchang, additional, Cai, Xiuyu, additional, Zhang, Shirong, additional, Lian, Bin, additional, Li, Wen, additional, Liu, Anwen, additional, Zhan, Ping, additional, Liu, Hongbing, additional, Lv, Tangfeng, additional, Miao, Liyun, additional, Min, Lingfeng, additional, Chen, Yu, additional, Yuan, Jingping, additional, Wang, Feng, additional, Jiang, Zhansheng, additional, Lin, Gen, additional, Pu, Xingxiang, additional, Rao, Chuangzhou, additional, Lv, Dongqing, additional, Yu, Zongyang, additional, Li, Xiaoyan, additional, Tang, Chuanhao, additional, Zhou, Chengzhi, additional, Xie, Congying, additional, Zhang, Junping, additional, Guo, Hui, additional, Chu, Qian, additional, Meng, Rui, additional, Wu, Jingxun, additional, Zhang, Rui, additional, Wang, Liping, additional, Zhu, Youcai, additional, Hu, Xiao, additional, Xie, Yanru, additional, Lin, Xinqing, additional, Cai, Jing, additional, Lan, Fen, additional, Feng, Huijing, additional, Wang, Lin, additional, Yao, Wang, additional, Shi, Xuefei, additional, Huang, Jianhui, additional, Chen, Huafei, additional, Zhang, Yinbin, additional, Sun, Pingli, additional, Wan, Bing, additional, Pang, Fei, additional, Xu, Zanmei, additional, Wang, Kai, additional, Xia, Yuanli, additional, Ye, Mingxiang, additional, Wang, Dong, additional, Wei, Qing, additional, Feng, Shuitu, additional, Zhou, Jianya, additional, Zhang, Jiexia, additional, Lv, Donglai, additional, Gao, Wenbin, additional, Kang, Jing, additional, Yu, Genhua, additional, Liang, Xianbin, additional, Yu, Chengtao, additional, Shi, Lin, additional, Yang, Nong, additional, Wu, Lin, additional, Hong, Zhuan, additional, Hong, Wei, additional, Fang, Meiyu, additional, Zhang, Yiping, additional, Lu, Yuanzhi, additional, Wang, Guansong, additional, Ma, Shenglin, additional, Si, Lu, additional, Fang, Wenfeng, additional, and Song, Yong, additional

Published
2022
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28. Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China

Author

Xu, Chunwei, primary, Si, Lu, additional, Wang, Wenxian, additional, Li, Ziming, additional, Song, Zhengbo, additional, Wang, Qian, additional, Liu, Aijun, additional, Yu, Jinpu, additional, Fang, Wenfeng, additional, Zhong, Wenzhao, additional, Wang, Zhijie, additional, Zhang, Yongchang, additional, Liu, Jingjing, additional, Zhang, Shirong, additional, Cai, Xiuyu, additional, Liu, Anwen, additional, Li, Wen, additional, Zhan, Ping, additional, Liu, Hongbing, additional, Lv, Tangfeng, additional, Miao, Liyun, additional, Min, Lingfeng, additional, Chen, Yu, additional, Yuan, Jingping, additional, Wang, Feng, additional, Jiang, Zhansheng, additional, Lin, Gen, additional, Pu, Xingxiang, additional, Lin, Rongbo, additional, Liu, Weifeng, additional, Rao, Chuangzhou, additional, Lv, Dongqing, additional, Yu, Zongyang, additional, Lei, Lei, additional, Li, Xiaoyan, additional, Tang, Chuanhao, additional, Zhou, Chengzhi, additional, Zhang, Junping, additional, Xue, Junli, additional, Guo, Hui, additional, Chu, Qian, additional, Meng, Rui, additional, Wu, Jingxun, additional, Zhang, Rui, additional, Hu, Xiao, additional, Zhou, Jin, additional, Zhu, Zhengfei, additional, Li, Yongheng, additional, Qiu, Hong, additional, Xia, Fan, additional, Lu, Yuanyuan, additional, Chen, Xiaofeng, additional, Ge, Rui, additional, Dai, Enyong, additional, Han, Yu, additional, Pan, Weiwei, additional, Luo, Jiancheng, additional, Jia, Hongtao, additional, Dong, Xiaowei, additional, Pang, Fei, additional, Wang, Kai, additional, Wang, Liping, additional, Zhu, Youcai, additional, Xie, Yanru, additional, Lin, Xinqin, additional, Cai, Jing, additional, Wei, Jia, additional, Lan, Fen, additional, Feng, Huijing, additional, Wang, Lin, additional, Du, Yingying, additional, Yao, Wang, additional, Shi, Xuefei, additional, Niu, Xiaomin, additional, Yuan, Dongmei, additional, Yao, Yanwen, additional, Huang, Jianhui, additional, Zhang, Yinbin, additional, Sun, Pingli, additional, Wang, Hong, additional, Ye, Mingxiang, additional, Wang, Dong, additional, Wang, Zhaofeng, additional, Wan, Bing, additional, Lv, Donglai, additional, Wei, Qing, additional, Kang, Jin, additional, Zhang, Jiatao, additional, Zhang, Chao, additional, Yu, Genhua, additional, Ou, Juanjuan, additional, Shi, Lin, additional, Li, Zhongwu, additional, Liu, Zhefeng, additional, Liu, Jing, additional, Yang, Nong, additional, Wu, Lin, additional, Wang, Huijuan, additional, Jin, Gu, additional, Yang, Liu, additional, Wang, Guansong, additional, Fang, Meiyu, additional, Fang, Yong, additional, Li, Yuan, additional, Wang, Xiaojia, additional, Zhang, Yiping, additional, Ma, Shenglin, additional, Wang, Biyun, additional, Zhang, Xiaotian, additional, Song, Yong, additional, and Lu, Yuanzhi, additional

Published
2022
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30. Chinese expert consensus on the diagnosis and treatment of HER2‐altered non–small cell lung cancer.

Author

Zhang, Shirong, Wang, Wenxian, Xu, Chunwei, Zhang, Yongchang, Cai, Xiuyu, Wang, Qian, Song, Zhengbo, Li, Ziming, Yu, Jinpu, Zhong, Wenzhao, Wang, Zhijie, Liu, Jingjing, Liu, Anwen, Li, Wen, Zhan, Ping, Liu, Hongbing, Lv, Tangfeng, Miao, Liyun, Min, Lingfeng, and Lin, Gen

Subjects
LUNG cancer treatment, LUNG cancer diagnosis, CONSENSUS (Social sciences), ONCOGENES, ATTITUDES of medical personnel, MEDICAL personnel, EXPERTISE
Abstract

Human epidermal growth factor receptor 2 (HER2) possesses tyrosine kinase activity and participates in cell growth, differentiation and migration, and survival. Its alterations, mainly including mutations, amplifications, and overexpression are associated with poor prognosis and are one of the major drivers in non–small cell lung cancer (NSCLC). Several clinical trials had been investigating on the treatments of HER2‐altered NSCLC, including conventional chemotherapy, programmed death 1 (PD‐1) inhibitors, tyrosine kinase inhibitors (TKIs) and antibody‐drug conjugates (ADCs), however, the results were either disappointing or encouraging, but inconsistent. Trastuzumab deruxtecan (T‐DXd) was recently approved by the Food and Drug Administration as the first targeted agent for treating HER2‐mutant NSCLC. Effective screening of patients is the key to the clinical application of HER2‐targeted agents such as TKIs and ADCs. Various testing methods are nowadays available, including polymerase chain reaction (PCR), next‐generation sequencing (NGS), fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), etc. Each method has its pros and cons and should be reasonably assigned to appropriate patients for diagnosis and guiding treatment decisions. To help standardize the clinical workflow, our expert group reached a consensus on the clinical management of HER2‐altered NSCLC, focusing on the diagnosis and treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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34. AMPK α1 Downregulates ROS Levels Through Regulating Trx Leading to Dysfunction of Apoptosis in Non-Small Cell Lung Cancer

Author

Gong,Daohui, Li,Ying, Wang,Yuxiu, Chi,Beiyuan, Zhang,Jun, Gu,Jianjun, Yang,JunJun, Xu,Xingxiang, Hu,Suwei, and Min,Lingfeng

Subjects
OncoTargets and Therapy
Abstract

Daohui Gong,1,* Ying Li,2,* Yuxiu Wang,1,* Beiyuan Chi,1 Jun Zhang,1 Jianjun Gu,1 JunJun Yang,1 Xingxiang Xu,1 Suwei Hu,3 Lingfeng Min1 1Department of Respiratory Medicine, Northern Jiangsu People’s Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 2Department of Medical Oncology, Northern Jiangsu People’s Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 3Medical Genetic Center, Yangzhou Maternal and Child Health Care Service Centre, The Affiliated Hospital of Yangzhou University Medical College, Yangzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingfeng MinDepartment of Respiratory Medicine, Northern Jiangsu People’s Hospital, Clinical Medical College of Yangzhou University, Nantong West Road 98, Yangzhou, Jiangsu 225001, People’s Republic of ChinaTel +86-18051061783Email minlingfeng@126.comSuwei HuMedical Genetic Center, Yangzhou Maternal and Child Health Care Service Centre, The Affiliated Hospital of Yangzhou University Medical College, Yangzhou, Jiangsu 225002, People’s Republic of ChinaTel +86-18912137872Email husuwei2004@126.comPurpose: AMP-activated protein kinase α 1 (AMPK α 1) associates closely with cancers. However, the relationship between AMPK α 1 and non-small cell lung cancer (NSCLC) is not fully understood. In this study, we aim to explore the role and mechanism of AMPK α 1 in NSCLC initiation and progression.Materials and Methods: A total of 165 clinical NSCLC specimens were included in the formalin-fixed and paraffin-embedded (FFPE) lung cancer tissue arrays. The expression levels of AMPK α 1 and thioredoxin (Trx) in NSCLC cancer tissues and adjacent non-tumor lung tissues were measured through using immunohistochemistry. MTT assay was used to detect cell proliferation. Intracellular ROS levels were measured by using H2DCFDA reagent. Lentiviruses including LV-PRKAA1-RNAi, LV-PRKAA1 and a negative LV-control were used to infect A549 cells to modulate AMPK α 1 expression in vitro. Immunoblotting was used to determine the modulation relationship between AMPK α 1 and Trx. Log rank test and Kaplan–Meier survival analysis were performed to evaluate the significances of AMPK α 1 and Trx expression levels on NSCLC patients’ prognoses.Results: AMPK α 1 was highly expressed in NSCLC cancer tissues and correlated with poor prognosis in patients with NSCLC. In A549 cells, overexpression of AMPK α 1 promoted proliferation, suppressed ROS levels and inhibited apoptosis. Moreover, inhibition of AMPK α 1 expression achieved the opposite effects. Trx was significantly overexpressed in NSCLC cancer tissues; furthermore, Trx expressed much more in cytoplasm when compared with cell nucleus. Trx expression levels were positively correlated with AMPK α 1 expression levels in NSCLC tissues. AMPK α 1 could regulate Trx in A549 cells. No significant correlations were observed between Trx expression variances and prognoses in NSCLC patients. Combination of AMPK α 1 and Trx had no advantage in predicting prognoses of NSCLC patients.Conclusion: These results suggest that AMPK α 1 serves a carcinogenic role at least in part through the regulation of Trx expression, and thus represents a potential treatment target in patients with NSCLC.Keywords: AMPK α 1, ROS, apoptosis, non-small cell lung cancer

Published
2020

41. Clinical efficacy of irinotecan plus raltitrexed chemotherapy in refractory esophageal squamous cell cancer: a retrospective study

Author

Liu, Min, primary, Jia, Qingqing, additional, Wang, Xiaolin, additional, Sun, Changjiang, additional, Yang, Jianqi, additional, Chen, Yanliang, additional, Li, Ying, additional, Min, Lingfeng, additional, Zhang, Xizhi, additional, Zhu, Caiyun, additional, Gubat, Johannes Artiaga, additional, and Chen, Yong, additional

Published
2019
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45. The benefit of taxane-based therapies over fluoropyrimidine plus platinum (FP) in the treatment of esophageal cancer: a meta-analysis of clinical studies

Author

Wang, Tao, primary, Yu, Jie, additional, Liu, Min, additional, Chen, Yanliang, additional, Zhu, Caiyun, additional, Lu, Lin, additional, Wang, Mingzhu, additional, Min, Lingfeng, additional, Liu, Xinxin, additional, Zhang, Xizhi, additional, Gubat, Johannes A, additional, and Chen, Yong, additional

Published
2019
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48. Menopausal status and the risk of lung cancer in women

Author

Min, Lingfeng, Wang, Fang, Liang, Sudong, Yang, Junjun, and Xu, Xingxiang

Subjects
meta-analysis, reproductive, Risk, lung cancer, Lung Neoplasms, menopause, Humans, Female, Systematic Review and Meta-Analysis, Research Article
Abstract

Background: Quantification of the association between menopausal status and risk of lung cancer is inconsistent. We carried out a meta-analysis of available studies to examine this issue. Methods: Relevant articles were identified by searching PudMed and Embase databases. Reference lists from selected papers were also reviewed. A random-effect model was used to calculate summary odds ratios (OR) and relative risk (RR) with 95% confidence interval (CI). Publication bias was estimated using Egger regression asymmetry test. Results: Eight eligible studies, including 5 case–control studies and 3 cohort studies, provided data for meta-analysis. Postmenopausal women had a statistically significant increased risk of lung cancer in all included studies (RR = 1.44, 95% CI: 1.12–1.85) and cohort studies (RR = 1.39, 95% CI: 1.05–1.86), but not in case–control studies (OR = 1.46, 95% CI: 0.95–2.24). Conclusions: Overall, there was evidence that postmenopause is related to increased lung cancer risk. However, studies have produced slightly heterogeneous results (I2 = 38.40%). To obtain a better indication of relationship, well-designed large prospective studies are required.

Published
2017

49. Nanozyme-triggered polymerization amplification strategy for constructing highly sensitive surface plasmon resonance immunosensing

Author

Shi, Feng, Li, Guiling, Zhu, Haibing, Li, Ling, Chen, Ming, Li, Juan, Shen, Huifang, Zeng, Hao, Min, Lingfeng, and Yang, Zhanjun

Abstract

Although diverse signal-amplified methods have been committed to improve the sensitivity of surface plasmon resonance (SPR) biosensing, introducing convenient and robust signal amplification strategy into SPR biosensing remains challenging. Here, a novel nanozyme-triggered polymerization amplification strategy was proposed for constructing highly sensitive surface plasmon resonance (SPR) immunosensor. In detail, Au@Pd core-shell nanooctahedra nanozyme with superior peroxidase (POD)-like activity was synthesized and utilized as a label probe. Simultaneously, Au@Pd core-shell nanooctahedra nanozyme can catalyze the decomposition of H2O2to form hydroxyl radicals (•OH) that triggers the polymerization of aniline to form polyaniline attaching on the surface of sensor chip, significantly amplifying SPR responses. The sensitivity of SPR immunosensor was enhanced by nanozyme-triggered polymerization amplification strategy. Using human immunoglobulin G (HIgG) as a model, the constructed SPR immunosensor obtains a wide linear range of 0.005-1.0 μg/mL with low detection limit of 0.106 ng/mL. This research provides new sights on establishing sensitive SPR immunosensor and may evokes more inspiration for developing signal amplification methods based on nanozyme in biosensing.

Published
2024
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50. A TiO2–SnS2 nanocomposite as a novel matrix for the development of an enzymatic electrochemical glucose biosensor.

Author

Yao, Pei, Yu, Suhua, Shen, Huifang, Yang, Juan, Min, Lingfeng, Yang, Zhanjun, and Zhu, Xiashi

Subjects
GLUCOSE analysis, GLUCOSE oxidase, FOURIER transform infrared spectroscopy, GLUCOSE, X-ray photoelectron spectroscopy, IMMOBILIZED proteins
Abstract

A titanium dioxide functionalized SnS2 nanocomposite was synthesized for the immobilization of glucose oxidase (GOx) to develop an enzymatic electrochemical glucose biosensor. Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy (XPS) and cyclic voltammetry were used to characterize the nanocomposite and the glucose biosensor. The TiO2–SnS2 composite shows a larger surface area and GOx entrapped in this matrix maintains excellent bioactivity and stability. The constructed glucose biosensor responds to glucose linearly over two concentration ranges of 0.008 to 1.13 mM and 1.13 to 5.53 mM at a working potential of −0.45 V. The biosensor exhibits a high sensitivity (18.9 mA M−1 cm−2), low detection limit (1.8 × 10−6 M) and good repeatability. The present biosensor has excellent selectivity and can be successfully applied for the detection of glucose in serum samples. The advantages of the glucose biosensor show that a TiO2–SnS2 nanocomposite provides a new avenue for immobilizing proteins and fabricating excellent biosensors. [ABSTRACT FROM AUTHOR]

Published
2019
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