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302 results on '"Minami, Hitomi"'

1. Remarkable response as a new indicator for endoscopic evaluation of local efficacy of non-surgical treatments for esophageal cancer

Author

Yano, Tomonori, Hayashi, Yoshito, Ishihara, Ryu, Iijima, Katsunori, Iwakiri, Katsuhiko, Uesato, Masaya, Oyama, Tsuneo, Katada, Chikatoshi, Kawada, Kenro, Kushima, Ryoji, Tateishi, Yoko, Fujii, Satoshi, Manabe, Noriaki, Minami, Hitomi, Kawakubo, Hirofumi, Tsubosa, Yasuhiro, Yamamoto, Sachiko, Kadota, Tomohiro, Minashi, Keiko, Takeuchi, Hiroya, Doki, Yuichiro, and Muto, Manabu

Published
2024
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3. Docking Proteins Upregulate IL-1β Expression in Lower Esophageal Sphincter Muscle in Esophageal Achalasia.

Author

Kanda, Tsutomu, Saiki, Karen, Kurumi, Hiroki, Yoshida, Akira, Ikebuchi, Yuichiro, Sakaguchi, Takuki, Urabe, Shigetoshi, Minami, Hitomi, Yamaguchi, Naoyuki, Nakao, Kazuhiko, Inoue, Haruhiro, and Isomoto, Hajime

Subjects
ESOPHAGEAL achalasia, ESOPHAGOGASTRIC junction, GENE expression, SIGNAL recognition particle receptor, SPHINCTERS
Abstract

Background/Objectives: Esophageal achalasia is an archetypal esophageal motility disorder characterized by abnormal peristalsis of the esophageal body and impaired lower esophageal sphincter (LES) relaxation. Methods: In this study, the mRNA expression of docking proteins 1 and 2 (DOK1 and DOK2, respectively) were analyzed and the mechanisms underlying achalasia onset were investigated. Results: DOK1 and DOK2 mRNA levels significantly increased in the LES of patients with achalasia. Moreover, significant correlations were observed between IL-1β and DOK1, IL-1β and DOK2, ATG16L1 and DOK1, and HSV1-miR-H1-3p and DOK2 expression levels. However, a correlation between ATG16L1 and DOK2 or between HSV-miR-H1-3p and DOK1 expression was not observed. In addition, a positive correlation was observed between patient age and DOK1 expression. Microarray analysis revealed a significant decrease in the expression of hsa-miR-377-3p and miR-376a-3p in the LES muscle of patients with achalasia. Conclusions: These miRNAs possessed sequences targeting DOK. The upregulation of DOK1 and DOK2 expression induces IL-1β expression in the LES of achalasia patients, which may contribute to the development of esophageal motility disorder. [ABSTRACT FROM AUTHOR]

Published
2024
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13. In vivo fluorescence navigation of gastric and upper gastrointestinal tumors by 5-aminolevulinic acid mediated photodynamic diagnosis with a laser-equipped video image endoscope

Author

Isomoto, Hajime, Nanashima, Atsushi, Senoo, Takemasa, Ogiwara, Kumi, Hashisako, Mikiko, Ohnita, Ken, Yamaguchi, Naoyuki, Kunizaki, Masaki, Hidaka, Shigekazu, Fukuda, Hiroko, Ishii, Hiroyuki, Matsushima, Kayoko, Minami, Hitomi, Akazawa, Yuko, Takeshima, Fuminao, Fukuoka, Junya, Nagayasu, Takeshi, and Nakao, Kazuhiko

Published
2015
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15. Peroral endoscopic myotomy as salvation technique post‐Heller: International experience

Author

Tyberg, Amy, Sharaiha, Reem Z., Familiari, Pietro, Costamagna, Guido, Casas, Fernando, Kumta, Nikhil A., Barret, Maximilien, Desai, Amit P., Schnoll‐Sussman, Felice, Saxena, Payal, Martínez, Guadalupe, Zamarripa, Felipe, Gaidhane, Monica, Bertani, Helga, Draganov, Peter V., Balassone, Valerio, Sharata, Ahmed, Reavis, Kevin, Swanstrom, Lee, Invernizzi, Martina, Seewald, Stefan, Minami, Hitomi, Inoue, Haruhiro, and Kahaleh, Michel

Published
2018
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17. Durability of per-oral endoscopic myotomy beyond 6 years

Author

AbiMansour, Jad P., additional, Ichkhanian, Yervant, additional, Minami, Hitomi, additional, Familiari, Pietro, additional, Landi, Rosario, additional, Costamagna, Guido, additional, Seewald, Stefan, additional, Callahan, Zachary M., additional, Ujiki, Michael B., additional, Pioche, Mathieu, additional, Ponchon, Thierry, additional, Roman, Sabine, additional, Cho, Joo Young, additional, Yoo, In Kyung, additional, Sippey, Megan, additional, Marks, Jeffrey M., additional, Eleftheriadis, Nikolas, additional, Khumbari, Vivek, additional, Gutierrez, Olaya I. Brewer, additional, and Khashab, Mouen A., additional

Published
2021
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19. Anesthetic management of peroral endoscopic myotomy for esophageal achalasia: a retrospective case series

Author

Tanaka, Eriko, Murata, Hiroaki, Minami, Hitomi, and Sumikawa, Koji

Subjects
Laser endoscopy -- Research -- Health aspects, Anesthesia -- Research -- Health aspects, Achalasia -- Care and treatment -- Research -- Risk factors -- Patient outcomes -- Complications and side effects, Health
Abstract

Peroral endoscopic myotomy (POEM) is a newly developed, less invasive treatment for esophageal achalasia that requires general anesthesia under positive pressure ventilation. In this retrospective case series, we describe the anesthetic management of 28 consecutive patients who underwent POEM for esophageal achalasia. Anesthesia was maintained with sevoflurane and remifentanil under positive pressure ventilation through a tracheal tube. Retained contents in the esophagus were evacuated just before anesthesia induction to prevent regurgitation into the trachea. The POEM procedure was performed using an orally inserted flexible fiberscope. Elevation of end-tidal carbon dioxide after initiating esophageal carbon dioxide insufflation was observed in all patients and was treated by minute adjustments to the ventilation volume. Scopolamine butylbromide-induced tachycardia in one patient was treated with landiolol hydrochloride, which is a short-acting beta 1-selective blocker. Minor subcutaneous emphysema around the neck was observed in one patient. POEM was successfully completed, and tracheas were extubated immediately after the procedure in all patients. Our findings suggest that prevention of aspiration pneumonia during anesthesia induction, preparation for carbon dioxide insufflation-related complications, and treatment of scopolamine butylbromide-induced tachycardia play important roles in safe anesthesia management of POEM for esophageal achalasia. Keywords Peroral endoscopic myotomy * Esophageal achalasia * Anesthetic management * Retrospective case series, Introduction Esophageal achalasia is a disorder characterized by a lack of peristalsis of the esophagus, incomplete lower esophageal sphincter relaxation, and increased tone [1]. Main clinical symptoms include dysphagia, regurgitation, [...]

Published
2014
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28. Use of vonoprazan for management of systemic sclerosis‑related gastroesophageal reflux disease

Author

Tabuchi, Maiko, primary, Minami, Hitomi, additional, Akazawa, Yuko, additional, Ashida, Miwa, additional, Hara, Toshihide, additional, Ichinose, Kunihiro, additional, Kitayama, Moto, additional, Hashiguchi, Keiichi, additional, Matsushima, Kayoko, additional, Yamaguchi, Naoyuki, additional, Takeshima, Fuminao, additional, Kondo, Hisayoshi, additional, Kawakami, Atsushi, additional, and Nakao, Kazuhiko, additional

Published
2020
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29. Autophagy‑related 16‑like 1 is influenced by human herpes virus 1‑encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per‑oral endoscopic myotomy for esophageal achalasia

Author

Kanda, Tsutomu, primary, Yoshida, Akira, additional, Ikebuchi, Yuichiro, additional, Ikeda, Haruo, additional, Sakaguchi, Takuki, additional, Urabe, Shigetoshi, additional, Minami, Hitomi, additional, Nakao, Kazuhiko, additional, Inoue, Haruhiro, additional, and Isomoto, Hajime, additional

Published
2020
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32. Outcomes of anterior versus posterior peroral endoscopic myotomy 2 years post-procedure: prospective follow-up results from a randomized clinical trial

Author

Ichkhanian, Yervant, additional, Abimansour, Jad P., additional, Pioche, Mathieu, additional, Vosoughi, Kia, additional, Eleftheriadis, Nicholas, additional, Chiu, Philip Wai Yan, additional, Minami, Hitomi, additional, Ogihara, Kumi, additional, Sanaei, Omid, additional, Jovani, Manol, additional, and Khashab, Mouen A., additional

Published
2020
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33. Identification of human herpes virus 1 encoded microRNAs in biopsy samples of lower esophageal sphincter muscle during peroral endoscopic myotomy for esophageal achalasia

Author

Ikebuchi, Yuichiro, primary, Kanda, Tsutomu, additional, Ikeda, Haruo, additional, Yoshida, Akira, additional, Sakaguchi, Takuki, additional, Urabe, Shigetoshi, additional, Minami, Hitomi, additional, Nakao, Kazuhiko, additional, Kuwamoto, Satoshi, additional, Inoue, Haruhiro, additional, and Isomoto, Hajime, additional

Published
2019
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34. Statement for gastroesophageal reflux disease after peroral endoscopic myotomy from an international multicenter experience

Author

Inoue, Haruhiro, primary, Shiwaku, Hironari, additional, Kobayashi, Yasutoshi, additional, Chiu, Philip W. Y., additional, Hawes, Robert H., additional, Neuhaus, Horst, additional, Costamagna, Guido, additional, Stavropoulos, Stavros N., additional, Fukami, Norio, additional, Seewald, Stefan, additional, Onimaru, Manabu, additional, Minami, Hitomi, additional, Tanaka, Shinwa, additional, Shimamura, Yuto, additional, Santi, Esperanza Grace, additional, Grimes, Kevin, additional, and Tajiri, Hisao, additional

Published
2019
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35. Outcomes of anterior versus posterior peroral endoscopic myotomy 2 years post-procedure: prospective follow-up results from a randomized clinical trial.

Author

Ichkhanian, Yervant, Abimansour, Jad P., Pioche, Mathieu, Vosoughi, Kia, Eleftheriadis, Nicholas, Chiu, Philip Wai Yan, Minami, Hitomi, Ogihara, Kumi, Sanaei, Omid, Jovani, Manol, and Khashab, Mouen A.

Subjects
CLINICAL trials, PROTON pump inhibitors, SPINAL tuberculosis, GASTROESOPHAGEAL reflux, MYOTOMY, RESEARCH, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, TREATMENT effectiveness, COMPARATIVE studies, RANDOMIZED controlled trials, QUESTIONNAIRES, ENDOSCOPY, ESOPHAGEAL achalasia, LONGITUDINAL method
Abstract

Background: Peroral endoscopic myotomy (POEM) is considered a primary treatment modality for achalasia. It can be performed using either the anterior or posterior approach. A previous randomized clinical trial (RCT) showed that the posterior approach was noninferior to the anterior approach at 1 year post-POEM in terms of clinical success, rate of adverse event, and risk of gastroesophageal reflux disease (GERD). The aim of this post-RCT study was to compare outcomes at ≥ 2 years post-POEM.Methods: Patients who previously completed the 1-year follow-up were contacted and their Eckardt, dysphagia, and GERD questionnaire (GERDQ) scores and frequency of proton pump inhibitor use were recorded. Clinical success was defined as an Eckardt score < 3.Results: 150 patients were initially randomized and 138 completed the 1-year follow-up. Of the 138, 111 (anterior group 54, posterior group 57) also completed ≥ 2 years of follow-up, with an overall clinical success decrease from 89 % to 82 %. At ≥ 2 years post-POEM, clinical success was achieved in 46/54 (85 %) and 45/57 (79 %) in the anterior and posterior groups, respectively (P = 0.43). A similar decrease in clinical success was noted in both groups at ≥ 2 years (anterior: 90 % to 85 %; posterior 89 % to 79 %; P = 0.47). GERDQ score was 6 (interquartile range 6 - 8; P = 0.08) in both treatment groups.Conclusions: The anterior and posterior POEM techniques remained equally effective at 2 years and decreases in efficacy were similar between the two approaches over time. GERD outcomes were also similar in both groups during medium-term follow-up. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Improvement of endocytoscopic findings after per oral endoscopic myotomy (POEM) in esophageal achalasia; does POEM reduce the risk of developing esophageal carcinoma? Per oral endoscopic myotomy, endocytoscopy and carcinogenesis

Author

Minami Hitomi, Yamaguchi Naoyuki, Matsushima Kayoko, Akazawa Yuko, Ohnita Ken, Takeshima Fuminao, Nakayama Toshiyuki, Hayashi Tomayoshi, Inoue Haruhiro, Nakao Kazuhiko, and Isomoto Hajime

Subjects
Esophageal achalasia, POEM, Per-oral endoscopic myotomy, Esophageal cancer, Squamous cell carcinoma, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Per oral endoscopic myotomy (POEM) has been reported to be a new therapeutic option for esophageal achalasia. The possibility that POEM could reduce the risk of developing esophageal squamous cell carcinoma was evaluated. Methods This was a single-centre, retrospective study. Fifteen consecutive patients with esophageal achalasia who underwent POEM in our institution between August 2010 and January 2012 were enrolled. Ultra-high magnification with endocytoscopy was performed, and both histopathological and immunohistochemical evaluations for Ki-67 and p53 were assessed before and 3 months after POEM. Results POEM was successfully performed and effectively released the dysphagia symptom in all patients without severe complications. Subjective symptoms (mean Ekcardt score, before 7.4 vs. after 0.5, p Conclusions POEM appears to be an effective and less invasive treatment of choice against achalasia and may reduce the risk of esophageal carcinogenesis. Endocytoscopy can be useful for the assessment of esophageal cellular proliferation.

Published
2013
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40. 470 LONG TERM OUTCOMES OF PER-ORAL ENDOSCOPIC MYOTOMY IN ACHALASIA PATIENTS WITH A MINIMUM FOLLOW-UP OF 6 YEARS: A MULTICENTER STUDY

Author

AbiMansour, Jad P., primary, Minami, Hitomi, additional, Familiari, Pietro, additional, Landi, Rosario, additional, Costamagna, Guido, additional, Seewald, Stefan, additional, Callahan, Zachary M., additional, Ujiki, Michael, additional, Pioche, Mathieu, additional, Ponchon, Thierry, additional, CHO, JOO YOUNG, additional, Yoo, In Kyung, additional, Sippey, Megan, additional, Marks, Jeffrey M., additional, Eleftheriadis, Nikolas P., additional, Ichkhanian, Yervant, additional, Vosoughi, Kia, additional, Brewer Gutierrez, Olaya I., additional, and Khashab, Mouen A., additional

Published
2019
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41. Sa1280 CLINICAL EFFICACY OF ANTERIOR VS POSTERIOR PER ORAL ENDOSCOPIC MYOTOMY TWO YEARS POST-PROCEDURE: PROSPECTIVE RESULTS FROM A RANDOMIZED CLINICAL TRIAL

Author

Ichkhanian, Yervant, primary, Vosoughi, Kia, additional, Pioche, Mathieu, additional, Eleftheriadis, Nikolas P., additional, Chiu, Philip Wai Yan W., additional, Minami, Hitomi, additional, Ogihara, Kumi, additional, Sanaei, Omid, additional, Kumbhari, Vivek, additional, Kalloo, Anthony N., additional, Brewer Gutierrez, Olaya I., additional, and Khashab, Mouen A., additional

Published
2019
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42. Persistent chest pain in young male patient: Jackhammer esophagus treated with peroral endoscopic myotomy

Author

Tabuchi, Maiko, primary, Minami, Hitomi, additional, Akazawa, Yuko, additional, Ogihara, Kumi, additional, Kitayama, Moto, additional, Hashiguchi, Keiichi, additional, Matsushima, Kayoko, additional, Yamaguchi, Naoyuki, additional, Ohnita, Ken, additional, Takeshima, Fuminao, additional, Inoue, Haruhiro, additional, and Nakao, Kazuhiko, additional

Published
2019
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44. Clinical practice guidelines for peroral endoscopic myotomy

Author

Inoue, Haruhiro, primary, Shiwaku, Hironari, additional, Iwakiri, Katsuhiko, additional, Onimaru, Manabu, additional, Kobayashi, Yasutoshi, additional, Minami, Hitomi, additional, Sato, Hiroki, additional, Kitano, Seigo, additional, Iwakiri, Ryuichi, additional, Omura, Nobuo, additional, Murakami, Kazunari, additional, Fukami, Norio, additional, Fujimoto, Kazuma, additional, and Tajiri, Hisao, additional

Published
2018
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45. Identification of human herpes virus 1 encoded microRNAs in biopsy samples of lower esophageal sphincter muscle during peroral endoscopic myotomy for esophageal achalasia.

Author

Ikebuchi, Yuichiro, Kanda, Tsutomu, Ikeda, Haruo, Yoshida, Akira, Sakaguchi, Takuki, Urabe, Shigetoshi, Minami, Hitomi, Nakao, Kazuhiko, Kuwamoto, Satoshi, Inoue, Haruhiro, and Isomoto, Hajime

Subjects
HUMAN herpesvirus 1, ESOPHAGEAL achalasia, SPHINCTERS, REVERSE transcriptase polymerase chain reaction, HIV, ESOPHAGOGASTRIC junction, HERPES simplex virus, GENETIC regulation
Abstract

Esophageal achalasia is a rare chronic debilitating disorder characterized by incomplete lower esophageal sphincter (LES) relaxation and abnormal peristalsis as a result of myenteric plexus degeneration. Although complex interactions among immunity, viruses and inheritance have been proposed, its causes remain unknown. MicroRNAs (miRs) play crucial roles in the regulation of gene expression during pathophysiological processes. Certain viruses such as herpes simplex virus (HSV) encode miRs derived from their own genomes. To determine the underlying relationship of miRNAs to achalasia, we analyzed the expression profile of miRNAs using biopsy samples obtained from LES muscle during peroral endoscopic myotomy. Peroral LES muscle biopsy sampling was uneventfully carried out in our case series of achalasia. Control biopsy tissues were also obtained from LES muscle of patients without symptoms relating to abnormal esophageal motility whose esophagogastric junction was surgically excised. RNA was extracted from biopsy specimens and analyzed using a microarray. Differentially expressed miRNAs in achalasia patients compared to controls were identified and analyzed using reverse transcription quantitative polymerase chain reaction. HSV‐1‐derived hsv1‐miR‐H1 and ‐H18 was significantly overexpressed in achalasia cohorts compared to controls. Correlations between the expression levels of viral miR and the patients' clinical characteristics including achalasia morphological type, dilatation grading, and disease duration were not identified. Further studies with a larger sample size are needed to replicate the current heuristic identification of neurotropic viral miRs and unravel their functional significance in order to provide new insight linking neurodegenerative etiology in achalasia. [ABSTRACT FROM AUTHOR]

Published
2020
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46. Anti-ganglionic AChR antibodies in Japanese patients with motility disorders

Author

Mukaino, Akihiro, primary, Minami, Hitomi, additional, Isomoto, Hajime, additional, Hamamoto, Hitomi, additional, Ihara, Eikichi, additional, Maeda, Yasuhiro, additional, Higuchi, Osamu, additional, Okanishi, Tohru, additional, Kokudo, Yohei, additional, Deguchi, Kazushi, additional, Sasaki, Fumisato, additional, Ueki, Toshihito, additional, Murata, Ken-ya, additional, Yoshida, Takeshi, additional, Kinjo, Mistuyo, additional, Ogawa, Yoshihiro, additional, Ido, Akio, additional, Matsuo, Hidenori, additional, Nakao, Kazuhiko, additional, and Nakane, Shunya, additional

Published
2018
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48. Peroral endoscopic myotomy as salvation technique post‐Heller: International experience

Author

Tyberg, Amy, primary, Sharaiha, Reem Z., additional, Familiari, Pietro, additional, Costamagna, Guido, additional, Casas, Fernando, additional, Kumta, Nikhil A., additional, Barret, Maximilien, additional, Desai, Amit P., additional, Schnoll‐Sussman, Felice, additional, Saxena, Payal, additional, Martínez, Guadalupe, additional, Zamarripa, Felipe, additional, Gaidhane, Monica, additional, Bertani, Helga, additional, Draganov, Peter V., additional, Balassone, Valerio, additional, Sharata, Ahmed, additional, Reavis, Kevin, additional, Swanstrom, Lee, additional, Invernizzi, Martina, additional, Seewald, Stefan, additional, Minami, Hitomi, additional, Inoue, Haruhiro, additional, and Kahaleh, Michel, additional

Published
2017
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50. Mo1191 Endoscopic Features of Early Duodenal Adenocarcinoma/Adenoma: Tumor Size, Microvascular/Microsurface Pattern, and Distribution of White Opaque Substance

Author

Hashiguchi, Keiichi, primary, Ohnita, Ken, additional, Kitayama, Moto, additional, Matsushima, Kayoko, additional, Minami, Hitomi, additional, Akazawa, Yuko, additional, Yamaguchi, Naoyuki, additional, Takeshima, Fuminao, additional, Nakashima, Masahiro, additional, and Nakao, Kazuhiko, additional

Published
2017
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