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198 results on '"Minerva M Carrasquillo"'

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1. 334 Identification of novel plasma protein biomarkers for diagnosis and prediction of Alzheimer’s disease in African Americans

2. Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies.

3. Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome.

4. ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

5. Exonic Re-Sequencing of the Chromosome 2q24.3 Parkinson's Disease Locus.

6. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

7. Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology.

8. Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.

9. Evaluation of the role of SNCA variants in survival without neurological disease.

10. Multiple insulin degrading enzyme variants alter in vitro reporter gene expression.

11. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

12. Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease.

14. New insights into the genetic etiology of Alzheimer's disease and related dementias

15. APOE ε4 influences within and between network functional connectivity in posterior cortical atrophy and logopenic progressive aphasia

16. Single Cell Approaches Reveal Perturbed Brain Vascular Molecules in Alzheimer’s Disease

17. Integrative single‐nucleus RNAseq analysis identifies cell‐type‐specific expression perturbations in progressive supranuclear palsy

18. Association of DNA methylation from the temporal cortex and cerebellum with AD‐related neuropathology and biochemistry

19. Gene‐based polygenic score analysis identifies novel immune genes with deleterious variants that associate with Alzheimer’s disease

20. Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genes ATP8B4, FCGR1A, and LILRB1 that associate with Alzheimer’s disease

21. Latent trait modeling of tau neuropathology in progressive supranuclear palsy

22. Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins

23. Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genesATP8B4, FCGR1A, andLILRB1that associate with Alzheimer’s disease

24. Investigating Heterogeneity and Neuroanatomic Correlates of Longitudinal Clinical Decline in Atypical Alzheimer Disease

25. Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s Disease related proteins

26. APOE ε4 influences medial temporal atrophy and tau deposition in atypical Alzheimer's disease

27. Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease

28. Comparative evaluation for the globin gene depletion methods for mRNA sequencing using the whole blood-derived total RNAs

29. Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy

30. Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer’s disease

31. Deciphering cellular transcriptional alterations in Alzheimer’s disease brains

32. Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions

33. Single Nuclei Transcriptome Reveals Perturbed Brain Vascular Molecules in Alzheimer’s Disease

34. Plasma transcript profiling identifies significant differentially expressed genes and expression of quantitative trait loci in African Americans

36. Transcript levels in plasma contribute substantial predictive value as potential Alzheimer's disease biomarkers in African Americans

37. Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi‐Ethnic (FLAME) cohort

38. Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer's disease

39. Conserved Architecture of Brain Transcriptome Changes between Alzheimer’s Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions

40. Leveraging selective hippocampal vulnerability among Alzheimer’s disease subtypes reveals a novel tau binding partner SERPINA5

41. Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy

42. Investigating gene expression changes underlying selective hippocampal vulnerability in Alzheimer’s disease using a translational neuropathology approach

43. Identification of novel Alzheimer’s disease genes co-expressed with TREM2

44. Correction to: Deciphering cellular transcriptional alterations in Alzheimer’s disease brains

45. Single Cell-type Integrative Network Modeling Identified Novel Microglial-specific Targets for the Phagosome in Alzheimer’s disease

46. Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy

47. TMEM106B haplotypes have distinct gene expression patterns in aged brain

48. Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer’s Disease Genes in African Americans Identifies Novel PSEN Variants

49. MAPT haplotype-stratified GWAS reveals differential association for AD risk variants

50. Evaluation of Associations of Alzheimer's Disease Risk Variants that Are Highly Expressed in Microglia with Neuropathological Outcome Measures

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