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Two new species belonging to the corticalis group of the sac spider genus Clubiona Latreille, 1804 are described from both males and females: Clubiona longyangensis sp. nov. and Clubiona multiprocessa sp. nov. The two species are currently known to occur in Baoshan City and Dali Bai Autonomous Prefecture, Yunnan, China, respectively. Detailed descriptions, diagnoses, and photographs of the two species are provided.

Phrurolithidae is a family of spiders with 405 species belonging to 25 genera distributed worldwide. Notably, 213 species belonging to 17 genera have been recorded in China.A new species of the genus Otacilia Thorell, 1897 is described from Duheyuan Nature Reserve, Hubei Province, China. Diagnosis, morphological description, living photos and photos of the habitus and genitalia of the new species are provided.

Abstract Carbon has been widely utilized as electrode in electrochemical energy storage, relying on the interaction between ions and electrode. The performance of a carbon electrode is determined by a variety of factors including the structural features of carbon material and the behavior of ions adsorbed on the carbon surface in the specific environment. As the fundamental unit of graphitic carbons, graphene has been employed as a model to understand the energy storage mechanism of carbon materials through various experimental and computational methods, ex‐situ or in‐situ. In this article, we provide a succinct overview of the state‐of‐the‐art proceedings on the ion storage mechanism on graphene. Topics include the structure engineering of carbons, electric gating effect of ions, ion dynamics on the interface or in the confined space, and specifically lithium‐ion storage/reaction on graphene. Our aim is to facilitate the understanding of electrochemistry on carbon electrodes.

BackgroundDiabetic kidney disease (DKD) is a severe microvascular complication of diabetes mellitus that can lead to end-stage renal disease. Colquhounia root tablet (CRT) has shown therapeutic potential in treating DKD, but its efficacy and underlying mechanisms remain to be elucidated.MethodsA randomized controlled clinical trial was conducted on 61 DKD patients. The treatment group received CRT in addition to standard therapy, while the control group received standard therapy alone. Treatment efficacy and adverse events were evaluated after 3 months. Additionally, in vitro experiments using human renal tubular epithelial cells (HK-2) were performed to investigate the effect of CRT on high glucose (HG)-induced epithelial-mesenchymal transition (EMT) and the involvement of the PTEN/PI3K/AKT signaling pathway.ResultsCRT treatment significantly improved proteinuria and increased the effective treatment rate in DKD patients compared to the control group, with no significant difference in adverse events. Moreover, CRT reversed HG-induced EMT in HK-2 cells, as evidenced by the downregulation of α-SMA and upregulation of E-cadherin at both mRNA and protein levels. Mechanistically, CRT increased PTEN expression and inhibited the PI3K/AKT pathway, similar to the effects of the PI3K inhibitor LY29400. The combination of CRT and LY29400 further enhanced PTEN mRNA expression under HG conditions.ConclusionCRT effectively improves proteinuria in DKD patients and ameliorates HG-induced EMT in HK-2 cells. The underlying mechanism may involve the upregulation of PTEN and subsequent inhibition of the PI3K/AKT signaling pathway. These findings provide new insights into the therapeutic potential of CRT for DKD treatment.

The Editorial Office retracts and removes the article, “Weld Defect Segmentation in X-ray Image with Boundary Label Smoothing” [...]

In this work, we demonstrate a Watt-level, high-quality Laguerre–Gaussian (LG) LG0±1 vortex mode directly output from an end-pumped Nd:YVO4 laser by using an axicon-based annular pump beam. A theoretical model for the annular beam end-pumped solid-state laser with an LG vortex mode output was established. Chirality control of the vortex laser was achieved by carefully tilting the output coupler. Watt-level 1064 nm lasers with pure LG0,1/LG0,−1 vortex mode, and the incoherent superposition mode of LG0,1 odd and even petal modes, were achieved successively in our experiments. The intensity profile of the generated pure LG0,1 vortex laser was measured, and it can be well fitted by using the standard expression of the LG0,1 vortex mode. The beam quality of the pure LG0,1 mode is Mx2 = 2.01 and My2 = 2.00 along the x-axis and y-axis, respectively. Our study demonstrates that that axicon-based annular pumping has great potential in developing high-power vortex solid-state lasers with simple and compact structures.

Abstract Transitions in the heterogamety of sex chromosomes (e.g., XY to ZW or vice versa) fundamentally alter the genetic basis of sex determination, however the details of these changes have been studied in only a few cases. In an XY to ZW transition, the X is likely to give rise to the W because they both carry feminizing genes and the X is expected to harbour less genetic load than the Y. Here, using a new reference genome for Salix exigua, we trace the X, Y, Z, and W sex determination regions during the homologous transition from an XY system to a ZW system in willow (Salix). We show that both the W and the Z arose from the Y chromosome. We find that the new Z chromosome shares multiple homologous putative masculinizing factors with the ancestral Y, whereas the new W lost these masculinizing factors and gained feminizing factors. The origination of both the W and Z from the Y was permitted by an unexpectedly low genetic load on the Y and this indicates that the origins of sex chromosomes during homologous transitions may be more flexible than previously considered.

Background: The Ze-Qi decoction (ZQD) is a traditional Chinese herbal formula commonly applied to treat lung cancer in China. This study aimed to assess the effective ingredients and molecular mechanisms of ZQD in treating non-small cell lung cancer (NSCLC) based on network pharmacology combined with experimental validation. Methods: Network pharmacology, bioinformatics, and molecular docking analyses were conducted to explore the mechanism of ZQD for treating NSCLC, which was further confirmed by animal experiments. Results: In total, 117 bioactive ingredients and 499 target proteins of ZQD were identified. Network pharmacology revealed 7 core active ingredients and 74 core target proteins. Kyoto Encyclopedia of Genes and Genomes enrichment analyses indicated that the PI3K/Akt and p53 signaling pathways may be crucial in NSCLC treatment. Molecular docking analysis revealed that the seven crucial bioactive ingredients complexed with PI3K, Akt, and p53. The animal experiment results validated that ZQD treatment promoted cell apoptosis and cell cycle arrest, thereby inhibiting NSCLC growth and metastasis. Furthermore, ZQD treatment caused a significant increase in p53 and Bax, while leading to a distinct reduction in p-PI3K (Tyr317), p-Akt (Ser473), VEGFA, CD31, MMP2, MMP9, Bcl2, and CDK2. Conclusions: ZQD inhibited the growth and metastasis of NSCLC subcutaneous tumors in C57BL/6J mice via the PI3K/Akt/p53 signaling pathway.

Vascular dementia (VD), a chronic syndrome of acquired intellectual impairment resulting from cerebrovascular diseases, is closely linked to neuronal autophagy and apoptosis. As a standardized extract from Ginkgo biloba L. leaves, EGb761 is widely applied for treating cerebrovascular diseases owing to its neuroprotective effects, with on-going research exploring its therapeutic mechanisms. Rat model of VD and SH-SY5Y cell model with OGD/R injury was applied for this study. Results showed that EGb761 reduces OGD/R-elicited apoptosis and autophagosome production, whereas improving the viability of hippocampal neurons. EGb761 treatment led to a decrease in the ratios of p-AMPK/AMPK, Bax/Bcl-2, cleaved caspase-3/caspase-3, cleaved caspase-9/caspase-9, LC3-II/LC3-I, and level of Beciln-1, as well as enhancing the proportion of p-mTOR/mTOR. Additionally, EGb761 indicated a protective effect on rats' cognitive function. These results demonstrated EGb761′s specific therapeutic mechanism in preventing apoptosis and autophagy in VD models and improving cognitive functioning in VD rats through AMPK-mTOR signalling.

Summary: Background: Pegmolesatide, a synthetic peptide-based erythropoietin (EPO) receptor agonist, is being evaluated as an alternative to epoetin alfa for treating anemia of chronic kidney disease (CKD) in Chinese dialysis patients. There is a critical need for a long-acting, cost-effective erythropoiesis-stimulating agent that does not produce EPO antibodies. Methods: A randomized, open-label, active-comparator, non-inferiority phase three trial was conducted at 43 dialysis centers in China between May 17th, 2019, and March 28th, 2022. Eligible patients aged 18–70 years were randomly assigned (2:1) to receive pegmolesatide once every four weeks or epoetin alfa one to three times per week, with doses adjusted to maintain a hemoglobin level between 10.0 and 12.0 g/dL. The primary efficacy endpoint was the mean change in hemoglobin level from baseline to the efficacy evaluation period in the per-protocol set (PPS) population. Non-inferiority of pegmolesatide to epoetin alfa was established if the lower limit of the two-sided 95% confidence interval for the between-group difference was ≥ −1.0 g/dL. Safety assessment included adverse events and potential anaphylaxis reactions. This trial is registered at ClinicalTrials.gov, NCT03902691. Findings: Three hundreds and seventy-two patients were randomly assigned to the pegmolesatide group (248 patients) or the epoetin alfa group (124 patients). A total of 347 patients (233 in the pegmolesatide group and 114 in the epoetin alfa group) were included in the PPS population. In the PPS, the mean change (standard deviation, SD) in hemoglobin level from baseline to the efficacy evaluation period was 0.07 (0.92) g/dL in the pegmolesatide group and −0.22 (0.97) g/dL in the epoetin alfa group. The between-group difference was 0.29 g/dL (95% confidence interval: 0.11–0.47), verifying non-inferiority of pegmolesatide to epoetin alfa. Adverse events occurred in 231 (94%) participants in the pegmolesatide group and in 110 (89%) in the epoetin alfa group. Hypertension was the most common treatment-related adverse event. No fatal cases of anaphylaxis or hypotension were reported. Interpretation: Monthly subcutaneously injection of pegmolesatide was as effective and safe as conventional epoetin alfa administrated one to three times a week in treating anemia in Chinese dialysis patients. Funding: The study was supported by Hansoh Medical Development Group.

Abstract Aconitum carmichaelii (Fuzi) is a traditional Chinese medicine that has been widely used in the clinic to save the dying life for over several thousand years. However, the medicinal components of Fuzi in treating vascular senescence (VS) and its potential mechanism remain unclear. In this study, a network pharmacology method was used to explore the possible components and further validated by experiments to get a candidate compound, deoxyandrographolide (DA). DA restrains aging biomarkers, such as p16, p21, γH2A.X, and p53 in vitro and in vivo blood co‐culture studies. Histone deacetylase 1 (HDAC1), mouse double minute2 (MDM2), cyclin‐dependent kinase 4, and mechanistic target of rapamycin kinase (mTOR) are predicted to be the possible targets of DA based on virtual screening. Subsequent bio‐layer interferometry results indicated that DA showed good affinity capability with HDAC1. DA enhances the protein expression of HDAC1 in the angiotensin II‐induced senescence process by inhibiting its ubiquitination degradation. Loss of HDAC1 by CRISPR/Cas9 leads to the disappearance of DA's anti‐aging property. The enhancement of HDAC1 represses H3K4me3 (a biomarker of chromosomal activity) and improves chromosome stability. RNA sequencing results also confirmed our hypothesis. Our evidence illuminated that DA may achieve as a novel compound in the treatment of VS by improving chromosome stability.

This study investigates the relationship between Chinese farmers' propensity to adopt environment-friendly practices and their membership in cooperatives. Based on data collected in 2021 from the Fujian China Household Survey, the Endogenous Switching Probit model (ESP) is applied to account for unobserved factors that could simultaneously affect farmers' cooperative membership and their willingness to adopt environment-friendly practices. First, the results indicate that a cooperative membership has a positive impact on the level of farmers' interest in green production practices. Second, there is evidence of some heterogeneity (based on both observable and unobservable characteristics) in the impact of cooperative membership; the higher the farmers' capital returns, the more prominent the role of cooperatives in guiding these farmers. Third, participation in cooperatives is conducive to raising farmers' interest in green production. The overall conclusion is that a cooperative membership raises the Chinese farmers’ willingness to adopt environment-friendly practices.

Abstract The gene encoding beta2-adrenergic receptor (β2-AR), adrenoceptor beta 2 (ADRB2), has been reported to closely associated with various cancers. However, its role in lung adenocarcinoma (LUAD) remains controversial. This research shed light on the prognostic value of ADRB2 in LUAD and further explored its association with immune cell infiltration. ADRB2 was significantly decreased in LUAD. ADRB2 expression in LUAD was significantly correlated with gender, smoking status, T classification, and pathologic stage. Patients in the low ADRB2 expression group presented with significantly poorer overall survival (OS) and disease-specific survival (DSS). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) results showed that ADRB2 participates in immune response. The expression of ADRB2 was positively correlated with the infiltration level of most immune cells. Notably, ADRB2 is involved in LUAD progression partly by regulating the immune microenvironment, which may potentially serve as a significant prognostic biomarker as well as a potential drug target.

We present 3D magnetohydrodynamic simulations of the fueling of supermassive black holes in elliptical galaxies from a turbulent cooling medium on galactic scales, taking M87* as a typical case. We find that the mass accretion rate is increased by a factor of ∼10 compared with analogous hydrodynamic simulations. The scaling of $\dot{M}\sim {r}^{1/2}$ roughly holds from ∼10 pc to ∼10 ^−3 pc (∼10 r _g ) with the accretion rate through the event horizon being ∼10 ^−2 M _⊙ yr ^−1 . The accretion flow on scales ∼0.03–3 kpc takes the form of magnetized filaments. Within ∼30 pc, the cold gas circularizes, forming a highly magnetized ( β ∼ 10 ^−3 ) thick disk supported by a primarily toroidal magnetic field. The cold disk is truncated and transitions to a turbulent hot accretion flow at ∼0.3 pc (10 ^3 r _g ). There are strong outflows toward the poles driven by the magnetic field. The outflow energy flux increases with smaller accretor size, reaching ∼3 × 10 ^43 erg s ^−1 for r _in = 8 r _g ; this corresponds to a nearly constant energy feedback efficiency of η ∼ 0.05–0.1 independent of accretor size. The feedback energy is enough to balance the total cooling of the M87/Virgo hot halo out to ∼50 kpc. The accreted magnetic flux at small radii is similar to that in magnetically arrested disk models, consistent with the formation of a powerful jet on horizon scales in M87. Our results motivate a subgrid model for accretion in lower-resolution simulations in which the hot gas accretion rate is suppressed relative to the Bondi rate by $\sim {(10\,{r}_{{\rm{g}}}/{r}_{{\rm{B}}})}^{1/2}$ .

The end of supernova remnant (SNR) evolution is characterized by a so-called “radiative” stage, in which efficient cooling of the hot bubble inside the forward shock slows expansion, leading to eventual shock breakup. Understanding SNR evolution at this stage is vital for predicting feedback in galaxies, since SNRs are expected to deposit their energy and momentum into the interstellar medium at the ends of their lives. A key prediction of SNR evolutionary models is the formation at the onset of the radiative stage of a cold, dense shell behind the forward shock. However, searches for these shells via their neutral hydrogen emission have had limited success. We instead introduce an independent observational signal of shell formation arising from the interaction between nonthermal particles accelerated by the SNR forward shock (cosmic rays) and the dense shell. Using a semi-analytic model of particle acceleration based on state-of-the-art simulations coupled with a high-resolution hydrodynamic model of SNR evolution, we predict the nonthermal emission that arises from this interaction. We demonstrate that the onset of the radiative stage leads to nonthermal signatures from radio to gamma rays, including radio and gamma-ray brightening by nearly 2 orders of magnitude. Such a signature may be detectable with current instruments, and will be resolvable with the next generation of gamma-ray telescopes (namely, the Cherenkov Telescope Array).

We have experimentally created perfect vortex beams (PVBs) by Fourier transformation of Bessel–Gaussian vortex beams, which are generated by modulating the fundamental Gaussian beam with the spiral phase plates and the axicons, respectively. Although the method has been used many times by other authors, as far as we know, few people pay attention to the quantitative relationship between the control parameters of the PVB and ring width. The effects of the waist radius of the fundamental Gaussian beam wg, base angle of the axicon γ, and focal length of the lens f on the spot parameters (ring radius ρ, and ring half-width Δ) of PVB are systematically studied. The beam pattern of the generated Bessel–Gaussian beam for different propagation distances behind the axicon and the fundamental Gaussian beam wg is presented. We showed experimentally that the ring radius ρ increases linearly with the increase of the base angle γ and focal length f, while the ring half-width Δ decreases with the increase of the fundamental beam waist radius wg, and increases with enlarging the focal length f. We confirmed the topological charge (TC) of the PVB by the interferogram between the PVB and the reference fundamental Gaussian beam. We also studied experimentally that the size of the generated PVB in the Fourier plane is independent of the TCs. Our approach to generate the PVB has the advantages of high-power tolerance and high efficiency.

The single-pass second-harmonic generation (SHG) of a vortex beam under low fundamental wave depletion is systematically studied. Vortex modes at 1064 nm with integer topological charges from ±1 to ±9 and fractional ones at ±0.75 are generated by modulating the fundamental Gaussian beam with different spiral phase plates. The frequency doubling of these fundamental vortex modes is realized via single-pass SHG through the KTP. A detailed theoretical model is set up in the single-pass SHG of the vortex beams. Theoretical analysis indicates that the higher the order of the vortex beams, the lower the SHG efficiency, when the beam waists and fundamental power are given. The experimentally measured SHG output characteristics verify those obtained via theoretical analysis. Conservation of the orbital angular momentum during the SHG process is also verified, regardless of the fractional or integer vortex beams. SH LG0,2l vortex beams with high mode purity are obtained. The beam waists of fundamental/SH in KTP measured using a 4f system demonstrate that the Rayleigh ranges of the fundamental wave and SH wave are the same. The paper comprehensively presents some basic laws in the single-pass SHG of a vortex beam. In addition, it also indicates that SHG is an effective method to improve the mode purity of vortex beam.

Abstract Polymers are widely studied materials with diverse properties and applications determined by molecular structures. It is essential to represent these structures clearly and explore the full space of achievable chemical designs. However, existing approaches cannot offer comprehensive design models for polymers because of their inherent scale and structural complexity. Here, a parametric, context‐sensitive grammar designed specifically for polymers (PolyGrammar) is proposed. Using the symbolic hypergraph representation and 14 simple production rules, PolyGrammar can represent and generate all valid polyurethane structures. An algorithm is presented to translate any polyurethane structure from the popular Simplified Molecular‐Input Line‐entry System (SMILES) string format into the PolyGrammar representation. The representative power of PolyGrammar is tested by translating a dataset of over 600 polyurethane samples collected from the literature. Furthermore, it is shown that PolyGrammar can be easily extended to other copolymers and homopolymers. By offering a complete, explicit representation scheme and an explainable generative model with validity guarantees, PolyGrammar takes an essential step toward a more comprehensive and practical system for polymer discovery and exploration. As the first bridge between formal languages and chemistry, PolyGrammar also serves as a critical blueprint to inform the design of similar grammars for other chemistries, including organic and inorganic molecules.

Abstract Objective The attraction and influx of monocytes into the retina has been considered a critical step in the development of diabetic retinopathy (DR). However, large population studies about the association between peripheral blood monocyte levels, an inexpensive and easily measurable laboratory index, and DR are limited. Thus, we aimed to investigate the association between peripheral blood monocyte levels and DR. Methods A total of 3223 participants out of 3277 adults with diabetes were enrolled from seven communities in China in this cross-sectional survey. Participants underwent several medical examinations, including the measurement of anthropometric factors, blood pressure, routinely analyzed leukocyte characteristics, glucose, lipid profiles, urine albumin/creatinine ratio and fundus photographs. Results The prevalence of DR among the participants in the highest quartile of peripheral blood monocyte levels significantly decreased by 41% (OR 0.59; 95% CI 0.43, 0.81) compared with the participants in the first quartile (P for trend 0.05). Associations between leukocyte, neutrophil and lymphocyte levels and DR were also not found (all P for trend > 0.05). These associations were all fully adjusted for age, sex, education status, duration of diabetes history, current smoking, BMI, HbA1c, dyslipidemia, systolic blood pressure and insulin therapy. Conclusion Decreased peripheral blood monocyte levels were associated with increased odds of DR after adjusting for potential confounders in diabetic adults. However, causation remains to be demonstrated.

Fanconi anemia (FA) group D2 (FANCD2) is a ferroptosis-related gene crucial for DNA damage repair and negative ferroptosis regulation. Our study aimed to evaluate its prognostic value as well as its association with ferroptosis and immune infiltration in lung adenocarcinoma (LUAD). Transcriptome sequencing data, clinical information, and immunohistochemistry data were collected from the TCGA, GEO, and HPA databases, respectively, for three independent cohorts. Univariate and multivariate analyses were used to assess the correlations between FANCD2 expression and overall survival or clinicopathological parameters. cBioPortal was utilized to investigate the FANCD2 alteration status. Gene and protein networks based on FANCD2 interactions were generated using GeneMANIA and STRING, respectively. Based on the CancerSEA database, the function of FANCD2 was explored at the single-cell level. The relationships between FANCD2 expression levels and tumor-infiltrating immune cells and their equivalent gene signatures were analyzed using TIMER, GEPIA, TISIDB, and ssGSEA databases. CIBERSORT was used to analyze the relevance of the infiltration of 24 types of immune cells. The results revealed that FANCD2 expression was significantly upregulated in LUAD and lung squamous cell carcinoma (LUSC) tissues than that in normal tissues. Further, the overexpression of FANCD2 was closely associated with poor survival for Patients with LUAD but not for patients with LUSC. FANCD2 expression levels were related to tumor-infiltrating immune cells and their matching gene signatures, including CD8+ T cells, natural killer (NK) cells, dendritic cells (DC), and Th2 cells in cases of LUAD. Therefore, FANCD2 was identified as a crucial molecule underlying the synergistic effects of ferroptosis and immunotherapy for Patients with LUAD.

We present high-resolution, three-dimensional hydrodynamic simulations of the fueling of supermassive black holes in elliptical galaxies from a turbulent medium on galactic scales, taking M87* as a typical case. The simulations use a new GPU-accelerated version of the Athena++ AMR code, and they span more than six orders of magnitude in radius, reaching scales similar to that of the black hole horizon. The key physical ingredients are radiative cooling and a phenomenological heating model. We find that the accretion flow takes the form of multiphase gas at radii less than about a kpc. The cold gas accretion includes two dynamically distinct stages: the typical disk stage in which the cold gas resides in a rotationally supported disk, and relatively rare chaotic stages (≲10% of the time) in which the cold gas inflows via chaotic streams. Though cold gas accretion dominates the time-averaged accretion rate at intermediate radii, accretion at the smallest radii is dominated by hot virialized gas at most times. The accretion rate scales with radius as $\dot{M}\propto {r}^{1/2}$ when hot gas dominates, and we obtain $\dot{M}\simeq {10}^{-4}\mbox{--}{10}^{-3}\,{M}_{\odot }\,{\mathrm{yr}}^{-1}$ near the event horizon, similar to what is inferred from EHT observations. The orientation of the cold gas disk can differ significantly on different spatial scales. We propose a subgrid model for accretion in lower-resolution simulations in which the hot gas accretion rate is suppressed relative to the Bondi rate by $\sim {({r}_{{\rm{g}}}/{r}_{\mathrm{Bondi}})}^{1/2}$ . Our results can also provide more realistic initial conditions for simulations of black hole accretion at the event horizon scale.

In order to study the coupling vibration between a bridge and a train under the action of crosswind loads, a dynamic interaction model of the wind–train–bridge system is established considering the geometric nonlinear factors of a long-span suspension bridge. A calculation frame is composed, and a corresponding computer program is written. A long-span highway–railway suspension bridge scheme is studied as an example. The linear and nonlinear vibration responses of the bridge under the simultaneous action of both train loads and wind loads are compared using the self-written program, and the influence of wind velocity and train speed on the dynamic responses of the bridge is studied. The results show that the large displacement nonlinearity of the structure does not influence the changing tendency of bridge displacement and acceleration time histories, but reduces the maximum values of the responses. The geometric nonlinear influence on the bridge accelerations is more obvious than that on the displacements. The natural frequencies of this long-span suspension bridge are very low and it is sensitive to wind action. The changes in train speed and average wind velocity have a great influence on the maximum value of bridge displacement, especially when the lateral deformation and acceleration increase sharply with the wind velocity, and the coupling vibration between wind, train, and the bridge can easily occur. The research results can provide references for the safe operation and maintenance of long-span bridges.

Weld defect segmentation (WDS) is widely used to detect defects from X-ray images for welds, which is of practical importance for manufacturing in all industries. The key challenge of WDS is that the labeled ground truth of defects is usually not accurate because of the similarities between the candidate defect and noisy background, making it difficult to distinguish some critical defects, such as cracks, from the weld line during the inference stage. In this paper, we propose boundary label smoothing (BLS), which uses Gaussian Blur to soften the labels near object boundaries to provide an appropriate representation of inaccuracy and uncertainty in ground truth labels. We incorporate BLS into dice loss, in combination with focal loss and weighted cross-entropy loss as a hybrid loss, to achieve improved performance on different types of segmentation datasets.

Due to the important application in the study of vibrational circular dichroism and helical dichroism of chiral molecules, the tunable vortex beam at mid-infrared region has attracted increasing attention. Based on orbital angular momentum (OAM) conservation in nonlinear interactions, the vortex pumped singly resonant optical parametric oscillator (SRO) is recognized as a versatile source of coherent vortex radiation providing high power and broad wavelength coverage from a single device. However, the low parametric gain and high oscillation threshold under continuous wave (cw) pumping has so far been the most challenging factor in generating cw tunable vortex beams. To predict the output characteristic of vortex pumped SRO, a theoretical model describing the vortex pumped SRO is needed. In this study, the theoretical model describing the vortex pumped SRO is set up under collimated Gaussian beam approximation. Output characteristics of different SROs are simulated numerically. By proper selection of pump scheme (such as double-pass pumping scheme), the vortex pumped mid-infrared SRO can oscillate at a relatively low pump power. By controlling the gain (mode overlap ratio between the pump and resonant wave in the nonlinear crystal) and loss (employing a spot-defect mirror with different defect size as the output coupler) of the resonant signal mode in the SRO, the OAM of the pump beam can be directionally transferred to a specific down converted beam. The transfer mechanism of the OAM among the pump light and the down-converted beams and factors affecting the transfer are studied. Our study provides the guidelines for the design and optimization of vortex pumped SRO under cw operation.

As one of the most important micro energy storage devices (MESDs), graphene-based micro-supercapacitors (G-MSCs) possess the advantages of excellent flexibility, long cycle life, affordability and high reliability. In most cases, constructing three-dimensional (3D) graphene networks is widely utilized to promote the permeation of electrolyte and enhance the utilization of active materials. In this work, conventional freeze-drying process is utilized in the fabrication of G-MSCs to constitute 3D interconnected networks micro-electrodes, and further by regulating the composition of inks, carbon spheres (CSs) at different mass loadings are introduced into the graphene scaffolds to further increase the active sites of the micro-electrodes. The fabricated all carbon-based MSC with the optimal mass loading of CSs (0.406 mg cm−2) exhibits a high specific areal capacitance of 17.01 mF cm−2 at the scan rate of 10 mV s−1 and a capacitance retention of 93.14% after 10000 cycles at the scan rate of 500 mV s−1. The proposed microfabrication process is facile and fully compatible with modern microtechnologies and will be highly suitable for large-scale production and integration. Keywords: Three-dimensional, Injecting, Freeze-drying, Mass loading, Supercapacitor

Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE) caused by uncontrolled activation of the complement system. Mesenchymal stem cells (MSCs) exhibit clinical efficacy for severe LN in our previous studies, but the underlying mechanisms of MSCs regulating complement activation remain largely unknown. Here we show that significantly elevated C5a and C5b-9 were found in patients with LN, which were notably correlated with proteinuria and different renal pathological indexes of LN. MSCs suppressed systemic and intrarenal activation of C5, increased the plasma levels of factor H (FH), and ameliorated renal disease in lupus mice. Importantly, MSCs transplantation up-regulated the decreased FH in patients with LN. Mechanistically, interferon-α enhanced the secretion of FH by MSCs. These data demonstrate that MSCs inhibit the activation of pathogenic C5 via up-regulation of FH, which improves our understanding of the immunomodulatory mechanisms of MSCs in the treatment of lupus nephritis. Keywords: Lupus nephritis, C5, MSCs, FH

Fabrication condition greatly influences the microstructures and properties of Al alloys. However, most of the available reports focus on a single fabrication technique, indicating there is still a lack of systematic comparisons among wider ranges of fabrication methods. In this paper, with conventional casting (via sand/Fe/Cu mold) and additive manufacturing (AM, via selective laser melting, SLM) methods, the effects of cooling rate (Ṫ) on the microstructures and mechanical properties of hypoeutectic Al-10Si-0.5Mg alloy are systematically investigated. The results show that with increasing cooling rate from sand-mold condition to SLM condition, the grain size (d) is continuously refined from ~3522 ± 668 μm to ~10 μm, and the grain morphology is gradually refined from coarse dendrites to a mixed grain structure composed of columnar plus fine grains (~10 μm). The eutectic Si particles are effectively refined from blocky shape under sand/Fe-mold conditions to needle-like under Cu-mold conditions, and finally to fine fibrous network under SLM condition. The tensile yield strength and elongation is greatly improved from 125 ± 5 MPa (sand-mold) to 262 ± 3 MPa (SLM) and from 0.8 ± 0.2% (sand-mold) to 4.0 ± 0.2% (SLM), respectively. The strengthening mechanism is discussed, which is mainly ascribed to the continuous refinement of grains and Si particles and an increase in super-saturation of Al matrix with increasing cooling rate.

In this study, we investigate the feasibility of improving the imaging quality for low-dose multislice helical computed tomography (CT) via iterative reconstruction with tensor framelet (TF) regularization. TF based algorithm is a high-order generalization of isotropic total variation regularization. It is implemented on a GPU platform for a fast parallel algorithm of X-ray forward band backward projections, with the flying focal spot into account. The solution algorithm for image reconstruction is based on the alternating direction method of multipliers or the so-called split Bregman method. The proposed method is validated using the experimental data from a Siemens SOMATOM Definition 64-slice helical CT scanner, in comparison with FDK, the Katsevich and the total variation (TV) algorithm. To test the algorithm performance with low-dose data, ACR and Rando phantoms were scanned with different dosages and the data was equally undersampled with various factors. The proposed method is robust for the low-dose data with 25% undersampling factor. Quantitative metrics have demonstrated that the proposed algorithm achieves superior results over other existing methods.

In this paper, we establish the blow-up theorems of Fujita type for a class of exterior problems of nonlinear diffusion equations subject to inhomogeneous Neumann boundary conditions. The critical Fujita exponents are determined and it is shown that the critical curve belongs to the blow-up case under any nontrivial initial data.

When a protein unfolds in the cell, its diffusion coefficient is affected by its increased hydrodynamic radius and by interactions of exposed hydrophobic residues with the cytoplasmic matrix, including chaperones. We characterize protein diffusion by photobleaching whole cells at a single point, and imaging the concentration change of fluorescent-labeled protein throughout the cell as a function of time. As a folded reference protein we use green fluorescent protein. The resulting region-dependent anomalous diffusion is well characterized by 2-D or 3-D diffusion equations coupled to a clustering algorithm that accounts for position-dependent diffusion. Then we study diffusion of a destabilized mutant of the enzyme phosphoglycerate kinase (PGK) and of its stable control inside the cell. Unlike the green fluorescent protein control's diffusion coefficient, PGK's diffusion coefficient is a non-monotonic function of temperature, signaling 'sticking' of the protein in the cytosol as it begins to unfold. The temperature-dependent increase and subsequent decrease of the PGK diffusion coefficient in the cytosol is greater than a simple size-scaling model suggests. Chaperone binding of the unfolding protein inside the cell is one plausible candidate for even slower diffusion of PGK, and we test the plausibility of this hypothesis experimentally, although we do not rule out other candidates.

The techniques for parametrizing nonsingular cubic surfaces have shown to be of great interest in recent years. This paper is devoted to the rational parametrization of nonsingular cubic blending surfaces. We claim that these nonsingular cubic blending surfaces can be parametrized using the symbolic computation due to their excellent geometric properties. Especially for the specific forms of these surfaces, we conclude that they must be 𝐹3, 𝐹4, or 𝐹5 surfaces, and a criterion is given for deciding their surface types. Besides, using the algorithm proposed by Berry and Patterson in 2001, we obtain the uniform rational parametric representation of these specific forms. It should be emphasized that our results in this paper are invariant under any nonsingular real projective transform. Two explicit examples are presented at the end of this paper.