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1. Conformational cycle of human polyamine transporter ATP13A2

Author

Jianqiang Mu, Chenyang Xue, Lei Fu, Zongjun Yu, Minhan Nie, Mengqi Wu, Xinmeng Chen, Kun Liu, Ruiqian Bu, Ying Huang, Baisheng Yang, Jianming Han, Qianru Jiang, Kevin C. Chan, Ruhong Zhou, Huilin Li, Ancheng Huang, Yong Wang, and Zhongmin Liu

Subjects
Science
Abstract

ATP13A2 is a lysosomal polyamine transporter, mutated in several diseases including juvenile-onset Parkinson’s disease. Here, the authors report structures of human ATP13A2 in six distinct intermediate states, illustrating most of its conformational cycle.

Published
2023
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