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2. Efficient chemoenzymatic dynamic kinetic resolution of 1-heteroaryl ethanols

Author

Vallin, Karl S.A., Posaric, David Wensbo, Hamersak, Zdenko, Svensson, Mats A., and Minidis, Alexander B.E.

Subjects
Pyrazoles -- Chemical properties, Pyrazoles -- Structure, Toluene -- Chemical properties, Toluene -- Structure, Racemization -- Analysis, Ruthenium -- Chemical properties, Ruthenium -- Structure, Density functionals -- Analysis, Alcohol -- Research, Alcohol, Denatured -- Research, Imidazole -- Chemical properties, Imidazole -- Structure, Biological sciences, Chemistry
Abstract

The studies related to the scope and limitation of the combined ruthenium-lipase induced dynamic kinetic resolution (DKR) through O-acetylation of racemic heteroaromatic secondary alcohols (1-heteroaryl substituted ethanols) are presented. The results obtained provide better understanding of the mechanistic aspects behind the difference in reactivity of 1-heteroaryl substituted ethanols in comparison to reference substrates.

Published
2009

3. Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development

Author

Raboisson, Patrick, Breitholtz-Emanuelsson, Anna, Dahllöf, Henrik, Edwards, Louise, Heaton, William L., Isaac, Methvin, Jarvie, Keith, Kers, Annika, Minidis, Alexander B.E., Nordmark, Anna, Sheehan, Susan M., Slassi, Abdelmalik, Ström, Peter, Terelius, Ylva, Wensbo, David, Wilson, Julie M., Xin, Tao, and McLeod, Donald A.

Published
2012
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