Search

Abstract Background Sarcopenia is a geriatric disease characterized by loss of muscle mass and strength. Although combined exercise and nutrition intervention are known to be effective for sarcopenia, clinical trials involving outpatients with sarcopenia in primary care are scarce. We describe a protocol for a trial to examine the effects of a 12-week combined exercise and nutrition intervention in Korean older adults with possible sarcopenia in community-based primary care. Methods This multicenter, randomized, controlled trial will include 94 community-dwelling older outpatients aged 65–85 years with possible sarcopenia (47 participants in the intervention and control groups each). Resistance exercises, which incorporate concentric and eccentric exercises, will consist of an introductory phase (3 weeks: twice-weekly supervised exercise sessions and once-weekly home exercises; contraction exercises), an expanded phase (3 weeks: twice-weekly supervised exercise sessions and once-weekly home exercises; eccentric exercises), and a maintenance phase (6 weeks: once-weekly supervised exercise sessions and twice-weekly home exercises; power/eccentric exercises). Nutritional supplementation will be provided according to the nutritional status of the participants using a Mini-Nutritional Assessment. Participants will be assessed at baseline, 12 and 24 weeks, and the primary outcome will be the 5-times chair stand test results. Discussion To the best of our knowledge, this will be the first clinical trial to evaluate the efficacy of a combined exercise and nutritional supplementation intervention in older outpatients with possible sarcopenia in community-based primary care clinics. These findings will provide new insights to clinicians regarding the long-term usability for doctors and outpatients with possible sarcopenia in community-based primary care. Trial registration This trial was prospectively registered at ClinicalTrials.gov on September 16, 2023 (registration number: NCT06049914).

Abstract The SARS‐CoV‐2 caused COVID‐19 pandemic has posed a global health hazard. While some vaccines have been developed, protection against viral infection is not perfect because of the urgent approval process and the emergence of mutant SARS‐CoV‐2 variants. Here, we employed UDCA as an FXR antagonist to regulate ACE2 expression, which is one of the key pathways activated by SARS‐CoV‐2 Delta variant infection. UDCA is a well‐known reagent of liver health supplements and the only clinically approved bile acid. In this paper, we investigated the protective efficacy of UDCA on Omicron variation, since it has previously been verified for protection against Delta variant. When co‐housing with an Omicron variant‐infected hamster group resulted in spontaneous airborne transmission, the UDCA pre‐supplied group was protected from weight loss relative to the non‐treated group at 4 days post‐infection by more than 5%–10%. Furthermore, UDCA‐treated groups had a 3‐fold decrease in ACE2 expression in nasal cavities, as well as reduced viral expressing genes in the respiratory tract. Here, the data show that the UDCA serves an alternative option for preventive drug, providing SARS‐CoV‐2 protection against not only Delta but also Omicron variant. Our results of this study will help to propose drug‐repositioning of UDCA from liver health supplement to preventive drug of SARS‐CoV‐2 infection.

Objectives: This study aims to estimate the transmission potential of mpox in East Asia, focusing on the hardest hit nations: Taiwan, China, Japan, and South Korea. Methods: We utilized six phenomenological dynamic growth models to fit the case incidence during the initial 30 epidemic days. The best-fit model was selected to calculate the reproduction number (Rt). Additionally, we used the latest case data and a Bayesian framework to compute the instantaneous effective Rt by applying the Cori et al. method. Results: During the early phase, China demonstrated the highest estimated Rt of 2.89 (95% CI: 1.44-3.33); followed by South Korea, 2.18 (95% CI: 0.96-3.57); Japan, 1.73 (95% CI: 0.66-3.94); and Taiwan, 1.36 (95% CI: 0.71-3.30). However, by June 30, 2023, estimated Rt dropped below 1.00 in all countries: China at 0.05 (95% credible interval [CrI]: 0.02-0.10), Japan at 0.32 (95% CrI: 0.15-0.59), South Korea at 0.23 (95% CrI: 0.11-0.42), and Taiwan at 0.41 (95% CrI: 0.31-0.53), indicating the potential decline of the outbreak. Conclusions: Our analysis shows effective containment by each country. It is crucial to sustain effective management to ensure the ultimate eradication of the outbreak.

Abstract Hearing impairment, the third largest health burden worldwide, currently lacks definitive treatments or preventive drugs. This study compared the effects of hydrophilic and lipophilic statin on hearing loss using a common database model. This retrospective multicenter study was conducted in three hospitals in South Korea (Anam, Guro, Ansan). We enrolled patients with hyperlipidemia with an initial hearing loss diagnosis. Data were collected during January 1, 2022–December 31, 2021 using the Observational Health Data Science and Informatics open-source software and Common Data Model database. The primary outcome was the occurrence of first-time hearing loss following a hyperlipidemia diagnosis, as documented in the Common Data Model cohort database. The measures of interest were hearing loss risk between hydrophilic and lipophilic statin use. Variables were compared using propensity score matching, Cox proportional regression, and meta-analysis. Among 37,322 patients with hyperlipidemia, 13,751 (7669 men and 6082 women) and 23,631 (11,390 men and 12,241 women) were treated with hydrophilic and lipophilic statins, respectively. After propensity score matching, according to the Kaplan–Meier curve, hearing loss risk did not significantly differ among the hospitals. The hazard ratio (HR) of the male patients from Anam (0.29, [95% confidence interval (CI), 0.05–1.51]), Guro (HR, 0.56, [95% CI 0.18–1.71]), and Ansan (hazard ratio, 0.29, [95% CI 0.05–1.51]) hospitals were analyzed using Cox proportional regression. Overall effect size (HR, 0.40, [95% CI 0.18–0.91]) was estimated using meta-analysis, which indicated that hearing loss risk among hydrophilic statin users was less than that among lipophilic statin users and was statistically significant. Men in the hydrophilic statin group had a lower risk of hearing impairment than those in the lipophilic statin group.

Over the past decades, nearly a million quasars have been explored to shed light on the evolution of supermassive black holes and galaxies. The ultraviolet-to-optical spectra of type-1 quasars particularly offer insights into their black hole activities. Recent findings, however, raise questions about the prevalence of red type-1 quasars of which colors might be due to dust obscuration and their potential influence on luminosity-related properties of quasars. We examine the fraction of red type-1 quasars within the redshift range of 0.68 ≤ z < 2.20, applying a spectral energy distribution (SED) fitting using optical-to-mid-infrared (MIR) photometric data of Sloan Digital Sky Survey Data Release 14 quasars. Approximately 10% of the type-1 quasars exhibit red colors suggestive of dust obscuration. There is an association between the brightness of the MIR luminosity and a higher fraction of red type-1 quasars, albeit with negligible redshift evolution. By employing E ( B − V ) values from the SED fitting, we obtained dereddened luminosity of the red type-1 quasars and reassess the quasar luminosity function (QLF) and black hole mass ( M _BH ) estimates. Result shows a modest increase in the number density of bright quasars, linking to more flatten bright-end slope of QLFs, while M _BH adjustments are minimal. Current SDSS selections with optical colors could miss a significant population of heavily dust-obscured quasars. As future MIR surveys like Spectro-Photometer for the History of the Universe, Epoch of Reionization, and Ices Explorer expand, they may reveal enough obscured quasars to prompt a more profound revision of fundamental quasar properties.

We present the main results from a long-term reverberation mapping campaign carried out for the Seoul National University AGN Monitoring Project (SAMP). High-quality data were obtained during 2015–2021 for 32 luminous active galactic nuclei (AGNs; i.e., continuum luminosity in the range of 10 ^44–46 erg s ^−1 ) at a regular cadence, of 20–30 days for spectroscopy and 3–5 days for photometry. We obtain time lag measurements between the variability in the H β emission and the continuum for 32 AGNs; 25 of those have the best lag measurements based on our quality assessment, examining correlation strength and the posterior lag distribution. Our study significantly increases the current sample of reverberation-mapped AGNs, particularly at the moderate-to-high-luminosity end. Combining our results with literature measurements, we derive an H β broadline region size–luminosity relation with a shallower slope than reported in the literature. For a given luminosity, most of our measured lags are shorter than the expectations, implying that single-epoch black hole mass estimators based on previous calibrations could suffer large systematic uncertainties.

Exposure to microgravity causes significant alterations in astronauts’ immune systems during spaceflight; however, it is unknown whether microgravity affects mast cell homeostasis and activation. Here we show that microgravity negatively regulates the survival and effector function of mast cells. Murine bone marrow-derived mast cells (BMMCs) were cultured with IL-3 in a rotary cell culture system (RCCS) that generates a simulated microgravity (SMG) environment. BMMCs exposed to SMG showed enhanced apoptosis along with the downregulation of Bcl-2, and reduced proliferation compared to Earth’s gravity (1G) controls. The reduction in survival and proliferation caused by SMG exposure was recovered by stem cell factor. In addition, SMG impaired mast cell degranulation and cytokine secretion. BMMCs pre-exposed to SMG showed decreased release of β-hexosaminidase, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) upon stimulation with phorbol 12-myristate-13-acetate (PMA) plus calcium ionophore ionomycin, which correlated with decreased calcium influx. These findings provide new insights into microgravity-mediated alterations of mast cell phenotypes, contributing to the understanding of immune system dysfunction for further space medicine research.

Using the multi-epoch mid-infrared (MIR) photometry from the Wide-field Infrared Survey Explorer spanning a baseline of ∼10 yr, we extensively investigate the MIR variability of nearby active galactic nuclei (AGNs) at 0.15 < z < 0.4. We find that the ensemble structure function in the W1 band (3.4 μ m) can be modeled with a broken power law. Type 1 AGNs tend to exhibit larger variability amplitudes than type 2 AGNs, possibly due to the extinction by the torus. The variability amplitude is inversely correlated with the AGN luminosity, consistent with a similar relation known in the optical. Meanwhile, the slope of the power law increases with AGN luminosity. This trend can be attributed to the fact that the inner radius of the torus is proportional to the AGN luminosity, as expected from the size−luminosity relation of the torus. Interestingly, low-luminosity type 2 AGNs, unlike low-luminosity type 1 AGNs, tend to exhibit smaller variability amplitude than do high-luminosity AGNs. We argue that either low-luminosity type 2 AGNs have distinctive central structures due to their low luminosity or their MIR brightness is contaminated by emission from the cold dust in the host galaxy. Our findings suggest that the AGN unification scheme may need to be revised. We find that the variability amplitude of dust-deficient AGNs is systematically larger than that of normal AGNs, supporting the notion that the hot and warm dust in dust-deficient AGNs may be destroyed and reformed according to the strength of the ultraviolet radiation from the accretion disk.

We search for quasi-stellar objects (QSOs) in a wide area of the south ecliptic pole (SEP) field, which has been and will continue to be intensively explored through various space missions. For this purpose, we obtain deep broadband optical images of the SEP field covering an area of ∼14.5 × 14.5 deg ^2 with the Korea Microlensing Telescope Network (KMTNet). The 5 σ detection limits for point sources in the BVRI bands are estimated to be ∼22.59, 22.60, 22.98, and 21.85 mag, respectively. Utilizing data from the Wide-field Infrared Survey Explorer, unobscured QSO candidates are selected among the optically pointlike sources using mid-infrared (MIR) and optical–MIR colors. To refine our selection further and eliminate any contamination not adequately removed by the color-based selection, we perform spectral energy distribution fitting with archival photometric data ranging from optical to MIR. As a result, we identify a total of 2383 unobscured QSO candidates in the SEP field. We also apply a similar method to the north ecliptic pole field using Pan-STARRS data and obtain a similar result of identifying 2427 candidates. The differential number count per area of our QSO candidates is in good agreement with those measured from spectroscopically confirmed ones in other fields. Finally, we compare the results with the literature and discuss how this work will impact future studies, especially upcoming space missions.

We present bolometric luminosity ( L _bol ) and black hole (BH) mass ( M _BH ) estimators based on mid-infrared (MIR) continuum luminosity (hereafter, L _MIR ) that are measured from infrared (IR) photometric data. The L _MIR -based estimators are relatively immune from dust extinction effects, hence they can be used for dust-obscured quasars. To derive the L _bol and M _BH estimators, we use unobscured quasars selected from the Sloan Digital Sky Survey (SDSS) quasar catalog, which have wide ranges of L _bol (10 ^44.62 –10 ^46.16 erg s ^−1 ) and M _BH (10 ^7.14 –10 ^9.69 M _⊙ ). We find empirical relations between (i) continuum luminosity at 5100 Å (hereafter, L5100) and L _MIR ; (ii) L _bol and L _MIR . Using these relations, we derive the L _MIR -based L _bol and M _BH estimators. We find that our estimators allow the determination of L _bol and M _BH at an accuracy of ∼0.2 dex against the fiducial estimates based on the optical properties of the unobscured quasars. We apply the L _MIR -based estimators to SDSS quasars at z ≲ 0.5 including obscured ones. The ratios of L _bol from the L _MIR -based estimators to those from the optical luminosity-based estimators become larger with the amount of the dust extinction, and a non-negligible fraction (∼15%) of the SDSS quasars exhibits ratios greater than 1.5. This result suggests that dust extinction can significantly affect physical parameter derivations even for SDSS quasars, and that dust extinction needs to be carefully taken into account when deriving quasar properties.

We assemble a broadband spectral energy distribution (SED) ranging from the optical to the mid-infrared of nearby active galactic nuclei (AGNs) at z < 0.4. The SED fitting analysis is performed using semiempirical templates derived from Palomar-Green quasars to classify the sample into normal, warm-dust-deficient (WDD), and hot-dust-deficient (HDD) AGNs. Kolmogorov–Smirnov tests reveal that HDD AGNs exhibit higher AGN luminosity on average than normal and WDD AGNs. The HDD fraction, on the other hand, is only weakly correlated with the black hole mass and inversely correlated with the Eddington ratio. By fixing the other parameters, we conclude that the HDD fraction is primarily connected with the AGN luminosity. This implies that there is a causal connection between the covering factor of the hot dust component and AGN luminosity, possibly due to the sublimation of the innermost dust or the thickening of the intervening gas in the broad-line region. Analysis of the outflow properties traced by the wing of [O iii ] λ 5007 suggests that outflows may be related to the formation and maintenance of the hot dust component. Finally, we demonstrate through comparison with previous studies that the classification of HDD AGNs requires careful subtraction of the host galaxy light.

The broad-line region (BLR) size–luminosity relation has paramount importance for estimating the mass of black holes in active galactic nuclei (AGNs). Traditionally, the size of the H β BLR is often estimated from the optical continuum luminosity at 5100 Å, while the size of the H α BLR and its correlation with the luminosity is much less constrained. As a part of the Seoul National University AGN Monitoring Project, which provides 6 yr photometric and spectroscopic monitoring data, we present our measurements of the H α lags of high-luminosity AGNs. Combined with the measurements for 42 AGNs from the literature, we derive the size–luminosity relations of the H α BLR against the broad H α and 5100 Å continuum luminosities. We find the slope of the relations to be 0.61 ± 0.04 and 0.59 ± 0.04, respectively, which are consistent with the H β size–luminosity relation. Moreover, we find a linear relation between the 5100 Å continuum luminosity and the broad H α luminosity across 7 orders of magnitude. Using these results, we propose a new virial mass estimator based on the H α broad emission line, finding that the previous mass estimates based on scaling relations in the literature are overestimated by up to 0.7 dex at masses lower than 10 ^7 M _⊙ .

We investigate the variation in the mid-infrared spectral energy distributions of 373 low-redshift ( z < 0.4) star-forming galaxies, which reflects a variety of polycyclic aromatic hydrocarbon (PAH) emission features. The relative strength of PAH emission is parameterized as q _PAH , which is defined as the mass fraction of PAH particles in the total dust mass. With the aid of continuous mid-infrared photometric data points covering 7–24 μ m and far-infrared flux densities, q _PAH values are derived through spectral energy distribution fitting. The correlation between q _PAH and other physical properties of galaxies, i.e., gas-phase metallicity ( $12+\mathrm{log}({\rm{O}}/{\rm{H}})$ ), stellar mass, and specific star-formation rate (sSFR) are explored. As in previous studies, q _PAH values of galaxies with high metallicity are found to be higher than those with low metallicity. The strength of PAH emission is also positively correlated with the stellar mass and negatively correlated with the sSFR. The correlation between q _PAH and each parameter still exists even after the other two parameters are fixed. In addition to the PAH strength, the application of metallicity-dependent gas-to-dust mass ratio appears to work well to estimate gas mass that matches the observed relationship between molecular gas and physical parameters. The result obtained will be used to calibrate the observed PAH luminosity-total infrared luminosity relation, based on the variation of MIR-FIR SED, which is used in the estimation of hidden star formation.

Influenza virus infections can cause a broad range of symptoms, form mild respiratory problems to severe and fatal complications. While influenza virus poses a global health threat, the frequent antigenic change often significantly compromises the protective efficacy of seasonal vaccines, further increasing the vulnerability to viral infection. Therefore, it is in great need to employ strategies for the development of universal influenza vaccines (UIVs) which can elicit broad protection against diverse influenza viruses. Using a mouse infection model, we examined the breadth of protection of the caspase-triggered live attenuated influenza vaccine (ctLAIV), which was self-attenuated by the host caspase-dependent cleavage of internal viral proteins. A single vaccination in mice induced a broad reactive antibody response against four different influenza viruses, H1 and rH5 (HA group 1) and H3 and rH7 subtypes (HA group 2). Notably, despite the lack of detectable neutralizing antibodies, the vaccination provided heterosubtypic protection against the lethal challenge with the viruses. Sterile protection was confirmed by the complete absence of viral titers in the lungs and nasal turbinates after the challenge. Antibody-dependent cellular cytotoxicity (ADCC) activities of non-neutralizing antibodies contributed to cross-protection. The cross-protection remained robust even after in vivo depletion of T cells or NK cells, reflecting the strength and breadth of the antibody-dependent effector function. The robust mucosal secretion of sIgA reflects an additional level of cross-protection. Our data show that the host-restricted designer vaccine serves an option for developing a UIV, providing pan-influenza A protection against both group 1 and 2 influenza viruses. The present results of potency and breadth of protection from wild type and reassortant viruses addressed in the mouse model by single immunization merits further confirmation and validation, preferably in clinically relevant ferret models with wild type challenges.

Vaccine adjuvants from natural resources have been utilized for enhancing vaccine efficacy against infectious diseases. This study examined the potential use of catechins, polyphenolic materials derived from green tea, as adjuvants for subunit and inactivated vaccines. Previously, catechins have been documented to have irreversible virucidal function, with the possible applicability in the inactivated viral vaccine platform. In a mouse model, the coadministration of epigallocatechin-3-gallate (EGCG) with influenza hemagglutinin (HA) antigens induced high levels of neutralizing antibodies, comparable to that induced by alum, providing complete protection against the lethal challenge. Adjuvant effects were observed for all types of HA antigens, including recombinant full-length HA and HA1 globular domain, and egg-derived inactivated split influenza vaccines. The combination of alum and EGCG further increased neutralizing (NT) antibody titers with the corresponding hemagglutination inhibition (HI) titers, demonstrating a dose-sparing effect. Remarkably, EGCG induced immunoglobulin isotype switching from IgG1 to IgG2a (approximately >64–700 fold increase), exerting a more balanced TH1/TH2 response compared to alum. The upregulation of IgG2a correlated with significant enhancement of antibody-dependent cellular cytotoxicity (ADCC) function (approximately 14 fold increase), providing a potent effector-mediated protection in addition to NT and HI. As the first report on a novel class of vaccine adjuvants with built-in virucidal activities, the results of this study will help improve the efficacy and safety of vaccines for pandemic preparedness.

The density of states (DOS) of a topological insulator nanowire is expected to show Aharonov-Bohm (AB) oscillations, but they are never observed so far. Here, Kim et al. reveal AB oscillations in the DOS of a Bi2Se3 nanowire via nanomechanical resonance measurements.

The characterization of detectors installed in space- and ground-based instruments is important to evaluate the system performance. We report the development of a detector performance test system for astronomical applications using the Andor iKon M CCD camera. The performance test system consists of a light source, monochromator, integrating sphere, and power meters. We adopted the Czerny–Tuner monochromator with three ruled gratings and one mirror, which covers a spectral range of 200–9,000 nm with a spectral resolution of ~1 nm in the visible region. Various detector characteristics, such as the quantum efficiency, sensitivity, and noise, can be measured in wide wavelength ranges from the visible to mid-infrared regions. We evaluated the Korea Astronomy and Space Science Institute (KASI) detector performance test system by using the performance verification of the Andor iKon-M CCD camera. The test procedure includes measurements of the conversion gain (2.86 e−/ADU), full well capacity (130 K e−), nonlinearity, and pixel defects. We also estimated the read noise, dark current, and quantum efficiency as a function of the temperature. The lowest measured read noise is 12 e−. The dark current at 223 K was determined to be 7 e−/s/pix and its doubling temperature is 5.3°C ± 0.2°C at an activation energy of 0.6 eV. The maximum quantum efficiency at 223 K was estimated to be 93 % ± 2 %. We proved that the quantum efficiency is sensitive to the operating temperature. It varies up to 5 % in the visible region, while the variation increases to 30 % in the near-infrared region. Based on the comparison of our results with the test report by the vendor, we conclude that our performance test results are consistent with those from the vendor considering the test environment. We also confirmed that the KASI detector performance test system is reliable and our measurement method and analysis are accurate.

For site-specific soil ecological risk assessments (SERAs), an integrated chemical, ecotoxicological, and ecological analysis needs to be performed. The SERA guidelines of international institutions and countries recommend that a SERA be initiated at the screening level to save time and social economic cost; however, they provide no unified test species for this screening level. This study performed SERAs for field soils and confirmed the importance of selecting bioassay test species that reflect the ecotoxicity of field soils at the screening level. To confirm test species that reflect the ecological risk of field soils, correlation analysis was performed on the results of each bioassay with the integrated ecotoxicological risk index (EtoxRI). Our results showed that soil algae, nematodes, and plants were the most representative species in soil assays, with high correlation coefficients with EtoxRI. The results imply the importance of selecting test species that represent ecological risk for the screening level of SERAs. Based on these findings, when using SERAs, species sensitivity, ecological relevance, and economic aspects should be considered when selecting the bioassay test species.

The effects of learner- and task-related variables on second language (L2) writing syntactic complexity (SC) have been extensively investigated. However, previous research has rarely assessed the reliability of computational tools for analyzing the SC of L2 spoken production, and we know less about the effects of such variables on L2 speaking SC. Using data from the International Corpus Network of Asian Learners of English, this study explores data preprocessing issues for preparing L2 English speech samples for automated SC analysis, evaluates the reliability of L2 Syntactic Complexity Analyzer on preprocessed L2 English speech samples, and examines the effects of proficiency, first language (L1) background, and topic on L2 speaking SC. Our manual analysis of 30 random speech samples identified several issues that can be addressed through preprocessing to improve the accuracy of automated SC analysis. Results from multiple linear mixed-effects models revealed significant effects of proficiency, L1 background, and topic on the mean length of clause, the number of complex AS-units per AS-unit, and the number of dependent clauses and complex nominals per clause in L2 learners' spoken production. Our findings have useful implications for L2 speaking pedagogy and assessment as well as future L2 speaking SC research.

Objective: To develop a population-specific instrument to inform hepatitis B virus (HBV) and human papilloma virus (HPV) prevention education and intervention based on data and evidence obtained from the targeted population of Khmer mothers reflecting their socio-cultural and health behaviors. Methods: The principles of community-based participatory research (CBPR) guided the development of a standardized survey interview. Four stages of development and testing of the survey instrument took place in order to inform the quantitative health survey used to collect data in stage five of the project. This article reports only on Stages 1-4. Results: This process created a new quantitative measure of HBV and HPV prevention behavior based on the revised Network Episode Model and informed by the targeted population. The CBPR method facilitated the application and translation of abstract theoretical ideas of HBV and HPV prevention behavior into culturally-relevant words and expressions of Cambodian Americans (CAs). Conclusions: The design of an instrument development process that accounts for distinctive socio-cultural backgrounds of CA refugee/immigrant women provides a model for use in developing future health surveys that are intended to aid minority-serving health care professionals and researchers as well as targeted minority populations.

PTPRCAP (CD45-AP) is a positive regulator of protein tyrosine phosphatase PTPRC (CD45), which activates Src family kinases implicated in tumorigenesis. Single-nucleotide polymorphism (SNP) rs869736 located at position -309 of the PTPRCAP promoter was associated with susceptibility to diffuse-type gastric cancer in the current case-control study. The minor-allele homozygote was significantly associated with a 2.5-fold increased susceptibility to diffuse-type gastric cancer (P = .0021, n = 252), but not to intestinal-type (P = .30, n = 178), versus the major-allele homozygote, when comparing unrelated Korean patients with healthy controls (n = 406). Nine other SNPs were in nearly perfect linkage disequilibrium (r2 ≥ 0.97) with this SNP, exhibiting the same association, and spread out for 26 kb on chromosome 11q13.1 covering RPS6KB2, PTPRCAP, CORO1B, and GPR152. Among the four genes, however, only PTPRCAP expression was affected by haplotypes of the 10 SNPs. Endogenous transcript levels of PTPRCAP were linearly correlated with copy numbers (0, 1, and 2) of the risk-haplotype (P = .0060) in 12 lymphoblastoid cells derived from blood samples, but those of the other three genes were not. Furthermore, the cancer-risk, minor-allele T of rs869736 increased both promoter activity and specific nuclear protein-binding affinity than the nonrisk, major-allele G in luciferase reporter and electrophoretic mobility shift assays, respectively. Accordingly, the minor allele of rs869736 in the PTPRCAP promoter is associated with increased susceptibility to diffuse-type gastric cancer by increasing PTPRCAP expression, possibly leading to activation of the oncogenic Src family kinases.

This paper presents a method for recognizing human actions from a single query action video. We propose an action recognition scheme based on the ordinal measure of accumulated motion, which is robust to variations of appearances. To this end, we first define the accumulated motion image (AMI) using image differences. Then the AMI of the query action video is resized to a N×N subimage by intensity averaging and a rank matrix is generated by ordering the sample values in the sub-image. By computing the distances from the rank matrix of the query action video to the rank matrices of all local windows in the target video, local windows close to the query action are detected as candidates. To find the best match among the candidates, their energy histograms, which are obtained by projecting AMI values in horizontal and vertical directions, respectively, are compared with those of the query action video. The proposed method does not require any preprocessing task such as learning and segmentation. To justify the efficiency and robustness of our approach, the experiments are conducted on various datasets.

Purpose: This study aims to measure the impact of depression, sleep quality, and mental health literacy on the quality of life in patients with breast cancer. Methods: A cross-sectional descriptive study was performed with the participation of 148 hospitalized breast cancer patients. The data analysis utilized independent t-tests, ANOVA, Pearson's correlation, and stepwise multiple linear regression. Results: The mean score of quality of life was 85.60±9.43, indicating significant differences according to perceived economic status, the time since diagnosis, and the use of hypnotics and antidepressants. Depression, sleep quality, and mental health literacy were found to have a significant association with quality of life. The regression analyses showed that significant predictors on quality of life were depression (β=-.64, p<.001), sleep quality (β=.19, p=.002), and mental health literacy (β=.11, p=.035). These variables explained 61.0% of the impact on the quality of life in the breast cancer patients. Conclusion: To enhance the quality of life for breast cancer patients, it will be essential to create a nursing program aimed at reducing depression, improving sleep quality, and enhancing mental health literacy. [ABSTRACT FROM AUTHOR]

This study examined the moderated mediating effect of teacher efficacy and resilience on the relationship between early childhood teachers' job satisfaction and teacher-child interactions. A survey was conducted on 409 early childhood teachers in Korea, and the collected data were analyzed using R 4.2.0 and the R version of PROCESSmacro 4.3. The results are as follows: first, early childhood teachers' job satisfaction had a positive effect on teacher efficacy and teacher-child interactions, and teacher efficacy had a positive effect on teacher-child interactions. Second, teacher efficacy had a positive mediating effect on the relationship between job satisfaction and teacher-child interactions. Third, resilience had a buffering moderating effect on the impact of job satisfaction on teacher efficacy. Lastly, the mediating effect of teacher efficacy on the relationship between early childhood teachers' job satisfaction and teacher-child interactions showed conditional effects depending on resilience. These results suggest the need to support the resilience of early childhood teachers as a part of their professionalism to connect the healthy professional life of early childhood teachers with the healthy growth of children. [ABSTRACT FROM AUTHOR]