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179 results on '"Minko, Peter"'

16. ASO Visual Abstract: Preoperative Sonographic Prediction of Limited Axillary Disease in Patients with Primary Breast Cancer Meeting the Z0011 Criteria: An Alternative to Sentinel-Node-Biopsy?

Author

Radosa, Julia Caroline, Solomayer, Erich-Franz, Deeken, Martin, Minko, Peter, Zimmermann, Julia Sarah Maria, Kaya, Askin Canguel, Radosa, Marc Philipp, Stotz, Lisa, Huwer, Sarah, Müller, Carolin, Karsten, Maria Margarete, Wagenpfeil, Gudrun, and Radosa, Christoph Georg

Published
2022
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17. ASO Author Reflections: An Alternative to Sentinel-Node Biopsy? Preoperative Sonographic Prediction of Limited Axillary Disease in Breast Cancer Patients Meeting the Z0011 Criteria

Author

Radosa, Julia Caroline, Solomayer, Erich-Franz, Deeken, Martin, Minko, Peter, Zimmermann, Julia Sarah Maria, Kaya, Askin Canguel, Radosa, Marc Philipp, Stotz, Lisa, Huwer, Sarah, Müller, Carolin, Karsten, Maria Margarete, Wagenpfeil, Gudrun, and Radosa, Christoph Georg

Published
2022
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18. Prediction of therapy response of breast cancer patients with machine learning based on clinical data and imaging data derived from breast [18F]FDG-PET/MRI

Author

Jannusch, Kai, primary, Dietzel, Frederic, additional, Bruckmann, Nils Martin, additional, Morawitz, Janna, additional, Boschheidgen, Matthias, additional, Minko, Peter, additional, Bittner, Ann-Kathrin, additional, Mohrmann, Svjetlana, additional, Quick, Harald H., additional, Herrmann, Ken, additional, Umutlu, Lale, additional, Antoch, Gerald, additional, Rubbert, Christian, additional, Kirchner, Julian, additional, and Caspers, Julian, additional

Published
2023
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20. Prediction of therapy response of breast cancer patients with machine learning based on clinical data and imaging data derived from breast [18F]FDG-PET/MRI.

Author

Jannusch, Kai, Dietzel, Frederic, Bruckmann, Nils Martin, Morawitz, Janna, Boschheidgen, Matthias, Minko, Peter, Bittner, Ann-Kathrin, Mohrmann, Svjetlana, Quick, Harald H., Herrmann, Ken, Umutlu, Lale, Antoch, Gerald, Rubbert, Christian, Kirchner, Julian, and Caspers, Julian

Subjects
MAGNETIC resonance mammography, BREAST, MACHINE learning, BREAST cancer, PATHOLOGIC complete response, RECEIVER operating characteristic curves, CANCER patients
Abstract

Purpose: To evaluate if a machine learning prediction model based on clinical and easily assessable imaging features derived from baseline breast [18F]FDG-PET/MRI staging can predict pathologic complete response (pCR) in patients with newly diagnosed breast cancer prior to neoadjuvant system therapy (NAST). Methods: Altogether 143 women with newly diagnosed breast cancer (54 ± 12 years) were retrospectively enrolled. All women underwent a breast [18F]FDG-PET/MRI, a histopathological workup of their breast cancer lesions and evaluation of clinical data. Fifty-six features derived from positron emission tomography (PET), magnetic resonance imaging (MRI), sociodemographic / anthropometric, histopathologic as well as clinical data were generated and used as input for an extreme Gradient Boosting model (XGBoost) to predict pCR. The model was evaluated in a five-fold nested-cross-validation incorporating independent hyper-parameter tuning within the inner loops to reduce the risk of overoptimistic estimations. Diagnostic model-performance was assessed by determining the area under the curve of the receiver operating characteristics curve (ROC-AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy. Furthermore, feature importances of the XGBoost model were evaluated to assess which features contributed most to distinguish between pCR and non-pCR. Results: Nested-cross-validation yielded a mean ROC-AUC of 80.4 ± 6.0% for prediction of pCR. Mean sensitivity, specificity, PPV, and NPV of 54.5 ± 21.3%, 83.6 ± 4.2%, 63.6 ± 8.5%, and 77.6 ± 8.1% could be achieved. Histopathological data were the most important features for classification of the XGBoost model followed by PET, MRI, and sociodemographic/anthropometric features. Conclusion: The evaluated multi-source XGBoost model shows promising results for reliably predicting pathological complete response in breast cancer patients prior to NAST. However, yielded performance is yet insufficient to be implemented in the clinical decision-making process. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Contrast medium free selective adrenal vein sampling in the management of primary aldosteronism

Author

Boschheidgen, Matthias, primary, Kantauskaite, Marta, additional, Stegbauer, Johannes, additional, Wenker, Kira, additional, Dringenberg, Till, additional, Radke, Karl-Ludger, additional, Ullrich, Tim, additional, Krieg, Andreas, additional, Steuwe, Andrea, additional, Minko, Peter, additional, Schott, Matthias, additional, Rump, Lars Christian, additional, Antoch, Gerald, additional, and Schimmöller, Lars, additional

Published
2023
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23. [18F]FDG PET/MRI in children suffering from lymphoma: does MRI contrast media make a difference?

Author

Jannusch, Kai, Morawitz, Janna, Schweiger, Bernd, Weiss, Daniel, Schimmöller, Lars, Minko, Peter, Herrmann, Ken, Fendler, Wolfgang P., Quick, Harald H., Antoch, Gerald, Umutlu, Lale, Kirchner, Julian, and Bruckmann, Nils-Martin

Subjects
CONTRAST media, MAGNETIC resonance imaging, NON-Hodgkin's lymphoma, DIFFUSION magnetic resonance imaging, CROSS-sectional imaging
Abstract

Objectives: Evaluate the influence of an MRI contrast agent application on primary and follow-up staging in pediatric patients with newly diagnosed lymphoma using [18F]FDG PET/MRI to avoid adverse effects and save time and costs during examination. Methods: A total of 105 [18F]FDG PET/MRI datasets were included for data evaluation. Two different reading protocols were analyzed by two experienced readers in consensus, including for PET/MRI-1 reading protocol unenhanced T2w and/or T1w imaging, diffusion-weighted imaging (DWI), and [18F]FDG PET imaging and for PET/MRI-2 reading protocol an additional T1w post contrast imaging. Patient-based and region-based evaluation according to the revised International Pediatric Non-Hodgkin's Lymphoma (NHL) Staging System (IPNHLSS) was performed, and a modified standard of reference was applied comprising histopathology and previous and follow-up cross-sectional imaging. Differences in staging accuracy were assessed using the Wilcoxon and McNemar tests. Results: In patient-based analysis, PET/MRI-1 and PET/MRI-2 both determined a correct IPNHLSS tumor stage in 90/105 (86%) exams. Region-based analysis correctly identified 119/127 (94%) lymphoma-affected regions. Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy for PET/MRI-1 and PET/MRI-2 were 94%, 97%, 90%, 99%, 97%, respectively. There were no significant differences between PET/MRI-1 and PET/MRI-2. Conclusions: The use of MRI contrast agents in [18F]FDG PET/MRI examinations has no beneficial effect in primary and follow-up staging of pediatric lymphoma patients. Therefore, switching to a contrast agent–free [18F]FDG PET/MRI protocol should be considered in all pediatric lymphoma patients. Clinical relevance statement: This study gives a scientific baseline switching to a contrast agent–free [18F]FDG PET/MRI staging in pediatric lymphoma patients. This could avoid side effects of contrast agents and saves time and costs by a faster staging protocol for pediatric patients. Key Points: • No additional diagnostic benefit of MRI contrast agents at [18F]FDG PET/MRI examinations of pediatric lymphoma primary and follow-up staging • Highly accurate primary and follow-up staging of pediatric lymphoma patients at MRI contrast–free [18F]FDG PET/MRI [ABSTRACT FROM AUTHOR]

Published
2023
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26. The Effect of Renal Denervation on T Cells in Patients with Resistant Hypertension

Author

Kantauskaite, Marta, primary, Vonend, Oliver, additional, Yakoub, Mina, additional, Heilmann, Philipp, additional, Maifeld, Andras, additional, Minko, Peter, additional, Schimmöller, Lars, additional, Antoch, Gerald, additional, Müller, Dominik N., additional, Schmidt, Claudia, additional, Duvnjak, Blanka, additional, Zierhut, Ulf, additional, Potthoff, Sebastian A., additional, Rump, Lars C., additional, Fischer, Johannes C., additional, and Stegbauer, Johannes, additional

Published
2023
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27. Influence of benign prostatic hyperplasia patterns detected with MRI on the clinical outcome after prostatic artery embolization

Author

Boschheidgen, Matthias, primary, Al-Monajjed, Rouvier, additional, Minko, Peter, additional, Jannusch, Kai, additional, Ullrich, Tim, additional, Radke, Karl-Ludger, additional, Michalski, Rene, additional, Radtke, Jan Phillip, additional, Albers, Peter, additional, Antoch, Gerald, additional, and Schimmöller, Lars, additional

Published
2023
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30. [¹⁸F]FDG PET/MRI in children suffering from lymphoma : does MRI contrast media make a difference?

Author

Jannusch, Kai, Morawitz, Janna, Schweiger, Bernd, Weiss, Daniel, Schimmöller, Lars, Minko, Peter, Herrmann, Ken, Fendler, Wolfgang, Quick, Harald H., Antoch, Gerald, Umutlu, Lale, Kirchner, Julian, and Bruckmann, Nils-Martin

Subjects
Medizin
Abstract

Objectives: Evaluate the influence of an MRI contrast agent application on primary and follow-up staging in pediatric patients with newly diagnosed lymphoma using [¹⁸F]FDG PET/MRI to avoid adverse effects and save time and costs during examination. Methods: A total of 105 [¹⁸F]FDG PET/MRI datasets were included for data evaluation. Two different reading protocols were analyzed by two experienced readers in consensus, including for PET/MRI-1 reading protocol unenhanced T2w and/or T1w imaging, diffusion-weighted imaging (DWI), and [¹⁸F]FDG PET imaging and for PET/MRI-2 reading protocol an additional T1w post contrast imaging. Patient-based and region-based evaluation according to the revised International Pediatric Non-Hodgkin’s Lymphoma (NHL) Staging System (IPNHLSS) was performed, and a modified standard of reference was applied comprising histopathology and previous and follow-up cross-sectional imaging. Differences in staging accuracy were assessed using the Wilcoxon and McNemar tests. Results: In patient-based analysis, PET/MRI-1 and PET/MRI-2 both determined a correct IPNHLSS tumor stage in 90/105 (86%) exams. Region-based analysis correctly identified 119/127 (94%) lymphoma-affected regions. Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy for PET/MRI-1 and PET/MRI-2 were 94%, 97%, 90%, 99%, 97%, respectively. There were no significant differences between PET/MRI-1 and PET/MRI-2. Conclusions: The use of MRI contrast agents in [¹⁸F]FDG PET/MRI examinations has no beneficial effect in primary and follow-up staging of pediatric lymphoma patients. Therefore, switching to a contrast agent–free [¹⁸F]FDG PET/MRI protocol should be considered in all pediatric lymphoma patients. Clinical relevance statement: This study gives a scientific baseline switching to a contrast agent–free [¹⁸F]FDG PET/MRI staging in pediatric lymphoma patients. This could avoid side effects of contrast agents and saves time and costs by a faster staging protocol for pediatric patients. Key Points: • No additional diagnostic benefit of MRI contrast agents at [¹⁸ F]FDG PET/MRI examinations of pediatric lymphoma primary and follow-up staging • Highly accurate primary and follow-up staging of pediatric lymphoma patients at MRI contrast–free [¹⁸ F]FDG PET/MRI in press

Published
2023

31. Runtime and aPTT predict venous thrombosis and thromboembolism in patients on extracorporeal membrane oxygenation: a retrospective analysis

Author

Trudzinski, Franziska C., Minko, Peter, Rapp, Daniel, Fähndrich, Sebastian, Haake, Hendrik, Haab, Myriam, Bohle, Rainer M., Flaig, Monika, Kaestner, Franziska, Bals, Robert, Wilkens, Heinrike, Muellenbach, Ralf M., Link, Andreas, Groesdonk, Heinrich V., Lensch, Christian, Langer, Frank, and Lepper, Philipp M.

Published
2016
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32. Current Developments of Selective Internal Radiotherapy (SIRT) in Germany: A Systematic Analysis of Indication and Hospital Mortality between 2012 and 2019

Author

Mertens, Alexander, primary, Essing, Tobias, additional, Minko, Peter, additional, Möllenhoff, Kathrin, additional, Mattes-György, Katalin, additional, Giesel, Frederik L., additional, Antoch, Gerald, additional, Luedde, Tom, additional, Roderburg, Christoph, additional, and Loosen, Sven H., additional

Published
2022
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36. Work and Training Conditions of German Residents and Young Radiologists in Interventional Radiology – A Nationwide Survey

Author

Sieren, Malte, additional, Katoh, Marcus, additional, Mahnken, Andreas H., additional, Reimer, Peter, additional, Westphalen, Kerstin, additional, Hoffmann, Ralf-Thorsten, additional, Paprottka, Philipp, additional, Rohde, Stefan, additional, Wacker, Frank K., additional, Minko, Peter, additional, Molwitz, Isabel, additional, Oechtering, Thekla Helene, additional, Afat, Saif, additional, Bucher, Andreas Michael, additional, Gerwing, Mirjam, additional, Storz, Corinna, additional, Ziegler, Henrike-Renate, additional, Barkhausen, Jörg, additional, and Frisch, Anne, additional

Published
2022
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40. Work and Training Conditions of German Residents and Young Radiologists in Interventional Radiology – A Nationwide Survey.

Author

Sieren, Malte, Katoh, Marcus, Mahnken, Andreas H., Reimer, Peter, Westphalen, Kerstin, Hoffmann, Ralf-Thorsten, Paprottka, Philipp, Rohde, Stefan, Wacker, Frank K., Minko, Peter, Molwitz, Isabel, Oechtering, Thekla Helene, Afat, Saif, Bucher, Andreas Michael, Gerwing, Mirjam, Storz, Corinna, Ziegler, Henrike-Renate, Barkhausen, Jörg, and Frisch, Anne

Published
2022
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