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1. Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Author

Dareng, Eileen O., Tyrer, Jonathan P., Barnes, Daniel R., Jones, Michelle R., Yang, Xin, Aben, Katja K. H., Adank, Muriel A., Agata, Simona, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Aravantinos, Gerasimos, Arun, Banu K., Augustinsson, Annelie, Balmaña, Judith, Bandera, Elisa V., Barkardottir, Rosa B., Barrowdale, Daniel, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q., Bjorge, Line, Black, Amanda, Bogdanova, Natalia V., Bonanni, Bernardo, Borg, Ake, Brenton, James D., Budzilowska, Agnieszka, Butzow, Ralf, Buys, Saundra S., Cai, Hui, Caligo, Maria A., Campbell, Ian, Cannioto, Rikki, Cassingham, Hayley, Chang-Claude, Jenny, Chanock, Stephen J., Chen, Kexin, Chiew, Yoke-Eng, Chung, Wendy K., Claes, Kathleen B. M., Colonna, Sarah, Cook, Linda S., Couch, Fergus J., Daly, Mary B., Dao, Fanny, Davies, Eleanor, de la Hoya, Miguel, de Putter, Robin, Dennis, Joe, DePersia, Allison, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer A., Domchek, Susan M., Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana M., Eliassen, Heather A., Engel, Christoph, Evans, Gareth D., Fasching, Peter A., Flanagan, James M., Fortner, Renée T., Machackova, Eva, Friedman, Eitan, Ganz, Patricia A., Garber, Judy, Gensini, Francesca, Giles, Graham G., Glendon, Gord, Godwin, Andrew K., Goodman, Marc T., Greene, Mark H., Gronwald, Jacek, Hahnen, Eric, Haiman, Christopher A., Håkansson, Niclas, Hamann, Ute, Hansen, Thomas V. O., Harris, Holly R., Hartman, Mikael, Heitz, Florian, Hildebrandt, Michelle A. T., Høgdall, Estrid, Høgdall, Claus K., Hopper, John L., Huang, Ruea-Yea, Huff, Chad, Hulick, Peter J., Huntsman, David G., Imyanitov, Evgeny N., Isaacs, Claudine, Jakubowska, Anna, James, Paul A., Janavicius, Ramunas, Jensen, Allan, Johannsson, Oskar Th., John, Esther M., Jones, Michael E., Kang, Daehee, Karlan, Beth Y., Karnezis, Anthony, Kelemen, Linda E., Khusnutdinova, Elza, Kiemeney, Lambertus A., Kim, Byoung-Gie, Kjaer, Susanne K., Komenaka, Ian, Kupryjanczyk, Jolanta, Kurian, Allison W., Kwong, Ava, Lambrechts, Diether, Larson, Melissa C., Lazaro, Conxi, Le, Nhu D., Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A., Li, Lian, Li, Jingmei, Loud, Jennifer T., Lu, Karen H., Lubiński, Jan, Mai, Phuong L., Manoukian, Siranoush, Marks, Jeffrey R., Matsuno, Rayna Kim, Matsuo, Keitaro, May, Taymaa, McGuffog, Lesley, McLaughlin, John R., McNeish, Iain A., Mebirouk, Noura, Menon, Usha, Miller, Austin, Milne, Roger L., Minlikeeva, Albina, Modugno, Francesmary, Montagna, Marco, Moysich, Kirsten B., Munro, Elizabeth, Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Yie, Joanne Ngeow Yuen, Nielsen, Henriette Roed, Nielsen, Finn C., Nikitina-Zake, Liene, Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olbrecht, Siel, Olopade, Olufunmilayo I., Olson, Sara H., Olsson, Håkan, Osorio, Ana, Papi, Laura, Park, Sue K., Parsons, Michael T., Pathak, Harsha, Pedersen, Inge Sokilde, Peixoto, Ana, Pejovic, Tanja, Perez-Segura, Pedro, Permuth, Jennifer B., Peshkin, Beth, Peterlongo, Paolo, Piskorz, Anna, Prokofyeva, Darya, Radice, Paolo, Rantala, Johanna, Riggan, Marjorie J., Risch, Harvey A., Rodriguez-Antona, Cristina, Ross, Eric, Rossing, Mary Anne, Runnebaum, Ingo, Sandler, Dale P., Santamariña, Marta, Soucy, Penny, Schmutzler, Rita K., Setiawan, V. Wendy, Shan, Kang, Sieh, Weiva, Simard, Jacques, Singer, Christian F., Sokolenko, Anna P., Song, Honglin, Southey, Melissa C., Steed, Helen, Stoppa-Lyonnet, Dominique, Sutphen, Rebecca, Swerdlow, Anthony J., Tan, Yen Yen, Teixeira, Manuel R., Teo, Soo Hwang, Terry, Kathryn L., Terry, Mary Beth, Thomassen, Mads, Thompson, Pamela J., Thomsen, Liv Cecilie Vestrheim, Thull, Darcy L., Tischkowitz, Marc, Titus, Linda, Toland, Amanda E., Torres, Diana, Trabert, Britton, Travis, Ruth, Tung, Nadine, Tworoger, Shelley S., Valen, Ellen, van Altena, Anne M., van der Hout, Annemieke H., Van Nieuwenhuysen, Els, van Rensburg, Elizabeth J., Vega, Ana, Edwards, Digna Velez, Vierkant, Robert A., Wang, Frances, Wappenschmidt, Barbara, Webb, Penelope M., Weinberg, Clarice R., Weitzel, Jeffrey N., Wentzensen, Nicolas, White, Emily, Whittemore, Alice S., Winham, Stacey J., Wolk, Alicja, Woo, Yin-Ling, Wu, Anna H., Yan, Li, Yannoukakos, Drakoulis, Zavaglia, Katia M., Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K., Kleibl, Zdenek, Easton, Douglas, Lawrenson, Kate, DeFazio, Anna, Sellers, Thomas A., Ramus, Susan J., Pearce, Celeste L., Monteiro, Alvaro N., Cunningham, Julie, Goode, Ellen L., Schildkraut, Joellen M., Berchuck, Andrew, Chenevix-Trench, Georgia, Gayther, Simon A., Antoniou, Antonis C., and Pharoah, Paul D. P.

Published
2022
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2. Abstract B037: Physical inactivity is associated with ovarian cancer in women of African ancestry

Author

Minlikeeva, Albina, primary, Lima, Sarah M., additional, Johnson, Courtney, additional, Bandera, Elisa V., additional, Beeghly-Fadiel, Alicia, additional, Bethea, Traci N., additional, Petrick, Jessica, additional, Joslin, Charlotte E., additional, Myers, Evan, additional, Harris, Holly R., additional, Peres, Lauren C., additional, Setiawan, V. Wendy, additional, Wu, Anna H., additional, Rosenberg, Lynn, additional, Schildkraut, Joellen M., additional, and Ochs-Balcom, Heather M., additional

Published
2024
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3. History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium

Author

Minlikeeva, Albina N, Freudenheim, Jo L, Eng, Kevin H, Cannioto, Rikki A, Friel, Grace, Szender, J Brian, Segal, Brahm, Odunsi, Kunle, Mayor, Paul, Diergaarde, Brenda, Zsiros, Emese, Kelemen, Linda E, Köbel, Martin, Steed, Helen, deFazio, Anna, Jordan, Susan J, Fasching, Peter A, Beckmann, Matthias W, Risch, Harvey A, Rossing, Mary Anne, Doherty, Jennifer A, Chang-Claude, Jenny, Goodman, Marc T, Dörk, Thilo, Edwards, Robert, Modugno, Francesmary, Ness, Roberta B, Matsuo, Keitaro, Mizuno, Mika, Karlan, Beth Y, Goode, Ellen L, Kjær, Susanne K, Høgdall, Estrid, Schildkraut, Joellen M, Terry, Kathryn L, Cramer, Daniel W, Bandera, Elisa V, Paddock, Lisa E, Kiemeney, Lambertus A, Massuger, Leon FAG, Sutphen, Rebecca, Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Gayther, Simon A, Ramus, Susan J, Gentry-Maharaj, Aleksandra, Pearce, Celeste L, Wu, Anna H, Kupryjanczyk, Jolanta, Jensen, Allan, Webb, Penelope M, and Moysich, Kirsten B

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Oncology and Carcinogenesis, Digestive Diseases, Rare Diseases, Liver Disease, Ovarian Cancer, Clinical Research, Cancer, Aging, Osteoporosis, Aetiology, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, 2.1 Biological and endogenous factors, Comorbidity, Disease-Free Survival, Female, Humans, Ovarian Neoplasms, Survival Analysis, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract

Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in ovarian cancer patients.Methods: Among patients diagnosed with invasive ovarian carcinoma who participated in 23 studies included in the Ovarian Cancer Association Consortium, we explored associations between histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, and neurological diseases and overall and progression-free survival. Using Cox proportional hazards regression models adjusted for age at diagnosis, stage of disease, histology, and study site, we estimated pooled HRs and 95% confidence intervals to assess associations between each comorbidity and ovarian cancer outcomes.Results: None of the comorbidities were associated with ovarian cancer outcome in the overall sample nor in strata defined by histologic subtype, weight status, age at diagnosis, or stage of disease (local/regional vs. advanced).Conclusions: Histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, or neurologic diseases were not associated with ovarian cancer overall or progression-free survival.Impact: These previously diagnosed chronic diseases do not appear to affect ovarian cancer prognosis. Cancer Epidemiol Biomarkers Prev; 26(9); 1470-3. ©2017 AACR.

Published
2017

4. History of hypertension, heart disease, and diabetes and ovarian cancer patient survival: evidence from the ovarian cancer association consortium

Author

Minlikeeva, Albina N, Freudenheim, Jo L, Cannioto, Rikki A, Szender, J Brian, Eng, Kevin H, Modugno, Francesmary, Ness, Roberta B, LaMonte, Michael J, Friel, Grace, Segal, Brahm H, Odunsi, Kunle, Mayor, Paul, Zsiros, Emese, Schmalfeldt, Barbara, Klapdor, Rüdiger, Dӧrk, Thilo, Hillemanns, Peter, Kelemen, Linda E, Kӧbel, Martin, Steed, Helen, de Fazio, Anna, on behalf of the Australian Ovarian Cancer Study Group, Jordan, Susan J, Nagle, Christina M, Risch, Harvey A, Rossing, Mary Anne, Doherty, Jennifer A, Goodman, Marc T, Edwards, Robert, Matsuo, Keitaro, Mizuno, Mika, Karlan, Beth Y, Kjær, Susanne K, Høgdall, Estrid, Jensen, Allan, Schildkraut, Joellen M, Terry, Kathryn L, Cramer, Daniel W, Bandera, Elisa V, Paddock, Lisa E, Kiemeney, Lambertus A, Massuger, Leon F, Kupryjanczyk, Jolanta, Berchuck, Andrew, Chang-Claude, Jenny, Diergaarde, Brenda, Webb, Penelope M, Moysich, Kirsten B, and on behalf of the Ovarian Cancer Association Consortium

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Oncology and Carcinogenesis, Clinical Research, Cancer, Diabetes, Ovarian Cancer, Rare Diseases, Genetics, Cardiovascular, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Adrenergic beta-Antagonists, Adult, Aged, Diabetes Mellitus, Disease-Free Survival, Female, Heart Diseases, Humans, Hypertension, Hypoglycemic Agents, Insulin, Middle Aged, Ovarian Neoplasms, Risk, Survival Rate, Ovarian cancer prognosis, Medications, Mortality, Beta blockers, Australian Ovarian Cancer Study Group, Ovarian Cancer Association Consortium, Public Health and Health Services, Oncology and carcinogenesis
Abstract

PurposeSurvival following ovarian cancer diagnosis is generally low; understanding factors related to prognosis could be important to optimize treatment. The role of previously diagnosed comorbidities and use of medications for those conditions in relation to prognosis for ovarian cancer patients has not been studied extensively, particularly according to histological subtype.MethodsUsing pooled data from fifteen studies participating in the Ovarian Cancer Association Consortium, we examined the associations between history of hypertension, heart disease, diabetes, and medications taken for these conditions and overall survival (OS) and progression-free survival (PFS) among patients diagnosed with invasive epithelial ovarian carcinoma. We used Cox proportional hazards regression models adjusted for age and stage to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) overall and within strata of histological subtypes.ResultsHistory of diabetes was associated with increased risk of mortality (n = 7,674; HR = 1.12; 95% CI = 1.01-1.25). No significant mortality associations were observed for hypertension (n = 6,482; HR = 0.95; 95% CI = 0.88-1.02) or heart disease (n = 4,252; HR = 1.05; 95% CI = 0.87-1.27). No association of these comorbidities was found with PFS in the overall study population. However, among patients with endometrioid tumors, hypertension was associated with lower risk of progression (n = 339, HR = 0.54; 95% CI = 0.35-0.84). Comorbidity was not associated with OS or PFS for any of the other histological subtypes. Ever use of beta blockers, oral antidiabetic medications, and insulin was associated with increased mortality, HR = 1.20; 95% CI = 1.03-1.40, HR = 1.28; 95% CI = 1.05-1.55, and HR = 1.63; 95% CI = 1.20-2.20, respectively. Ever use of diuretics was inversely associated with mortality, HR = 0.71; 95% CI = 0.53-0.94.ConclusionsHistories of hypertension, diabetes, and use of diuretics, beta blockers, insulin, and oral antidiabetic medications may influence the survival of ovarian cancer patients. Understanding mechanisms for these observations could provide insight regarding treatment.

Published
2017

5. No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival

Author

Sucheston-Campbell, Lara E, Cannioto, Rikki, Clay, Alyssa I, Etter, John Lewis, Eng, Kevin H, Liu, Song, Battaglia, Sebastiano, Hu, Qiang, Szender, J Brian, Minlikeeva, Albina, Joseph, Janine M, Mayor, Paul, Abrams, Scott I, Segal, Brahm H, Wallace, Paul K, Soh, Kah Teong, Zsiros, Emese, Anton-Culver, Hoda, Bandera, Elisa V, Beckmann, Matthias W, Berchuck, Andrew, Bjorge, Line, Bruegl, Amanda, Campbell, Ian G, Campbell, Shawn Patrice, Chenevix-Trench, Georgia, Study, on behalf of the Australian Ovarian Cancer, Cramer, Daniel W, Dansonka-Mieszkowska, Agnieszka, Dao, Fanny, Diergaarde, Brenda, Doerk, Thilo, Doherty, Jennifer A, du Bois, Andreas, Eccles, Diana, Engelholm, Svend Aage, Fasching, Peter A, Gayther, Simon A, Gentry-Maharaj, Aleksandra, Glasspool, Rosalind M, Goodman, Marc T, Gronwald, Jacek, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hillemmanns, Peter, Høgdall, Claus, Høgdall, Estrid VS, Huzarski, Tomasz, Jensen, Allan, Johnatty, Sharon E, Jung, Audrey, Karlan, Beth Y, Klapdor, Reudiger, Kluz, Tomasz, Konopka, Bożena, Kjær, Susanne Krüger, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lester, Jenny, Lubiński, Jan, Levine, Douglas A, Lundvall, Lene, McGuire, Valerie, McNeish, Iain A, Menon, Usha, Modugno, Francesmary, Ness, Roberta B, Orsulic, Sandra, Paul, James, Pearce, Celeste Leigh, Pejovic, Tanja, Pharoah, Paul, Ramus, Susan J, Rothstein, Joseph, Rossing, Mary Anne, Rübner, Matthias, Schildkraut, Joellen M, Schmalfeldt, Barbara, Schwaab, Ira, Siddiqui, Nadeem, Sieh, Weiva, Sobiczewski, Piotr, Song, Honglin, Terry, Kathryn L, Van Nieuwenhuysen, Els, Vanderstichele, Adriaan, Vergote, Ignace, Walsh, Christine S, Webb, Penelope M, Wentzensen, Nicolas, Whittemore, Alice S, Wu, Anna H, Ziogas, Argyrios, Odunsi, Kunle, Chang-Claude, Jenny, Goode, Ellen L, and Moysich, Kirsten B

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Clinical Research, Cancer, Ovarian Cancer, Rare Diseases, Prevention, Genetics, Genetic Testing, 2.1 Biological and endogenous factors, Aetiology, Carcinoma, Ovarian Epithelial, Female, Genetic Association Studies, Genetic Variation, Humans, Myeloid-Derived Suppressor Cells, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Australian Ovarian Cancer Study, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract

Background: The precise mechanism by which the immune system is adversely affected in cancer patients remains poorly understood, but the accumulation of immunosuppressive/protumorigenic myeloid-derived suppressor cells (MDSCs) is thought to be a prominent mechanism contributing to immunologic tolerance of malignant cells in epithelial ovarian cancer (EOC). To this end, we hypothesized genetic variation in MDSC pathway genes would be associated with survival after EOC diagnoses.Methods: We measured the hazard of death due to EOC within 10 years of diagnosis, overall and by invasive subtype, attributable to SNPs in 24 genes relevant in the MDSC pathway in 10,751 women diagnosed with invasive EOC. Versatile Gene-based Association Study and the admixture likelihood method were used to test gene and pathway associations with survival.Results: We did not identify individual SNPs that were significantly associated with survival after correction for multiple testing (P < 3.5 × 10-5), nor did we identify significant associations between the MDSC pathway overall, or the 24 individual genes and EOC survival.Conclusions: In this well-powered analysis, we observed no evidence that inherited variations in MDSC-associated SNPs, individual genes, or the collective genetic pathway contributed to EOC survival outcomes.Impact: Common inherited variation in genes relevant to MDSCs was not associated with survival in women diagnosed with invasive EOC. Cancer Epidemiol Biomarkers Prev; 26(3); 420-4. ©2016 AACR.

Published
2017

6. Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Author

Dareng, Eileen O., Tyrer, Jonathan P., Barnes, Daniel R., Jones, Michelle R., Yang, Xin, Aben, Katja K. H., Adank, Muriel A., Agata, Simona, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Aravantinos, Gerasimos, Arun, Banu K., Augustinsson, Annelie, Balmaña, Judith, Bandera, Elisa V., Barkardottir, Rosa B., Barrowdale, Daniel, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q., Bjorge, Line, Black, Amanda, Bogdanova, Natalia V., Bonanni, Bernardo, Borg, Ake, Brenton, James D., Budzilowska, Agnieszka, Butzow, Ralf, Buys, Saundra S., Cai, Hui, Caligo, Maria A., Campbell, Ian, Cannioto, Rikki, Cassingham, Hayley, Chang-Claude, Jenny, Chanock, Stephen J., Chen, Kexin, Chiew, Yoke-Eng, Chung, Wendy K., Claes, Kathleen B. M., Colonna, Sarah, Cook, Linda S., Couch, Fergus J., Daly, Mary B., Dao, Fanny, Davies, Eleanor, de la Hoya, Miguel, de Putter, Robin, Dennis, Joe, DePersia, Allison, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer A., Domchek, Susan M., Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana M., Eliassen, Heather A., Engel, Christoph, Evans, Gareth D., Fasching, Peter A., Flanagan, James M., Fortner, Renée T., Machackova, Eva, Friedman, Eitan, Ganz, Patricia A., Garber, Judy, Gensini, Francesca, Giles, Graham G., Glendon, Gord, Godwin, Andrew K., Goodman, Marc T., Greene, Mark H., Gronwald, Jacek, Hahnen, Eric, Haiman, Christopher A., Håkansson, Niclas, Hamann, Ute, Hansen, Thomas V. O., Harris, Holly R., Hartman, Mikael, Heitz, Florian, Hildebrandt, Michelle A. T., Høgdall, Estrid, Høgdall, Claus K., Hopper, John L., Huang, Ruea-Yea, Huff, Chad, Hulick, Peter J., Huntsman, David G., Imyanitov, Evgeny N., Isaacs, Claudine, Jakubowska, Anna, James, Paul A., Janavicius, Ramunas, Jensen, Allan, Johannsson, Oskar Th., John, Esther M., Jones, Michael E., Kang, Daehee, Karlan, Beth Y., Karnezis, Anthony, Kelemen, Linda E., Khusnutdinova, Elza, Kiemeney, Lambertus A., Kim, Byoung-Gie, Kjaer, Susanne K., Komenaka, Ian, Kupryjanczyk, Jolanta, Kurian, Allison W., Kwong, Ava, Lambrechts, Diether, Larson, Melissa C., Lazaro, Conxi, Le, Nhu D., Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A., Li, Lian, Li, Jingmei, Loud, Jennifer T., Lu, Karen H., Lubiński, Jan, Mai, Phuong L., Manoukian, Siranoush, Marks, Jeffrey R., Matsuno, Rayna Kim, Matsuo, Keitaro, May, Taymaa, McGuffog, Lesley, McLaughlin, John R., McNeish, Iain A., Mebirouk, Noura, Menon, Usha, Miller, Austin, Milne, Roger L., Minlikeeva, Albina, Modugno, Francesmary, Montagna, Marco, Moysich, Kirsten B., Munro, Elizabeth, Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Yie, Joanne Ngeow Yuen, Nielsen, Henriette Roed, Nielsen, Finn C., Nikitina-Zake, Liene, Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olbrecht, Siel, Olopade, Olufunmilayo I., Olson, Sara H., Olsson, Håkan, Osorio, Ana, Papi, Laura, Park, Sue K., Parsons, Michael T., Pathak, Harsha, Pedersen, Inge Sokilde, Peixoto, Ana, Pejovic, Tanja, Perez-Segura, Pedro, Permuth, Jennifer B., Peshkin, Beth, Peterlongo, Paolo, Piskorz, Anna, Prokofyeva, Darya, Radice, Paolo, Rantala, Johanna, Riggan, Marjorie J., Risch, Harvey A., Rodriguez-Antona, Cristina, Ross, Eric, Rossing, Mary Anne, Runnebaum, Ingo, Sandler, Dale P., Santamariña, Marta, Soucy, Penny, Schmutzler, Rita K., Setiawan, V. Wendy, Shan, Kang, Sieh, Weiva, Simard, Jacques, Singer, Christian F., Sokolenko, Anna P., Song, Honglin, Southey, Melissa C., Steed, Helen, Stoppa-Lyonnet, Dominique, Sutphen, Rebecca, Swerdlow, Anthony J., Tan, Yen Yen, Teixeira, Manuel R., Teo, Soo Hwang, Terry, Kathryn L., Terry, Mary Beth, Thomassen, Mads, Thompson, Pamela J., Thomsen, Liv Cecilie Vestrheim, Thull, Darcy L., Tischkowitz, Marc, Titus, Linda, Toland, Amanda E., Torres, Diana, Trabert, Britton, Travis, Ruth, Tung, Nadine, Tworoger, Shelley S., Valen, Ellen, van Altena, Anne M., van der Hout, Annemieke H., Van Nieuwenhuysen, Els, van Rensburg, Elizabeth J., Vega, Ana, Edwards, Digna Velez, Vierkant, Robert A., Wang, Frances, Wappenschmidt, Barbara, Webb, Penelope M., Weinberg, Clarice R., Weitzel, Jeffrey N., Wentzensen, Nicolas, White, Emily, Whittemore, Alice S., Winham, Stacey J., Wolk, Alicja, Woo, Yin-Ling, Wu, Anna H., Yan, Li, Yannoukakos, Drakoulis, Zavaglia, Katia M., Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K., Kleibl, Zdenek, Easton, Douglas, Lawrenson, Kate, DeFazio, Anna, Sellers, Thomas A., Ramus, Susan J., Pearce, Celeste L., Monteiro, Alvaro N., Cunningham, Julie, Goode, Ellen L., Schildkraut, Joellen M., Berchuck, Andrew, Chenevix-Trench, Georgia, Gayther, Simon A., Antoniou, Antonis C., and Pharoah, Paul D. P.

Published
2022
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7. Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium

Author

Minlikeeva, Albina N., Cannioto, Rikki, Jensen, Allan, Kjaer, Susanne K., Jordan, Susan J., Diergaarde, Brenda, Szender, J. Brian, Odunsi, Kunle, Almohanna, Hani, Mayor, Paul, Starbuck, Kirsten, Zsiros, Emese, Bandera, Elisa V., Cramer, Daniel W., Doherty, Jennifer A., DeFazio, Anna, Edwards, Robert, Goode, Ellen L., Goodman, Marc T., Høgdall, Estrid, Matsuo, Keitary, Mizuno, Mika, Nagle, Christina M., Ness, Roberta B., Paddock, Lisa E., Pearce, Celeste L., Risch, Harvey A., Rossing, Mary Anne, Terry, Kathryn L., Wu, Anna H., Modugno, Francesmary, Webb, Penelope M., and Moysich, Kirsten B.

Published
2019

8. Anthropometric characteristics and ovarian cancer risk and survival

Author

Minlikeeva, Albina N., Moysich, Kirsten B., Mayor, Paul C., Etter, John L., Cannioto, Rikki A., Ness, Roberta B., Starbuck, Kristen, Edwards, Robert P., Segal, Brahm H., Lele, Sashikant, Odunsi, Kunle, Diergaarde, Brenda, and Modugno, Francesmary

Published
2018

10. Supplemental Tables S1-S4 from Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

Author

Cannioto, Rikki, primary, LaMonte, Michael J., primary, Risch, Harvey A., primary, Hong, Chi-Chen, primary, Sucheston-Campbell, Lara E., primary, Eng, Kevin H., primary, Brian Szender, J., primary, Chang-Claude, Jenny, primary, Schmalfeldt, Barbara, primary, Klapdor, Ruediger, primary, Gower, Emily, primary, Minlikeeva, Albina N., primary, Zirpoli, Gary R., primary, Bandera, Elisa V., primary, Berchuck, Andrew, primary, Cramer, Daniel, primary, Doherty, Jennifer A., primary, Edwards, Robert P., primary, Fridley, Brooke L., primary, Goode, Ellen L., primary, Goodman, Marc T., primary, Hogdall, Estrid, primary, Hosono, Satoyo, primary, Jensen, Allan, primary, Jordan, Susan, primary, Kjaer, Susanne K., primary, Matsuo, Keitaro, primary, Ness, Roberta B., primary, Olsen, Catherine M., primary, Olson, Sara H., primary, Leigh Pearce, Celeste, primary, Pike, Malcolm C., primary, Anne Rossing, Mary, primary, Szamreta, Elizabeth A., primary, Thompson, Pamela J., primary, Tseng, Chiu-Chen, primary, Vierkant, Robert A., primary, Webb, Penelope M., primary, Wentzensen, Nicolas, primary, Wicklund, Kristine G., primary, Winham, Stacey J., primary, Wu, Anna H., primary, Modugno, Francesmary, primary, Schildkraut, Joellen M., primary, Terry, Kathryn L., primary, Kelemen, Linda E., primary, and Moysich, Kirsten B., primary

Published
2023
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11. Data from Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

Author

Cannioto, Rikki, primary, LaMonte, Michael J., primary, Risch, Harvey A., primary, Hong, Chi-Chen, primary, Sucheston-Campbell, Lara E., primary, Eng, Kevin H., primary, Brian Szender, J., primary, Chang-Claude, Jenny, primary, Schmalfeldt, Barbara, primary, Klapdor, Ruediger, primary, Gower, Emily, primary, Minlikeeva, Albina N., primary, Zirpoli, Gary R., primary, Bandera, Elisa V., primary, Berchuck, Andrew, primary, Cramer, Daniel, primary, Doherty, Jennifer A., primary, Edwards, Robert P., primary, Fridley, Brooke L., primary, Goode, Ellen L., primary, Goodman, Marc T., primary, Hogdall, Estrid, primary, Hosono, Satoyo, primary, Jensen, Allan, primary, Jordan, Susan, primary, Kjaer, Susanne K., primary, Matsuo, Keitaro, primary, Ness, Roberta B., primary, Olsen, Catherine M., primary, Olson, Sara H., primary, Leigh Pearce, Celeste, primary, Pike, Malcolm C., primary, Anne Rossing, Mary, primary, Szamreta, Elizabeth A., primary, Thompson, Pamela J., primary, Tseng, Chiu-Chen, primary, Vierkant, Robert A., primary, Webb, Penelope M., primary, Wentzensen, Nicolas, primary, Wicklund, Kristine G., primary, Winham, Stacey J., primary, Wu, Anna H., primary, Modugno, Francesmary, primary, Schildkraut, Joellen M., primary, Terry, Kathryn L., primary, Kelemen, Linda E., primary, and Moysich, Kirsten B., primary

Published
2023
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12. Supplemental Table 1 from History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium

Author

Minlikeeva, Albina N., primary, Freudenheim, Jo L., primary, Eng, Kevin H., primary, Cannioto, Rikki A., primary, Friel, Grace, primary, Szender, J. Brian, primary, Segal, Brahm, primary, Odunsi, Kunle, primary, Mayor, Paul, primary, Diergaarde, Brenda, primary, Zsiros, Emese, primary, Kelemen, Linda E., primary, Köbel, Martin, primary, Steed, Helen, primary, deFazio, Anna, primary, Jordan, Susan J., primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Risch, Harvey A., primary, Rossing, Mary Anne, primary, Doherty, Jennifer A., primary, Chang-Claude, Jenny, primary, Goodman, Marc T., primary, Dörk, Thilo, primary, Edwards, Robert, primary, Modugno, Francesmary, primary, Ness, Roberta B., primary, Matsuo, Keitaro, primary, Mizuno, Mika, primary, Karlan, Beth Y., primary, Goode, Ellen L., primary, Kjær, Susanne K., primary, Høgdall, Estrid, primary, Schildkraut, Joellen M., primary, Terry, Kathryn L., primary, Cramer, Daniel W., primary, Bandera, Elisa V., primary, Paddock, Lisa E., primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Sutphen, Rebecca, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Menon, Usha, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Gentry-Maharaj, Aleksandra, primary, Pearce, Celeste L., primary, Wu, Anna H., primary, Kupryjanczyk, Jolanta, primary, Jensen, Allan, primary, Webb, Penelope M., primary, and Moysich, Kirsten B., primary

Published
2023
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13. Data from History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium

Author

Minlikeeva, Albina N., primary, Freudenheim, Jo L., primary, Eng, Kevin H., primary, Cannioto, Rikki A., primary, Friel, Grace, primary, Szender, J. Brian, primary, Segal, Brahm, primary, Odunsi, Kunle, primary, Mayor, Paul, primary, Diergaarde, Brenda, primary, Zsiros, Emese, primary, Kelemen, Linda E., primary, Köbel, Martin, primary, Steed, Helen, primary, deFazio, Anna, primary, Jordan, Susan J., primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Risch, Harvey A., primary, Rossing, Mary Anne, primary, Doherty, Jennifer A., primary, Chang-Claude, Jenny, primary, Goodman, Marc T., primary, Dörk, Thilo, primary, Edwards, Robert, primary, Modugno, Francesmary, primary, Ness, Roberta B., primary, Matsuo, Keitaro, primary, Mizuno, Mika, primary, Karlan, Beth Y., primary, Goode, Ellen L., primary, Kjær, Susanne K., primary, Høgdall, Estrid, primary, Schildkraut, Joellen M., primary, Terry, Kathryn L., primary, Cramer, Daniel W., primary, Bandera, Elisa V., primary, Paddock, Lisa E., primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Sutphen, Rebecca, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Menon, Usha, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Gentry-Maharaj, Aleksandra, primary, Pearce, Celeste L., primary, Wu, Anna H., primary, Kupryjanczyk, Jolanta, primary, Jensen, Allan, primary, Webb, Penelope M., primary, and Moysich, Kirsten B., primary

Published
2023
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16. Design and Implementation of a Course to Meet the Demand for a Skilled Public Health Workforce to Address the Needs of People With Disabilities.

Author

Minlikeeva, Albina N. and Przybyla, Sarahmona

Subjects
*STUDENTS with disabilities, *PEOPLE with disabilities, *PUBLIC health education, *PUBLIC health, *SOCIAL determinants of health, *LABOR supply, *MEDICAL personnel
Abstract

People with disabilities experience a higher burden of chronic diseases compared to people with no disabilities. To emphasize the importance of addressing health-related disparities affecting this population, multiple objectives of Healthy People 2030 focus on people with disabilities. Accomplishing these objectives requires a culturally competent public health workforce knowledgeable about the health issues and health-related factors affecting people with disabilities and evidence-based public health strategies for effective interventions. To prepare future public health professionals to be a part of efforts of diversity, equity, and inclusion, we developed and implemented a course on disability which was offered as an upper-level elective to students pursuing undergraduate training in public health. We structured the course around selected objectives of Healthy People 2030 and evidence-based strategies mapped to these objectives. The course framework allows for the development of proficiency and competency in these areas through learning about the basic disability-related terms, health issues, health-related behaviors, and social determinants of health affecting people with disabilities. We also aligned the course with the specific accreditation criteria outlined by the Council on Education for Public Health and disability competencies. There is an urgent need for future public health professionals to understand the challenges experienced by people with disabilities and be able to address them. Designing and implementing courses meeting the accreditation criteria and aligned with the national public health objectives could help strengthen the appropriate knowledge and skills of the future public health workforce. [ABSTRACT FROM AUTHOR]

Published
2024
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20. No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival

Author

Sucheston-Campbell, Lara E., primary, Cannioto, Rikki, additional, Clay, Alyssa I., additional, Etter, John Lewis, additional, Eng, Kevin H., additional, Liu, Song, additional, Battaglia, Sebastiano, additional, Hu, Qiang, additional, Szender, J. Brian, additional, Minlikeeva, Albina, additional, Joseph, Janine M., additional, Mayor, Paul, additional, Abrams, Scott I., additional, Segal, Brahm H., additional, Wallace, Paul K., additional, Soh, Kah Teong, additional, Zsiros, Emese, additional, Anton-Culver, Hoda, additional, Bandera, Elisa V., additional, Beckmann, Matthias W., additional, Berchuck, Andrew, additional, Bjorge, Line, additional, Bruegl, Amanda, additional, Campbell, Ian G., additional, Campbell, Shawn Patrice, additional, Chenevix-Trench, Georgia, additional, Cramer, Daniel W., additional, Dansonka-Mieszkowska, Agnieszka, additional, Dao, Fanny, additional, Diergaarde, Brenda, additional, Doerk, Thilo, additional, Doherty, Jennifer A., additional, du Bois, Andreas, additional, Eccles, Diana, additional, Engelholm, Svend Aage, additional, Fasching, Peter A., additional, Gayther, Simon A., additional, Gentry-Maharaj, Aleksandra, additional, Glasspool, Rosalind M., additional, Goodman, Marc T., additional, Gronwald, Jacek, additional, Harter, Philipp, additional, Hein, Alexander, additional, Heitz, Florian, additional, Hillemmanns, Peter, additional, Høgdall, Claus, additional, Høgdall, Estrid V.S., additional, Huzarski, Tomasz, additional, Jensen, Allan, additional, Johnatty, Sharon E., additional, Jung, Audrey, additional, Karlan, Beth Y., additional, Klapdor, Reudiger, additional, Kluz, Tomasz, additional, Konopka, Bożena, additional, Kjær, Susanne Krüger, additional, Kupryjanczyk, Jolanta, additional, Lambrechts, Diether, additional, Lester, Jenny, additional, Lubiński, Jan, additional, Levine, Douglas A., additional, Lundvall, Lene, additional, McGuire, Valerie, additional, McNeish, Iain A., additional, Menon, Usha, additional, Modugno, Francesmary, additional, Ness, Roberta B., additional, Orsulic, Sandra, additional, Paul, James, additional, Pearce, Celeste Leigh, additional, Pejovic, Tanja, additional, Pharoah, Paul, additional, Ramus, Susan J., additional, Rothstein, Joseph, additional, Rossing, Mary Anne, additional, Rübner, Matthias, additional, Schildkraut, Joellen M., additional, Schmalfeldt, Barbara, additional, Schwaab, Ira, additional, Siddiqui, Nadeem, additional, Sieh, Weiva, additional, Sobiczewski, Piotr, additional, Song, Honglin, additional, Terry, Kathryn L., additional, Van Nieuwenhuysen, Els, additional, Vanderstichele, Adriaan, additional, Vergote, Ignace, additional, Walsh, Christine S., additional, Webb, Penelope M., additional, Wentzensen, Nicolas, additional, Whittemore, Alice S., additional, Wu, Anna H., additional, Ziogas, Argyrios, additional, Odunsi, Kunle, additional, Chang-Claude, Jenny, additional, Goode, Ellen L., additional, and Moysich, Kirsten B., additional

Published
2016
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21. Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk

Author

Cannioto, Rikki, primary, LaMonte, Michael J., additional, Risch, Harvey A., additional, Hong, Chi-Chen, additional, Sucheston-Campbell, Lara E., additional, Eng, Kevin H., additional, Szender, J. Brian, additional, Chang-Claude, Jenny, additional, Schmalfeldt, Barbara, additional, Klapdor, Ruediger, additional, Gower, Emily, additional, Minlikeeva, Albina N., additional, Zirpoli, Gary, additional, Bandera, Elisa V., additional, Berchuck, Andrew, additional, Cramer, Daniel, additional, Doherty, Jennifer A., additional, Edwards, Robert P., additional, Fridley, Brooke L., additional, Goode, Ellen L., additional, Goodman, Marc T., additional, Hogdall, Estrid, additional, Hosono, Satoyo, additional, Jensen, Allan, additional, Jordan, Susan, additional, Kjaer, Susanne K., additional, Matsuo, Keitaro, additional, Ness, Roberta B., additional, Olsen, Catherine M., additional, Olson, Sara H., additional, Pearce, Celeste Leigh, additional, Pike, Malcolm C., additional, Rossing, Mary Anne, additional, Szamreta, Elizabeth A., additional, Thompson, Pamela J., additional, Tseng, Chiu-Chen, additional, Vierkant, Robert A., additional, Webb, Penelope M., additional, Wentzensen, Nicolas, additional, Wicklund, Kristine G., additional, Winham, Stacey J., additional, Wu, Anna H., additional, Modugno, Francesmary, additional, Schildkraut, Joellen M., additional, Terry, Kathryn L., additional, Kelemen, Linda E., additional, and Moysich, Kirsten B., additional

Published
2016
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22. Impact of Physical Inactivity on Risk of Developing Cancer of the Uterine Cervix: A Case-Control Study

Author

Szender, James Brian, primary, Cannioto, Rikki, additional, Gulati, Nicolas R., additional, Schmitt, Kristina L., additional, Friel, Grace, additional, Minlikeeva, Albina, additional, Platek, Alexis, additional, Gower, Emily H., additional, Nagy, Ryan, additional, Khachatryan, Edgar, additional, Mayor, Paul C., additional, Kasza, Karin A., additional, Lele, Shashikant B., additional, Odunsi, Kunle, additional, and Moysich, Kirsten B., additional

Published
2016
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25. Use of Common Analgesics Is Not Associated with Ovarian Cancer Survival

Author

Minlikeeva, Albina N., primary, Freudenheim, Jo L., additional, Lo-Ciganic, Wei-Hsuan, additional, Eng, Kevin H., additional, Friel, Grace, additional, Diergaarde, Brenda, additional, Modugno, Francesmary, additional, Cannioto, Rikki, additional, Gower, Emily, additional, Szender, J. Brian, additional, Grzankowski, Kassondra, additional, Odunsi, Kunle, additional, Ness, Roberta B., additional, and Moysich, Kirsten B., additional

Published
2015
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26. History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.

Author

Minlikeeva, Albina N, Freudenheim, Jo L, Cannioto, Rikki A, Eng, Kevin H, Szender, J Brian, Mayor, Paul, Etter, John L, Cramer, Daniel W, Diergaarde, Brenda, Doherty, Jennifer A, Dörk, Thilo, Edwards, Robert, deFazio, Anna, Friel, Grace, Goodman, Marc T, Hillemanns, Peter, Høgdall, Estrid, Jensen, Allan, Jordan, Susan J, and Karlan, Beth Y

Subjects
*HYPERTHYROIDISM, *HYPOTHYROIDISM, *OVARIAN tumors, *RESEARCH funding, *SURVIVAL, *TIME, *PROPORTIONAL hazards models
Abstract

Background: Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited.Methods: We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Using multivariate Cox proportional hazards models, we estimated associations between hyper- and hypothyroidism and medications prescribed for these conditions with 5-year all-cause survival among women diagnosed with invasive ovarian cancer.Results: Overall, there was a nonsignificant association with history of hyperthyroidism (n=160 cases) and mortality (HR=1.22; 95% CI=0.97-1.53). Furthermore, diagnosis of hyperthyroidism within the 5 years before ovarian cancer diagnosis was associated with an increased risk of death (HR=1.94; 95% CI=1.19-3.18). A more modest association was observed with history of hypothyroidism (n=624 cases) and mortality (HR=1.16; 95% CI=1.03-1.31). Neither duration of hypothyroidism nor use of thyroid medications was associated with survival.Conclusions: In this large study of women with ovarian cancer, we found that recent history of hyperthyroidism and overall history of hypothyroidism were associated with worse 5-year survival. [ABSTRACT FROM AUTHOR]

Published
2017
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27. Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium.

Author

Cannioto, Rikki, LaMonte, Michael J., Risch, Harvey A., Chi-Chen Hong, Sucheston-Campbell, Lara E., Eng, Kevin H., Szender, J. Brian, Chang-Claude, Jenny, Schmalfeldt, Barbara, Klapdor, Ruediger, Gower, Emily, Minlikeeva, Albina N., Zirpoli, Gary R., Bandera, Elisa V., Berchuck, Andrew, Cramer, Daniel, Doherty, Jennifer A., Edwards, Robert P., Fridley, Brooke L., and Goode, Ellen L.

Abstract

Background: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between recreational physical inactivity andEOCrisk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium to investigate the association between chronic recreational physical inactivity and EOC risk. Methods: In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the ORs and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race, and body mass index. Results: The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR = 1.34; 95% CI, 1.14-1.57), and similar associations were observed for each histotype. Conclusions: In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes. Impact: These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease. [ABSTRACT FROM AUTHOR]

Published
2016
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28. Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.

Author

Cannioto, Rikki A, LaMonte, Michael J, Kelemen, Linda E, Risch, Harvey A, Eng, Kevin H, Minlikeeva, Albina N, Hong, Chi-Chen, Szender, J Brian, Sucheston-Campbell, Lara, Joseph, Janine M, Berchuck, Andrew, Chang-Claude, Jenny, Cramer, Daniel W, DeFazio, Anna, Diergaarde, Brenda, Dörk, Thilo, Doherty, Jennifer A, Edwards, Robert P, Fridley, Brooke L, and Friel, Grace

Subjects
EPITHELIAL cell tumors, EXERCISE, OVARIAN tumors, RECREATION, RESEARCH funding, PROPORTIONAL hazards models
Abstract

Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality.Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years.Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively.Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC. [ABSTRACT FROM AUTHOR]

Published
2016
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29. Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk

Author

Dareng, Eileen O, Tyrer, Jonathan, Barnes, Daniel, Jones, Michelle R, Yang, Xin, Aben, Katja KH, Adank, Muriel A, Agata, Simona, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Aravantinos, Gerasimos, Arun, Banu K, Augustinsson, Annelie, Balma��a, Judith, Bandera, Elisa V, Barkardottir, Rosa B, Barrowdale, Daniel, Beckmann, Matthias W, Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q, Bjorge, Line, Black, Amanda, Bogdanova, Natalia V, Bonanni, Bernardo, Borg, Ake, Brenton, James, Budzilowska, Agnieszka, Butzow, Ralf, Buys, Saundra S, Cai, Hui, Caligo, Maria A, Campbell, Ian, Cannioto, Rikki, Cassingham, Hayley, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Kexin, Chiew, Yoke-Eng, Chung, Wendy K, Claes, Kathleen BM, Colanna, Sarah, Cook, Linda S, Couch, Fergus J, Daly, Mary B, Dao, Fanny, Davies, Eleanor, De La Hoya, Miguel, Putter, Robin De, Dennis, Joe, DePersia, Allison, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer A, Domchek, Susan M, D��rk, Thilo, Bois, Andreas Du, D��rst, Matthias, Eccles, Diana M, Eliassen, Heather A, Engel, Christoph, Evans, D Gareth, Fasching, Peter A, Flanagan, James M, Foretova, Lenka, Fortner, Ren��e T, Friedman, Eitan, Ganz, Patricia A, Garber, Judy, Gensini, Francesca, Giles, Graham G, Glendon, Gord, Godwin, Andrew K, Goodman, Marc T, Greene, Mark H, Gronwald, Jacek, Hahnen, Eric, Haiman, Christopher A, H��kansson, Niclas, Hamann, Ute, Hansen, Thomas VO, Harris, Holly R, Hartman, Mikael, Heitz, Florian, Hildebrandt, Michelle AT, H��gdall, Estrid, H��gdall, Claus K, Hopper, John L, Huang, Ruea-Yea, Huff, Chad, Hulick, Peter J, Huntsman, David G, Imyanitov, Evgeny N, Isaacs, Claudine, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, Jensen, Allan, Johannsson, Oskar Th, John, Esther M, Jones, Michael E, Kang, Daehee, Karlan, Beth Y, Karnezis, Anthony, Kelemen, Linda E, Khusnutdinova, Elza, Kiemeney, Lambertus A, Kim, Byoung-Gie, Kjaer, Susanne K, Komenaka, Ian, Kupryjanczyk, Jolanta, Kurian, Allison W, Kwong, Ava, Lambrechts, Diether, Larson, Melissa C, Lazaro, Conxi, Le, Nhu D, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A, Li, Lian, Li, Jingmei, Loud, Jennifer T, Lu, Karen H, Lubi��ski, Jan, Machackova, Eva, Mai, Phuong L, Manoukian, Siranoush, Marks, Jeffrey R, Matsuno, Rayna Kim, Matsuo, Keitaro, May, Taymaa, McGuffog, Lesley, McLaughlin, John R, McNeish, Iain A, Mebirouk, Noura, Menon, Usha, Miller, Austin, Milne, Roger L, Minlikeeva, Albina, Modugno, Francesmary, Montagna, Marco, Moysich, Kirsten B, Munro, Elizabeth, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Yie, Joanne Ngeow Yuen, Nielsen, Henriette Roed, Nielsen, Finn C, Nikitina-Zake, Liene, Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olbrecht, Siel, Olopade, Olufunmilayo I, Olson, Sara H, Olsson, H��kan, Osorio, Ana, Papi, Laura, Park, Sue K, Parsons, Michael T, Pathak, Harsha, Pedersen, Inge Sokilde, Peixoto, Ana, Pejovic, Tanja, Perez-Segura, Pedro, Permuth, Jennifer B, Peshkin, Beth, Peterlongo, Paolo, Piskorz, Anna, Prokofyeva, Darya, Radice, Paolo, Rantala, Johanna, Riggan, Marjorie J, Risch, Harvey A, Rodriguez-Antona, Cristina, Ross, Eric, Rossing, Mary Anne, Runnebaum, Ingo, Sandler, Dale P, Santamari��a, Marta, Soucy, Penny, Schmutzler, Rita K, Setiawan, V Wendy, Shan, Kang, Sieh, Weiva, Simard, Jacques, Singer, Christian F, Sokolenko, Anna P, Song, Honglin, Southey, Melissa C, Steed, Helen, Stoppa-Lyonnet, Dominique, Sutphen, Rebecca, Swerdlow, Anthony J, Tan, Yen Yen, Teixeira, Manuel R, Teo, Soo Hwang, Terry, Kathryn L, Terry, Mary Beth, Thomassen, Mads, Thompson, Pamela J, Vestrheim Thomsen, Liv Cecilie, Thull, Darcy L, Tischkowitz, Marc, Titus, Linda, Toland, Amanda E, Torres, Diana, Trabert, Britton, Travis, Ruth, Tung, Nadine, Tworoger, Shelley S, Valen, Ellen, Van Altena, Anne M, Van Der Hout, Annemieke H, Van Nieuwenhuysen, Els, Van Rensburg, Elizabeth J, Vega, Ana, Edwards, Digna Velez, Vierkant, Robert A, Wang, Frances, Wappenschmidt, Barbara, Webb, Penelope M, Weinberg, Clarice R, Weitzel, Jeffrey N, Wentzensen, Nicolas, White, Emily, Whittemore, Alice S, Winham, Stacey J, Wolk, Alicja, Woo, Yin-Ling, Wu, Anna H, Yan, Li, Yannoukakos, Drakoulis, Zavaglia, Katia M, Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K, Easton, Douglas, Lawrenson, Kate, DeFazio, Anna, Sellers, Thomas A, Ramus, Susan J, Pearce, Celeste L, Monteiro, Alvaro N, Cunningham, Julie, Goode, Ellen L, Schildkraut, Joellen M, Berchuck, Andrew, Chenevix-Trench, Georgia, Gayther, Simon A, Antoniou, Antonis C, and Pharoah, Paul DP

Subjects
3. Good health
Abstract

Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally-efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, ���select and shrink for summary statistics��� (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestry; 7,669 women of East Asian ancestry; 1,072 women of African ancestry, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestry. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38(95%CI:1.28���1.48,AUC:0.588) per unit standard deviation, in women of European ancestry; 1.14(95%CI:1.08���1.19,AUC:0.538) in women of East Asian ancestry; 1.38(95%CI:1.21-1.58,AUC:0.593) in women of African ancestry; hazard ratios of 1.37(95%CI:1.30���1.44,AUC:0.592) in BRCA1 pathogenic variant carriers and 1.51(95%CI:1.36-1.67,AUC:0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.

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