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219 results on '"Minsky, B. D."'

1. Neo-adjuvant Therapy

Author

Minsky, B. D., Köhne, C.-H., Greco, C., Audisio, Riccardo A., editor, Geraghty, James G., editor, and Longo, Walter E., editor

Published
2001
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6. International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer

Author

Fokas, E., Appelt, A., Glynne-Jones, R., Beets, G., Perez, R., Garcia-Aguilar, J., Rullier, E., Joshua Smith, J., Marijnen, C., Peters, F. P., van der Valk, M., Beets-Tan, R., Myint, A. S., Gerard, J. -P., Bach, S. P., Ghadimi, M., Hofheinz, R. D., Bujko, K., Gani, C., Haustermans, K., Minsky, B. D., Ludmir, E., West, N. P., Gambacorta, Maria Antonietta, Valentini, Vincenzo, Buyse, M., Renehan, A. G., Gilbert, A., Sebag-Montefiore, D., Rodel, C., Gambacorta M. A. (ORCID:0000-0001-5455-8737), Valentini V. (ORCID:0000-0003-4637-6487), Fokas, E., Appelt, A., Glynne-Jones, R., Beets, G., Perez, R., Garcia-Aguilar, J., Rullier, E., Joshua Smith, J., Marijnen, C., Peters, F. P., van der Valk, M., Beets-Tan, R., Myint, A. S., Gerard, J. -P., Bach, S. P., Ghadimi, M., Hofheinz, R. D., Bujko, K., Gani, C., Haustermans, K., Minsky, B. D., Ludmir, E., West, N. P., Gambacorta, Maria Antonietta, Valentini, Vincenzo, Buyse, M., Renehan, A. G., Gilbert, A., Sebag-Montefiore, D., Rodel, C., Gambacorta M. A. (ORCID:0000-0001-5455-8737), and Valentini V. (ORCID:0000-0003-4637-6487)

Abstract

Multimodal treatment strategies for patients with rectal cancer are increasingly including the possibility of organ preservation, through nonoperative management or local excision. Organ preservation strategies can enable patients with a complete response or near-complete clinical responses after radiotherapy with or without concomitant chemotherapy to safely avoid the morbidities associated with radical surgery, and thus to maintain anorectal function and quality of life. However, standardization of the key outcome measures of organ preservation strategies is currently lacking; this includes a lack of consensus of the optimal definitions and selection of primary end points according to the trial phase and design; the optimal time points for response assessment; response-based decision-making; follow-up schedules; use of specific anorectal function tests; and quality of life and patient-reported outcomes. Thus, a consensus statement on outcome measures is necessary to ensure consistency and facilitate more accurate comparisons of data from ongoing and future trials. Here, we have convened an international group of experts with extensive experience in the management of patients with rectal cancer, including organ preservation approaches, and used a Delphi process to establish the first international consensus recommendations for key outcome measures of organ preservation, in an attempt to standardize the reporting of data from both trials and routine practice in this emerging area.

Published
2021

10. The diagnosis and management of gastric cancer: expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2010

Author

Van Cutsem, E., Dicato, M., Geva, R., Arber, N., Bang, Y., Benson, A., Cervantes, A., Diaz-Rubio, E., Ducreux, M., Glynne-Jones, R., Grothey, A., Haller, D., Haustermans, K., Kerr, D., Nordlinger, B., Marshall, J., Minsky, B. D., Kang, Y. K., Labianca, R., Lordick, F., Ohtsu, A., Pavlidis, N., Roth, A., Rougier, P., Schmoll, H. J., Sobrero, A., Tabernero, J., Van de Velde, C., and Zalcberg, J.

Published
2011
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12. The diagnosis and management of rectal cancer: expert discussion and recommendations derived from the 9th World Congress on Gastrointestinal Cancer, Barcelona, 2007

Author

Van Cutsem, E., Dicato, M., Haustermans, K., Arber, N., Bosset, J.-F, Cunningham, D., De Gramont, A., Diaz-Rubio, E., Ducreux, M., Goldberg, R., Glynne-Jones, R., Haller, D., Kang, Y.-K., Kerr, D., Labianca, R., Minsky, B. D., Moore, M., Nordlinger, B., Rougier, P., Scheithauer, W., Schmoll, H.-J., Sobrero, A., Tabernero, J., Tempero, M., Van de Velde, C., and Zalcberg, J.

Published
2008

15. Outcome measures in multimodal rectal cancer trials

Author

Fokas, E., Glynne-Jones, R., Appelt, A., Beets-Tan, R., Beets, G., Haustermans, K., Marijnen, C., Minsky, B. D., Ludmir, E., Quirke, P., Sebag-Montefiore, D., Garcia-Aguilar, J., Gambacorta, M. A., Valentini, V., Buyse, M., Rodel, C., Gambacorta M. A. (ORCID:0000-0001-5455-8737), Valentini V. (ORCID:0000-0003-4637-6487), Fokas, E., Glynne-Jones, R., Appelt, A., Beets-Tan, R., Beets, G., Haustermans, K., Marijnen, C., Minsky, B. D., Ludmir, E., Quirke, P., Sebag-Montefiore, D., Garcia-Aguilar, J., Gambacorta, M. A., Valentini, V., Buyse, M., Rodel, C., Gambacorta M. A. (ORCID:0000-0001-5455-8737), and Valentini V. (ORCID:0000-0003-4637-6487)

Abstract

There is a large variability regarding the definition and choice of primary endpoints in phase 2 and phase 3 multimodal rectal cancer trials, resulting in inconsistency and difficulty of data interpretation. Also, surrogate properties of early and intermediate endpoints have not been systematically assessed. We provide a comprehensive review of clinical and surrogate endpoints used in trials for non-metastatic rectal cancer. The applicability, advantages, and disadvantages of these endpoints are summarised, with recommendations on clinical endpoints for the different phase trials, including limited surgery or non-operative management for organ preservation. We discuss how early and intermediate endpoints, including patient-reported outcomes and involvement of patients in decision making, can be used to guide trial design and facilitate consistency in reporting trial results in rectal cancer.

Published
2020

19. The diagnosis and management of gastric cancer: expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2010

Author

Van Cutsem, E., Dicato, M., Geva, R., Arber, N., Bang, Y., Benson, A., Cervantes, A., Diaz-Rubio, E., Ducreux, M., Glynne-Jones, R., Grothey, A., Haller, D., Haustermans, K., Kerr, D., Nordlinger, B., Marshall, J., Minsky, B. D., Kang, Y. K., Labianca, R., Lordick, F., Ohtsu, A., Pavlidis, N., Roth, A., Rougier, P., Schmoll, H. J., Sobrero, A., Tabernero, J., Van de Velde, C., Zalcberg, J., Van Cutsem, E., Dicato, M., Geva, R., Arber, N., Bang, Y., Benson, A., Cervantes, A., Diaz-Rubio, E., Ducreux, M., Glynne-Jones, R., Grothey, A., Haller, D., Haustermans, K., Kerr, D., Nordlinger, B., Marshall, J., Minsky, B. D., Kang, Y. K., Labianca, R., Lordick, F., Ohtsu, A., Pavlidis, N., Roth, A., Rougier, P., Schmoll, H. J., Sobrero, A., Tabernero, J., Van de Velde, C., and Zalcberg, J.

Abstract

Well-recognized experts in the field of gastric cancer discussed during the 12th European Society Medical Oncology (ESMO)/World Congress Gastrointestinal Cancer (WCGIC) in Barcelona many important and controversial topics on the diagnosis and management of patients with gastric cancer. This article summarizes the recommendations and expert opinion on gastric cancer. It discusses and reflects on the regional differences in the incidence and care of gastric cancer, the definition of gastro-esophageal junction and its implication for treatment strategies and presents the latest recommendations in the staging and treatment of primary and metastatic gastric cancer. Recognition is given to the need for larger and well-designed clinical trials to answer many open questions

Published
2017

20. The diagnosis and management of gastric cancer: Expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2010

Author

Cutsem, E. van, Dicato, M., Geva, R., Arber, N., Bang, Y., Benson, A., Cervantes, A., Diaz-Rubio, E., Ducreux, M., Glynne-Jones, R., Grothey, Axel, Haller, D., Haustermans, K., Kerr, D., Nordlinger, B., Marshall, J., Minsky, B. D., Kang, Y. K., Labianca, R., Lordick, F., Ohtsu, A., Pavlidis, Nicholas, Roth, A., Rougier, P., Schmoll, H. J., Sobrero, A., Tabernero, Josep, Velde, C. van de, Zalcberg, J., and Pavlidis, Nicholas [0000-0002-2195-9961]

Subjects
Continuous infusion, Computer assisted radiotherapy, Folic acid, Fluorodeoxyglucose f 18, Gimeracil plus oteracil potassium plus tegafur, Infection control, Intensity modulated radiation therapy, Docetaxel, Cancer staging, Metastatic gastric cancer, Risk Factors, Prevalence, Drug fatality, Overall survival, Neoplasm Metastasis, Priority journal, ddc:616, Conference paper, digestive, oral, and skin physiology, Folinic acid, Hematology, Prognosis, Oxaliplatin, Nuclear magnetic resonance imaging, Bevacizumab, Survival Rate, Oncology, Cyanocobalamin, Practice Guidelines as Topic, Drug dose reduction, Fluorouracil, Esophageal adenocarcinoma, Human, Positron emission tomography, medicine.medical_specialty, Neutropenia, Stomach cancer, Stomach neoplasms, MEDLINE, Side effect, Stomach adenocarcinoma, Patient care, Irinotecan, Helicobacter infection, Primary tumor, Endoscopic echography, Advanced cancer, Endoscopic mucosal resection, Computer assisted tomography, Stomach Neoplasms/*diagnosis/pathology/*therapy, medicine, Humans, Genetic Predisposition to Disease, Gastrointestinal cancer, Phase 3 clinical trial (topic), Intensive care medicine, Survival rate, Placebo, Capecitabine, Epirubicin, Ca 19-9 antigen, Stomach Neoplasms/diagnosis/pathology/therapy, Helicobacter pylori, business.industry, Cancer, Trastuzumab, Cardiovascular risk, medicine.disease, Cancer susceptibility, digestive system diseases, Surgery, Clinical trial, Metastasis potential, Expert opinion, Meta analysis (topic), Cancer adjuvant therapy, Carcinoembryonic antigen, Lower esophagus sphincter, Cisplatin, Caloric intake, business, Cancer incidence, Regional differences
Abstract

Well-recognized experts in the field of gastric cancer discussed during the 12th European Society Medical Oncology (ESMO)/World Congress Gastrointestinal Cancer (WCGIC) in Barcelona many important and controversial topics on the diagnosis and management of patients with gastric cancer. This article summarizes the recommendations and expert opinion on gastric cancer. It discusses and reflects on the regional differences in the incidence and care of gastric cancer, the definition of gastro-esophageal junction and its implication for treatment strategies and presents the latest recommendations in the staging and treatment of primary and metastatic gastric cancer. Recognition is given to the need for larger and well-designed clinical trials to answer many open questions. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. 22 SUPPL. 5 v1 v9

Published
2011

39. Preoperative radiation with or without chemotherapy and full-thickness transanal excision for selected T2 and T3 distal rectal cancers.

Author

Ruo, L., Guillem, J. G., Minsky, B. D., Quan, S. H. Q., Paty, P. B., and Cohen, A. M.

Subjects
RADIATION, SURGICAL excision, RECTAL cancer, LASERS, COLD therapy
Abstract

Background and aims: To evaluate the clinical outcome of selected patients with distal rectal cancer treated by preoperative radiation with or without chemotherapy and full-thickness local excision (FTLE). Patients and methods: Ten patients with invasive distal rectal cancer (six T2, four T3) were treated with preoperative radiotherapy (3600–5040 cGy) with or without 5-fluorouracil based chemotherapy. FTLE was performed 4–6 weeks after completion of radiotherapy, primarily because of comorbid diseases or patient refusal of a permanent colostomy. Median follow-up was 28.5 months. Results: There were no prolonged wound complications, and only one positive microscopic margin was detected. Among three cases of complete pathological response, two remain without evidence of disease. All patients retained sphincter function and avoided creation of a stoma. Two patients developed recurrence, one with widespread disease including pelvic recurrence 26 months after surgery and the other with distant disease only at 23 months. There were four deaths: two unrelated to cancer, one of undetermined cause after 7 years, and one after widespread recurrence at 26 months, with death 4 months later. Two-year actuarial survival was 78%. Conclusions: This pilot study demonstrates that preoperative radiotherapy and FTLE avoids major abdominal surgery yet facilitates sphincter preservation, excision with negative margins, and short-term local control in selected patients with distal rectal cancer. [ABSTRACT FROM AUTHOR]

Published
2002
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40. The evaluation and treatment of patients receiving radiation therapy for carcinoma of the esophagus: results of the 1992-1994 Patterns of Care Study.

Author

Coia, Lawrence R., Minsky, Bruce D., John, Madhu J., Haller, Daniel G., Landry, Jerome, Pisansky, Thomas M., Willett, Christopher G., Hoffman, John P., Berkey, Brian A., Owen, Jean B., Hanks, Gerald E., Coia, L R, Minsky, B D, John, M J, Haller, D G, Landry, J, Pisansky, T M, Willett, C G, Hoffman, J P, and Berkey, B A

Published
1999
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