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117 results on '"Minushkina, L. O."'

2. Prospects for Using Chromatography-Mass Spectrometry for the Determination of Lipids in Clinical Cardiolipidology

Author

Alessenko, A. V., Shupik, M. A., Gutner, U. A., Zateyshchikov, D. A., Minushkina, L. O., Rogozhina, A. A., and Lebedev, A. T.

Subjects
Physiological aspects, Spectroscopy -- Physiological aspects, Atherosclerosis -- Physiological aspects, Lipids -- Physiological aspects, Sphingosine -- Physiological aspects, Cardiology -- Physiological aspects, Chromatography -- Physiological aspects, Cholesterol -- Physiological aspects, Ceramides -- Physiological aspects, Cardiovascular diseases -- Physiological aspects, Spectrum analysis -- Physiological aspects
Abstract

Author(s): A. V. Alessenko [sup.1], M. A. Shupik [sup.1], U. A. Gutner [sup.1], D. A. Zateyshchikov [sup.2], L. O. Minushkina [sup.2], A. A. Rogozhina [sup.2], A. T. Lebedev [sup.3], O. [...], Cardiolipidology - a new direction in cardiology - is developing intensively owing to the method of mass spectrometry. This method has acquired particular importance for the determination of molecular types of sphingolipids, the metabolism of which is closely related to the metabolism of cholesterol. Changes in the level of a number of sphingolipids claiming to be markers of cardiovascular diseases (CVDs) (molecular forms of sphingomyelins, ceramides, glucosylceramides, sphingosine, and sphinganin), in the blood plasma of patients with hereditary forms of early atherosclerosis (familial hyperlipidemia, FHL) were studied by chromatography-mass spectrometry. The study group (52 people) consisted of patients with acute manifestations of atherosclerosis, with postinfarction cardiosclerosis, and with dyslipidemia or early CVD. In patients with FHL, there was an increase in the proportion of long-chain sphingomyelin SM18:1/22:0 and the level of ceramides with carbon chains C20-1 and C22-1. An increase in the level of sphingosine, possessing proapoptotic properties, which can be considered as a marker of an additional risk of cardiovascular complications, was revealed in patients with a high clinical probability of FHL. The search for new CVD markers will improve personalized approach to the management of such patients and improve the results of their treatment.

Published
2022
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4. Incidence of familial hypercholesterolemia in patients with early manifestations of coronary artery disease: data from a Russian multicenter study and meta-analysis

Author

Rogozhina, A. A., primary, Averkova, A. O., additional, Zubova, E. A., additional, Minushkina, L. O., additional, Brazhnik, V. A., additional, Ivanova, O. N., additional, Chichkova, M. A., additional, Khasanov, N. R., additional, Kosmacheva, E. D., additional, Boeva, O. I., additional, and Zateyshchikov, D. A., additional

Published
2023
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7. Polymorphic markers Ala455Val of the THBD gene and Arg353Gln of the F7 gene and genetic association with unfavorable outcomes of coronary atherosclerosis in patients with a history of acute ischemic heart disease

Author

Pushkov, A. A., Blagodatskikh, K. A., Nikitin, A. G., Agapkina, Yu. V., Brovkin, A. N., Chudakova, D. A., Evdokimova, M. A., Aseycheva, O. Yu., Osmolovskaya, V. S., Minushkina, L. O., Baklanova, T. N., Talyzin, P. A., Donetskaya, O. P., Tereschenko, S. N., Dzhaiani, N. A., Akanova, E. V., Glezer, M. G., Galyavich, A. S., Zakirova, V. B., Koziolova, N. A., Yagoda, A. V., Boyeva, O. I., Horolets, E. V., Shlyk, S. V., Volkova, E. G., Margaryan, M. P., Guz, I. O., Konstantinov, V. O., Sidorenko, B. A., Zeteyshchikov, D. A., and Nosikov, V. V.

Published
2011
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8. The polymorphisms G(−174)C in IL6 gene and G(−1082)A in IL10 gene are associated with poor outcomes in patients with acute coronary syndrome

Author

Blagodatskikh, K. A., Evdokimova, M. A., Agapkina, Yu. V., Nikitin, A. G., Brovkin, A. N., Pushkov, A. A., Blagodatskikh, E. G., Kudryashova, O. Yu., Osmolovskaya, V. S., Minushkina, L. O., Kochkina, M. S., Selezneva, N. D., Dankovtseva, E. N., Chumakova, O. S., Baklanova, T. N., Talyzin, P. A., Reznichenko, N. E., Donetskaya, O. P., Tereshchenko, S. N., Krasil’nikova, E. S., Dzhaiani, N. A., Akatova, E. V., Glezer, M. G., Galyavich, A. S., Zakirova, V. B., Koziolova, N. A., Timofeeva, I. V., Yagoda, A. V., Boeva, O. I., Katel’nitskaya, L. I., Khorolets, E. V., Shlyk, S. V., Volkova, E. G., Margaryan, M. P., Guz’, I. O., Konstantinov, V. O., Timofeeva, N. V., Sidorenko, B. A., Zateishchikov, D. A., and Nosikov, V. V.

Published
2010
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9. Association of the polymorphic markers G(−455)A in the FGB gene and C(−1654)T in the PROC gene with hereditary predisposition to unfavourable outcome in patients with history of acute coronary syndrome

Author

Agapkina, Yu. V., Nikitin, A. G., Brovkin, A. N., Pushkov, A. A., Evdokimova, M. A., Aseycheva, O. Yu., Osmolovskaya, V. S., Minushkina, L. O., Kochkina, M. S., Selezneva, N. D., Dankovtseva, E. N., Chumakova, O. S., Baklanova, T. N., Talyzin, P. A., Reznichenko, N. E., Donetskaya, O. P., Tereschenko, S. N., Krasil’nikova, E. S., Dzhaiani, N. A., Akatova, E. V., Glezer, M. G., Galyavich, A. S., Zakirova, V. B., Koziolova, N. A., Timofeeva, I. V., Yagoda, A. V., Boyeva, O. I., Katelnitskaya, L. I., Horolets, E. V., Shlyk, S. V., Volkova, E. G., Margaryan, M. P., Guz, I. O., Konstantinov, V. O., Timofeyeva, A. N., Sidorenko, B. A., Zateyshchikov, D. A., and Nosikov, V. V.

Published
2010
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10. Left ventricular global function index as a predictor of adverse cardiovascular events in patients with acute coronary syndrome

Author

Kapustina, A. Yu., primary, Minushkina, L. O., additional, Alekhin, M. N., additional, Selezneva, N. D., additional, Safaryan, V. I., additional, Brazhnik, V. A., additional, Chumakova, O. S., additional, Evdokimova, M. A., additional, Galyavich, A. S., additional, Khasanov, N. R., additional, Chichkova, M. A., additional, Kosmacheva, E. D., additional, Tereshchenko, S. N., additional, Koziolova, N. A., additional, Glezer, M. G., additional, Boeva, O. I., additional, Konstantinov, V. O., additional, and Zateyshchikov, D. A., additional

Published
2021
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18. Changes in the management of patients with acute coronary syndrome – have the disease outcomes changed?

Author

Zateyshchikov, D. A., primary, Minushkina, L. O., additional, Brazhnik, V. A., additional, Galyavich, A. S., additional, Khasanov, N. R., additional, Chichkova, M. A., additional, Kosmacheva, E. D., additional, Tereshchenko, S. N., additional, Koziolova, N. A., additional, Glezer, M. G., additional, Boeva, O. I., additional, Khorolets, E. V., additional, and Konstantinov, V. O., additional

Published
2020
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25. MODERN ADVANCED ARTIFICIAL INTELLIGENCE FOR SMART MEDICINE

Author

Kolesnichenko, O. Yu., primary, Martynov, A. V., additional, Pulit, V. V., additional, Kolesnichenko, Yu. Yu., additional, Shakirov, V. V., additional, Mazelis, L. S., additional, Varlamov, O. O., additional, Minushkina, L. O., additional, Sotnik, A. Yu., additional, Zhilina, T. N., additional, Dorofeev, V. P., additional, Smorodin, G. N., additional, and Zhaparov, M. K., additional

Published
2019
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26. Bleeding risk factors in patients with acute coronary syndrome: data from observational studies ORACUL II

Author

Brazhnik, V. A., primary, Minushkina, L. O., additional, Guliev, R. R., additional, Averkova, A. O., additional, Rogozhina, A. A., additional, Koroleva, O. S., additional, Zubova, E. A., additional, Karmanchikova, E. A., additional, Khasanov, N. R., additional, Chichkova, M. A., additional, Boeva, O. I., additional, Galyavich, A. S., additional, and Zateyshchikov, D. A., additional

Published
2019
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39. Association of Polymorphic Marker G(–455)A of Gene FGB with Coronary Artery Disease.

Author

Tchoudakova, D. A., Minushkina, L. O., Zateyshchikov, D. A., and Nosikov, V. V.

Subjects
CORONARY disease, HEART diseases, MEDICAL genetics, HUMAN genetics, GENETIC disorders, HUMAN abnormality genetics
Abstract

Patients with coronary artery disease (CAD), including those who have had myocardial infarction (MI), and control subjects have been compared with respect to the distributions of the alleles and genotypes of polymorphic marker G(–455)A of gene FGB encoding the fibrinogen β-chain. The groups studied do not differ significantly with respect to the distributions of G(–455)A alleles and genotypes. This indicates that this marker is not associated with CAD in the Moscow population. Allele A of the G(–455)A polymorphic marker has been found to be associated with an increased fibrinogen content of blood plasma in women with CAD. [ABSTRACT FROM AUTHOR]

Published
2004
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42. Prognostic Value of Aortic Stenosis in Patients After Acute Coronary Sindrom

Author

Chumakova, O. S., Selezneva, N. D., Evdokimova, M. A., Osmolovskaya, V. S., Kochkina, M. S., Aseycheva, O. Yu, Minushkina, L. O., Baklanova, T. N., Talysin, P. A., Tereshchenko, S. N., Dzhaiani, N. A., Akatova, E. V., Glezer, M. G., Galyavich, A. S., Zakirova, V. B., Kosiolova, N. A., Polyanskaya, E. A., Yagoda, A. V., Boeva, O. I., Khorolets, E. V., Shlyk, S. V., Volkova, E. G., Rodicheva, O. A., Levashov, S. Yu, Konstantinov, V. O., Kalishevich, N. B., and Dmitry Zateyshchikov

46. [Polymorphic markers G(-455)A of gene FGB and C(-1654)T of gene PROC and genetic predisposition to unfavorable outcomes patients undergoing acute coronary syndrome]

Author

Agapkina, I. V., Nikitin, A. G., Brovkin, A. N., Pushkov, A. A., Evdokimova, M. A., Kudriashova, O. I., Osmolovskaia, V. S., Minushkina, L. O., Kochkina, M. S., Selezneva, N. D., Dankovtseva, E. N., Chumakova, O. S., Baklanova, T. N., Talyzin, P. A., Reznichenko, N. E., Donetskaia, O. P., Tereshchenko, S. N., Krasil Nikova, E. S., Nino Dzhaiani, Akatova, E. V., Glezer, M. G., Galiavich, A. S., Zakirova, V. B., Kaziolova, N. A., Timofeeva, I. V., Iagoda, A. V., Boeva, O. I., Katel Nitskaia, L. I., Khorolets, E. V., Shlyk, S. V., Volkova, E. G., Margarian, M. P., Guz, I. O., Konstantinov, V. O., Timofeeva, A. N., Sidorenko, B. A., Zateǐshchikiov, D. A., and Nosikov, V. V.

Subjects
Male, Genotype, Fibrinogen, Middle Aged, Polymorphism, Single Nucleotide, Disease-Free Survival, Russia, Survival Rate, Humans, Female, Genetic Predisposition to Disease, Acute Coronary Syndrome, Alleles, Protein C
Abstract

We investigated the association of polymorphisms of genes FGB G(-455)A and PROCC(-1654)T with coronary artery disease (CAD) in the Russian population. A total of 1145 patients with CAD diagnose on the basis of clinical studies in cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol and Rostov-on-Don. Supervision term was 1.14 +/- +/- 0.33 years (the maximum term 3.2 years). The group studied do not differ significantly with respect to the distributions of G(-455)A alleles and genotypes. However in case of gene PROC C(-1654)T polymorphism we determined that patients with CAD diagnose and Talleles of PROC gene had unfavorable outcome more often than patients with homozygous C alleles. Survival time from end point from carrier phenotype TT and CTis 2.19 +/- 0.18 r. years against 2.46 +/- 0.16 from carrier phenotype CCgene PROC. The obtained data allows to assume the important role of the genes which are responsible for functioning of system of a hemostasis, in the accelerated formation of failures at the patients who had a coronary syndrome.

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