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764 results on '"Mir, Lluis"'

8. Glossary on atmospheric electricity and its effects on biology

Author

Fdez-Arroyabe, Pablo, Kourtidis, Konstantinos, Haldoupis, Christos, Savoska, Snezana, Matthews, James, Mir, Lluis M., Kassomenos, Pavlos, Cifra, Michal, Barbosa, Susana, Chen, Xuemeng, Dragovic, Snezana, Consoulas, Christos, Hunting, Ellard R., Robert, Daniel, van der Velde, Oscar A., Apollonio, Francesca, Odzimek, Anna, Chilingarian, Ashot, Royé, Dominic, Mkrtchyan, Hripsime, Price, Colin, Bór, József, Oikonomou, Christina, Birsan, Marius-Victor, Crespo-Facorro, Benedicto, Djordjevic, Milan, Salcines, Ciro, López-Jiménez, Amparo, Donner, Reik V., Vana, Marko, Pedersen, Jens Olaf Pepke, Vorenhout, Michel, and Rycroft, Michael

Published
2021
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17. Cell Membrane Electropulsation: Chemical Analysis of Cell Membrane Modifications and Associated Transport Mechanisms

Author

Azan, Antoine, Gailliègue, Florian, Mir, Lluis M., Breton, Marie, Korf, Horst-Werner, Series editor, Boeckers, T.M., Series editor, Clascá, Francisco, Series editor, Kmiec, Z., Series editor, Singh, Baljit, Series editor, Sutovsky, Peter, Series editor, Timmermans, Jean-Pierre, Series editor, Kulbacka, Julita, editor, and Satkauskas, Saulius, editor

Published
2017
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18. Biological Responses

Author

Yano, Ken-ichi, Rems, Lea, Kotnik, Tadej, Miklavčič, Damijan, Weaver, James C., Smith, Kyle C., Son, Reuben S., Gowrishankar, Thiruvallur R., Vernier, P. Thomas, Levine, Zachary A., Rols, Marie-Pierre, Teissie, Justin, Mir, Lluis M., Pakhomov, Andrei G., Nick, Peter, Frey, Wolfgang, Dean, David A., Morotomi-Yano, Keiko, Neal, Robert E., II, Bhonsle, Suyashree, Davalos, Rafael V., Beebe, Stephen J., Akiyama, Hidenori, editor, and Heller, Richard, editor

Published
2017
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19. Medical Applications

Author

Heller, Richard, Teissie, Justin, Rols, Marie-Pierre, Gehl, Julie, Sersa, Gregor, Mir, Lluis M., Neal, Robert E., II, Bhonsle, Suyashree, Davalos, Rafael, Beebe, Stephen, Hargrave, Barbara, Nuccitelli, Richard, Jiang, Chunqi, Cemazar, Maja, Tamzali, Youssef, Tozon, Natasa, Akiyama, Hidenori, editor, and Heller, Richard, editor

Published
2017
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22. Tumor ablation with irreversible electroporation.

Author

Al-Sakere, Bassim, André, Franck, Bernat, Claire, Connault, Elisabeth, Opolon, Paule, Davalos, Rafael V, Rubinsky, Boris, and Mir, Lluis M

Subjects
Cell Line, Tumor, Animals, Mice, Inbred C57BL, Mice, Sarcoma, Experimental, DNA Damage, Electroporation, Immunohistochemistry, In Situ Nick-End Labeling, Temperature, General Science & Technology
Abstract

We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale defects in the cell membrane. Mathematical models of the electrical and thermal fields that develop during the application of the pulses were used to design an efficient treatment protocol with minimal heating of the tissue. Tumor regression was confirmed by histological studies which also revealed that it occurred as a direct result of irreversible cell membrane permeabilization. Parametric studies show that the successful outcome of the procedure is related to the applied electric field strength, the total pulse duration as well as the temporal mode of delivery of the pulses. Our best results were obtained using plate electrodes to deliver across the tumor 80 pulses of 100 micros at 0.3 Hz with an electrical field magnitude of 2500 V/cm. These conditions induced complete regression in 12 out of 13 treated tumors, (92%), in the absence of tissue heating. Irreversible electroporation is thus a new effective modality for non-thermal tumor ablation.

Published
2007

28. Experimental and theoretical brownian dynamics analysis of ion transport during cellular electroporation of E. coli bacteria

Author

Universidad Nacional de Asunción. Facultad de Ingeniería, Gonzalez Cuevas, Juan Alberto, Argüello, Ricardo, Florentin, Marcos, André, Franck M., Mir, Lluis M., Universidad Nacional de Asunción. Facultad de Ingeniería, Gonzalez Cuevas, Juan Alberto, Argüello, Ricardo, Florentin, Marcos, André, Franck M., and Mir, Lluis M.

Abstract

Escherichia coli bacterium is a rod-shaped organism composed of a complex double membrane structure. Knowledge of electric field driven ion transport through both membranes and the evolution of their induced permeabilization has important applications in biomedical engineering, delivery of genes and antibacterial agents. However, few studies have been conducted on Gram-negative bacteria in this regard considering the contribution of all ion types. To address this gap in knowledge, we have developed a deterministic and stochastic Brownian dynamics model to simulate in 3D space the motion of ions through pores formed in the plasma membranes of E. coli cells during electroporation. The diffusion coefficient, mobility, and translation time of Ca2+, Mg2+, Na+, K+, and Cl− ions within the pore region are estimated from the numerical model. Calculations of pore’s conductance have been validated with experiments conducted at Gustave Roussy. From the simulations, it was found that the main driving force of ionic uptake during the pulse is the one due to the externally applied electric field. The results from this work provide a better understanding of ion transport during electroporation, aiding in the design of electrical pulses for maximizing ion throughput, primarily for application in cancer treatment.

Published
2023

29. Electrochemotherapy in radiotherapy-resistant epidural spinal cord compression in metastatic cancer patients

Author

Deschamps, Frédéric; https://orcid.org/0000-0002-6015-4349, Tselikas, Lambros; https://orcid.org/0000-0002-8878-4916, Yevich, Steven, Bonnet, Baptiste; https://orcid.org/0000-0002-1061-321X, Roux, Charles; https://orcid.org/0000-0002-9584-3048, Kobe, Adrian; https://orcid.org/0000-0002-8931-7412, Besse, Benjamin, Berthelot, Kevin, Gaudin, Amelie, Mir, Lluis M, de Baère, Thierry; https://orcid.org/0000-0002-4556-7663, Deschamps, Frédéric; https://orcid.org/0000-0002-6015-4349, Tselikas, Lambros; https://orcid.org/0000-0002-8878-4916, Yevich, Steven, Bonnet, Baptiste; https://orcid.org/0000-0002-1061-321X, Roux, Charles; https://orcid.org/0000-0002-9584-3048, Kobe, Adrian; https://orcid.org/0000-0002-8931-7412, Besse, Benjamin, Berthelot, Kevin, Gaudin, Amelie, Mir, Lluis M, and de Baère, Thierry; https://orcid.org/0000-0002-4556-7663

Abstract

Objective: To report efficacy and safety of percutaneous electrochemotherapy (ECT) in patients with radiotherapy-resistant metastatic epidural spinal cord compression (MESCC). Material/ methods: This retrospective study analyzed all consecutive patients treated with bleomycin-based ECT between February-2020 and September-2022 in a single tertiary referral cancer center. Changes in pain were evaluated with the Numerical Rating Score (NRS), in neurological deficit with the Neurological Deficit Scale, and changes in epidural spinal cord compression were evaluated with the epidural spinal cord compression scale (ESCCS) using an MRI. Results: Forty consecutive solid tumour patients with previously radiated MESCC and no effective systemic treatment options were eligible. With a median follow-up of 5.1 months [1-19.1], toxicities were temporary acute radicular pain (25%), prolonged radicular hypoesthesia (10%), and paraplegia (7.5%). At 1 month, pain was significantly improved over baseline (median NRS: 1.0 [0-8] versus 7.0 [1.0-10], P < .001) and neurological benefits were considered as marked (28%), moderate (28%), stable (38%), or worse (8%). Three-month follow-up (21 patients) confirmed improved over baseline (median NRS: 2.0 [0-8] versus 6.0 [1.0-10], P < .001) and neurological benefits were considered as marked (38%), moderate (19%), stable (33.5%), and worse (9.5%). One-month post-treatment MRI (35 patients) demonstrated complete response in 46% of patients by ESCCS, partial response in 31%, stable disease in 23%, and no patients with progressive disease. Three-month post-treatment MRI (21 patients) demonstrated complete response in 28.5%, partial response in 38%, stable disease in 24%, and progressive disease in 9.5%. Conclusions: This study provides the first evidence that ECT can rescue radiotherapy-resistant MESCC.

Published
2023

30. Supplementary Information from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents

Author

Azan, Antoine, primary, Caspers, Peter J., primary, Bakker Schut, Tom C., primary, Roy, Séverine, primary, Boutros, Céline, primary, Mateus, Christine, primary, Routier, Emilie, primary, Besse, Benjamin, primary, Planchard, David, primary, Seck, Atmane, primary, Kamsu Kom, Nyam, primary, Tomasic, Gorana, primary, Koljenović, Senada, primary, Noordhoek Hegt, Vincent, primary, Texier, Matthieu, primary, Lanoy, Emilie, primary, Eggermont, Alexander M.M., primary, Paci, Angelo, primary, Robert, Caroline, primary, Puppels, Gerwin J., primary, and Mir, Lluis M., primary

Published
2023
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31. Supplementary Table S2 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents

Author

Azan, Antoine, primary, Caspers, Peter J., primary, Bakker Schut, Tom C., primary, Roy, Séverine, primary, Boutros, Céline, primary, Mateus, Christine, primary, Routier, Emilie, primary, Besse, Benjamin, primary, Planchard, David, primary, Seck, Atmane, primary, Kamsu Kom, Nyam, primary, Tomasic, Gorana, primary, Koljenović, Senada, primary, Noordhoek Hegt, Vincent, primary, Texier, Matthieu, primary, Lanoy, Emilie, primary, Eggermont, Alexander M.M., primary, Paci, Angelo, primary, Robert, Caroline, primary, Puppels, Gerwin J., primary, and Mir, Lluis M., primary

Published
2023
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32. Data from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents

Author

Azan, Antoine, primary, Caspers, Peter J., primary, Bakker Schut, Tom C., primary, Roy, Séverine, primary, Boutros, Céline, primary, Mateus, Christine, primary, Routier, Emilie, primary, Besse, Benjamin, primary, Planchard, David, primary, Seck, Atmane, primary, Kamsu Kom, Nyam, primary, Tomasic, Gorana, primary, Koljenović, Senada, primary, Noordhoek Hegt, Vincent, primary, Texier, Matthieu, primary, Lanoy, Emilie, primary, Eggermont, Alexander M.M., primary, Paci, Angelo, primary, Robert, Caroline, primary, Puppels, Gerwin J., primary, and Mir, Lluis M., primary

Published
2023
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33. Supplementary Figure S1 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents

Author

Azan, Antoine, primary, Caspers, Peter J., primary, Bakker Schut, Tom C., primary, Roy, Séverine, primary, Boutros, Céline, primary, Mateus, Christine, primary, Routier, Emilie, primary, Besse, Benjamin, primary, Planchard, David, primary, Seck, Atmane, primary, Kamsu Kom, Nyam, primary, Tomasic, Gorana, primary, Koljenović, Senada, primary, Noordhoek Hegt, Vincent, primary, Texier, Matthieu, primary, Lanoy, Emilie, primary, Eggermont, Alexander M.M., primary, Paci, Angelo, primary, Robert, Caroline, primary, Puppels, Gerwin J., primary, and Mir, Lluis M., primary

Published
2023
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39. Adaptive management of Mediterranean Pinus halepensis forests in the face of climate change 

Author

Díaz Montero, Asunción, primary, Peña Molina, Esther, additional, Fajardo Cantos, Álvaro, additional, González Romero, Javier, additional, Botella Bou, Raúl, additional, Moya Navarro, Daniel, additional, de las Heras Ibáñez, Jorge Antonio, additional, Lucas Borja, Manuel Esteban, additional, Martín Alcón, Santiago, additional, Tomé Morán, José Luis, additional, Jordán Gonzalez, Esteban, additional, Coll Mir, Lluis, additional, Ameztegui González, Aitor, additional, del Campo García, Antonio, additional, and González Sanchís, María, additional

Published
2023
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