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215 results on '"Miron, Veronique E."'

2. Author Correction: Microglia regulate central nervous system myelin growth and integrity

Author

McNamara, Niamh B., Munro, David A. D., Bestard-Cuche, Nadine, Uyeda, Akiko, Bogie, Jeroen F. J., Hoffmann, Alana, Holloway, Rebecca K., Molina-Gonzalez, Irene, Askew, Katharine E., Mitchell, Stephen, Mungall, William, Dodds, Michael, Dittmayer, Carsten, Moss, Jonathan, Rose, Jamie, Szymkowiak, Stefan, Amann, Lukas, McColl, Barry W., Prinz, Marco, Spires-Jones, Tara L., Stenzel, Werner, Horsburgh, Karen, Hendriks, Jerome J. A., Pridans, Clare, Muramatsu, Rieko, Williams, Anna, Priller, Josef, and Miron, Veronique E.

Published
2024
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3. Microglia states and nomenclature: A field at its crossroads

Author

Paolicelli, Rosa C, Sierra, Amanda, Stevens, Beth, Tremblay, Marie-Eve, Aguzzi, Adriano, Ajami, Bahareh, Amit, Ido, Audinat, Etienne, Bechmann, Ingo, Bennett, Mariko, Bennett, Frederick, Bessis, Alain, Biber, Knut, Bilbo, Staci, Blurton-Jones, Mathew, Boddeke, Erik, Brites, Dora, Brône, Bert, Brown, Guy C, Butovsky, Oleg, Carson, Monica J, Castellano, Bernardo, Colonna, Marco, Cowley, Sally A, Cunningham, Colm, Davalos, Dimitrios, De Jager, Philip L, de Strooper, Bart, Denes, Adam, Eggen, Bart JL, Eyo, Ukpong, Galea, Elena, Garel, Sonia, Ginhoux, Florent, Glass, Christopher K, Gokce, Ozgun, Gomez-Nicola, Diego, González, Berta, Gordon, Siamon, Graeber, Manuel B, Greenhalgh, Andrew D, Gressens, Pierre, Greter, Melanie, Gutmann, David H, Haass, Christian, Heneka, Michael T, Heppner, Frank L, Hong, Soyon, Hume, David A, Jung, Steffen, Kettenmann, Helmut, Kipnis, Jonathan, Koyama, Ryuta, Lemke, Greg, Lynch, Marina, Majewska, Ania, Malcangio, Marzia, Malm, Tarja, Mancuso, Renzo, Masuda, Takahiro, Matteoli, Michela, McColl, Barry W, Miron, Veronique E, Molofsky, Anna Victoria, Monje, Michelle, Mracsko, Eva, Nadjar, Agnes, Neher, Jonas J, Neniskyte, Urte, Neumann, Harald, Noda, Mami, Peng, Bo, Peri, Francesca, Perry, V Hugh, Popovich, Phillip G, Pridans, Clare, Priller, Josef, Prinz, Marco, Ragozzino, Davide, Ransohoff, Richard M, Salter, Michael W, Schaefer, Anne, Schafer, Dorothy P, Schwartz, Michal, Simons, Mikael, Smith, Cody J, Streit, Wolfgang J, Tay, Tuan Leng, Tsai, Li-Huei, Verkhratsky, Alexei, von Bernhardi, Rommy, Wake, Hiroaki, Wittamer, Valérie, Wolf, Susanne A, Wu, Long-Jun, and Wyss-Coray, Tony

Subjects
Microglia, Neurosciences, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.

Published
2022

5. Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

Author

Tzioras, Makis, Daniels, Michael J.D., Davies, Caitlin, Baxter, Paul, King, Declan, McKay, Sean, Varga, Balazs, Popovic, Karla, Hernandez, Madison, Stevenson, Anna J., Barrington, Jack, Drinkwater, Elizabeth, Borella, Julia, Holloway, Rebecca K., Tulloch, Jane, Moss, Jonathan, Latta, Clare, Kandasamy, Jothy, Sokol, Drahoslav, Smith, Colin, Miron, Veronique E., Káradóttir, Ragnhildur Thóra, Hardingham, Giles E., Henstridge, Christopher M., Brennan, Paul M., McColl, Barry W., and Spires-Jones, Tara L.

Published
2023
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6. Microglia regulate central nervous system myelin growth and integrity

Author

McNamara, Niamh B., Munro, David A. D., Bestard-Cuche, Nadine, Uyeda, Akiko, Bogie, Jeroen F. J., Hoffmann, Alana, Holloway, Rebecca K., Molina-Gonzalez, Irene, Askew, Katharine E., Mitchell, Stephen, Mungall, William, Dodds, Michael, Dittmayer, Carsten, Moss, Jonathan, Rose, Jamie, Szymkowiak, Stefan, Amann, Lukas, McColl, Barry W., Prinz, Marco, Spires-Jones, Tara L., Stenzel, Werner, Horsburgh, Karen, Hendriks, Jerome J. A., Pridans, Clare, Muramatsu, Rieko, Williams, Anna, Priller, Josef, and Miron, Veronique E.

Published
2023
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10. CNS macrophage contributions to myelin health.

Author

Hoffmann, Alana and Miron, Veronique E.

Subjects
*OLIGODENDROGLIA, *CENTRAL nervous system, *WHITE matter (Nerve tissue), *CHOROID plexus, *NEUROLOGICAL disorders
Abstract

Summary Myelin is the membrane surrounding neuronal axons in the central nervous system (CNS), produced by oligodendrocytes to provide insulation for electrical impulse conduction and trophic/metabolic support. CNS dysfunction occurs following poor development of myelin in infancy, myelin damage in neurological diseases, and impaired regeneration of myelin with disease progression in aging. The lack of approved therapies aimed at supporting myelin health highlights the critical need to identify the cellular and molecular influences on oligodendrocytes. CNS macrophages have been shown to influence the development, maintenance, damage and regeneration of myelin, revealing critical interactions with oligodendrocyte lineage cells. CNS macrophages are comprised of distinct populations, including CNS‐resident microglia and cells associated with CNS border regions (the meninges, vasculature, and choroid plexus), in addition to macrophages derived from monocytes infiltrating from the blood. Importantly, the distinct contribution of these macrophage populations to oligodendrocyte lineage responses and myelin health are only just beginning to be uncovered, with the advent of new tools to specifically identify, track, and target macrophage subsets. Here, we summarize the current state of knowledge on the roles of CNS macrophages in myelin health, and recent developments in distinguishing the roles of macrophage populations in development, homeostasis, and disease. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Reflective imaging of myelin integrity in the human and mouse central nervous systems.

Author

Craig, Georgina A., Ryan, Lucy, Thapar, Jessica, McNamara, Niamh B., Hoffmann, Alana, Page, Danielle, Rose, Jamie, Cox, Simon R., and Miron, Veronique E.

Subjects
CENTRAL nervous system, MYELIN proteins, MYELIN, MYELIN sheath, WHITE matter (Nerve tissue), SPECTRAL reflectance
Abstract

The structural integrity of myelin sheaths in the central nervous system (CNS) is crucial for the maintenance of its function. Electron microscopy (EM) is the gold standard for visualizing individual myelin sheaths. However, the tissue processing involved can induce artifacts such as shearing of myelin, which can be difficult to distinguish from true myelin abnormalities. Spectral confocal reflectance (SCoRe) microscopy is an imaging technique that leverages the differential refractive indices of compacted CNS myelin in comparison to surrounding parenchyma to detect individual compact myelin internodes with reflected light, positioning SCoRe as a possible complementary method to EM to assess myelin integrity. Whether SCoRe is sensitive enough to detect losses in myelin compaction when myelin quantity is otherwise unaffected has not yet been directly tested. Here, we assess the capacity of SCoRe to detect differences in myelin compaction in two mouse models that exhibit a loss of myelin compaction without demyelination: microglia-deficient mice (Csf1r-FIREΔ/Δ) and wild-type mice fed with the CSF1R inhibitor PLX5622. In addition, we compare the ability to detect compact myelin sheaths using SCoRe in fixedfrozen versus paraffin-embedded mouse tissue. Finally, we show that SCoRe can successfully detect individual sheaths in aged human paraffin-embedded samples of deep white matter regions. As such, we find SCoRe to be an attractive technique to investigate myelin integrity, with sufficient sensitivity to detect myelin ultrastructural abnormalities and the ability to perform equally well in tissue preserved using different methods. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Key roles of glial cells in the encephalopathy of prematurity

Author

Van Steenwinckel, Juliette, primary, Bokobza, Cindy, additional, Laforge, Mireille, additional, Shearer, Isabelle K., additional, Miron, Veronique E., additional, Rua, Rejane, additional, Matta, Samantha M., additional, Hill‐Yardin, Elisa L., additional, Fleiss, Bobbi, additional, and Gressens, Pierre, additional

Published
2023
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21. Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration

Author

Molina-Gonzalez, Irene, primary, Holloway, Rebecca K., additional, Jiwaji, Zoeb, additional, Dando, Owen, additional, Kent, Sarah A., additional, Emelianova, Katie, additional, Lloyd, Amy F., additional, Forbes, Lindsey H., additional, Mahmood, Ayisha, additional, Skripuletz, Thomas, additional, Gudi, Viktoria, additional, Febery, James A., additional, Johnson, Jeffrey A., additional, Fowler, Jill H., additional, Kuhlmann, Tanja, additional, Williams, Anna, additional, Chandran, Siddharthan, additional, Stangel, Martin, additional, Howden, Andrew J. M., additional, Hardingham, Giles E., additional, and Miron, Veronique E., additional

Published
2023
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24. Haemorrhage of human foetal cortex associated with SARS-CoV-2 infection

Author

Massimo, Marco, primary, Barelli, Carlotta, additional, Moreno, Catalina, additional, Collesi, Chiara, additional, Holloway, Rebecca K, additional, Crespo, Berta, additional, Zentilin, Lorena, additional, Williams, Anna, additional, Miron, Veronique E, additional, Giacca, Mauro, additional, and Long, Katherine R, additional

Published
2023
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25. Microglia regulate central nervous system myelin growth and integrity

Author

McNamara, Niamh B., primary, Munro, David A. D., additional, Bestard-Cuche, Nadine, additional, Uyeda, Akiko, additional, Bogie, Jeroen F. J., additional, Hoffmann, Alana, additional, Holloway, Rebecca K., additional, Molina-Gonzalez, Irene, additional, Askew, Katharine E., additional, Mitchell, Stephen, additional, Mungall, William, additional, Dodds, Michael, additional, Dittmayer, Carsten, additional, Moss, Jonathan, additional, Rose, Jamie, additional, Szymkowiak, Stefan, additional, Amann, Lukas, additional, McColl, Barry W., additional, Prinz, Marco, additional, Spires-Jones, Tara L., additional, Stenzel, Werner, additional, Horsburgh, Karen, additional, Hendriks, Jerome J. A., additional, Pridans, Clare, additional, Muramatsu, Rieko, additional, Williams, Anna, additional, Priller, Josef, additional, and Miron, Veronique E., additional

Published
2022
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26. Early-life inflammatory markers and subsequent psychotic and depressive episodes between 10 to 28 years of age

Author

Edmondson-Stait, Amelia J., primary, Shen, Xueyi, additional, Adams, Mark J., additional, Barbu, Miruna C., additional, Jones, Hannah J., additional, Miron, Veronique E., additional, Allardyce, Judith, additional, Boardman, James P., additional, Lawrie, Stephen M., additional, McIntosh, Andrew M., additional, Khandaker, Golam M., additional, Kwong, Alex S.F., additional, and Whalley, Heather C., additional

Published
2022
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28. Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders

Author

Conole, Eleanor L.S., primary, Vaher, Kadi, additional, Cabez, Manuel Blesa, additional, Sullivan, Gemma, additional, Stevenson, Anna J., additional, Hall, Jill, additional, Murphy, Lee, additional, Thrippleton, Michael J., additional, Quigley, Alan J., additional, Bastin, Mark E., additional, Miron, Veronique E., additional, Whalley, Heather C., additional, Marioni, Riccardo E., additional, Boardman, James P., additional, and Cox, Simon R., additional

Published
2022
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29. Astrocyte-Oligodendrocyte interaction regulates central nervous system regeneration

Author

Molina-Gonzalez, Irene, primary, Holloway, Rebecca K., additional, Jiwaji, Zoeb, additional, Dando, Owen, additional, Emelianova, Katie, additional, Lloyd, Amy F., additional, Forbes, Lindsey H., additional, Mahmood, Ayisha, additional, Skripuletz, Thomas, additional, Gudi, Viktoria, additional, Febery, James A., additional, Johnson, Jeffrey A., additional, Fowler, Jill H., additional, Kuhlmann, Tanja, additional, Williams, Anna, additional, Chandran, Siddharthan, additional, Stangel, Martin, additional, Howden, Andrew J.M., additional, Hardingham, Giles E., additional, and Miron, Veronique E., additional

Published
2022
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31. T79. ASSOCIATIONS BETWEEN MARKERS OF INFLAMMATION AND LATER EPISODES OF DEPRESSION AND PSYCHOTIC LIKE EXPERIENCES FROM 10 TO 28 YEARS OLD

Author

Edmondson-Stait, Amelia, primary, Shen, Xueyi, additional, Adams, Mark J., additional, Barbu, Miruna C., additional, Jones, Hannah J., additional, Miron, Veronique E., additional, Allardyce, Judith, additional, Lawrie, Stephen M., additional, Khandaker, Golam M., additional, McIntosh, Andrew M., additional, Kwong, Alex S.F., additional, and Whalley, Heather C., additional

Published
2022
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32. The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation

Author

Smith, Katie J., primary, Minns, Danielle, additional, McHugh, Brian J., additional, Holloway, Rebecca K., additional, O’Connor, Richard, additional, Williams, Anna, additional, Melrose, Lauren, additional, McPherson, Rhoanne, additional, Miron, Veronique E., additional, Davidson, Donald J., additional, and Gwyer Findlay, Emily, additional

Published
2022
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33. Early-life inflammatory markers and subsequent episodes of depression and psychotic experiences in the ALSPAC birth cohort

Author

Edmondson-Stait, Amelia J, primary, Shen, Xueyi, additional, Adams, Mark James, additional, Barbu, Miruna C, additional, Jones, Hannah J, additional, Miron, Veronique E, additional, Allardyce, Judith, additional, Boardman, James P, additional, Lawrie, Stephen M, additional, McIntosh, Andrew M, additional, Khandaker, Golam M, additional, Kwong, Alex S. F., additional, and Whalley, Heather C, additional

Published
2022
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35. Microglia states and nomenclature: A field at its crossroads.

Author

Paolicelli, Rosa C., Sierra, Amanda, Stevens, Beth, Tremblay, Marie-Eve, Aguzzi, Adriano, Ajami, Bahareh, Amit, Ido, Audinat, Etienne, Bechmann, Ingo, Bennett, Mariko, Bennett, Frederick, Bessis, Alain, Biber, Knut, Bilbo, Staci, Blurton-Jones, Mathew, Boddeke, Erik, Brites, Dora, Brône, Bert, Brown, Guy C., Butovsky, Oleg, Carson, Monica J., Castellano, Bernardo, Colonna, Marco, Cowley, Sally A., Cunningham, Colm, Davalos, Dimitrios, De Jager, Philip L., de Strooper, Bart, Denes, Adam, Eggen, Bart J. L., Eyo, Ukpong, Galea, Elena, Garel, Sonia, Ginhoux, Florent, Glass, Christopher K., Gokce, Ozgun, Gomez-Nicola, Diego, González, Berta, Gordon, Siamon, Graeber, Manuel B., Greenhalgh, Andrew D., Gressens, Pierre, Greter, Melanie, Gutmann, David H., Haass, Christian, Heneka, Michael, Heppner, Frank L., Hong, Soyon, Hume, David A., Jung, Steffen, Kettenmann, Helmut, Kipnis, Jonathan, Koyama, Ryuta, Lemke, Greg, Lynch, Marina, Majewska, Ania, Malcangio, Marzia, Malm, Tarja, Mancuso, Renzo, Masuda, Takahiro, Matteoli, Michela, McColl, Barry W., Miron, Veronique E., Molofsky, Anna Victoria, Monje, Michelle, Mracsko, Eva, Nadjar, Agnes, Neher, Jonas J., Neniskyte, Urte, Neumann, Harald, Noda, Mami, Peng, Bo, Peri, Francesca, Perry, V. Hugh, Popovich, Phillip G., Pridans, Clare, Priller, Josef, Prinz, Marco, Ragozzino, Davide, Ransohoff, Richard M., Salter, Michael W., Schaefer, Anne, Schafer, Dorothy P., Schwartz, Michal, Simons, Mikael, Smith, Cody J., Streit, Wolfgang J., Tay, Tuan Leng, Tsai, Li-Huei, Verkhratsky, Alexei, von Bernhardi, Rommy, Wake, Hiroaki, Wittamer, Valérie, Wolf, Susanne A., Wu, Long-Jun, Wyss-Coray, Tony, Paolicelli, Rosa C., Sierra, Amanda, Stevens, Beth, Tremblay, Marie-Eve, Aguzzi, Adriano, Ajami, Bahareh, Amit, Ido, Audinat, Etienne, Bechmann, Ingo, Bennett, Mariko, Bennett, Frederick, Bessis, Alain, Biber, Knut, Bilbo, Staci, Blurton-Jones, Mathew, Boddeke, Erik, Brites, Dora, Brône, Bert, Brown, Guy C., Butovsky, Oleg, Carson, Monica J., Castellano, Bernardo, Colonna, Marco, Cowley, Sally A., Cunningham, Colm, Davalos, Dimitrios, De Jager, Philip L., de Strooper, Bart, Denes, Adam, Eggen, Bart J. L., Eyo, Ukpong, Galea, Elena, Garel, Sonia, Ginhoux, Florent, Glass, Christopher K., Gokce, Ozgun, Gomez-Nicola, Diego, González, Berta, Gordon, Siamon, Graeber, Manuel B., Greenhalgh, Andrew D., Gressens, Pierre, Greter, Melanie, Gutmann, David H., Haass, Christian, Heneka, Michael, Heppner, Frank L., Hong, Soyon, Hume, David A., Jung, Steffen, Kettenmann, Helmut, Kipnis, Jonathan, Koyama, Ryuta, Lemke, Greg, Lynch, Marina, Majewska, Ania, Malcangio, Marzia, Malm, Tarja, Mancuso, Renzo, Masuda, Takahiro, Matteoli, Michela, McColl, Barry W., Miron, Veronique E., Molofsky, Anna Victoria, Monje, Michelle, Mracsko, Eva, Nadjar, Agnes, Neher, Jonas J., Neniskyte, Urte, Neumann, Harald, Noda, Mami, Peng, Bo, Peri, Francesca, Perry, V. Hugh, Popovich, Phillip G., Pridans, Clare, Priller, Josef, Prinz, Marco, Ragozzino, Davide, Ransohoff, Richard M., Salter, Michael W., Schaefer, Anne, Schafer, Dorothy P., Schwartz, Michal, Simons, Mikael, Smith, Cody J., Streit, Wolfgang J., Tay, Tuan Leng, Tsai, Li-Huei, Verkhratsky, Alexei, von Bernhardi, Rommy, Wake, Hiroaki, Wittamer, Valérie, Wolf, Susanne A., Wu, Long-Jun, and Wyss-Coray, Tony

Abstract

Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.

Published
2022

36. Microglia states and nomenclature: A field at its crossroads.

Author

Paolicelli, Rosa RC, Sierra, Amanda, Stevens, Beth, Tremblay, Marie-Eve, Aguzzi, Adriano, Ajami, Bahareh, Amit, Ido, Audinat, Etienne, Bechmann, Ingo, Bennett, Mariko, Bennett, Frederick, Bessis, Alain, Biber, Knut, Bilbo, Staci, Blurton-Jones, Mathew, Boddeke, Erik, Brites, Dora, Brône, Bert, Brown, Guy C, Butovsky, Oleg, Carson, Monica J, Castellano, Bernardo, Colonna, Marco, Cowley, Sally A, Cunningham, Colm, Davalos, Dimitrios, De Jager, Philip L, De Strooper, Bart, Denes, Adam, Eggen, Bart BJL, Eyo, Ukpong, Galea, Elena, Garel, Sonia, Ginhoux, Florent, Glass, Christopher K, Gokce, Ozgun, Gomez-Nicola, Diego, González, Berta, Gordon, Siamon, Graeber, Manuel MB, Greenhalgh, Andrew AD, Gressens, Pierre, Greter, Melanie, Gutmann, David DH, Haass, Christian, Heneka, Michael MT, Heppner, Frank FL, Hong, Soyon, Hume, David DA, Jung, Steffen, Kettenmann, Helmut, Kipnis, Jonathan, Koyama, Ryuta, Lemke, Greg, Lynch, Marina, Majewska, Ania, Malcangio, Marzia, Malm, Tarja, Mancuso, Renzo, Masuda, Takahiro, Matteoli, Michela, McColl, Barry W, Miron, Veronique E, Molofsky, Anna Victoria, Monje, Michelle, Mracsko, Eva, Nadjar, Agnes, Neher, Jonas JJ, Neniskyte, Urte, Neumann, Frank Harald, Noda, Mami, Peng, Bo, Peri, Francesca, Perry, Hugh VH, Popovich, Phillip PG, Pridans, Clare, Priller, Josef, Prinz, Marco, Ragozzino, Davide, Ransohoff, Richard M, Salter, Michael W, Schaefer, Anne, Schafer, Dorothy P, Schwartz, Michal, Simons, Mikael, Smith, Cody J, Streit, Wolfgang WJ, Tay, Tuan Leng, Tsai, Li-Huei, Verkhratsky, Alexei, von Bernhardi, Rommy, Wake, Hiroaki, Wittamer, Valérie, Wolf, Susanne A, Wu, Long-Jun, Wyss-Coray, Tony, Paolicelli, Rosa RC, Sierra, Amanda, Stevens, Beth, Tremblay, Marie-Eve, Aguzzi, Adriano, Ajami, Bahareh, Amit, Ido, Audinat, Etienne, Bechmann, Ingo, Bennett, Mariko, Bennett, Frederick, Bessis, Alain, Biber, Knut, Bilbo, Staci, Blurton-Jones, Mathew, Boddeke, Erik, Brites, Dora, Brône, Bert, Brown, Guy C, Butovsky, Oleg, Carson, Monica J, Castellano, Bernardo, Colonna, Marco, Cowley, Sally A, Cunningham, Colm, Davalos, Dimitrios, De Jager, Philip L, De Strooper, Bart, Denes, Adam, Eggen, Bart BJL, Eyo, Ukpong, Galea, Elena, Garel, Sonia, Ginhoux, Florent, Glass, Christopher K, Gokce, Ozgun, Gomez-Nicola, Diego, González, Berta, Gordon, Siamon, Graeber, Manuel MB, Greenhalgh, Andrew AD, Gressens, Pierre, Greter, Melanie, Gutmann, David DH, Haass, Christian, Heneka, Michael MT, Heppner, Frank FL, Hong, Soyon, Hume, David DA, Jung, Steffen, Kettenmann, Helmut, Kipnis, Jonathan, Koyama, Ryuta, Lemke, Greg, Lynch, Marina, Majewska, Ania, Malcangio, Marzia, Malm, Tarja, Mancuso, Renzo, Masuda, Takahiro, Matteoli, Michela, McColl, Barry W, Miron, Veronique E, Molofsky, Anna Victoria, Monje, Michelle, Mracsko, Eva, Nadjar, Agnes, Neher, Jonas JJ, Neniskyte, Urte, Neumann, Frank Harald, Noda, Mami, Peng, Bo, Peri, Francesca, Perry, Hugh VH, Popovich, Phillip PG, Pridans, Clare, Priller, Josef, Prinz, Marco, Ragozzino, Davide, Ransohoff, Richard M, Salter, Michael W, Schaefer, Anne, Schafer, Dorothy P, Schwartz, Michal, Simons, Mikael, Smith, Cody J, Streit, Wolfgang WJ, Tay, Tuan Leng, Tsai, Li-Huei, Verkhratsky, Alexei, von Bernhardi, Rommy, Wake, Hiroaki, Wittamer, Valérie, Wolf, Susanne A, Wu, Long-Jun, and Wyss-Coray, Tony

Abstract

Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2022

38. The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease

Author

Smith, Katie J, primary, Minns, Danielle, additional, McHugh, Brian, additional, Holloway, Rebecca, additional, O'Connor, Richard, additional, Williams, Anna, additional, Melrose, Lauren, additional, McPherson, Rhoanne, additional, Miron, Veronique E, additional, Davidson, Donald J, additional, and Gwyer Findlay, Emily, additional

Published
2022
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39. Defining Microglial States and Nomenclature: A Roadmap to 2030

Author

Paolicelli, Rosa, primary, Sierra, Amanda, additional, Stevens, Beth, additional, Tremblay, Marie-Eve, additional, Aguzzi, Adriano, additional, Ajami, Bahareh, additional, Amit, Ido, additional, Audinat, Etienne, additional, Bechmann, Ingo, additional, Bennett, Mariko, additional, Bennett, Frederick, additional, Bessis, Alain, additional, Biber, Knut, additional, Bilbo, Staci, additional, Blurton-Jones, Mathew, additional, Boddeke, Erik, additional, Brites, Dora, additional, Brône, Bert, additional, Brown, Guy C., additional, Butovsky, Oleg, additional, Carson, Monica J., additional, Castellano, Bernardo, additional, Colonna, Marco, additional, Cowley, Sally A., additional, Cunningham, Colm, additional, Davalos, Dimitrios, additional, De Jager, Philip L., additional, De Strooper, Bart, additional, Dénes, Ádám, additional, Eggen, Bart J.L., additional, Eyo, Ukpong, additional, Galea, Elena, additional, Garel, Sonia, additional, Ginhoux, Florent, additional, Glass, Christopher K., additional, Gokce, Ozgun, additional, Gomez-Nicola, Diego, additional, González, Berta, additional, Gordon, Siamon, additional, Graeber, Manuel B., additional, Greenhalgh, Andrew D., additional, Gressens, Pierre, additional, Greter, Melanie, additional, Gutmann, David H., additional, Haass, Christian, additional, Heneka, Michael T., additional, Heppner, Frank, additional, Hong, Soyon, additional, Jung, Steffen, additional, Kettenmann, Helmut, additional, Kipnis, Jonathan, additional, Koyama, Ryuta, additional, Lemke, Greg, additional, Lynch, Marina, additional, Majewska, Ania, additional, Malcangio, Marzia, additional, Malm, Tarja, additional, Mancuso, Renzo, additional, Matteoli, Michela, additional, McColl, Barry, additional, Miron, Veronique E., additional, Molofsky, Anna Victoria, additional, Monje, Michelle, additional, Mracsko, Eva, additional, Nadjar, Agnes, additional, Neher, Jonas J., additional, Neniskyte, Urte, additional, Neumann, Harald, additional, Noda, Mami, additional, Peng, Bo, additional, Peri, Francesca, additional, Perry, V. Hugh, additional, Popovich, Phillip G., additional, Priller, Josef, additional, Ragozzino, Davide, additional, Ransohoff, Richard M., additional, Salter, Michael W., additional, Schaefer, Anne, additional, Schafer, Dorothy P., additional, Schwartz, Michal, additional, Simons, Mikael, additional, Streit, Wolfgang J., additional, Tay, Tuan Leng, additional, Tsai, Li-Huei, additional, Verkhratsky, Alexei, additional, von Bernhardi, Rommy, additional, Wake, Hiroaki, additional, Wittamer, Valerie, additional, Wolf, Susanne A., additional, Wu, Long-Jun, additional, and Wyss-Coray, Tony, additional

Published
2022
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45. Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030

Author

MacKenzie, Georgina, primary, Subramaniam, Sumithra, additional, Caldwell, Lindsey J, additional, Fitzgerald, Denise, additional, Harrison, Neil A, additional, Hong, Soyon, additional, Irani, Sarosh R, additional, Khandaker, Golam M, additional, Liston, Adrian, additional, Miron, Veronique E, additional, Mondelli, Valeria, additional, Morgan, B Paul, additional, Pariante, Carmine, additional, Shah, Divya K, additional, Taams, Leonie S, additional, Teeling, Jessica L, additional, and Upthegrove, Rachel, additional

Published
2021
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49. Microglia regulation of central nervous system myelin health and regeneration

Author

Kent, Sarah A. and Miron, Veronique E.

Abstract

Microglia are resident macrophages of the central nervous system that have key functions in its development, homeostasis and response to damage and infection. Although microglia have been increasingly implicated in contributing to the pathology that underpins neurological dysfunction and disease, they also have crucial roles in neurological homeostasis and regeneration. This includes regulation of the maintenance and regeneration of myelin, the membrane that surrounds neuronal axons, which is required for axonal health and function. Myelin is damaged with normal ageing and in several neurodegenerative diseases, such as multiple sclerosis and Alzheimer disease. Given the lack of approved therapies targeting myelin maintenance or regeneration, it is imperative to understand the mechanisms by which microglia support and restore myelin health to identify potential therapeutic approaches. However, the mechanisms by which microglia regulate myelin loss or integrity are still being uncovered. In this Review, we discuss recent work that reveals the changes in white matter with ageing and neurodegenerative disease, how this relates to microglia dynamics during myelin damage and regeneration, and factors that influence the regenerative functions of microglia.

Published
2023
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