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Your search keyword '"Mishra, Avshesh"' showing total 22 results
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22 results on '"Mishra, Avshesh"'

3. Multi-gene testing in neurological disorders showed an improved diagnostic yield: data from over 1000 Indian patients

Author

Ganapathy, Aparna, Mishra, Avshesh, Soni, Megha Rani, Kumar, Priyanka, Sadagopan, Mukunth, Kanthi, Anil Vittal, Patric, Irene Rosetta Pia, George, Sobha, Sridharan, Aparajit, Thyagarajan, T. C., Aswathy, S. L., Vidya, H. K., Chinnappa, Swathi M., Nayanala, Swetha, Prakash, Manasa B., Raghavendrachar, Vijayashree G., Parulekar, Minothi, Gowda, Vykuntaraju K., Nampoothiri, Sheela, Menon, Ramshekhar N., Pachat, Divya, Udani, Vrajesh, Naik, Neeta, Kamate, Mahesh, Devi, A. Radha Rama, Mohammed Kunju, P. A., Nair, Mohandas, Hegde, Anaita Udwadia, Kumar, M. Pradeep, Sundaram, Soumya, Tilak, Preetha, Puri, Ratna D., Shah, Krati, Sheth, Jayesh, Hasan, Qurratulain, Sheth, Frenny, Agrawal, Pooja, Katragadda, Shanmukh, Veeramachaneni, Vamsi, Chandru, Vijay, Hariharan, Ramesh, and Mannan, Ashraf U.

Published
2019
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6. Detection of high frequency of mutations in a breast and/or ovarian cancer cohort: implications of embracing a multi-gene panel in molecular diagnosis in India

Author

Mannan, Ashraf U, Singh, Jaya, Lakshmikeshava, Ravikiran, Thota, Nishita, Singh, Suhasini, Sowmya, T S, Mishra, Avshesh, Sinha, Aditi, Deshwal, Shivani, Soni, Megha R, Chandrasekar, Anbukayalvizhi, Ramesh, Bhargavi, Ramamurthy, Bharat, Padhi, Shila, Manek, Payal, Ramalingam, Ravi, Kapoor, Suman, Ghosh, Mithua, Sankaran, Satish, Ghosh, Arunabha, Veeramachaneni, Vamsi, Ramamoorthy, Preveen, Hariharan, Ramesh, and Subramanian, Kalyanasundaram

Published
2016
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13. Impact of Renin-Angiotensin-Aldosterone System Gene Polymorphisms on Left Ventricular Dysfunction in Coronary Artery Disease Patients

Author

Mishra, Avshesh, Srivastava, Anshika, Mittal, T., Garg, N., and Mittal, B.

Subjects
lcsh:R5-920, Biochemistry (medical), Clinical Biochemistry, Genetics, General Medicine, lcsh:Medicine (General), Molecular Biology
Abstract

Background: Left ventricular dysfunction (LVD), followed by fall in cardiac output is one of the major complications in some coronary artery disease (CAD) patients. The decreased cardiac output over time leads to activation of the renin-angiotensin-aldosterone system which results in vasoconstriction by influencing salt-water homeostasis. Therefore, the purpose of the present study was to explore the association of single nucleotide polymorphisms (SNPs) in angiotensin I converting enzyme;ACE(rs4340), angiotensin II type1 receptor; AT1 (rs5186) and aldosterone synthase;CYP11B2(rs1799998) with LVD.Methods and results: The present study was carried out in two cohorts. The primary cohort included 308 consecutive patients with angiographically confirmed CAD and 234 healthy controls. Among CAD, 94 with compromised left ventricle ejection fraction (LVEF ≤ 45) were categorized as LVD. The ACE I/D, AT1 A1166C andCYP11B2T-344C polymorphisms were determined by PCR. Our results showed that ACE I/D was significantly associated with CAD but not with LVD. However, AT1 1166C variant was significantly associated with LVD (LVEF ≤ 45) (p value=0.013; OR=3.69), butCYP11B2(rs1799998) was not associated with either CAD or LVD. To validate our results, we performed a replication study in additional 200 cases with similar clinical characteristics and results again confirmed consistent findings (p value=0.020; OR=5.20).Conclusion: AT1 A1166C plays important role in conferring susceptibility of LVD.

Published
2012

21. Significant role of ADRB3rs4994 towards the development of coronary artery disease

Author

Kumar, Surendra, Mishra, Avshesh, Srivastava, Anshika, Mittal, Tulika, Garg, Naveen, and Mittal, Balraj

Abstract

Coronary artery disease (CAD) is the most common type of heart disease and cause of heart attacks. It has been proposed that both the susceptibility to disease and the interindividual variability in response to treatment relates in part to genetic polymorphisms, particularly those polymorphisms for neurotransmitter and drug receptors. Common functional polymorphisms in -adrenergic receptor genes (ADRB) have been associated with heart failure phenotypes. Therefore, the purpose of the present study was to explore the association of genetic variants in ADRB3(C190T or Trp64Arg) ADRB1(C1165G or Arg389Gly), and ADRA2A(C-1291G) with CAD.

Published
2014
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22. A Retrospective Analysis of BCR-ABL1 Kinase Domain Mutations in the Frontline Drug Intolerant or Resistant Chronic Myeloid Leukemia Patients: An Indian Experience from a High-End Referral Laboratory.

Author

Majumdar A, Katara R, Mishra A, Gupta A, Sharma DK, Srivastava AK, Sharma S, Jaiswal A, Dixit M, Kumar V, Kumar S, Kumar V, Sharma R, and Mohanty SK

Abstract

Atreye MajumdarSambit K. Mohanty Objective  This article identifies and evaluates the frequency of mutations in the BCR-ABL1 kinase domain (KD) of chronic myeloid leukemia (CML) patients who showed suboptimal response to their current tyrosine kinase inhibitor (TKI) regime and assesses their clinical value in further treatment decisions. Materials and Methods  Peripheral and/or bone marrow were collected from 791 CML patients. Ribonucleic acid was extracted, reverse transcribed, and Sanger sequencing method was utilized to detect single-nucleotide variants (SNVs) in BCR-ABL1 KD. Results  Thirty-eight different SNVs were identified in 29.8% ( n  = 236/791) patients. T315I, E255K, and M244V were among the most frequent mutations detected. In addition, one patient harbored a novel L298P mutation. A subset of patients from the abovementioned harbored compound mutations (13.3%, n  = 33/236). Follow-up data was available in 28 patients that demonstrated the efficacy of TKIs in correlation with mutation analysis and BCR-ABL1 quantitation. Molecular response was attained in 50% patients following an appropriate TKI shift. A dismal survival rate of 40% was observed in T315I-harboring patients on follow-up. Conclusion  This study shows the incidence and pattern of mutations in one of the largest sets of Indian CML patients. In addition, our findings strengthen the prognostic value of KD mutation analysis among strategies to overcome TKI resistance., Competing Interests: Conflict of Interest None declared., (MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)

Published
2022
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