Search

Nowadays, there are several websites that allow customers to buy and post reviews of purchased products, which results in incremental accumulation of a lot of reviews written in natural language. Moreover, conversance with E-commerce and social media has raised the level of sophistication of online shoppers and it is common practice for them to compare competing brands of products before making a purchase. Prevailing factors such as availability of online reviews and raised end-user expectations have motivated the development of opinion mining systems that can automatically classify and summarize users’ reviews. This paper proposes an opinion mining system that can be used for both binary and fine-grained sentiment classifications of user reviews. Feature-based sentiment classification is a multistep process that involves preprocessing to remove noise, extraction of features and corresponding descriptors, and tagging their polarity. The proposed technique extends the feature-based classification approach to incorporate the effect of various linguistic hedges by using fuzzy functions to emulate the effect of modifiers, concentrators, and dilators. Empirical studies indicate that the proposed system can perform reliable sentiment classification at various levels of granularity with high average accuracy of 89% for binary classification and 86% for fine-grained classification.

The growth of E-commerce has led to the invention of several websites that market and sell products as well as allow users to post reviews. It is typical for an online buyer to refer to these reviews before making a buying decision. Hence, automatic summarization of users’ reviews has a great commercial significance. However, since the product reviews are written by nonexperts in an unstructured, natural language text, the task of summarizing them is challenging. This paper presents a semisupervised approach for mining online user reviews to generate comparative feature-based statistical summaries that can guide a user in making an online purchase. It includes various phases like preprocessing and feature extraction and pruning followed by feature-based opinion summarization and overall opinion sentiment classification. Empirical studies indicate that the approach used in the paper can identify opinionated sentences from blog reviews with a high average precision of 91% and can classify the polarity of the reviews with a good average accuracy of 86%.

Abstract Aims Clinical pathways have been shown to improve outcomes in patients with heart failure (HF). Although patients with HF often have a cardiac implantable electronic device, few studies have reported the utility of device‐derived risk scores to augment and organize care. TriageHF Plus is a device‐based HF clinical pathway (DHFP) that uses remote monitoring alerts to trigger structured telephone assessment for HF stability and optimization. We aimed to evaluate the impact of TriageHF Plus on hospitalizations and describe the associated workforce burden. Methods and results TriageHF Plus was a multi‐site, prospective study that compared outcomes for patients recruited between April 2019 and February 2021. All alert‐triggered assessments were analysed to determine the appropriateness of the alert and the workload burden. A negative‐binomial regression with inverse probability treatment weighting using a time‐matched usual care cohort was applied to estimate the effect of TriageHF Plus on non‐elective hospitalizations. A post hoc pre‐COVID‐19 sensitivity analysis was also performed. The TriageHF Plus cohort (n = 443) had a mean age of 68.8 ± 11.2 years, 77% male (usual care cohort: n = 315, mean age of 66.2 ± 14.5 years, 65% male). In the TriageHF Plus cohort, an acute medical issue was identified following an alert in 79/182 (43%) cases. Fifty assessments indicated acute HF, requiring clinical action in 44 cases. At 30 day follow‐up, 39/66 (59%) of initially symptomatic patients reported improvement, and 20 (19%) initially asymptomatic patients had developed new symptoms. On average, each assessment took 10 min. The TriageHF Plus group had a 58% lower rate of hospitalizations across full follow‐up [incidence relative ratio: 0.42, 95% confidence interval (CI): 0.23–0.76, P = 0.004]. Across the pre‐COVID‐19 window, hospitalizations were 31% lower (0.69, 95% CI: 0.46–1.04, P = 0.077). Conclusions These data represent the largest real‐world evaluation of a DHFP based on multi‐parametric risk stratification. The TriageHF Plus clinical pathway was associated with an improvement in HF symptoms and reduced all‐cause hospitalizations.

This study presents a structuration approach to reach a high luminous transmittance (T l u m ) and solar modulation efficiency (Δ T s o l ) of thermochromic vanadium dioxide ( VO 2 ) thin films. Before starting optical simulations, we confirm that the optical properties of monoclinic VO 2 continuous films deposited by reactive magnetron sputtering show a good correspondence with numerical results. Then, calculations on ordered VO 2 nanostripes demonstrate an enhanced transmittance due to the presence of vertical openings, leading to a variety of photonic effects. A series of optimizations by varying the column width, period, and film thickness establishes that 20 nm wide and 10 nm separated nanostripes have a Δ T s o l of 14.2% and a T l u m of 47.6% for a film thickness of 250 nm. In comparison to a dense film without nanostructuring, the film transparency (related to T l u m ) is significantly enhanced, while Δ T s o l remains unchanged. Furthermore, this also translates into a favorable, less opaque color, so the geometry could be useful for various thermochromic applications, such as smart windows. [ABSTRACT FROM AUTHOR]

The U.S. Supreme Court ruling in United Automobile Workers versus Johnson Controls prohibits hiring policies that exclude fertile women from industries posing reproductive health risks to workers and fetuses. Many toxic substances that threaten the developing fetus also pose risks to adult male and female workers. Exclusionary employment policies are socially undesirable for the following reasons: they may lead to worse reproductive outcomes if the indirect effects of lower wages and less adequate health insurance in the alternative available jobs are considered. Second, the effect of such policies could damage the individual woman's overall well-being through its economic impact and her potential loss in autonomy. Third, occupational segregation into less hazardous but lower-paying jobs reinforces gender stereotypes that are restrictive to women. The Supreme Court ruling in the Johnson Controls case reaffirms the importance of the Civil Rights Act as both a shield against unfair treatment for individual women and a commitment to eradicate sexist attitudes and economic inequality throughout society.

We studied microsatellite frequency and distribution in 21.76-Mb random genomic sequences, 0.67-Mb BAC sequences from the Z chromosome, and 6.3-Mb EST sequences of Bombyx mori. We mined microsatellites of [greater than or equal to] 15 bases of mononucleotide repeats and [greater than or equal to] 5 repeat units of other classes of repeats. We estimated that microsatellites account for 0.31% of the genome of B. mori. Microsatellite tracts of A, AT, and ATT were the most abundant whereas their number drastically decreased as the length of the repeat motif increased. In general, tri- and hexanucleotide repeats were overrepresented in the transcribed sequences except TAA, GTA, and TGA, which were in excess in genomic sequences. The Z chromosome sequences contained shorter repeat types than the rest of the chromosomes in addition to a higher abundance of AT-rich repeats. Our results showed that base composition of the flanking sequence has an influence on the origin and evolution of microsatellites. Transitions/transversions were high in microsatellites of ESTs, whereas the genomic sequence had an equal number of substitutions and indels. The average heterozygosity value for 23 polymorphic microsatellite loci surveyed in 13 diverse silkmoth strains having 2-14 alleles was 0.54. Only 36 (18.2%) of 198 microsatellite loci were polymorphic between the two divergent silkworm populations and 10 (5%) loci revealed null alleles. The microsatellite map generated using these polymorphic markers resulted in 8 linkage groups. B. mori microsatellite loci were the most conserved in its immediate ancestor, B. mandarina, followed by the wild saturniid silkmoth, Antheraea assama.

Abstract Single‐arm cohorts/trials are often used in early phase oncology programs to support preliminary clinical activity assessments for investigational products, administered alone or in combination with standard of care (SOC) agents. Benchmarking clinical activity of those combinations against other treatments, including SOC, requires indirect comparisons against external trials, which presents challenges including cross‐study differences in trial populations/other factors. To facilitate such nonrandomized comparisons, we developed a comprehensive model‐based meta‐analysis (MBMA) framework to quantitatively adjust for factors related to efficacy in metastatic non‐small cell lung cancer (mNSCLC). Data were derived from 15 published studies assessing key programmed cell death protein‐1 (PD‐1) inhibitors pembrolizumab (n = 8) and nivolumab (n = 7), representing current SOC in mNSCLC. In the first stage, a mixed‐effects logistic regression model for overall response rate (ORR) was developed accounting for effects of various population covariates on ORR. The ORR model results indicated an odds ratio (OR) of 1.02 for squamous versus non‐squamous histology and OR of 1.20 for PD‐ligand 1 tumor proportion score (TPS) per every 10% increase of TPS level. Next, a nonparametric mixed‐effects model for overall survival (OS) was developed with ORR/other clinical covariates as input. Subsequently, MBMA simulations of relevant hypothetical scenarios involving single‐arm trial design predicted OS hazard ratios as a function of ORR with matched patient characteristics. Findings from this MBMA and derived parameter estimates can be generally applied by the reader as a framework for interpreting efficacy data from early phase trials to support ORR‐based go/no‐go decisions and futility rules, illustrated through examples in this report.

We present an experimental setup capable of quantitative examination of acoustic whistlers in tubes of varying lengths and diameters. It is simple enough to be used as an undergraduate lab or classroom demonstration. The setup can be used to show the transverse modes of a cavity, and the difference between the group and phase velocity of a wave, It can also be used to determine the velocity of sound to an accuracy of 3%. We present the results of several experiments used to determine the acoustic modes present in transient whistlers. Our results differ significantly from a 'geometrical acoustics' derivation of the acoustic whistler made in an earlier paper.

Idealizations and approximations of physical circuits are used to mathematically demonstrate the general condition under which energy transfer to a capacitor is complete. It is proven that energy delivery to the capacitor is complete, without the missing energy, for so long as the voltage across a capacitor is continuous and differentiable. Two idealized circuits that are exceptions to this general condition are also analyzed.

Introduction: In present scenario of food crisis, there is a need to explore new plants which can serve nutrition. Methods: Randomized clinical trial was designed; to revalidate efficacy of Madhooka pushpa, quoted Balya-Brimhana by Madanpala-Bhavaprakasha-Priyanighantu; on 90 healthy volunteers (3 groups of 30each). Group A and B were administered Drug D and I 5 g BD with normal water empty stomach for 90 days. Group C was on normal routine diet without any intervention. Subjective and objective parameters analyzed using “Wilcoxon signed rank test,” “KruskalWallis test with posttest” and “Student's paired t-test,” “ANNOVA” respectively. Results: There was significant improvement in symptoms of overall sarata, Samhanana, Pramana, Satmya, Satva, Aharasakti, Vyayamasakti with 30.92%, 9.09%, 3.75%, 10.59%, 27.46%, 20.31%, 42.73% improvement in Group A and 28.28%, 7.88%, 3.10%, 8.94%, 25.07%, 16.67%, 21.875% improvement in Group B; significant increase in weight, body mass index, chest-midarm-midthigh-abdominal circumference, chest expansion, handgrip power, foot pressure with 3.90%, 4.04%, 1.57%, 3.45%, 2.20%, 1.84%, 19.10%, 15.37%, 6.75% improvement in Group A and 3.81%, 3.18%, 0.50%, 3.34%, 1.93%, 1.28%, 13.77%, 8.73%, 5.98% improvement in Group B; significant decrease in walking time with 11.17% reduction in Group A and 8.71% reduction in Group B. Conclusion: Drugs D and I showed improvement in most parameters, former being slightly more efficacious. (Drug D/D1: Fresh flower juice concentrated by direct heat, Drug I/D2: Fresh flower juice concentrated by indirect heat).

Abstract Background Maize (Zea Mays) is one of the world’s most important crops. Hybrid maize lines resulted a major improvement in corn production in the previous and current centuries. Understanding the genetic mechanisms of the corn production associated traits greatly facilitate the development of superior hybrid varieties. Result In this study, four ear traits associated with corn production of Nested Association Mapping (NAM) population were analyzed using a full genetic model, and further, optimal genotype combinations and total genetic effects of current best lines, superior lines, and superior hybrids were predicted for each of the traits at four different locations. The analysis identified 21–34 highly significant SNPs (−log 10 P > 5), with an estimated total heritability of 37.31–62.34%, while large contributions to variations was due to dominance, dominance-related epistasis, and environmental interaction effects ( $${h}_{D+}^2\hat{=}$$ h D + 2 = ^ 14.06% ~ 49.28%), indicating these factors contributed significantly to phenotypic variations of the ear traits. Environment-specific genetic effects were also discovered to be crucial for maize ear traits. There were four SNPs found for three ear traits: two for ear length and weight, and two for ear row number and length. Using the Enumeration method and the stepwise tuning technique, optimum multi-locus genotype combinations for superior lines were identified based on the information obtained from GWAS. Conclusions Predictions of genetic breeding values showed that different genotype combinations in different geographical regions may be better, and hybrid-line variety breeding with homozygote and heterozygote genotype combinations may have a greater potential to improve ear traits.