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37 results on '"Mitic, Milos"'

24. The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol

Author

Radic, Ivan, primary, Nestorovic, Vojkan, additional, Mijovic, Milica, additional, Tatalovic, Nikola, additional, Joksimovic, Bojan, additional, Lukic, Vera, additional, Mitic, Milos, additional, Adzic, Miroslav, additional, Blagojevic, Dusko, additional, Velickovic, Stefan, additional, Bulajic, Sonja, additional, Djerkovic, Branislav, additional, Miric, Mirjana, additional, and Janicijevic-Hudomal, Snezana, additional

Published
2018
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29. Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats

Author

Adzic, Miroslav, Djordjevic, Jelena, Mitic, Milos, Simic, Iva, Rackov, Gorjana, Ana Djordjevic, Elakovic, Ivana, Matic, Gordana, and Radojcic, Marija

Subjects
chronic isolation, Fluoxetine, erythrocytes, Wistar rat, glutathione reductase
Abstract

Alterations in the antioxidative defense parameters upon chronic stress are considered critical for pathophysiology of stress related psychiatric disorders, and their status in blood serves as biomarker for effects of pharmacological treatments. The present study was designed to investigate the modulation of erythrocyte antioxidant enzymes (AOEs): CuZn superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR) activities and their protein expression in Wistar male rats subjected to chronic psychosocial isolation and/or to pharmacological treatment with fluoxetine. Chronically isolated animals exhibited decreased levels of serum corticosterone, as opposed to other chronic stress paradigms. In addition to that, SOD, CAT and GPx status was not altered either by chronic psychosocial isolation or by fluoxetine treatment. In contrast, GLR activity and its protein level were both markedly reduced by fluoxetine. Since, GLR is crucial for overall oxido-reductive balance through maintaining optimal ratio of reduced/oxidized glutathione level (GSH/GSSG) in erythrocytes, these results could indicate that in spite of numerous beneficial effects of fluoxetine, it may compromise both haemoglobin function and oxygen transport. Ministry of Science of the Republic of Serbia [143042B, 43003]

Published
2011

36. Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients

Author

Lukic, Iva, primary, Mitic, Milos, additional, Djordjevic, Jelena, additional, Tatalovic, Nikola, additional, Bozovic, Natalija, additional, Soldatovic, Ivan, additional, Mihaljevic, Marina, additional, Pavlovic, Zorana, additional, Radojcic, Marija B., additional, Maric, Nadja P., additional, and Adzic, Miroslav, additional

Published
2014
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37. Fluoxetine decreases glutathione reductase in erythrocytes of chronically isolated wistar rats.

Author

Adzic M, Djordjevic J, Mitic M, Simic I, Rackov G, Djordjevic A, Elakovic I, Gordana M, and Radojcic M

Abstract

Alterations in the antioxidative defense parameters upon chronic stress are considered critical for pathophysiology of stress related psychiatric disorders, and their status in blood serves as biomarker for effects of pharmacological treatments. The present study was designed to investigate the modulation of erythrocyte antioxidant enzymes (AOEs): CuZn superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR) activities and their protein expression in Wistar male rats subjected to chronic psychosocial isolation and/or to pharmacological treatment with fluoxetine. Chronically isolated animals exhibited decreased levels of serum corticosterone, as opposed to other chronic stress paradigms. In addition to that, SOD, CAT and GPx status was not altered either by chronic psychosocial isolation or by fluoxetine treatment. In contrast, GLR activity and its protein level were both markedly reduced by fluoxetine. Since, GLR is crucial for overall oxido-reductive balance through maintaining optimal ratio of reduced/oxidized glutathione level (GSH/GSSG) in erythrocytes, these results could indicate that in spite of numerous beneficial effects of fluoxetine, it may compromise both haemoglobin function and oxygen transport.

Published
2011

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