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14. Fecal microbiota transplantation in recurrent

Author

Kim, Pamela, Gadani, Akash, Abdul‐Baki, Heitham, Mitre, Ricardo, and Mitre, Marcia

Subjects
diarrhea, fecal microbiota transplantation, Original Article, Original Articles, Clostridium difficile
Abstract

Background and Aim Fecal microbiota transplantation (FMT) has been proposed as a treatment option for patients with recurrent Clostridium difficile (C. difficile) infection but remains a novel option. We examined if FMT is an effective means of treating recurrent C. difficile infection. Methods A retrospective review of 35 patients who underwent FMT was completed. Demographics and other variables, including the use of proton pump inhibitor therapy and history of inflammatory bowel disease, were collected. Results Twenty‐five patients (71.4%) belonged to a high‐risk population (working in a hospital setting, rehabilitation center, or nursing facility) and a total of 74.3% of patients (n = 26 patients) had no history of proton pump inhibitor use. Twenty‐five patients (71.4%) had used metronidazole prior to transplantation, 35 patients (100%) had used vancomycin, and 7 patients (20%) had used fidaxomicin for prior infection. Four patients (11.4%) had used all three antibiotics during prior treatment. Of the eight patients who had a history of inflammatory bowel disease, six (75%) experienced resolution of symptoms after transplantation. A total of 30 patients (85.7%) had resolution of their symptoms 6–8 weeks’ posttransplant, while 5 patients (14.3%) continued to have symptoms. Conclusions Our retrospective chart review supports that patients benefit from FMT in the setting of recurrent C. difficile infection.

Published
2018

15. Survival Trends for Resectable Pancreatic Cancer Using a Multidisciplinary Conference: the Impact of Post-operative Chemotherapy

Author

Syed, Aslam R., primary, Carleton, Neil M., additional, Horne, Zachary, additional, Dhawan, Annika, additional, Bedi, Gurneet, additional, Kochhar, Gursimran, additional, Morrissey, Suzanne, additional, Williams, Harry, additional, Atkinson, Donald, additional, Schiffman, Suzanne, additional, Monga, Dulabh, additional, Lupetin, Anthony, additional, Kirichenko, Alexander, additional, Mitre, Marcia, additional, Dhawan, Manish, additional, Kulkarni, Abhijit, additional, and Thakkar, Shyam, additional

Published
2019
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16. 240 Impact and Outcomes of a Weekend Screening Colonoscopy Program in a Large Health Network in Western Pennsylvania

Author

Umar, Shifa, primary, Gladys-Oryhon, Jordan, additional, Cole, Rita, additional, Thakkar, Payal, additional, Syed, Aslam, additional, Aoun, Elie, additional, Abdul-Baki, Heitham, additional, Babich, Michael, additional, Bradley, Bruce, additional, Kulkarni, Abhijit, additional, Flannagan, Renee, additional, Goswami, Raktima, additional, El-Hachem, Sandra, additional, Lebovitz, Paul J., additional, Dhawan, Manish, additional, Hadam, Jennifer, additional, Gomez, Gustavo, additional, Kandil, Hussam, additional, Mitre, Marcia, additional, Strahotin, Cristina, additional, Mlecko, Michael L., additional, Gottfried, Irving, additional, Glick, Kenneth, additional, Midian, Robin, additional, Toney, Rachel, additional, Morrissey, Suzanne, additional, Gadani, Akash, additional, Chintamaneni, Preethi, additional, Appasamy, Ragunath, additional, Oliva, Jose, additional, Pfister, Michelle, additional, Deweese, Dianna, additional, Kochhar, GurSimran, additional, Manzi, Susan, additional, Parker, Brian M., additional, Thakkar, Shyam, additional, and Farah, Katie, additional

Published
2019
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18. Endoscopic ultrasound guided fine‐needle aspiration vs core needle biopsy for solid pancreatic lesions: Comparison of diagnostic accuracy and procedural efficiency

Author

Syed, Aslam, primary, Babich, Olivia, additional, Rao, Bharat, additional, Singh, Shailendra, additional, Carleton, Neil, additional, Gulati, Abhishek, additional, Kulkarni, Archana, additional, Garg, Mrinal, additional, Farah, Katie, additional, Kochhar, Gursimran, additional, Morrissey, Suzanne, additional, Mitre, Marcia, additional, Kulkarni, Abhijit, additional, Dhawan, Manish, additional, Silverman, Jan F., additional, Pharaon, Majed, additional, and Thakkar, Shyam, additional

Published
2019
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22. Mo1371 – Survival of Resectable Pancreatic Cancer: the Impact of Post-Operative Chemotherapy

Author

Syed, Aslam, primary, Carleton, Neil M., additional, Dhawan, Annika, additional, Horne, Zachary, additional, Kochhar, Gursimran, additional, Morrissey, Suzanne, additional, Williams, Harry K., additional, Atkinson, Donald, additional, Schiffman, Suzanne, additional, Monga, Dulabh, additional, Lupetin, Anthony, additional, Kirichenko, Alexander, additional, Mitre, Marcia, additional, Dhawan, Manish K., additional, Kulkarni, Abhijit, additional, and Thakkar, Shyam, additional

Published
2019
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28. Saturday Screening Saves the Day!

Author

Syed, Aslam, primary, Cole, Rita, additional, Deweese, Dianna, additional, Pfister, Michelle, additional, Thakkar, Shyam, additional, Babich, Michael, additional, Abdul-Baki, Heitham, additional, Kulkarni, Abhijit, additional, Flannagan, Renee, additional, Goswami, Raktima, additional, Hadam, Jennifer, additional, Kandil, Hossam, additional, Mitre, Marcia, additional, Strahotin, Cristina, additional, Bradley, Bruce, additional, Gomez, Gustavo, additional, Gottfried, Irving, additional, Mlecko, Michael, additional, and Farah, Katie, additional

Published
2018
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32. Su1311 Endoscopic Ultrasound-Guided Fine Needle Aspiration Versus Fine Needle Core Biopsy for Solid Pancreatic Lesions: Comparison of Diagnostic Accuracy and Procedural Efficiency

Author

Rao, Bharat, primary, Singh, Shailendra, additional, Kulkarni, Archana A., additional, Gulati, Abhishek, additional, Garg, Mrinal, additional, Morrissey, Suzanne, additional, Mitre, Marcia, additional, Kulkarni, Abhijit, additional, Dhawan, Manish, additional, and Thakkar, Shyam, additional

Published
2017
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33. Performance of a Multidisciplinary Team in Predicting and Managing Resectable Pancreatic Cancer

Author

Rao, Bharat, primary, Singh, Shailendra, additional, Gulati, Abhishek, additional, Garg, Mrinal, additional, Sharma, Manav, additional, Kulkarni, Abhijit, additional, Morrissey, Suzanne, additional, Kirichenko, Alexander, additional, Williams, Harry K., additional, Atkinson, Donald, additional, Schiffman, Suzanne, additional, Mitre, Marcia, additional, Monga, Dulabh, additional, Lupetin, Anthony, additional, Dhawan, Manish, additional, and Thakkar, Shyam, additional

Published
2017
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34. Surgical Outcomes in Patients with Borderline Resectable Pancreatic Adenocarcinoma After Neoadjuvant Chemotherapy and Fiducial Targeted IGRT: An Institutional Experience

Author

Sharma, Manav, primary, Singh, Shailendra, additional, Rao, Bharat, additional, Kirichenko, Alexander, additional, Morrissey, Suzanne, additional, Mitre, Marcia, additional, Garg, Mrinal, additional, Kumar, Ujjala, additional, Kulkarni, Abhijit, additional, Monga, Dulabh, additional, Schiffman, Suzanne, additional, Williams, Harry K., additional, Atkinson, Donald, additional, Lupetin, Anthony, additional, Dhawan, Manish, additional, and Thakkar, Shyam, additional

Published
2017
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36. Fecal microbiota transplantation in recurrent Clostridium difficile infection: A retrospective single‐center chart review.

Author

Kim, Pamela, Gadani, Akash, Abdul‐Baki, Heitham, Mitre, Ricardo, and Mitre, Marcia

Subjects
FECAL microbiota transplantation, CLOSTRIDIOIDES difficile, DISEASE relapse
Abstract

Background and Aim: Fecal microbiota transplantation (FMT) has been proposed as a treatment option for patients with recurrent Clostridium difficile (C. difficile) infection but remains a novel option. We examined if FMT is an effective means of treating recurrent C. difficile infection. Methods: A retrospective review of 35 patients who underwent FMT was completed. Demographics and other variables, including the use of proton pump inhibitor therapy and history of inflammatory bowel disease, were collected. Results: Twenty‐five patients (71.4%) belonged to a high‐risk population (working in a hospital setting, rehabilitation center, or nursing facility) and a total of 74.3% of patients (n = 26 patients) had no history of proton pump inhibitor use. Twenty‐five patients (71.4%) had used metronidazole prior to transplantation, 35 patients (100%) had used vancomycin, and 7 patients (20%) had used fidaxomicin for prior infection. Four patients (11.4%) had used all three antibiotics during prior treatment. Of the eight patients who had a history of inflammatory bowel disease, six (75%) experienced resolution of symptoms after transplantation. A total of 30 patients (85.7%) had resolution of their symptoms 6–8 weeks' posttransplant, while 5 patients (14.3%) continued to have symptoms. Conclusions: Our retrospective chart review supports that patients benefit from FMT in the setting of recurrent C. difficile infection. Recurrent Clostridium difficile infections are becoming more prevalent, and new methods of treatment are being encouraged, such as fecal microbiota transplantation. In our manuscript, we show that fecal microbiota transplantation is an effective means of treating recurrent Clostridium difficile infections. [ABSTRACT FROM AUTHOR]

Published
2019
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37. Sa1463 The Role of Multidisciplinary Pancreatic Conference in the Management of Resectable Pancreatic Ductal Adenocarcinoma

Author

Kumar, Ujjala, primary, Garg, Mrinal, additional, Sharma, Manav, additional, Gulati, Abhishek, additional, Kulkarni, Abhijit, additional, Dhawan, Manish, additional, Morrissey, Suzanne, additional, Schiffman, Suzanne, additional, Mitre, Marcia, additional, Atkinson, Donald, additional, Maheshwary, Rishi, additional, Monga, Dulabh, additional, Williams, Harry, additional, Kirichenko, Alexander, additional, and Thakkar, Shyam, additional

Published
2016
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38. Sa1462 The Effect of Fiducials on Resection Margin and Nodal Disease in Patients Receiving Neoadjuvant Chemoradiation Therapy for Borderline Resectable Pancreatic Adenocarcinoma

Author

Kumar, Ujjala, primary, Garg, Mrinal, additional, Sharma, Manav, additional, Gulati, Abhishek, additional, Kulkarni, Abhijit, additional, Dhawan, Manish, additional, Kirichenko, Alexander, additional, Morrissey, Suzanne, additional, Monga, Dulabh, additional, Atkinson, Donald, additional, Schiffman, Suzanne, additional, Williams, Harry, additional, Maheshwary, Rishi, additional, Mitre, Marcia, additional, and Thakkar, Shyam, additional

Published
2016
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43. Sa1324 - Surgical Outcomes in Patients with Borderline Resectable Pancreatic Adenocarcinoma After Neoadjuvant Chemotherapy and Fiducial Targeted IGRT: An Institutional Experience

Author

Sharma, Manav, Singh, Shailendra, Rao, Bharat, Kirichenko, Alexander, Morrissey, Suzanne, Mitre, Marcia, Garg, Mrinal, Kumar, Ujjala, Kulkarni, Abhijit, Monga, Dulabh, Schiffman, Suzanne, Williams, Harry K., Atkinson, Donald, Lupetin, Anthony, Dhawan, Manish, and Thakkar, Shyam

Published
2017
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47. Diarrhoea, weight loss and polyposis: think Cronkhite- Canada syndrome.

Author

Aoun, Elie, Victain, Michelle, and C Mitre, Marcia

Abstract

A 71-year-old male presented with nausea, diarrhoea and weight loss. He had mild to moderate alopecia, paucity of eyebrow hair, erythematous non-pruritic nodular rash on the wrists, toenail onychomychosis and scalp hyperpigmentation. A colonoscopy revealed an irregular, haemorrhagic 5 cm rectosigmoid mass. Biopsies revealed mucin distended glands and focal ischemic changes. A CT scan showed numerous polypoid-like lesions in the stomach. Upper endoscopy showed mucosal erythema and nodularity with polypoid-like lesions. Biopsies showed cystic glandular dilatation, lamina propria oedema and chronic inflammation consistent with Cronkhite-Canada syndrome (CCS). The patient was started on nutrition supplementation. His skin manifestations were treated topically and with mineral supplements. He improved within 10 weeks and is currently asymptomatic. A high index of suspicion for CCS should exist in patients who present with weight loss, diarrhoea and polyposis. If diagnosed early, the disease can be treated with the goal of clinical remission. [ABSTRACT FROM AUTHOR]

Published
2011
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