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1. Objectively Measured Intensity-specific Physical Activity and Hippocampal Volume Among Community-dwelling Older Adults

Author

Masaki Machida, Tomoko Takamiya, Shiho Amagasa, Hiroshi Murayama, Takeo Fujiwara, Yuko Odagiri, Hiroyuki Kikuchi, Noritoshi Fukushima, Mitsuo Kouno, Yu Saito, Fumitoshi Yoshimine, Shigeru Inoue, and Yugo Shobugawa

Subjects
epidemiology, accelerometry, aging, hippocampus, compositional data analysis, Medicine (General), R5-920
Abstract

Background: The hippocampus is a brain structure important for memory and cognitive function. Physical activity may help prevent hippocampal atrophy. However, few studies have measured sedentary behavior (SB) and intensity-specific physical activity using an accelerometer. This study aimed to examine the cross-sectional associations of objectively-determined SB, light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) measured by an accelerometer with hippocampal volume among community-dwelling older adults using compositional data analysis (CoDa) approach. Methods: This cross-sectional study was part of the Neuron to Environmental Impact across Generations (NEIGE) study. A randomly recruited sample of 485 Japanese older adults (47% male; aged 65–84 years) wore tri-axial accelerometers (Omron Healthcare) for 7 consecutive days in 2017. Hippocampal volume was measured with magnetic resonance imaging and the left and right hippocampal volumes were automatically segmented using FreeSurfer software. Associations of sedentary and physically active behaviors with hippocampal volume were examined with compositional linear regression analysis based on isometric log-ratio transformations of time use adjusted for potential confounding factors. Results: The relative proportion of time spent in MVPA, compared to the other two activities, was significantly positively associated with right hippocampal volume (β: 57.1, P-value = 0.027). However, no association existed between higher proportions of MVPA and left hippocampal volume, or between proportions of SB or LPA with either left or right hippocampal volumes. Conclusion: The proportion of time spent in MVPA, relative to the other two activities, was significantly positively associated with right hippocampal volume. MVPA may be beneficial for maintaining hippocampal volume.

Published
2022
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2. National trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study

Author

Satoshi Suzuki, Kenji Yamamoto, Hiroaki Tanaka, Hiroshi Ozawa, Yuji Okamoto, Tatsuya Abe, Hidenori Suzuki, Akiko Kada, Shigeki Nishino, Nobuyuki Sakai, Kunihiro Nishimura, Tomoyoshi Oikawa, Takanari Kitazono, Hiroshi Tanaka, Daisuke Onozuka, Akihito Hagihara, Hiroshi Ooyama, Akira Watanabe, Shinichi Yoshimura, Toru Iwama, Hiroki Sato, Satoshi Ushikoshi, Kiyohiro Houkin, Nobuhiro Mikuni, Naoyuki Nakao, Michio Nakamura, Nanako Tamiya, Naofumi Isono, Koji Iihara, Yutaka Yamaguchi, Kuniaki Ogasawara, Osamu Onodera, Yusaku Nakamura, Naoki Hayashi, Akira Takada, Masayuki Ezura, Akio Hyodo, Shigeru Miyachi, Susumu Miyamoto, Yuji Matsumaru, Ichiro Nakahara, Tomoaki Terada, Kazunari Yoshida, Ai Kurogi, Ataru Nishimura, Yoshiaki Shiokawa, Koichi Arimura, Kaoru Kurisu, Fusao Ikawa, Kenji Ohata, Kyoichi Nomura, Nobuhito Saito, Hiroaki Fujiwara, Susumu Suzuki, Masanori Isobe, Soshiro Ogata, Takeshi Matsuoka, Junichiro Satomi, Takashi Matsumoto, Hiroyuki Nakase, Yasunari Niimi, Manabu Kinoshita, Mamoru Murakami, Masaaki Uno, Junichi Iida, Takashi Matsuoka, Tatsuya Sasaki, Shinichi Wakabayashi, Hiroki Toda, Hideki Sakai, Hajime Ohta, Osamu Yamamura, Hideyuki Ohnishi, Hiroko Oyama, Junichi Ono, Izumi Nagata, Hiroharu Kataoka, Ryota Kurogi, Hajime Arai, Atsuo Yoshino, Tsuyoshi Ohta, Hiroshi Sugimori, Hidehiro Hirabayashi, Hiroyuki Masaoka, Satoshi Yamamoto, Hideki Murakami, Kazuhiko Nozaki, Hiroyuki Matsumoto, Yuichiro Tanaka, Takahisa Mori, Keizo Yasui, Akira Takahashi, Ichiro Suzuki, Sachio Suzuki, TAKASHI YOSHIDA, Masanori Morimoto, Tetsuya Ueba, Hiromu Hadeishi, Masaki Chin, Michihiro Kohno, Hitoshi Fukuda, Toru Nishi, Kazunari Koga, Toshihiko Wakabayashi, Hiroki Ohkuma, Kazuhiro Hongo, Hiroshi Nakane, Kazumi Nitta, Satoshi Utsuki, Toshihiko Iuchi, Nice Ren, Hidefuku Gi, Kensuke Kawai, Masayuki Ishihara, Eiji Kohmura, Yoshihiro Nishiura, Kazutaka Yatsushiro, Kensaku Yoshida, Atsushi Tominaga, Masayuki Sumida, Hidenori Yoshida, Atsushi Sato, Takashi Inoue, Hiroaki Shimizu, Eiichiro Kamatsuka, Makoto Ichinose, Naoya Takeda, Tsuyoshi Inoue, Hidekazu Takahashi, Satoshi Kuroda, Toshiaki Osato, Nobutaka Horie, Isao Date, Yoichiro Hashimoto, Haruhiko Hoshino, Takafumi Shimogawa, Koji Yoshimoto, Teiji Tominaga, Isao Sasaki, Kazuo Kitazawa, Minoru Saitoh, Hitoshi Saito, Minoru Asahi, Makoto Goda, Atsuhito Takemura, Masaaki Shibukawa, Isao Fuwa, Saburo Watanabe, Seiko Kataoka, Koji Takasaki, Kouji Shiga, Kensuke Hayashida, Ryunosuke Uranishi, Chiaki Ito, Kenji Wakui, Takashi Saegusa, Isao Kitahara, Yasushi Ejima, Satoru Hayashi, Kazuyoshi Hattori, Shinji Okita, Toshikazu Ichihashi, Tsugumichi Ichioka, Shinichi Shirakami, Teruo Kimura, Tomonori Kobayashi, Kanehisa Kohno, Kazunori Yamanaka, Akira Morooka, Nozomi Mori, Hideo Kunimine, Masahiro Satoh, Syougo Imae, Hirochiyo Wada, Masanori Kabuto, Katsuyuki Hirakawa, Isao Inoue, Kiyoshi Kazekawa, Masani Nonaka, Kouzou Fukuyama, Shigenari Kin, Kiyoshi Saito, Yoichi Watanabe, Tadashi Arisawa, Kou Takahashi, Tetsuya Tanigawara, Junki Ito, Kei Hisada, Makoto Takeda, Jun Niwa, Mikio Nishiya, Shuji Hayashi, Ichiro Fujishima, Teiji Nakayama, Yoshihiko Watanabe, Koichirou Matsukado, Takamichi Yuguchi, Tadahisa Shono, Hiroyuki Nishimura, Jyunya Hayashi, Keisuke Migita, Kazuhiro Yokoyama, Hirotoshi Ohtaka, Takata Hisashi, Takamitsu Uchizawa, Naoki Shinohara, Mitsunobu Kaijima, Junkoh Yamamoto, Yoshio Sakagami, Hideo Aihara, Takayuki Sakaki, Keishi Fujita, Sumio Kobayashi, Nobuaki Momozaki, Masahito Hara, Akazi Kazunori, Fumitaka Miya, Hisato Minamide, Shinichiro Kurokawa, Syuichi Ishikawa, Naohisa Miura, Shinya Noda, Shoji Mashiyama, Shinji Amano, Takayuki Sugawara, Yukihiko Shimizu, Keiichi Saito, Kazuyuki Miura, Akinori Yabuta, Tatumi Yamanome, Hiroshi Seto, Makoto Hasebe, Hikaru Mizobuchi, Junkoh Sasaki, Shin Tsuruoka, Keiichi Nishimaki, Katsumi Takizawa, Hitoshi Tsugu, Nozomi Suzuki, Takeshi Kohno, Shu Hasegawa, Ken Asakura, Masaki Miyatake, Hiromu Konno, Katsunobu Takenaka, Akira Ikeda, Keizou Yamamoto, Keigo Matsumoto, Satoshi Inoha, Masaki Morisige, Kunihiko Harada, Hirofumi Hiyama, Yasuaki Takeda, Taturou Mori, Takekazu Akiyama, Osamu Okuda, Kazuaki Awamori, Naoki Shirasaki, Kimihiro Yoshino, Atsushi Shindo, Kazuho Hirahara, Shunichi Tanaka, Teruaki Kawano, Kazunori Arita, Hiroaki Sawaura, Yoichi Uozumi, Masahiko Tanaka, Shunsuke Shiraga, Shuji Sato, Mitsutoshi Nakada, Kimihisa Kinoshita, Nakazawa Kazutomo, Yasuhiro Fujimoto, Kunikazu Yoshimura, Masaaki Iwase, Shinichi Yagi, Atsushi Tsuchiya, Junichi Harashina, Sadao Kaneko, Naoto Kuwayama, Junya Hayashi, Masayuki Sasou, Sotaro Higashi, Masakazu Kitahara, Sumio Suda, Amami Kato, Satoshi Magarisawa, Kenji Hashimoto, Hirotoshi Hamaguchi, Tomohiko Satou, Masaru Idei, Haruhisa Tsukamoto, Toshihiro Kumabe, Naoaki Sato, Yasuyuki Toba, Takashi Tominaga, Haruo Yamashita, Toyoaki Shinohara, Kazuyoshi Watanabe, Hidenori Endo, Kenjirou Hujiwara, Toshinori Hasegawa, Hisashi Nitta, Kuroyanagi Takayuki, Nobuhiko Mizutani, Akira Tsunoda, Fumio Suzuki, Tetsuya Morimoto, Takuya Kawai, Mitsuyuki Fujitsuka, Hiromasa Tsuiki, Junichi Kuratsu, Hidemichi Sasayama, Shigehiro Ohmori, Seiko Hasegawa, Kazuhiro Kikuchi, Motohiro Morioka, Masayuki Yokota, Nozomu Murai, Yasumasa Yamamoto, Nobuhito Mori, Minoru Kidooka, Hiroshi Tenjin, Yoshihiro Iwamoto, Hitonori Takaba, Sei Haga, Yoshinori Arai, Toshiyuki Tsukada, Hirohide Karasudani, Masakazu Suga, Kawamoto Yukihiko, Naoto Izumi, Youtarou Takeuchi, Motohiro Arai, Shinji Okumura, Hisashi Tanaka, Yasushi Shibata, Tetsuya Masaoka, Masahiko Kasai, Hitoshi Miyake, Osamu Hamasaki, Misao Nishikawa, Naohiko Kubo, Yosimasa Kinosita, Hiroyuki Kaidu, Tarou Komuro, Hiroaki Shigeta, Yoshikazu Kusano, Shigekazu Takeuchi, Takayuki Matsuo, Yoshiharu Tokunaga, Norimoto Nakahara, Nobukazu Hashimoto, Mitsuhito Mase, Junpei Yoshimoto, Jin Momoji, Kenji Kamiyama, Koji Oka, Hiromichi Koga, Kazuya Morimoto, Tsutomu Kadekaru, Naoki Tokumitsu, Yasuyuki Nagai, Hirokazu Tanno, Takato Kagawa, Masaaki Saiki, Kotaro Ogihara, Junichi Imamura, Katsuhiro Yamashita, Akira Nakamizo, Yoshinari Nakamura, Ei-Ichirou Urasaki, Noriyuki Suzaki, Chiaki Takahashi, Youichirou Namba, Kazuo Hashikawa, Tomonori Yamada, Kazuyuki Kuwayama, Keiichi Sakai, Katsuhiro Kuroda, Hideyuki Kurihara, Masayuki Miyazono, Kosuke Miyahara, Hideaki Takahashi, Akihiko Saito, Igarashi Michitoku, Mitsuo Kouno, Shiro Kobayashi, Shunichi Yoneda, Hiroshi Kusunoki, Hiroji Miyake, Toshio Yokoe, Tatsuya Nakamura, Takayuki Kubodera, Mitsuhiko Hokari, Yasunari Otawara, Cheho Park, Hidemitu Nakagawa, Souichi Obara, Haruki Takahashi, Masafumi Ohtaki, Atsuya Okubo, Katsuhiko Hayashi, Masahisa Kawakami, Yu Takeda, Akihiko Kaga, Ryoichi Hayashi, Koji Tokunaga, Hiroyuki Nakashima, Yasuyuki Miyoshi, Atusi Kimoto, Toshimitsu Uchihara, Tomoaki Nagamine, Masahiro Noha, Hiromichi Sadashima, Toshihiko Kinjo, Osamu Tao, Masayuki Nakajima, Akira Isoshima, Kouichi Kuramoto, Shigeru Daido, Yoshiyasu Iwai, Toshihiko Kuroiwa, Akatsuki Wakayama, Kohsuke Yamashita, Yasunobu Gotou, Kouich Iwatsuki, Yoshida Masahiro, Nobuaki Kobayasi, Yoshimasa Niiya, Syouji Mabuchi, Motohiro Takayama, Kazuo Yamamoto, Junta Moroi, Masato Sugitani, Akio Ookura, Naoko Fujimura, Osamu Nishizaki, Sumio Isimaru, Hiroshi Wanihuchi, Nobukuni Murakami, Hiroto Murata, Naoki Kitagawa, Katsuhiko Kono, Michiya Kubo, Masashi Nakatsukasa, Makoto Inaba, Hidetoshi Ooigawa, Atsuhiro Kojima, Takamitsu Fujimaki, Osamu Fukuda, Yoshikazu Nakajima, Kazuyuki Kouno, Takaaki Yoshida, Reizou Kanemaru, Yohei Kudoh, Toshitaka Nakamura, Masayoshi Takigami, Shogo Nishi, Rokuya Tanikawa, Seisaburo Sakamoto, Makio Kaminogo, Seiichiro Hoshi, Yoshinari Okumura, Shinichi Okabe, Haruhiko Sato, Shiro Miyata, Kotaro Tsumura, Hiroshi Karibe, Noriaki Watabe, Ryuji Nakamura, Norifumi Shimoeda, Tsutomu Hitotsumatsu, Tomoaki Kameda, Hiroshi Ishiguchi, Atsuo Shinoda, Masanobu Hokama, Akinori Yamamura, Takeshi Kondoh, Kenichi Murao, Takafumi Wataya, Seiji Fukazawa, Shinsuke Muraoka, Hirosuke Fujisawa, Tsuneo Shishido, Mayumi Mori, Arai Hiroaki, Shinjitsu Nishimura, Zenichiro Watanabe, Susumu Nakashima, Kazuhito Nakamura, Yukinari Kakizawa, Hiroki Takano, Norihito Shirakawa, Masahiro Kagawa, Eiichiro Mabuchi, Kazusige Maeno, Takayuki Koizumi, Warou Taki, Yusuke Nakagaki, Kazuyuki Tane, Hiromichi Ooishi, Katsuyuki Asaoka, Yoshinori Akiyama, Tadao Kawamura, Atumi Takenobu, Takehisa Tuji, Masami Shimoda, Mitsunori Matsumae, Shinji Noda, Koiti Moroki, Hirofumi Oka, Masahito Agawa, Hajimu Miyake, Masateru Katayama, Shinichi Numazawa, Taketoshi Maehara, Hiroyuki Jimbo, Satoshi Ihara, Koji Matuoka, Oikawa Akihiro, Takahiro Oota, Makoto Noguchi, Takakazu Kawamata, Youichi Hashimoto, Keiichirou Onitsuka, Masahiko Kitano, Jae-Hyun Son, Toru Masuoka, Naoki Koketsu, Keiichi Akatsuka, Masamichi Kurosaki, Miyamori Tadao, Hiroaki Hondo, Kazumasa Yamatani, Hirofumi Oyama, Junji Koyama, Ogura Koichiro, Shinji Yamamoto, Hitoshi Tabata, Kazuya Uemura, Kazuhiko Sato, Hideyuki Yoshida, Takafumi Nishizaki, Hiroshi Egami, Hideo Takeshima, Shogo Ishiuchi, Akira Matsumura, Hiroyuki Kinouchi, Susumu Mekaru, Mikihiko Takeshita, Hitoshi Ozawa, Kiichiro Zenke, Takeshi Matsuyama, Toshikazu Kuwata, Teruyuki Habu, Tomoyoshi Okumura, Seiya Takehara, Rei Kondo, Takashi Kumagai, Keiten So, Sunao Takemura, Sonoda Yukihiko, Manabu Urakawa, Yasuhiro Hamada, Michiyasu Suzuki, Mikito Uchida, Hidehito Koizumi, Masaru Yamada, Takashi Tsuruno, Gen Ishida, Ryouichi Masuda, Makoto Kimura, Shinichirou Ishihara, Masashi Morikawa, Hidetoshi Murata, Katsumi Sakata, Motohiro Nomura, Akihiro Nemoto, Sumio Endou, Nobuo Hirota, Kennji Itou, Hiroaki Minami, and Yoshihumi Teramoto

Subjects
Medicine
Abstract

Objectives To examine the national, 6-year trends in in-hospital clinical outcomes of patients with subarachnoid haemorrhage (SAH) who underwent clipping or coiling and the prognostic influence of temporal trends in the Comprehensive Stroke Center (CSC) capabilities on patient outcomes in Japan.Design Retrospective study.Setting Six hundred and thirty-one primary care institutions in Japan.Participants Forty-five thousand and eleven patients with SAH who were urgently hospitalised, identified using the J-ASPECT Diagnosis Procedure Combination database.Primary and secondary outcome measures Annual number of patients with SAH who remained untreated, or who received clipping or coiling, in-hospital mortality and poor functional outcomes (modified Rankin Scale: 3–6) at discharge. Each CSC was assessed using a validated scoring system (CSC score: 1–25 points).Results In the overall cohort, in-hospital mortality decreased (year for trend, OR (95% CI): 0.97 (0.96 to 0.99)), while the proportion of poor functional outcomes remained unchanged (1.00 (0.98 to 1.02)). The proportion of patients who underwent clipping gradually decreased from 46.6% to 38.5%, while that of those who received coiling and those left untreated gradually increased from 16.9% to 22.6% and 35.4% to 38%, respectively. In-hospital mortality of coiled (0.94 (0.89 to 0.98)) and untreated (0.93 (0.90 to 0.96)) patients decreased, whereas that of clipped patients remained stable. CSC score improvement was associated with increased use of coiling (per 1-point increase, 1.14 (1.08 to 1.20)) but not with short-term patient outcomes regardless of treatment modality.Conclusions The 6-year trends indicated lower in-hospital mortality for patients with SAH (attributable to better outcomes), increased use of coiling and multidisciplinary care for untreated patients. Further increasing CSC capabilities may improve overall outcomes, mainly by increasing the use of coiling. Additional studies are necessary to determine the effect of confounders such as aneurysm complexity on outcomes of clipped patients in the modern endovascular era.

Published
2023
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3. Objectively Measured Intensity-specific Physical Activity and Hippocampal Volume Among Community-dwelling Older Adults

Author

Yu Saito, Hiroshi Murayama, Masaki Machida, Yugo Shobugawa, Fumitoshi Yoshimine, Yuko Odagiri, Noritoshi Fukushima, Shiho Amagasa, Tomoko Takamiya, Shigeru Inoue, Hiroyuki Kikuchi, Takeo Fujiwara, and Mitsuo Kouno

Subjects
Male, medicine.medical_specialty, Epidemiology, Physical activity, 030209 endocrinology & metabolism, Isometric exercise, Audiology, Hippocampal formation, Hippocampus, 03 medical and health sciences, 0302 clinical medicine, Accelerometry, Humans, Medicine, Hippocampus (mythology), 030212 general & internal medicine, Exercise, Aged, Aged, 80 and over, business.industry, Confounding, Cognition, General Medicine, Intensity (physics), Cross-Sectional Studies, Hippocampal volume, Female, Independent Living, business
Abstract

Background The hippocampus is a brain structure important for memory and cognitive function. Physical activity may help prevent hippocampal atrophy. However, few studies have measured sedentary behavior (SB) and intensity-specific physical activity using an accelerometer. This study aimed to examine the cross-sectional associations of objectively-determined SB, light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) measured by an accelerometer with hippocampal volume among community-dwelling older adults using compositional data analysis (CoDa) approach. Methods This cross-sectional study was part of the Neuron to Environmental Impact across Generations (NEIGE) study. A randomly recruited sample of 485 Japanese older adults (47% male; aged 65-84 years) wore tri-axial accelerometers (Omron Healthcare) for seven consecutive days in 2017. Hippocampal volume was measured with magnetic resonance imaging and the left and right hippocampal volumes were automatically segmented using FreeSurfer software. Associations of sedentary and physically active behaviors with hippocampal volume were examined with compositional linear regression analysis based on isometric log-ratio transformations of time use adjusted for potential confounding factors. Results The relative proportion of time spent in MVPA, compared to the other two activities, was significantly positively associated with right hippocampal volume (β: 57.1, p-value = 0.027).However, no association existed between higher proportions of MVPA and left hippocampal volume, or between proportions of SB or LPA with either left or right hippocampal volumes. Conclusions The proportion of time spent in MVPA, relative to the other two activities, was significantly positively associated with right hippocampal volume. MVPA may be beneficial for maintaining hippocampal volume.

Published
2022

4. The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)

Author

Keitaro Yamagami, Ryota Kurogi, Ai Kurogi, Kunihiro Nishimura, Daisuke Onozuka, Nice Ren, Akiko Kada, Ataru Nishimura, Koichi Arimura, Keisuke Ido, Masahiro Mizoguchi, Tetsuya Sakamoto, Takamasa Kayama, Michiyasu Suzuki, Hajime Arai, Akihito Hagihara, Koji Iihara, Masayoshi Takigami, Kenji Kamiyama, Kiyohiro Houkin, Shougo Nishi, Tetsuyuki Yoshimoto, Sadao Kaneko, Koji Oka, Hiroshi Ooyama, Kyousuke Kamada, Kenichi Makino, Naoki Tokumitsu, Kazuhiro Sako, Susumu Suzuki, Nozomi Suzuki, Naoto Izumi, Kazumi Nitta, Masahumi Ootaki, Masanori Isobe, Mikio Nishiya, Takaaki Yamazaki, Syouji Mabuchi, Kuniaki Ogasawara, Naohiko Kubo, Yukihiko Shimizu, Keiichi Saito, Tatumi Yamanome, Atsuo Yoshino, Mitsuyuki Fujitsuka, Masaaki Takami, Hirotoshi Ohtaka, Teruyuki Hirano, Yosiaki Shiokawa, Takaharu Okada, Ichiro Suzuki, Michihiro Kohno, Jou Haraoka, Yoshinori Arai, Noriyoshi Kawamura, Akira Isoshima, Masaharu Yasue, Mitsuhiko Hokari Takayoshi Kobayashi, Kensuke Kawai, Taketoshi Maehara, Makoto Noguchi, Haruhiko Hoshino, Hirofumi Hiyama, Kensaku Yoshida, Osamu Utsugi, Yasuaki Takeda, Kouichi Tamaki, Hirohide Karasudani, Takao Urabe, Shiro Kobayashi, Michio Nakamura, Yorio Koguchi, Junichi Ono, Sumio Suda, Hiromu Hadeishi, Toshio Fukutake, Kenji Wakui, Hirokazu Tanno, Naoki Ishige, Takashi Ohasi, Hideki Sakai, Yasuaki Nishimura, Takayuki Watanabe, Takashi Matsumoto, Naoki Koketsu, Yuichi Hirose, Manabu Doyu, Toshinori Hasegawa, Naoto Kuwayama, Shinichi Terao, Nobuhiko Mizutani, Noriyuki Suzaki, Satoshi Okuda, Keizo Yasui, Yukio Seki, Yasuhiro Hasegawa, Akira Ikeda, Youtarou Takeuchi, Sigeki Ohara, Yoshio Araki, Toshihiko Wakabayashi, Hisashi Tanaka, Junpei Yoshimoto, Makoto Sugiura, Ogura Koichiro, Nozomu Kobayashi, Tomonori Yamada, Amami Kato, Ohtsuki Toshiho, Akatsuki Wakayama, Jun Takahashi, Hiroharu Kataoka, Toshiki Yoshimine, Yoshikazu Nakajima, Hidehuku Gi, Ryunosuke Uranishi, Yusaku Nakamura, Kazunori Yamanaka, Kazumi Ohmori, Hiroyuki Matsumoto, Yoshitugu Oiwa, Yosihiko Uemura, Hiroaki Fujiwara, Yoshiyasu Iwai, Masashi Morikawa, Kazuyuki Tane, Kazuo Hashikawa, Toshiyuki Fujinaka, Shunichi Yoneda, Kohsuke Yamashita, Masahiko Kitano, Shinsuke Tominaga, Kazuhito Nakamura, Katsuhiko Kono, Kenji Ohata, Hirokatsu Taniguchi, Takanori Hazama, Toshihiko Kuroiwa, Yoji Tamura, Kazusige Maeno, Motohiro Arai, Masaaki Iwase, Kenji Hashimoto, Keisuke Yamada, Takashi Turuno, Tsutomu Ichinose, Shinichiro Kurokawa, Takeshi Matsuyama, Toshiaki Fujita, Takamichi Yuguchi, Yoshihumi Teramoto, Hiroto Kakita, Takayuki Matsuo, Tsuyoshi Izumo, Nobutoshi Ryu, Wataru Haraguchi Naoki Kitagawa, Makio Kaminogo, Seisaburo Sakamoto, Yosiharu Tokunaga, Ei-Ichirou Urasaki, Junichi Kuratsu, Akira Takada, Tadashi Terasaki, Isao Fuwa Hisami Oosima, Shigeo Yamashiro, Makoto Yoshikawa Hiromasa Tsuiki, Kazunari Koga, Hiroshi Egami, Tadao Kawamura, Kunihiko Mitsuo, Takamitu Hikawa Masaki Morisige, Yuu Takeda, Yutaka Yamaguchi, Shiro Miyata Shunro Uchinokura, Tomokazu Goya, Hideo Takeshima, Kazutaka Yatsushiro, Hajime Ohta, Tatsui Nagadou, Kazuho Hirahara, Souichi Obara, Hiroshi Seto, Koiti Moroki, Kazunori Arita, Shogo Ishiuchi, Toshimitsu Uchihara, Susumu Mekaru, Tomoaki Nagamine, Naoki Tomiyama Jin Momoji, Kouzi Idomari Atusi Kimoto, Tsutomu Kadekaru, Hirosi Syamoto, Osamu Sasaki, Makoto Minagawa, Hideaki Takahashi, Kiyoshi Onda Hiroyuki Arai, Shigekazu Takeuchi, Hiroshi Abe, Osamu Fukuda, Mitsuo Kouno, Tetsuro Tamura, Yukio Horie Michiya Kubo, Hiroaki Hondo, Hisashi Takada, Toru Masuoka, Naoki Shirasaki, Hisashi Nitta, Makoto Kimura Yasuo Katsuki, Yutaka Hayashi Hisato Minamide, Shigeru Munemoto, Kiyonobu Ikeda, Mitsutoshi Nakada Yutaka Hayashi, Syuji Sato, Taketo Hatano, Osamu Yamamura, Masanori Kabuto, Takahiro Sakuma Jyunya Hayashi, Hiroyuki Kinouchi, Hidehito Koizumi, Syougo Imae, Manabu Fujita, Masakazu Suga, Shinji Iwata Kanehisa Kohno, Kiichiro Zenke, Mutsuo Fujisawa, Hikaru Mizobuchi, Satoru Hayashi, Masanori Morimoto, Tetsuya Ueba, Hiroyuki Nishimura, Naoki Ikawa, Yuzo Matsumoto, Seiji Kannuki, Masahiro Kagawa, Naoki Hayashi, Takashi Tamiya Atsushi Shindo, Kimihiro Yoshino, Tetsuya Masaoka, Ichiro Nakahara, Akira Nakamizo Satoshi Suzuki, Yuji Okamoto, Haruki Takahashi, Katsuyuki Hirakawa, Shinji Nagata, Akio Ookura, Hidenori Yoshida Yoshiro Kaneko, Hiroshi Nakane, Isao Inoue, Tsutomu Hitotsumatsu, Terukazu Kuramoto Kouichi Kuramoto, Yoshihisa Matumoto Hiromichi Ooishi, Tooru Inoue Masani Nonaka, Motohiro Morioka, Hiroshi Sugimori Shuji Sakata, Hiroshi Takashima, Shin-Ichiro Ishihara, Kenji Suzuyama, Masayuki Miyazono, Masafumi Morimoto Itaro Hattori, Satoshi Ozaki, Nobuo Hirota, Yasunori Takemoto Yasuhiko Mochimatsu, Makoto Takagi, Isao Yamamoto Kenji Nakayama, Yoshinori Uchida Hiroshi Tanaka, Katsumi Sakata, Kawahara Nobutaka, Motohiro Nomura, Hitoshi Ozawa, Kotaro Tsumura, Makoto Inaba Michiyuki Maruyama, Tatsuro Mori, Takahisa Mori, Masato Sugitani, Yuichiro Tanaka, Masaru Yamada, Mitsunori Matsumae, Keiichirou Onitsuka, Kosuke Miyahara Tatsuya Takahashi, Sumio Endou, Hidekazu Takahashi, Hiroyuki Kaidu, Akira Tsunoda Chikashi Maruki, Takamitsu Fujimaki, Hidetoshi Ooigawa, Masahiko Tanaka Masatsugu Uchida, Hiroshi Wanihuti Kouiti Katoh, Akio Hyodo, Ken Asakura, Shigeyoshi Nakajima, Takao Kanzawa, Hideyuki Kurihara, Sigehiro Ohmori, Mitsugi Yoshinao Hiroshi Kusunoki, Satoshi Magarisawa, Shinichi Okabe, Yuuji Kujiraoka, Shin Tsuruoka, Mikihiko Takeshita, Tetsuya Yamamoto Akira Matsumura, Kazuya Uemura, Hitoshi Tabata, Makoto Sonobe, Masashi Nakatsukasa Ryoji Yoshida, Norifumi Shimoeda, Hideo Kunimine, Masayuki Ishihara, Nozomu Murai, Nobukuni Murakami, Minoru Kidooka, Yoshihiro Iwamoto, Hiroshi Tenjin, Kouji Shiga Masahiko Takamasu, Nobuhito Mori, Shigeru Kose, Eiji Kohmura, Keigo Matsumoto, Takayuki Sakaki, Hiroji Miyake, Eiichiro Mabuchi, Masayuki Yokota, Hideyuki Ohnishi Yosihiro Kuga, Mitsuru Kimura, Osamu Narumi Masaaki Saiki, Norio Nakajima, Minoru Asahi, Junji Koyama, Shinya Noda, Junichi Iida, Toyohisa Fujita, Hiroyuki Nakase, Hidehiro Hirabayashi Toru Hoshida, Takayoshi Fujimoto, Naoyuki Nakao, Yoshiyuki Tanaka, Fuminori Ozaki, Yoshinari Nakamura, Kazuhito Miki, Takashi Watanabe, Seiko Hasegawa, Hiromu Konno, Atsuhito Takemura, Atsuya Okubo, Hitoshi Saito, Tatsuya Ishikawa Taizen Nakase, Hiroaki Shimizu Toshio Sasajima, Masayuki Sasou, Yoichi Watanabe, Taku Sato Kiyoshi Saito, Satoshi Taira Masahiro Satoh, Takayuki Koizumi, Yasuhiro Suzuki Shoji Mashiyama, Tomoyoshi Oikawa, Yukihiko Sonoda, Rei Kondo Shinjiro Saito, Atsuo Shinoda, Eiichiro Kamatsuka, Keiten So, Toshihiko Kinjo, Tooru Sasaki Kennji Itou, Hidenori Endo Hiroaki Shimizu, Hirosi Karibe, Kou Takahashi, Masayuki Nakajima, Kazuyoshi Watanabe, Motohiro Takayama, Taro Komuro, Hisao Hirai Fumio Suzuki, Hidenori Suzuki, Hiroto Murata, Fumitaka Miya, Kenji Kanamaru, Akira Tamura, Kiyoshi Harada, Seiji Fukazawa, Seiya Takehara, Yoshihiko Watanabe, Teiji Nakayama, Haruhiko Sato Hiroshi Nagura, Shinji Amano Chiharu Tanoi, Katsuhiro Kuroda, Satoru Morooka, Takafumi Wataya Masashi Kitagawa, Kazuo Koide, Tetsuya Tanigawara, Toru Iwama, Junki Ito, Shinji Noda, Kazuyuki Kouno, Kazuo Kitazawa, Yoshikazu Kusano Toshiki Takemae, Masanobu Hokama, Hiroki Sato Yoshihisa Nishiyama, Tatsuya Seguchi, Sumio Kobayashi Yoshihiko Inui, Youji Oohigashi, Shinsuke Muraoka, Masaki Miyatake, Kensuke Hayashida Nakagawa Shinichi, Atsushi Inoue, Keiichi Sakai, Shuhei Yamaguchi, Tatsuya Mizoue Fusao Ikawa, Gen Ishida Hideki Irie, Takato Kagawa, Yoichiro Namba, Hiroyuki Nakashima, Isao Date Koji Abe, Masaaki Uno, Masaki Chin Sen Yamagata, Hidemiti Sasayama Soitiro Takao, Hideyuki Yoshida Kouji Muneda, Akira Watanebe, Syouichi Katou, Yasuhiro Hamada, Takafumi Nishizaki, Katsuhiro Yamashita, Takaharu Nakamura Ryuji Nakamura, Shinichi Wakabayashi, Takahito Okazaki, Kaoru Kurisu, Masayasu Matsumoto, Atsushi Tominaga Katsuzo Kiya, Masaaki Shibukawa Syuichi Oki, Toshinori Nakahara, Shinji Okita, Tuyosi Torii, Minoru Nakagawa Kenjirou Fujiwara, Takashi Matsuoka Syuuhei Nishimura, Osamu Hamasaki Naoyuki Isobe, Junichiro Satomi Shinji Nagahiro, Masahito Agawa, Hirofumi Oka, Kunikazu Yoshimura, Tsutomu Kato, Nobuaki Kobayasi Satoshi Minoshima, Nobuhiro Mikuni, Rokuya Tanikawa, Jyunkou Sasaki, Yasunari Otawara, Teiji Tominaga, Tatsuya Sasaki, Sunao Takemura, Masahisa Kawakami, Satoshi Ihara, Yasushi Shibata, Takashi Saegusa, Toshihiko Iuchi, Chiaki Ito, Osamu Okuda, Kazunari Yoshida, Sadao Suga Masateru Katayama, Oikawa Akihiro, Naohisa Miura, Takahiro Ota, Toshihiro Kumabe, Sachio Suzuki, Takashi Kumagai, Keiichi Nishimaki, Kazuhiro Hongo, Hiroaki Shigeta, Kazuyoshi Hattori, Yoichi Uozumi, Norimoto Nakahara, Nobukazu Hashimoto, Shinichi Shirakami Shu Imai, Yoshinari Okumura, Ryo Tamaki Kazuhiro Yokoyama, Susumu Miyamoto, Kazuo Yamamoto, Tsugumichi Ichioka, Tsuyoshi Inoue, Manabu Kinoshita, Minoru Saitoh, Hideo Aihara, Hajimu Miyake, Kotaro Ogihara Tukasa Nishiura, Shigeki Nishino, Yasuyuki Miyoshi, Tadashi Arisawa, Shigeru Daido Shoji Tsuchimoto, Kimihisa Kinoshita, Kiyoshi Yuki Keisuke Migita, Keiichi Akatsuka, Hirosuke Fujisawa, Tadahisa Shono, Hitoshi Tsugu, Shuji Hayashi, Tatsuya Abe Toshio Matsushima, Susumu Nakashima, Takehisa Tuji, Akihiko Kaga, Reizou Kanemaru, Koji Takasaki, Junichi Imamura, Masahiro Noha, Saburo Watanabe, Nobuyuki Sakai, Yasuhisa Yoshida Hiroaki Minami, Tomoyoshi Okumura, Shinjitsu Nishimura, Shinichi Numazawa, Kiyoshi Kazekawa Masanori Tsutsumi, Kouzou Fukuyama, and Yasuhiro Fujimoto

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Databases, Factual, Traumatic brain injury, Nationwide survey, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Level of consciousness, Japan, Surveys and Questionnaires, Epidemiology, Brain Injuries, Traumatic, medicine, Humans, Hospital Mortality, Child, Aged, Retrospective Studies, Aged, 80 and over, Univariate analysis, business.industry, Neurological status, Glasgow Coma Scale, Age Factors, Infant, Newborn, Infant, Odds ratio, Middle Aged, medicine.disease, Patient Discharge, 030220 oncology & carcinogenesis, Child, Preschool, Emergency medicine, Surgery, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging societies. We assessed the influence of age on outcomes of patients with TBI and sought to identify prognostic factors for in-hospital mortality of TBI among elderly patients.Using a nationwide database, we analyzed data from 5651 patients with TBI. Univariate analysis was conducted to compare patient demographics, neurologic status on admission, radiologic findings, systemic complication rates, length of hospital stay, in-hospital mortality, and home discharge rates between elderly and nonelderly groups. Multivariable analysis was conducted to determine prognostic factors for in-hospital mortality among elderly patients.Overall in-hospital mortality was significantly higher in elderly patients (12.8% vs. 19.3%; P0.001). In-hospital mortality of elderly patients with mild TBI increased significantly at7 days after admission, whereas that of elderly patients with moderate or severe TBI was significantly higher immediately after admission. Age (odds ratio [OR], 1.62; P = 0.024), male sex (OR, 1.30; P = 0.004), Japan Coma Scale score on admission (OR, 5.95, P0.001), and incidence of acute subdural hematoma (OR, 1.89; P0.001) were associated with in-hospital mortality in elderly patients with TBI.Elderly patients with TBI showed significantly higher in-hospital mortality. Delayed increases in in-hospital mortality were observed among elderly patients with mild TBI. Level of consciousness on admission was the strongest predictor of in-hospital mortality among elderly patients.

Published
2019

5. Primary Malignant Lymphoma of the Brain: Mutation Pattern of Rearranged Immunoglobulin Heavy Chain Gene

Author

Toshihiko Kuroiwa, Takafumi Saito, Kazuo Washiyama, Mitsuo Kouno, Shu-Jing Zhang, Sumio Endo, and Toshiro Kumanishi

Subjects
Male, Immunoglobulin gene, Cancer Research, Lymphoma, B-Cell, Lymphoma, Molecular Sequence Data, Immunoglobulin Variable Region, Biology, Polymerase Chain Reaction, Article, Germline mutation, B‐cell lymphoma, medicine, Humans, B-cell lymphoma, Aged, Gene Rearrangement, Brain lymphoma, Genetics, Base Sequence, Genes, Immunoglobulin, Brain Neoplasms, Large-cell lymphoma, Germinal center, Gene rearrangement, Middle Aged, medicine.disease, Molecular biology, Oncology, Mutation, Immunoglobulin heavy chain, Female, Immunoglobulin Heavy Chains, In situ hybridization
Abstract

Using reverse transcription-polymerase chain reaction (RT-PCR), six primary brain lymphomas, pathologically diagnosed as diffuse large B-cell lymphoma, were examined for rearranged V H -D-J H sequences of the immunoglobulin heavy chain gene, focusing on somatic mutations and intraclonal heterogeneity. The reliability of the isolated PCR clones was confirmed by in situ hybridization (ISH) with complementarity-determining region (CDR) 3 oligonucleotide probes. Sequence analysis of the PCR clones revealed a high frequency of somatic mutation, ranging from 8.8 to 27.3% (mean 18.2%) in the V H gene segments in all the lymphomas. A significantly lower frequency of replacement (R) mutations than expected was also seen in their frameworks (FRs) in all cases. These findings suggested that the precursor cells were germinal center (GC)-related cells in these lymphomas. However, despite extensive cloning experiments, intraclonal heterogeneity was not detected in any case except for one in which it could not be ruled out. Thus, it seemed likely that all of our brain lymphomas were derived from GC-related cells and that at least most of them were from post-GC cells.

Published
2002

6. Primary malignant lymphoma of the brain: frequent abnormalities and inactivation of p14 tumor suppressor gene

Author

Takafumi Saito, Toshihiko Kuroiwa, Shu-Jing Zhang, Toshiro Kumanishi, Sumio Endo, Mitsuo Kouno, and Kazuo Washiyama

Subjects
Adult, Male, Cancer Research, Tumor suppressor gene, Lymphoma, Biology, medicine.disease_cause, Exon, Tumor Suppressor Protein p14ARF, medicine, Missense mutation, Humans, Genes, Tumor Suppressor, Southern blot, Aged, Mutation, Base Sequence, Brain Neoplasms, General Medicine, Methylation, DNA Methylation, Middle Aged, medicine.disease, Blotting, Southern, Oncology, Cancer research, Female, Carcinogenesis
Abstract

Ten primary central nervous system lymphomas (PCNSL, brain lymphomas) were examined for p14 gene exon 1β deletion, mutation and methylation by Southern blot analysis, nucleotide analysis of polymerase chain reaction clones and Southern blot-based methylation assay. In Southern blot analysis, from the signal densities of the hybridized bands and their similarities to those of exons 2 and 3 in our previous quantitative study, we found that exon 1β was homozygously deleted in four cases, hemizygously deleted in five cases and not deleted in one case. Thus, the same deletion patterns covered the entire p14 gene for all cases except for one case, which suggested the hemizygous deletion of exons 1β and 2 and homozygous deletion of exon 3. In addition, although exon 1β mutation is rare in various tumors, we detected a missense mutation (L50R) in one case with a hemizygous deletion. Methylation of the 5′CpG island of the p14 gene was not suggested for any case without homozygous deletion. Our observation of frequent p14 gene abnormalities (90%) and inactivation (40–60%) was in striking contrast to the same pathological subtype of systemic lymphoma in which p14 gene abnormalities and inactivation were infrequent, suggesting a difference in carcinogenesis between PCNSL and systemic lymphoma. (Cancer Sci 2005; 96: 38 –41)

Published
2005

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