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12. Cover Image

Author

Wang, Jushuo, primary, Fan, Yingli, additional, Mittal, Balraj, additional, Sanger, Jean M., additional, and Sanger, Joseph W., additional

Published
2022
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21. Differences in the serum metabolic profile to identify potential biomarkers for cyanotic versus acyanotic heart disease.

Author

Vimal, Suman, Ranjan, Renuka, Yadav, Surabhi, Majumdar, Gauranga, Mittal, Balraj, Sinha, Neeraj, and Agarwal, Surendra Kumar

Subjects
AMINO acid metabolism, BIOMARKERS, PILOT projects, STATISTICS, ENERGY metabolism, SCIENTIFIC observation, METABOLOMICS, MULTIVARIATE analysis, CONGENITAL heart disease, NUCLEAR magnetic resonance spectroscopy, METABOLIC disorders, T-test (Statistics), COMPARATIVE studies, PEARSON correlation (Statistics), OXIDATIVE stress, DESCRIPTIVE statistics, RESEARCH funding, RECEIVER operating characteristic curves, EVALUATION
Abstract

Background: Growth retardation, malnutrition, and failure to thrive are some of the consequences associated with congenital heart diseases. Several metabolic factors such as hypoxia, anoxia, and several genetic factors are believed to alter the energetics of the heart. Timely diagnosis and patient management is one of the major challenges faced by the clinicians in understanding the disease and provide better treatment options. Metabolic profiling has shown to be potential diagnostic tool to understand the disease. Objective: The present experiment was designed as a single center observational pilot study to classify and create diagnostic metabolic signatures associated with the energetics of congenital heart disease in cyanotic and acyanotic groups. Methods: Metabolic sera profiles were obtained from 35 patients with cyanotic congenital heart disease (TOF) and 23 patients with acyanotic congenital heart disease (ASD and VSD) using high resolution 1D 1H NMR spectra. Univariate and multivariate statistical analysis were performed to classify particular metabolic disorders associated with cyanotic and acyanotic heart disease. Results: The results show dysregulations in several metabolites in cyanotic CHD patients versus acyanotic CHD patients. The discriminatory metabolites were further analyzed with area under receiver operating characteristic (AUROC) curve and identified four metabolic entities (i.e. mannose, hydroxyacetone, myoinositol, and creatinine) which could differentiate cyanotic CHDs from acyanotic CHDs with higher specificity. Conclusion: An untargeted metabolic approach proved to be helpful for the detection and distinction of disease-causing metabolites in cyanotic patients from acyanotic ones and can be useful for designing better and personalized treatment protocol. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Contributors

Author

Acharya, Chandan Kumar, Adhikari, Madhuchhanda, Adhikari, Suman, Aggarwal, Ritu, Aggarwal, Shyam, Arora, Aashima, Assolini, João Paulo, B.K., Iyshwarya, Bachhal, Vikas, Banerjee, Chiranjib, Behera, Biplab Kumar, Bhavsar, Smit, Biswas, Chayan, Biswas, Paramita, Buttar, Harpal S., Chatterjee, Ankit, Chaudhuri, Punarbasu, Chumber, Sunil, Concato, Virginia Marcia, Conchon-Costa, Ivete, da Silva, Thais Peron, da Silva Siqueira, Elaine, Datta, Abhijit, de Lima, Debora Messagi, Deka, R.C., Elekofehinti, Olusola O., Fagundes, Tatiane Renata, Ferreira, Mariane Okamoto, Gadi, Vaishnavi, Ganguly, Nirmal Kumar, Gnanasampanthapandian, Dhanavathy, Gonçalves, Manoela Daiele, Goni, Vijay, Gulati, Anubha, Gupta, Dhruv S., Hirokawa, Yoshifumi S., Inoue, Fabrício Seidy Ribeiro, Jain, Kriti, Jaiswal, Preeti, Jakaria, Md Golam, Jayaraman, Selvaraj, Kadian, Monika, Kanayama, Kazuki, Kataria, Mohak, Kaur, Manveen, Kawassaki, Aedra Carla Bufalo, Kumar, Anil, Kumar, Maushmi S., Kumar, Rajappan Chandra Satish, Kumar, Ravinder, Madhu, Nithar Ranjan, Maitra, Dhritiman, Maity, Sukhendu, Mangat, Navdeep Kaur, Merchant, Moin, Mitra, Sayantani, Mittal, Balraj, Molehin, Olorunfemi R., Munuswamy-Ramanujam, Ganesh, Naskar, Nabanita, Nath, Priyatosh, Negi, Deepak, Ogunleye, Tiwa M., Ohunayo, Adeniyi S., Oyeyemi, Ajibade O., Palaniyandi, Kanagaraj, Palta, Anshu, Pan, Animesh, Pandita, Shivani, Panis, Carolina, Parsad, Davinder, Patwardhan, Aryaman, Pavanelli, Wander Rogério, Pooja, Pramanick, Kousik, Rajagopal, Ponnulakshmi, Ramachandran, Vasukidevi, Ramachandran, Veerakumar, Rana, Anusha, Reeves, Arijit, Roychoudhury, Shubhadeep, Sahd, Claudia Stoeglehner, Sarkar, Bhanumati, Sekar, Durairaj, Sekar, Ramya, Semba, Remi, Sen, Koushik, Sen, Tanushree, Shankar, Dhayasankar Prabhu, Sharma, Himani, Sharma, Kritika, Sharma, Ramica, Shazia Fathima, JH, Shrivasatava, Kanishka, Silva, Taylon Felipe, Sobti, R.C., Srinivasan, Varunvenkat M., Srivastava, Anshika, Subbaraj, Gowtham Kumar, Tharrun Daniel Paul, L., Tsuboi, Junya, Uchida, Katsunori, Veerabathiran, Ramakrishnan, Yadav, Saurabh, and Yamada, Reiko

Published
2024
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27. Nuclear factor kappa-B and histopathology of chronic gastritis

Author

Moorchung Nikhil, Srivastava A, Sharma A, Achyut B, and Mittal Balraj

Subjects
Gastritis, nuclear factor kappa B, antral biopsy, Pathology, RB1-214, Microbiology, QR1-502
Abstract

Background: Studies suggest that nuclear factor kappa-B (NFκB) activation may be a critical event in the production of proinflammatory molecules in Helicobacter pylori-associated gastritis. Materials and Methods: This study examines the expression and activity of NFκB in situ in antral biopsies of 42 consecutive patients with immunohistochemical techniques. Results: NFκB was highly expressed in the gastric epithelial cells. The number of cells showing activated NFκB correlated with the activity of gastritis (P < 0.05), a measure of neutrophil influx, whereas no correlation was found with the chronicity of inflammation, a measure of the presence of mononuclear inflammatory cells. There was also a strong inverse association with the presence and grade of atrophy. Conclusion: This correlation is direct evidence of the importance of NFκB dependent signal transduction for neutrophil influx in gastritis. The role of NFκB appears to be only in the initial stages of gastritis, there is no role for the molecule in the development of chronic inflammation or atrophy.

Published
2010

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