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199 results on '"Mittal, Jeenu"'

10. Diabetes mellitus, hearing loss, and therapeutic interventions: A systematic review of insights from preclinical animal models.

Author

Mittal, Rahul, Keith, Grant, Lacey, Mitchel, Lemos, Joana R. N., Mittal, Jeenu, Assayed, Amro, and Hirani, Khemraj

Subjects
HEARING disorders, HAIR cells, DIABETES, ANIMAL models in research, HIDDEN hearing loss
Abstract

Objectives: The aim of this systematic review article is to evaluate the relationship between diabetes mellitus (DM) and sensorineural hearing loss (SNHL) utilizing preclinical animal models. The review focused on studies assessing SNHL in diabetic animal models, elucidating the mechanisms of DM-associated SNHL, and exploring the response of diabetic animal models to noise overexposure. We also discussed studies investigating the efficacy of potential therapeutic strategies for amelioration of DM-associated SNHL in the animal models. Methods: A protocol of this systematic review was designed a priori and was registered in the PROSPERO database (registration number: CRD42023439961). We conducted a comprehensive search on PubMed, Science Direct, Web of Science, Scopus, and EMBASE databases. A minimum of three reviewers independently screened, selected, and extracted data. The risk of bias assessment of eligible studies was conducted using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool. Results: Following the screening of 238 studies, twelve original articles were included in this systematic review. The studies revealed that hyperglycemia significantly affects auditory function, with various pathological mechanisms contributing to DM-induced hearing impairment, including cochlear synaptopathy, microangiopathy, neuropathy, oxidative stress, mitochondrial abnormalities, and apoptosis-mediated cell death. Emerging interventions, such as Asiaticoside, Trigonelline, Chlorogenic acid, and Huotanquyu granules, demonstrated efficacy in providing otoprotection for preserving cochlear hair cells and hearing function. Conclusions: Our systematic review delves into the intricate relationship between DM and hearing impairment in animal models. Future research should focus on targeted therapies to enhance cochlear mitochondrial function, alleviate oxidative stress, and regulate apoptosis. The association between SNHL and social isolation as well as cognitive decline underscores the necessity for innovative therapeutic modalities addressing yet undiscovered mechanisms. Translating findings from animal models to human studies will validate these findings, offering a synergistic approach to effectively manage DM-associated co-morbidities such as hearing impairment. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Evaluating the Efficacy of L-N-acetylcysteine and Dexamethasone in Combination to Provide Otoprotection for Electrode Insertion Trauma

Author

Eshraghi, Adrien A., primary, Shahal, David, additional, Davies, Camron, additional, Mittal, Jeenu, additional, Shah, Viraj, additional, Bulut, Erdogan, additional, Garnham, Carolyn, additional, Sinha, Priyanka, additional, Mishra, Dibyanshi, additional, Marwede, Hannah, additional, and Mittal, Rahul, additional

Published
2020
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34. Otoprotection to Implanted Cochlea Exposed to Noise Trauma With Dexamethasone Eluting Electrode

Author

Eshraghi, Adrien A., primary, Wolfovitz, Amit, additional, Yilmazer, Rasim, additional, Garnham, Carolyn, additional, Yilmazer, Ayca Baskadem, additional, Bas, Esperanza, additional, Ashman, Peter, additional, Roell, Jonathan, additional, Bohorquez, Jorge, additional, Mittal, Rahul, additional, Hessler, Roland, additional, Sieber, Daniel, additional, and Mittal, Jeenu, additional

Published
2019
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39. Nutritional interventions for autism spectrum disorder.

Author

Karhu, Elisa, Zukerman, Ryan, Eshraghi, Rebecca S, Mittal, Jeenu, Deth, Richard C, Castejon, Ana M, Trivedi, Malav, Mittal, Rahul, and Eshraghi, Adrien A

Subjects
AUTISM, BEHAVIOR therapy, CANDIDA, CASEINS, COGNITION, DIETARY supplements, FOLIC acid, GASTROINTESTINAL diseases, GLUTEN-free diet, KETOGENIC diet, MAGNESIUM, NUTRITION, SPEECH therapy, UNSATURATED fatty acids, VITAMIN A, VITAMIN B12, VITAMIN B6, VITAMIN C, COMORBIDITY, OXIDATIVE stress, PROBIOTICS, SINGLE nucleotide polymorphisms
Abstract

Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental disorder with considerable clinical heterogeneity. With no cure for the disorder, treatments commonly center around speech and behavioral therapies to improve the characteristic social, behavioral, and communicative symptoms of ASD. Gastrointestinal disturbances are commonly encountered comorbidities that are thought to be not only another symptom of ASD but to also play an active role in modulating the expression of social and behavioral symptoms. Therefore, nutritional interventions are used by a majority of those with ASD both with and without clinical supervision to alleviate gastrointestinal and behavioral symptoms. Despite a considerable interest in dietary interventions, no consensus exists regarding optimal nutritional therapy. Thus, patients and physicians are left to choose from a myriad of dietary protocols. This review, summarizes the state of the current clinical and experimental literature on nutritional interventions for ASD, including gluten-free and casein-free, ketogenic, and specific carbohydrate diets, as well as probiotics, polyunsaturated fatty acids, and dietary supplements (vitamins A, C, B6, and B12; magnesium and folate). [ABSTRACT FROM AUTHOR]

Published
2020
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49. Zika Virus: An Emerging Global Health Threat

Author

Mittal, Rahul, primary, Nguyen, Desiree, additional, Debs, Luca H., additional, Patel, Amit P., additional, Liu, George, additional, Jhaveri, Vasanti M., additional, S. Kay, Sae-In, additional, Mittal, Jeenu, additional, Bandstra, Emmalee S., additional, Younis, Ramzi T., additional, Chapagain, Prem, additional, Jayaweera, Dushyantha T., additional, and Liu, Xue Zhong, additional

Published
2017
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