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Your search keyword '"Mittempergher, L."' showing total 144 results
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144 results on '"Mittempergher, L."'

5. A novel biomarker to predict DNA-Repair-inhibitor response in stage I-III high risk breast cancer patients

Author

Barcaru, A., primary, Kuilman, M.M., additional, Wolf, D., additional, Yau, C., additional, Choy, E.B.M., additional, Audeh, W.M., additional, Brown-Swigart, L., additional, Hirst, G.L., additional, Symmans, F.W., additional, Liu, M.C., additional, Nanda, R., additional, Esserman, L.J., additional, van ‘t Veer, L.J., additional, Glas, A.M., additional, and Mittempergher, L., additional

Published
2022
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7. 161P MammaPrint and BluePrint diagnostic tests can be robustly assessed on Whole-Transcriptome NGS platform

Author

Liefaard, M.C., primary, Bhaskaran, R., additional, Bijl, Y., additional, Israeli, D., additional, Jong-Raadsen, S., additional, van Montfort, E., additional, Bao, S., additional, Mee, S., additional, Cavness, T., additional, Gallagher, A., additional, Falk, J., additional, Piel, T., additional, Witteveen, A., additional, van der Voort, A., additional, Vonk, S., additional, Lips, E., additional, Sonke, G.S., additional, Kleijn, M., additional, Glas, A., additional, and Mittempergher, L., additional

Published
2022
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16. Abstracts of papers presented at the second Israeli-Italian phytopathological symposium July 14–17, 1991 Belgirate, Italy

Author

Barkai-Golan, Rivka, Kritzman, G., Temkin-Gorodeiski, Naomi, Conti, M., Guglielmone, Laura, Vaira, Anna Maria, Luisoni, E., Milne, R. G., Lisa, Vittoria, Marzachi, Cristina, Boccardo, G., Masenga, Vera, Lenzi, R., Ramasso, Eliana, Crespi, Stefania, Accotto, G. P., Caciagli, P., Altomare, C., Rotem, Y., Sztejnberg, A., Lin, A., Henis, Y., Chet, I., Katan, J., Gamliel, A., Uziel, Aviva, Assaraf, M., Ben-Gal, Osnat, Traversa, Erminia, Ippolito, A., De Cicco, V., Casulli, F., Lima, G., Nigro, F., Savino, V., Martelli, G. P., Boscia, D., Minafra, A., Cariddi, C., Piglionica, V., Gallitelli, D., Corazza, Luciana, Chilosi, G., Balmas, V., Aragona, Maria, Haegi, A., Serrone, Paola Del, Innocenti, Gloria, Govi, Germana, Rossi, V., Frisullo, S., Battilani, Paola, Paster, N., Fanelli, C., Kennedy, R., Lacey, J., Mora, M., Shetty, H. Shekara, Aharonson, N., Grinstein, A., Elad, Y., Frankel, H., Yunis, H., Zimand, Gilly, Katan, Talma, Pressman, E., Ben-Yehoshua, S., Kim, J., Rodov, V., Shapiro, B., Fallik, E., Lalazar, A., Afek, U., Blaier, B., Cohen, R., Schaffer, A. A., Menge, J. A., Bertaccini, Assunta, Bellardi, Maria Grazia, Faccioli, G., Colombarini, A., Cirvilleri, Gabriella, Catara, A., Rosa, Rosa La, Renis, M., Delogu, G., Gatti, A., Pecchia, Susanna, Vannacci, G., Pecchia, Susanna, Vannacci, G., Bottalico, A., Graniti, A., Ghisellini, L., Roberti, R., Bonforte, M., Silvestro, Isabella Di, Mallegni, C., Cortellini, W., Tartari, C., Tamietti, G., Benzi, D., Martini, Patrizia, Garibaldi, A., Aloi, C., Bergonzoni, P., Mezzalama, Monica, Gullino, M. Lodovica, Palitto, M., Crescenzi, A., Arpaia, S., Sarindu, N., Marino, R., Leonardi, M., Scala, A., Mittempergher, L., Tegli, S., and Goggioli, V.

Published
1991
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20. Abstract P4-02-07: Comparison of breast cancer molecular subtyping by Immunohistochemistry and by BluePrint® next generation RNA sequencing-based test at University Hospitals Leuven and Curie Institute Paris

Author

Darrigues, L, primary, Slembrouck, L, additional, Mittempergher, L, additional, Delahaye, LJ, additional, Vanden Bempt, I, additional, Vander Borght, S, additional, Vliegen, L, additional, Sintubin, P, additional, Raynal, V, additional, Bohec, M, additional, Reyes, C, additional, Rapinat, A, additional, Helsmoortel, C, additional, Jongen, L, additional, Hoste, G, additional, Neven, P, additional, Wildiers, H, additional, Smeets, A, additional, Nevelsteen, I, additional, Punie, K, additional, Van Nieuwenhuysen, E, additional, Han, S, additional, Laurent, C, additional, Vincent-Salomon, A, additional, Laas-Faron, E, additional, Witteveen, AT, additional, Neijenhuis, S, additional, Glas, AM, additional, Floris, G, additional, and Reyal, F, additional

Published
2019
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21. Abstract P4-08-25: Decentralized beta testing of MammaPrint and BluePrint NGS kit at University Hospitals Leuven and Curie Institute Paris

Author

Slembrouck, L, primary, Laurent, C, additional, Delahaye, LJ, additional, Mittempergher, L, additional, Vanden Bempt, I, additional, Vander Borght, S, additional, Darrigues, L, additional, Vliegen, L, additional, Sintubin, P, additional, Raynal, V, additional, Bohec, M, additional, Reyes, C, additional, Rapinat, A, additional, Helsmoortel, C, additional, Jongen, L, additional, Hoste, G, additional, Neven, P, additional, Wildiers, H, additional, Smeets, A, additional, Nevelsteen, I, additional, Punie, K, additional, Van Nieuwenhuysen, E, additional, Han, S, additional, Salomon, AV, additional, Faron, EL, additional, Cynober, T, additional, Witteveen, AT, additional, Neijenhuis, S, additional, Glas, AM, additional, Reyal, F, additional, and Floris, G, additional

Published
2019
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43. Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.

Author

Michaut, M, Chin, S-F, Majewski, I, Severson, TM, Bismeijer, T, de Koning, L, Peeters, JK, Schouten, PC, Rueda, OM, Bosma, AJ, Tarrant, F, Fan, Y, He, B, Xue, Z, Mittempergher, L, Kluin, RJC, Heijmans, J, Snel, M, Pereira, B, Schlicker, A, Provenzano, E, Ali, HR, Gaber, A, O'Hurley, G, Lehn, S, Muris, JJF, Wesseling, J, Kay, E, Sammut, SJ, Bardwell, HA, Barbet, AS, Bard, F, Lecerf, C, O'Connor, DP, Vis, DJ, Benes, CH, McDermott, U, Garnett, MJ, Simon, IM, Jirström, K, Dubois, T, Linn, SC, Gallagher, WM, Wessels, LFA, Caldas, C, Bernards, R, Michaut, M, Chin, S-F, Majewski, I, Severson, TM, Bismeijer, T, de Koning, L, Peeters, JK, Schouten, PC, Rueda, OM, Bosma, AJ, Tarrant, F, Fan, Y, He, B, Xue, Z, Mittempergher, L, Kluin, RJC, Heijmans, J, Snel, M, Pereira, B, Schlicker, A, Provenzano, E, Ali, HR, Gaber, A, O'Hurley, G, Lehn, S, Muris, JJF, Wesseling, J, Kay, E, Sammut, SJ, Bardwell, HA, Barbet, AS, Bard, F, Lecerf, C, O'Connor, DP, Vis, DJ, Benes, CH, McDermott, U, Garnett, MJ, Simon, IM, Jirström, K, Dubois, T, Linn, SC, Gallagher, WM, Wessels, LFA, Caldas, C, and Bernards, R

Abstract

Invasive lobular carcinoma (ILC) is the second most frequently occurring histological breast cancer subtype after invasive ductal carcinoma (IDC), accounting for around 10% of all breast cancers. The molecular processes that drive the development of ILC are still largely unknown. We have performed a comprehensive genomic, transcriptomic and proteomic analysis of a large ILC patient cohort and present here an integrated molecular portrait of ILC. Mutations in CDH1 and in the PI3K pathway are the most frequent molecular alterations in ILC. We identified two main subtypes of ILCs: (i) an immune related subtype with mRNA up-regulation of PD-L1, PD-1 and CTLA-4 and greater sensitivity to DNA-damaging agents in representative cell line models; (ii) a hormone related subtype, associated with Epithelial to Mesenchymal Transition (EMT), and gain of chromosomes 1q and 8q and loss of chromosome 11q. Using the somatic mutation rate and eIF4B protein level, we identified three groups with different clinical outcomes, including a group with extremely good prognosis. We provide a comprehensive overview of the molecular alterations driving ILC and have explored links with therapy response. This molecular characterization may help to tailor treatment of ILC through the application of specific targeted, chemo- and/or immune-therapies.

Published
2016

49. Screening European elms for resistance to Ophiostoma novo-ulmi

Author

Solla, A., Bohnens, J., Collin, E., Diamandis, S., Franke, A., Luis Gil, Buron, M., Santini, A., Mittempergher, L., Pinon, J., Broeck, Av, UNIVERSIDAD DE EXTREMADURA DEPARTAMENTO DE BIOLOGIA Y PRODUCCION DE LOS VEGETALES PLASENCIA ESP, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), HESSEN FORSTEINRICHTUNG INFORMATION VERSUCHSWESEN HANN MUNDEN DEU, Écosystèmes forestiers et paysages (UR EFNO), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), NATIONAL AGRICULTURAL RESEARCH FOUNDATION FOREST RESEARCH INSTITUTE VASSILIKA THESSALONIKI GRC, FORSTLICHE VERSUCHS UND FORSCHUNGSANSTALT FREIBURG DEU, UNIVERSIDAD POLITECNICA DE MADRID ETSI DE MONTES MADRID ESP, ISTITUTO PER LA PROTEZIONE DELLE PIANTE CNR SESTO FIORENTINO ITA, Institut National de la Recherche Agronomique (INRA), and INSTITUT FOR FORESTRY AND GAME MANAGEMENT GERAARDSBERGEN BEL

Subjects
environmental management, OPHIOSTOMA NOVO ULMI, EUROPE, Ulmus, [SDE]Environmental Sciences, plant breeding, forest management, Ophiostoma ulmi
Abstract

Resistance breeding of the native elms against Dutch elm disease, caused by the fungus Ophiostoma novo-ulmi Brasier, is a major objective in Europe for the conservation of this tree species. More than 2,500 cuttings of 324 elm clones (Ulmus minor Miller, U. glabra Huds., U. laevis Pall., U. pumila L., U. minor x U. glabra, and U. minor x U. pumila) from eight European countries, planted in several randomized two-block designed plots were inoculated with various O. novo-ulmi strains. Crown wilting and dieback were recorded during the first year after inoculation. The wilting of the control trees varied among the plots, making the results difficult to compare, but analysis of variance (ANOVA) within each plot showed significant differences in disease severity among the clones tested, allowing study of the variation of the response among elm taxa. Results showed that 19 European inoculated clones recovered from O. novo-ulmi attack, giving hope for the reestablishment of native elms in countryside hedges and forests.

Published
2005

50. Variation among italian and french elm clones in their response to Ophiostoma novo-ulmi inoculation

Author

Santini A., Fagnani A., Ferrini F., Ghelardini L., and Mittempergher L.

Subjects
Ophiostoma novo-ulmi, resistance, disease, elm clones
Abstract

In 1995 a clone bank of elms from across Italy was created at Antella (Florence, I) under a European Union project. In 1998 an experimental planting of some clones from this source was established in Antella together with material from a similar clone bank in France and two reference clones: Commelin (relatively susceptible) and Lobel (relatively resistant). In May 2001, the elms were inoculated with Ophiostoma novo-ulmi and disease development was assessed throughout that summer and the next. Significant differences in susceptibility were found between taxonomic groups, with putative natural hybrids between Ulmus minor and Ulmus pumila being the most resistant and Ulmus glabra the most susceptible. Significant differences were also found within U. minor, some clones being as resistant as Lobel. For U. minor, a statistically significant relation was found with latitude, southerly clones showing less disease than more northerly ones. Relationships were also found between disease severity and times to bud burst, these relationships applying both to the different taxonomic groups and within U. minor. Relationships between growth increment and disease severity were inconsistent. These results are discussed in relation to the intrinsic genetically-controlled differences that exist between elms and to differences in susceptibility that occur as the growing season proceeds and as a consequence of environmental influences.

Published
2005

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