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218 results on '"Miwa, Masao"'

6. A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice

Author

Yamazaki, Yasuhiro, Yasuda, Kengo, Matsuyama, Tensei, Ishihara, Takuya, Higa, Ryoko, Sawairi, Taira, Yamaguchi, Masahiko, Egi, Masahiro, Akai, Shuji, Miyase, Toshio, Ikari, Akira, Miwa, Masao, and Sugatani, Junko

Published
2013
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12. Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets

Author

Suzuki, Masahiro, Sugatani, Junko, Ino, Mitsuhiro, Shimura, Masahiko, Akiyama, Masaki, Yamazaki, Ryuta, Suzuki, Yasuo, and Miwa, Masao

Subjects
Platelet activating factor -- Physiological aspects, Blood platelets -- Aggregation, Rabbits -- Physiological aspects, Biological sciences
Abstract

Human and rabbit platelets that were aggregated by platelet-activating factor (PAF) underwent slow disaggregation but were rapidly disaggregated by several PAF receptor antagonists. PAF deacetylation activity in intact rabbit platelets as directly proportional with PAF concentrations. The amount of P-selectin determined on the platelet cell surface was established by enzyme-linked immunosorbent assay while rabbit platelets in Tyrode-gelatin buffer were incubated with proteinase K.

Published
1998

17. Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet

Author

Sugatani Junko, Sadamitsu Satoshi, Wada Tadashi, Yamazaki Yasuhiro, Ikari Akira, and Miwa Masao

Subjects
Synthetic inulin, Hepatic steatosis, CYP1A1/2, CYP2E1, Lipid-lowering drug, Fluvastatin, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Abstract Background Rats fed a high-fat and high-sucrose (HF) diet develop hepatic steatosis and hyperlipidemia. There are several reports that a change in nutritional status affects hepatic levels of drug-metabolizing enzymes. Synthetic inulin is a dietary component that completely evades glucide digestion. Supplementing a HF diet with inulin ameliorates hypertriglycemia and hepatic steatosis, but not hypercholesterolemia. This study aimed at distinguishing the effects of synthetic inulin and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin), which inhibit cholesterol biosynthesis. Methods We examined effects of co-treatment with synthetic inulin (5%) and fluvastatin (0, 4, and 8 mg/kg, per os) on body weight, epidydimal white adipose tissue weight, serum and hepatic lipid profiles, and hepatic cytochrome P450 (CYP) mRNA and protein profiles in rats fed a standard diet or a HF diet for 3 weeks. Results Treatment with the synthetic inulin (5%) or fluvastatin at 4 mg/kg (lethal dose in rats fed the HF diet, 8 mg/kg) ameliorated the elevation in hepatic triacylglycerol and total cholesterol levels in rats fed the HF diet. Whereas co-treatment with the inulin (5%) and fluvastatin (4 mg/kg) had a tendency to more strongly suppress the elevation in serum levels of very low density lipoprotein triacylglycerol than either treatment alone, no additive or synergistic effect was found in decrease in hepatic lipid levels. Hepatic levels of CYP1A1/2 and CYP2E1 mRNA and protein and methoxyresorufin O-demethylase and ethoxyresorufin O-deethylase activities were reduced in rats fed the HF diet. The synthetic inulin alleviated the reduction in hepatic levels of CYP1A1/2 and CYP2E1 mRNA and protein more strongly than fluvastatin, and no synergistic effects were observed on co-treatment. Furthermore, hepatic levels of aryl hydrocarbon receptor mRNA were decreased in rats fed the HF diet and recovered to near normal values with the intake of dietary inulin, which correlated with change in CYP1A1/2. Conclusions Dietary inulin alone was effective to prevent the development of hepatic steatosis, ameliorate nutritional effects, and alleviate the hepatic change in the expression of CYP1A1/2 and CYP2E1, while co-treatment with statin did not have additive or synergistic effects and statin may cause adverse effects in rats fed the HF diet.

Published
2012
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22. Antiobese function of platelet‐activating factor: increased adiposity in platelet‐activating factor receptor‐deficient mice with age

Author

Sugatani, Junko, primary, Sadamitsu, Satoshi, additional, Yamaguchi, Masahiko, additional, Yamazaki, Yasuhiro, additional, Higa, Ryoko, additional, Hattori, Yoshiki, additional, Uchida, Takahiro, additional, Ikari, Akira, additional, Sugiyama, Wataru, additional, Watanabe, Tatsuo, additional, Ishii, Satoshi, additional, Miwa, Masao, additional, and Shimizu, Takao, additional

Published
2013
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26. Modulation by drugs acting on the autonomic nervous system of platelet-activating factor in the stomach of rats

Author

Miwa Masao, Fujimura Kazuyo, Sugatani Junko, and Saito Kunihiko

Subjects
Atropine, Male, medicine.medical_specialty, Dopamine, Endogeny, Gastric erosion, Biochemistry, chemistry.chemical_compound, Catecholamines, Stress, Physiological, Internal medicine, medicine, Animals, Platelet Activating Factor, Rats, Wistar, Oxidopamine, Pharmacology, Platelet-activating factor, Stomach, digestive, oral, and skin physiology, respiratory system, medicine.disease, Autonomic Agents, digestive system diseases, Rats, Autonomic nervous system, Endocrinology, medicine.anatomical_structure, chemistry, Gastric Mucosa, Cholinergic, lipids (amino acids, peptides, and proteins), Carbachol, medicine.drug
Abstract

Platelet-activating factor (PAF), an ether linked choline glycerophospholipid, is a potent initiator of diverse physiological and pathological processes. We have reported that gastric endogenous PAF levels were reduced and the contents of each of its molecular species changed during waterimmersion stress in rats (Sugatani J et al ., FASEB J 3 : 65–70, 1989 and Sugatani J et al ., Lipids 26 : 1347–1353, 1991). In this study, we determined the effects of autonomie drugs on the level of gastric PAF, its molecular heterogeneity and formation of gastric erosions in unstressed rats and those subjected to water-immersion stress. Atropine, an anticholinergic drug, suppressed both the stress-induced changes and development of gastric lesions. 6-Hydroxydopamine-induced sympathectomy induced a small decrease in the gastric PAF levels and the addition of stress further decreased the PAF levels and development of gastric lesions. Carbamylcholine induced a transient decrease in the gastric PAF level of normal rats, which was not associated with gastric erosion formation. In contrast, the endogenous gastroprotective factor dopamine evoked transient dose- and time-dependent increases in the gastric PAF levels. These observations indicate that cholinergic muscarinic-receptor activation in rats led to decreases in gastric PAF levels and a prolonged and marked decrease in its level was associated with the development of gastric lesions, and that dopamine increases gastric PAF levels. Gastric endogenous PAF levels are closely associated with the autonomie nervous system and should be considered further in investigations of gastric function.

Published
1993

45. Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting Protein 1

Author

Sugatani, Junko, primary, Nishitani, Shinichi, additional, Yamakawa, Kasumi, additional, Yoshinari, Kouichi, additional, Sueyoshi, Tatsuya, additional, Negishi, Masahiko, additional, and Miwa, Masao, additional

Published
2004
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