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14. Mechanisms of amino acid formation using optical emission spectroscopy

Author

Miyakawa, S., Sawaoka, A.B., Ushio, K., and Kobayashi, K.

Subjects
Amino acids -- Research, Optical spectrometers -- Usage, Emission spectroscopy -- Usage, Physics
Abstract

The properties of a magnetoplasma dynamic arc jet were studied by optical emission spectroscopy to investigate the mechanisms of amino acid formation induced by electric discharge. Nitrogen, oxygen and hydrogen atoms and CN radicals were produced by instantaneously heating a CO-N2-H2O gas mixture to 10,000 K. These plasma species were rapidly cooled to produce an amorphous film with amino acid precursors by directly colliding against a wall of a glass tube.

Published
1999

28. Renal Tubular Calcium Transport

Author

Bomsztyk, K., Miyakawa, S., Walker, Valerie R., editor, Sutton, Roger A. L., editor, Cameron, E. C. Bert, editor, Pak, Charles Y. C., editor, and Robertson, William G., editor

Published
1989
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32. Simultaneous LC-MS analysis of plasma concentrations of sildenafil, tadalafil, bosentan, ambrisentan, and macitentan in patients with pulmonary arterial hypertension

Author

Tanaka, S., Uchida, S., Hakamata, A., Miyakawa, S., Odagiri, K., Inui, N., Watanabe, H., and Namiki, N.

Abstract

Phosphodiesterase-5 (PDE-5) inhibitors and endothelin receptor antagonists (ERAs) are standard therapies for pulmonary arterial hypertension (PAH). The inter-individual variability of these pharmacokinetics is reported remarkably large, and therapeutic drug monitoring (TDM) can be useful to improve the likelihood of the desired therapeutic and safety outcomes. This study aimed to develop a LC-MS method to determine the concentrations of five PAH drugs (PDE-5 inhibitors: sildenafil and tadalafil, ERAs: bosentan, macitentan, and ambrisentan) from plasma samples using a simple process followed by a single mass spectrometric run, and to validate this approach through pharmacokinetic analyses in patients. A solid extraction method was used for sample preparation of the drugs from human plasma. The total run time for a single injection was within 10 min. The calibration curves for all drugs were linear, and the lower limits of quantitation were 1 (sildenafil), 2 (tadalafil), 5 (ambrisentan), and 10 ng/mL (bosentan, macitentan). The accuracy and precision values suggested that the assay had high accuracy and reliability. To prove the utility of this method, the plasma concentrations of the five PAH drugs were determined after their oral administration to nine PAH patients.

Published
2020
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33. Effects of mean shear stress on the torsional fatigue strength of a spring steel with small scratches.

Author

Nishimura, Y, Yanase, K, Tanaka, Y, Miyamoto, N, Miyakawa, S, Endo, M, Sun, Lizhi, and Ju, Jiann-wen Woody

Subjects
SHEARING force, HIGH cycle fatigue, TORSIONAL load, FATIGUE testing machines, RESIDUAL stresses, STEEL
Abstract

The torsional fatigue behavior of a high-strength spring steel, SWOSC-V, was investigated. Of particular interest were the influences of small scratches and superimposed static shear stress in the very high cycle fatigue regime. To achieve the research objectives, an ultrasonic torsional fatigue testing machine was developed. S-N curves showed the fatigue limit for the tested material condition (i.e. with no residual stresses at specimen surface). This study revealed that a notable influence of the stress ratio, R, on the torsional fatigue behavior was not explicitly recognized. Concerning the influence of small scratches, it was found that the area -parameter model can predict the lower bound of the torsional fatigue limit, irrespective of the value of R. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Proceedings of the 25th Annual Meeting from October 13–15, 1983—Yamaguchi, Japan

Author

Kawano, Sunao, Kamada, Takenobu, Arakawa, T., Kobayashi, K., Oda, Masaya, Nakamura, Masahiko, Watanabe, Norihito, Tsukada, Nobuhiro, Komatsu, Hirokazu, Yonei, Yoshikazu, Akaiwa, Hirofumi, Ichikawa, Eiki, Tsuchiya, Masaharu, Tatsuta, Masaharu, Okuda, Shigeru, Tsukamoto, Yoshihisa, Segawa, Kosei, Yoshida, Yukika, Fukuchi, Sotaro, Iida, Yozo, Takeuchi, Ken, Sato, Masanobu, Kano, Atsushi, Oka, Hiroyuki, Asada, Shuji, Mizushima, Kazuo, Shibata, Yoshimi, Sakai, Masahiko, Miyake, Takeo, Sakai, Hideaki, Yoshida, Yukio, Aoki, Teruaki, Kitajima, M., Sohma, S., Matsueda, Kei, Umeda, Noritsugu, Noda, Ken-ichi, Esaki, Takaro, Takahashi, Seiichi, Konishi, Yoichi, Higashi, Shunsaku, Mizumoto, Ryuji, Ohta, Goroku, Nakanuma, Yasuni, Tateno, Hiroo, Kido, Choichiro, Kojiro, Masamichi, Nakashima, Toshiro, Kagawa, Keizo, Ashihara, Tsukasa, Nakamura, Tatsuya, Tsuchiya, Masaharu, Nomoto, Minoru, Ichida, Fumihiro, Kobayashi, Kenichi, Unoura, Masashi, Ushio, Kyosuke, Yamada, Tatsuya, Tanaka, Keiji, Yao, Tsuneyoshi, Kobayashi, Shigeo, Matsukawa, Masaaki, Tanabe, Makoto, Yamada, Akiyoshi, Kawamura, Ryoki, Okabe, Masato, Fuchigami, Tadahiko, Kohrogi, Norio, Taniyama, S., Katsumata, Tomoe, Atari, Hideo, Yamagata, Shoichi, Sato, Toshio, Matsushiro, Takashi, Suzuki, Noriyoshi, Kameda, Haruo, Nakayama, Fumio, Osuga, Toshiaki, Maki, Tetsuo, Higasa, Yorinori, Miyoshi, Akima, Kasugai, Tatsuzo, Tomita, Eiichi, Hashimoto, Osamu, Suzuki, Kazuyuki, Sato, Shunichi, Fujiwara, Kenji, Yoshiba, Makoto, Akamatsu, Kouichi, Tada, Kouji, Yamada, Nobuo, Shibata, Hisao, Matsuda, Shoshi, Hanta, Tetsuro, Abe, Hirohiko, Tanikawa, Kyuichi, Imawari, M., Kato, Yasuhiro, Noda, Yatsugi, Unoura, Masashi, Tanaka, Nobuyoshi, Kobayashi, Kenichi, Hattori, Nobu, Hatano, Kiichi, Kobayashi, Shigeyasu, Sato, Nobuhiro, Kamada, Takenobu, Yamaguchi, Masayuki, Okazaki, Yukinori, Kurosaka, Hanzo, Oohara, Takeshi, Yamashita, Yoshimasa, Onji, Morikazu, Kashiwagi, Toru, Koizumi, Takeo, Noguchi, Takashi, Mizumoto, Ryuji, Toda, Satoshi, Mimura, Hisashi, Moriyasu, Fuminori, Ban, Nobuyuki, Ohnishi, Kunihiko, Saito, Masayuki, Ohnishi, Kunihiko, Saito, Masayuki, Saito, Masaaki, Tanabe, Takayoshi, Tobe, Kazuo, Miyakawa, S., Araki, T., Mimura, Kazuo, Tatsuno, Jiro, Kojima, Kuniaki, Sugiura, Mitsuo, Kaneko, Masayuki, Nakajima, Toshio, Tanaka, Masato, Onizuka, Toshio, Adachi, K., Shirota, A., Iwakoshi, Kazuhiko, Watanabe, Shigenori, Sasaki, Hiroaki, Yaguchi, Tomoaki, Satake, Yoshiharu, Fujita, Rikiya, Iida, Mitsuo, Nakada, Kō, Aoyama, Iwao, Yamamoto, Yasuro, Okazaki, Kazuichi, Aoki, Yoshihiro, Nishiyama, Akitsugu, Suzuki, Koichi, Kitahora, Tetsuji, Inaniwa, Kenichi, Yoshimasu, Hitoshi, Tomizawa, Mineo, Ichida, Fumihiro, Shirai, Tadashi, Yamaguchi, Kotaro, Tada, Masahiro, Watanabe, Yoshiyuki, Kitano, Atsuo, Kobayashi, Kenzo, Fukuda, Hirohide, Makiyama, Kazuya, Harada, Hideo, Oto, Masao, Kuroda, Akira, Kojima, Kuniji, Takebe, Takaaki, Hayakawa, Tetsuo, Kasugai, Tatsuzo, Oi, Itaru, Kitamura, Tsugio, Saisho, Hiromitsu, and Komatsu, Kanji

Published
1984
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44. Intravascular lipoma of the inferior vena cava and left renal vein

Author

Hirofumi Koike, MD, Miyakawa Suzuka, MD, Minoru Morikawa, MD, Eijyun Sueyoshi, MD, and Masataka Uetani, MD

Subjects
Intravascular lipoma, CT, MRI, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Intravenous lipoma of the inferior vena cava is an incidental finding on contrast-enhanced computed tomography in 0.5% of individuals. We report a case of multiple intravenous lipomas discovered during diagnosis of cholangitis in a 39-year-old woman. Imaging revealed three fatty masses that appeared connected by cordlike structures: one in the left renal vein with wide mural attachment and two in the inferior vena cava, the higher of which was mobile. We hypothesize that these originated as a single lipoma that subsequently divided into three distinct masses. Because mobile masses may cause pulmonary thromboembolism, surgery is recommended in these cases.

Published
2021
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45. Clinical and histopathological spectrum of cutaneous vasculitis in rheumatoid arthritis

Author

K-R Chen, Miyakawa S, Suzuki A, and Toyohara A

Subjects
Adult, Male, Vasculitis, Pathology, medicine.medical_specialty, Cutaneous Polyarteritis Nodosa, Dermatology, Skin Diseases, Vascular, Arthritis, Rheumatoid, Medicine, Humans, Arteritis, Purpura, Livedo reticularis, Palpable purpura, Aged, business.industry, Mononeuritis Multiplex, Middle Aged, medicine.disease, Prognosis, Erythema elevatum diutinum, Rheumatoid vasculitis, Female, medicine.symptom, business, Phlebitis
Abstract

SummaryBackground Cutaneous manifestations are the most frequent, and often the initial feature of extra-articular involvement in patients with rheumatoid vasculitis. Objectives The purpose of the study was to evaluate the clinical and histological spectrum of cutaneous vasculitis and the associated systemic involvement in patients with rheumatoid vasculitis. Methods Among 525 patients with rheumatoid arthritis, 20 tissue specimens with histologically proven cutaneous necrotizing vasculitis from 11 patients were investigated by studying the types and levels of affected vessels and related clinical features. Results Small-vessel vasculitis identified as dermal necrotizing venulitis was found in 10 patients, clinically characterized by palpable purpura, maculopapular erythema, erythema elevatum diutinum and haemorrhagic blisters. Arteritis histologically resembling cutaneous polyarteritis nodosa, clinically characterized by subcutaneous nodules, livedo reticularis, atrophie blanche and deep ulcers was identified in four patients all with systemic complications. Coexistence of venulitis and arteritis was identified in three patients. Different cutaneous vasculitic manifestations often coexisted and recurred in the same patient. Three patients with systemic complications of mononeuritis multiplex (two of three), interstitial pulmonary fibrosis (two of three) and abdominal microaneurysms (one of three) died within 1 year of onset of the cutaneous vasculitis. Immunofluorescence demonstrated vessel wall deposition of IgM and/or complement in six of the seven patients examined. Conclusions Features of cutaneous rheumatoid vasculitis overlapping both the characteristics of cutaneous necrotizing venulitis and cutaneous polyarteritis nodosa together with coexistence of these different type of vasculitis in the same or different lesional skin account for the associated diverse cutaneous vasculitic manifestations. Although dermal venulitis (leucocytoclastic vasculitis) was the most common presentation, the presence of leucocytoclastic vasculitis in rheumatoid patients did not necessarily indicate a favourable prognosis. Associations with mononeuritis multiplex and bowel involvement had a fatal prognosis, while patients with superficial dermal venulitis without other extra-articular involvement may follow a favourable prognosis.

Published
2002

49. Crystal structure of a human IgG-aptamer complex

Author

Nomura, Y., primary, Sugiyama, S., additional, Sakamoto, T., additional, Miyakawa, S., additional, Adachi, H., additional, Takano, K., additional, Murakami, S., additional, Inoue, T., additional, Mori, Y., additional, Nakamura, Y., additional, and Matsumura, H., additional

Published
2010
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