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Your search keyword '"Miyako, Eijiro"' showing total 292 results
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292 results on '"Miyako, Eijiro"'

7. Biomimetic Functional Nanocomplexes for Photothermal Cancer Chemoimmunotheranostics.

Author

Sang, Nina, Qi, Yun, Nishimura, Shun, and Miyako, Eijiro

Subjects
CARBON nanohorns, PHOTOTHERMAL conversion, TREATMENT effectiveness, ANTINEOPLASTIC agents, CANCER treatment, PHOTOTHERMAL effect
Abstract

This study presents a novel multimodal cancer theranostic platform developed using tumor cell‐coated biomimetic carbon nanohorn (CNH) complexes that encapsulate the anticancer drug paclitaxel (PTX). This platform combines photothermal therapy, chemotherapy, and immunotherapy to fight against malignant colorectal cancer. These engineered nanocomplexes are designed to deliver sufficient PTX molecules into a targeted solid tumor in a light‐controllable manner while inducing significant photothermal and antitumor immune responses. The outstanding photothermal conversion property of the CNHs under near‐infrared light enables effective cancer cell ablation and awakening of cytotoxic immune responses. Tumor cell membrane‐coated CNHs show improved water dispersibility, immune evasion, and targeting capabilities alongside enhanced immune activation against tumors. The efficacy of the biomimetic functional CNH nanocomplexes is demonstrated through excellent tumor‐targeting, controlled drug‐releasing behavior, and induction of cancer cell death, contributing to a robust antitumor response. This study provides a promising approach to cancer treatment by integrating multiple therapeutic modalities into a single platform, potentially enhancing treatment efficacy to combat intractable cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Light‐Activatable Liquid Metal Immunostimulants for Cancer Nanotheranostics.

Author

Qi, Yun, Miyahara, Mikako, Iwata, Seigo, and Miyako, Eijiro

Subjects
NANOSTRUCTURED materials, LIQUID metals, PHOTOTHERMAL conversion, COLON tumors, DENDRITIC cells
Abstract

Gallium‐based liquid metal (LM) nanoparticles are among the most promising nanoscale materials for biomedicinal applications because of their outstanding physicochemical properties, including unique flexibility, easy surface modification, excellent photothermal conversion efficiency, and high biocompatibility. Further exploration of the modification and remote‐controlling performances of LM nanoparticles with functional bioactive molecules for the development of an innovative treatment modality for diseases is challenging. Herein, it is reported that near‐infrared (NIR) light‐activatable LM nanoparticle, which functionalized with immunological activators of T and dendritic cells, can work as highly immunogenic and photo‐exothermic nanoscale stimulants for cancer treatment. The synthesized LM nanostimulant, which has low toxicity, powerful photothermal conversion property, and high immunogenic features, can effectively eliminate cancer cells, cancer spheroids, and colorectal tumors in living mice under NIR laser illumination. Moreover, the fluorescent LM nanostimulant can express strong fluorescence as a reporter agent to identify the targeted tumors in living mice for optical cancer diagnosis. Therefore, such a smart nanostimulant represents a way toward combination photothermal immunotheranostics. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells

Author

Wang, Jia, primary, Bhargava, Priyanshu, additional, Yu, Yue, additional, Sari, Anissa Nofita, additional, Zhang, Huayue, additional, Ishii, Noriyuki, additional, Yan, Kangmin, additional, Zhang, Zhenya, additional, Ishida, Yoshiyuki, additional, Terao, Keiji, additional, Kaul, Sunil C., additional, Miyako, Eijiro, additional, and Wadhwa, Renu, additional

Published
2020
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