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13 results on '"Miyakubo, Tomoko"'

1. Validation of a new technique using 4-0 nylon thread as a guide for tube insertion of the Ahmed glaucoma valve into the ciliary sulcus

Author

Nitta, Keisuke, Miyakubo, Tomoko, Tokui, Shunsuke, Takayama, Mayuko, Shinohara, Yoichiro, Saito, Kazuma, Endo, Tomomi, and Akiyama, Hideo

Subjects
Care and treatment, Evaluation, Usage, Methods, Eye surgery -- Methods -- Evaluation, Drainage (Surgical) -- Methods, Nylon -- Usage, Glaucoma -- Care and treatment, Drainage, Surgical -- Methods, Eye -- Surgery
Abstract

Author(s): Keisuke Nitta (corresponding author) [1]; Tomoko Miyakubo [1,2]; Shunsuke Tokui [1]; Mayuko Takayama [1]; Yoichiro Shinohara [1]; Kazuma Saito [1]; Tomomi Endo [1]; Hideo Akiyama [1] Ciliary sulcus insertion [...], In this study, we validated the new technique for inserting the tube of the Ahmed glaucoma valve (AGV) into the ciliary sulcus. AGV tube insertion was performed by introducing a 4-0 nylon thread into the anterior chamber from the corneal incision on the opposite side of the AGV. The thread was placed in the lumen of a 23-G needle that was inserted into the sclera and ciliary sulcus from the AGV side. Withdrawing the 23-G needle, the thread was led out of the eye from the scleral wound, passing through the ciliary sulcus. The thread was then placed in the AGV tube lumen, and the tube was inserted through the scleral wound into the ciliary sulcus by using the thread as a guide, as per the Seldinger technique. In all seven eyes, the tube was precisely inserted into the ciliary sulcus without serious intraoperative complications such as vitreous straying of the tube. Keywords: Ahmed glaucoma valve (AGV), ciliary sulcus, glaucoma surgery, Seldinger technique, tube shunt

Published
2024
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5. Comparison of the 2-Year Results of Photodynamic Therapy with Aflibercept and Aflibercept Monotherapy for Polypoidal Choroidal Vasculopathy

Author

Miyakubo,Tomoko, Mukai,Ryo, Matsumoto,Hidetaka, Morimoto,Masahiro, Takahashi,Maki, Nagai,Kazuki, Nakamura,Kosuke, Hoshino,Junki, Akiyama,Hideo, Miyakubo,Tomoko, Mukai,Ryo, Matsumoto,Hidetaka, Morimoto,Masahiro, Takahashi,Maki, Nagai,Kazuki, Nakamura,Kosuke, Hoshino,Junki, and Akiyama,Hideo

Abstract

Tomoko Miyakubo, Ryo Mukai, Hidetaka Matsumoto, Masahiro Morimoto, Maki Takahashi, Kazuki Nagai, Kosuke Nakamura, Junki Hoshino, Hideo Akiyama Department of Ophthalmology, Gunma University, Graduate School of Medicine, Maebashi, Gunma, JapanCorrespondence: Ryo Mukai, Department of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan, Tel +81-27-220-8338, Fax +81-27-233-3841, Email rmukai@gunma-u.ac.jpPurpose: To compare the efficacies of photodynamic therapy (PDT) combined with intravitreal aflibercept (IVA) injections and IVA monotherapy using a treat-and-extend regimen (TAE) for treatment-naïve polypoidal choroidal vasculopathy (PCV).Patients and Methods: One hundred and nine eyes treated with PDT combined with IVA (PDT+IVA group: 51 eyes) or IVA monotherapy (IVA group: 58 eyes) were assessed for 2 years. The main outcome measures included best-corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), number of IVA injections, and macular atrophy (MA). Polypoidal lesions before and after the loading phase were assessed using indocyanine green angiography.Results: In both groups, BCVA significantly improved after the loading phase and was maintained for 2 years. CMT and CCT were significantly reduced in both groups, without significant differences after 2 years between the groups (P=0.2708). The mean number of IVA injections in the IVA and PDT+IVA groups during the 2 years were 13.2± 3.3 and 12.7± 1.8, respectively, without a significant difference (P=0.06). The frequencies of MA expansion in the IVA and PDT+IVA groups during the 2 years were 25.9% and 33.4%, respectively, with no significant difference in the incidence (odds ratio: 1.40, P=0.4253). The ratios of polyp regression after the loading phase in the IVA and PDT+IVA groups were 55.2% and 94.1%, respectively, with a significant difference (P< 0.0001).Conclusion: PDT combined with IVA injections usi

Published
2023

7. Successful Management of Fungal Keratitis by <italic>Alternaria alternata</italic> Complicating Mooren’s Ulcer.

Author

Todokoro, Daisuke, Miyakubo, Tomoko, Komori, Aya, Tamura, Takashi, Makimura, Koichi, and Akiyama, Hideo

Abstract

Mooren’s ulcer is an idiopathic peripheral ulcerative keratitis whose pathogenesis is thought to be due to an autoimmune reaction. The first-line treatment for Mooren’s ulcer is the use of topical steroids, which can be difficult to discontinue. The 76-year-old patient in this case was receiving topical steroids for bilateral Mooren’s ulcer and developed a feathery corneal infiltration and perforation in the left eye. On suspicion of a fungal keratitis complication, we started topical voriconazole treatment and performed lamellar keratoplasty. Topical betamethasone was continued twice a day. The identified causative fungus was Alternaria alternata, which is known to be susceptible to voriconazole. The minimum inhibitory concentration of voriconazole was later proven to be 0.5 μg/mL. After 3 months of treatment, the residual feathery infiltration disappeared and the left vision recovered to 0.7. In this case, topical voriconazole was effective, and the eye was successfully treated with continuing topical steroids. Fungal species identification and antifungal susceptibility test proved helpful for symptom management. [ABSTRACT FROM AUTHOR]

Published
2023
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8. A Case Of Ipilimumab-Induced Unusual Serous Retinal Detachment In Bilateral Eyes

Author

Miyakubo, Tomoko, Mukai, Ryo, Nakamura, Kosuke, Matsumoto, Hidetaka, and Akiyama, Hideo

Subjects
genetic structures, serous retinal detachment, Case Report, metastatic malignant melanoma, ipilimumab, eye diseases
Abstract

Purpose Ipilimumab is an immune checkpoint inhibitor that is now widely used for patients with metastatic malignant melanoma. However, this immune checkpoint inhibitor can induce related adverse events in various organs. Here, we report a case of bilateral drug (ipilimumab)-induced serous retinal detachment (SRD), and the characteristic features found during swept-source optical coherence tomography (SS-OCT). Case A 78-year-old man with metastatic melanoma received 4 cycles of dacarbazine, nimustine, vincristine, and interferon-beta starting in January 2014, followed by 47 cycles of nivolumab starting in September 2014. Treatment with ipilimumab was started in June 2017. After 2 cycles of ipilimumab, the patient noticed impairment of the visual field in both of his eyes (at day 22) and visited our department in August 2017. Best corrected visual acuity at this initial visit was 16/20 in both eyes, while a fundus examination revealed SRD and retinal pigment epithelial detachments in both eyes. When using the horizontal and vertical 12 mm B-scanned images of SS-OCT, we detected SRD accompanied by a widely distributed high reflection of the photoreceptor outer segment, including the area where the SRD appeared. In addition, the image also showed the interdigitation zone was indistinguishable. Fluorescein angiography showed little leakage in the maculae. During his course of follow-up examinations, there was an increase in the SRD at the beginning, after which it then gradually decreased. However, the obscurity of the interdigitation zone remained. Conclusion Ipilimumab may cause impairment of the outer retinal layer. We suggest that this is a presumed ipilimumab-induced SRD.

Published
2019

12. A Case Of Ipilimumab-Induced Unusual Serous Retinal Detachment In Bilateral Eyes

Author

Miyakubo,Tomoko, Mukai,Ryo, Nakamura,Kosuke, Matsumoto,Hidetaka, Akiyama,Hideo, Miyakubo,Tomoko, Mukai,Ryo, Nakamura,Kosuke, Matsumoto,Hidetaka, and Akiyama,Hideo

Abstract

Tomoko Miyakubo, Ryo Mukai, Kosuke Nakamura, Hidetaka Matsumoto, Hideo Akiyama Department of Ophthalmology, Gunma University Graduate School of Medicine, Maebashi, Gunma, JapanCorrespondence: Ryo MukaiDepartment of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-15 Showa-Machi, Maebashi, Gunma 371-8511, JapanTel +81 27 220 8338Fax +81 27 233 3841Email ryohmukai@gmail.comPurpose: Ipilimumab is an immune checkpoint inhibitor that is now widely used for patients with metastatic malignant melanoma. However, this immune checkpoint inhibitor can induce related adverse events in various organs. Here, we report a case of bilateral drug (ipilimumab)-induced serous retinal detachment (SRD), and the characteristic features found during swept-source optical coherence tomography (SS-OCT).Case: A 78-year-old man with metastatic melanoma received 4 cycles of dacarbazine, nimustine, vincristine, and interferon-beta starting in January 2014, followed by 47 cycles of nivolumab starting in September 2014. Treatment with ipilimumab was started in June 2017. After 2 cycles of ipilimumab, the patient noticed impairment of the visual field in both of his eyes (at day 22) and visited our department in August 2017. Best corrected visual acuity at this initial visit was 16/20 in both eyes, while a fundus examination revealed SRD and retinal pigment epithelial detachments in both eyes. When using the horizontal and vertical 12 mm B-scanned images of SS-OCT, we detected SRD accompanied by a widely distributed high reflection of the photoreceptor outer segment, including the area where the SRD appeared. In addition, the image also showed the interdigitation zone was indistinguishable. Fluorescein angiography showed little leakage in the maculae. During his course of follow-up examinations, there was an increase in the SRD at the beginning, after which it then gradually decreased. However, the obscurity of the interdigitation zone remained.Conclusion: Ipilimumab may cause impai

Published
2019

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