1,626 results on '"Mocroft, Amanda"'
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2. Long-term impact of immediate versus deferred antiretroviral therapy on kidney health in people with HIV
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Pelchen-Matthews, Annegret, Mocroft, Amanda, Ryom, Lene, Ross, Michael J., Sharma, Shweta, Coca, Steven, Achhra, Amit, Cornell, Elaine, Tracy, Russell, Phillips, Andrew, Alonso, Marta Montero, Toulomi, Giota, Agan, Brian K., Medland, Nicholas, and Wyatt, Christina M.
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- 2024
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3. Associations between change in BMI and the risk of hypertension and dyslipidaemia in people receiving integrase strand-transfer inhibitors, tenofovir alafenamide, or both compared with other contemporary antiretroviral regimens: a multicentre, prospective observational study from the RESPOND consortium cohorts
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Byonanebye, Dathan M, Polizzotto, Mark N, Maltez, Fernando, Rauch, Andri, Grabmeier-Pfistershammer, Katharina, Wit, Ferdinand, De Wit, Stéphane, Castagna, Antonella, d'Arminio Monforte, Antonella, Mussini, Cristina, Wasmuth, Jan-Christian, Fontas, Eric, Abela, Irene, Sarcletti, Mario, Bansi-Matharu, Loveleen, Jaschinski, Nadine, Peters, Lars, Hosein, Sean R, Vannappagari, Vani, Cohen, Cal, Bissio, Emiliano, Mocroft, Amanda, Law, Matthew, Ryom, Lene, and Petoumenos, Kathy
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- 2024
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4. Heavy antiretroviral exposure and exhausted/limited antiretroviral options: predictors and clinical outcomes
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Mocroft, Amanda, Pelchen-Matthews, Annegret, Hoy, Jennifer, Llibre, Josep M., Neesgaard, Bastian, Jaschinski, Nadine, Domingo, Pere, Rasmussen, Line Dahlerup, Günthard, Huldrych F., Surial, Bernard, Öllinger, Angela, Knappik, Michael, de Wit, Stephane, Wit, Ferdinand, Mussini, Cristina, Vehreschild, Joerg, Monforte, Antonella D’Arminio, Sonnerborg, Anders, Castagna, Antonella, Anne, Alain Volny, Vannappagari, Vani, Cohen, Cal, Greaves, Wayne, Wasmuth, Jan C., Spagnuolo, Vincenzo, and Ryom, Lene
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- 2024
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5. Increased incidence rates of positive blood cultures shortly after chemotherapy compared to radiotherapy among individuals treated for solid malignant tumours
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Roen, Ashley, Terrones, Cynthia, Bannister, Wendy, Helleberg, Marie, Andersen, Michael Asger, Niemann, Carsten Utoft, Daugaard, Gedske, Specht, Lena, Mocroft, Amanda, Reekie, Joanne, and Lundgren, Jens
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- 2023
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6. Long-term outcomes after tuberculosis for people with HIV in eastern Europe
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Kraef, Christian, Bentzon, Adrian, Roen, Ashley, Bolokadze, Natalie, Thompson, Magdalena, Azina, Inga, Tetradov, Simona, Skrahina, Alena, Karpov, Igor, Mitsura, Viktar, Paduto, Dmitriy, Trofimova, Tatiana, Borodulina, Elena, Mocroft, Amanda, Kirk, Ole, and Podlekareva, Daria N.
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- 2023
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7. External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection
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Abela, I., Aebi-Popp, K., Anagnostopoulos, A., Battegay, M., Bernasconi, E., Braun, D.L., Bucher, H.C., Calmy, A., Cavassini, M., Ciuffi, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Fux, C.A., Günthard, H.F., Hachfeld, A., Haerry, D., Hasse, B., Hirsch, H.H., Hoffmann, M., Hösli, I., Huber, M., Jackson-Perry, D., Kahlert, C.R., Kaiser, L., Keiser, O., Klimkait, T., Kouyos, R.D., Kovari, H., Kusejko, K., Labhardt, N., Leuzinger, K., de Tejada B, Martinez, Marzolini, C., Metzner, K.J., Müller, N., Nemeth, J., Nicca, D., Notter, J., Paioni, P., Pantaleo, G., Perreau, M., Rauch, A., Salazar-Vizcaya, L., Schmid, P., Speck, R., Stöckle, M., Tarr, P., Trkola, A., Wandeler, G., Weisser, M., Yerly, S., van der Valk, M., Geerlings, S.E., Goorhuis, A., Harris, V.C., Hovius, J.W., Lempkes, B., Nellen, F.J.B., van der Poll, T., Prins, J.M., Spoorenberg, V., van Vugt, M., Wiersinga, W.J., Wit, F.W.M.N., Bruins, C., van Eden, J., Hylkema-van den Bout, I.J., van Hes, A.M.H., Pijnappel, F.J.J., Smalhout, S.Y., Weijsenfeld, A.M., Back, N.K.T., Berkhout, B., Cornelissen, M.T.E., van Houdt, R., Jonges, M., Jurriaans, S., Schinkel, C.J., Wolthers, K.C., Zaaijer, H.L., Peters, E.J.G., van Agtmael, M.A., Autar, R.S., Bomers, M., Sigaloff, K.C.E., Heitmuller, M., Laan, L.M., van den Berge, M., Stegeman, A., Baas, S., Hage de Looff, L., van Arkel, A., Stohr, J., Wintermans, B., Pronk, M.J.H., Ammerlaan, H.S.M., de Munnik, E.S., Deiman, B., Jansz, A.R., Scharnhorst, V., Tjhie, J., Wegdam, M.C.A., van Eeden, A., Hoornenborg, E., Nellen, J., Alers, W., Elsenburg, L.J.M., Nobel, H., van Kasteren, M.E.E., Berrevoets, M.A.H., Brouwer, A.E., de Kruijf-van de Wiel, B.A.F.M., Adams, A., Rijkevoorsel, M. Pawels-van, Buiting, A.G.M., Murck, J.L., Rokx, C., Anas, A.A., Bax, H.I., van Gorp, E.C.M., de Mendonça Melo, M., van Nood, E., Nouwen, J.L., Rijnders, B.J.A., Schurink, C.A.M., Slobbe, L., de Vries-Sluijs, T.E.M.S., Bassant, N., van Beek, J.E.A., Vriesde, M., van Zonneveld, L.M., de Groot, J., van Kampen, J.J.A., Koopmans, M.P.G., Rahamat-Langendoen, J.C., Branger, J., Douma, R.A., Cents-Bosma, A.S., Duijf-van de Ven, C.J.H.M., Schippers, E.F., van Nieuwkoop, C., Geilings, J., van Winden, S., van der Hut, G., van Burgel, N.D., Leyten, E.M.S., Gelinck, L.B.S., Mollema, F., Wildenbeest, G.S., Nguyen, T., Groeneveld, P.H.P., Bouwhuis, J.W., Lammers, A.J.J., van Hulzen, A.G.W., Kraan, S., Kruiper, M.S.M., van der Bliek, G.L., Bor, P.C.J., Debast, S.B., Wagenvoort, G.H.J., Roukens, A.H.E., de Boer, M.G.J., Jolink, H., Lambregts, M.M.C., Scheper, H., Dorama, W., van Holten, N., Claas, E.C.J., Wessels, E., Hollander, J.G. den, El Moussaoui, R., Pogany, K., Brouwer, C.J., Heida-Peters, D., Mulder, E., Smit, J.V., Struik-Kalkman, D., van Niekerk, T., Pontesilli, O., van Tienen, C., Lowe, S.H., Lashof, A.M.L. Oude, Posthouwer, D., van Wolfswinkel, M.E., Ackens, R.P., Burgers, K., Elasri, M., Schippers, J., Havenith, T.R.A., van Loo, M., van Vonderen, M.G.A., Kampschreur, L.M., van Broekhuizen, M.C., S, Faber, Al Moujahid, A., Kootstra, G.J., Delsing, C.E., van der Burg-van de Plas, M., Scheiberlich, L., Kortmann, W., van Twillert, G., Renckens, R., Wagenaar, J., Ruiter-Pronk, D., van Truijen-Oud, F.A., Stuart, J.W.T. Cohen, Hoogewerf, M., Rozemeijer, W., Sinnige, J.C., Brinkman, K., van den Berk, G.E.L., Lettinga, K.D., de Regt, M., Schouten, W.E.M., Stalenhoef, J.E., Veenstra, J., Vrouenraets, S.M.E., Blaauw, H., Geerders, G.F., Kleene, M.J., Knapen, M., Kok, M., van der Meché, I.B., Toonen, A.J.M., Wijnands, S., Wttewaal, E., Kwa, D., van de Laar, T.J.W., van Crevel, R., van Aerde, K., Dofferhoff, A.S.M., Henriet, S.S.V., Hofstede, H.J.M. ter, Hoogerwerf, J., Richel, O., Albers, M., Grintjes-Huisman, K.J.T., de Haan, M., Marneef, M., McCall, M., Burger, D., Gisolf, E.H., Claassen, M., Hassing, R.J., Beest, G. ter, van Bentum, P.H.M., Gelling, M., Neijland, Y., Swanink, C.M.A., Velderman, M. Klein, van Lelyveld, S.F.L., Soetekouw, R., van der Prijt, L.M.M., van der Swaluw, J., Kalpoe, J.S., Wagemakers, A., Vahidnia, A., Lauw, F.N., Verhagen, D.W.M., van Wijk, M., Bierman, W.F.W., Bakker, M., van Bentum, R.A., van den Boomgaard, M.A., Kleinnijenhuis, J., Kloeze, E., Middel, A., Postma, D.F., Schenk, H.M., Stienstra, Y., Wouthuyzen-Bakker, M., Boonstra, A., de Jonge, H., Maerman, M.M.M., de Weerd, D.A., van Eije, K.J., Knoester, M., van Leer-Buter, C.C., Niesters, H.G.M., T.Mudrikova, Barth, R.E., Bruns, A.H.W., Ellerbroek, P.M., Hensgens, M.P.M., Oosterheert, J.J., Schadd, E.M., Verbon, A., van Welzen, B.J., Berends, H., Santen, B.M.G. Griffioen-van, de Kroon, I., Lunel, F.M. Verduyn, Wensing, A.M.J., Zaheri, S., Boyd, A.C., Bezemer, D.O., van Sighem, A.I., Smit, C., Hillebregt, M.M.J., Woudstra, T.J., Rutkens, T., Bergsma, D., Brétin, N.M., Lelivelt, K.J., van de Sande, L., van der Vliet, K.M. Visser.S.T., Paling, F., de Groot-Berndsen, L.G.M., van den Akker, M., Alexander, R., Bakker, Y., El Berkaoui, A., Bezemer-Goedhart, M., Djoechro, E.A., Groters, M., Koster, L.E., Lodewijk, C.R.E., Lucas, E.G.A., Munjishvili, L., Peeck, B.M., Ree, C.M.J., Regtop, R., van Rijk, A.F., Ruijs-Tiggelman, Y.M.C., Schnörr, P.P., Schoorl, M.J.C., Tuijn, E.M., Veenenberg, D.P., Witte, E.C.M., Bretin, N.M., Karpov, I., Losso, M., Lundgren, J., Rockstroh, J., Aho, I., Rasmussen, L.D., Novak, P., Pradier, C., Chkhartishvili, N., Matulionyte, R., Oprea, C., Kowalska, J.D., Begovac, J., Miró, J.M., Guaraldi, G., Paredes, R., Peters, L., Larsen, J.F., Neesgaard, B., Jaschinski, N., Fursa, O., Raben, D., Kristensen, D., Fischer, A.H., Jensen, S.K., Elsing, T.W., Gardizi, M., Mocroft, A., Phillips, A., Reekie, J., Cozzi-Lepri, A., Pelchen-Matthews, A., Roen, A., Tusch, E.S., Bannister, W., Bellecave, P., Blanco, P., Bonnet, F., Bouchet, S., Breilh, D., Cazanave, C., Desjardin, S., Gaborieau, V., Gimbert, A., Hessamfar, M., Lacaze-Buzy, L., Lacoste, D., Lafon, M.E., Lazaro, E., Leleux, O., Le Marec, F., Le Moal, G., Malvy, D., Marchand, L., Mercié, P., Neau, D., Pellegrin, I., Perrier, A., Petrov-Sanchez, V., Vareil, M.O., Wittkop, L., Bernard, N., Chaussade, D. Bronnimann H., Dondia, D., Duffau, P., Faure, I., Morlat, P., Mériglier, E., Paccalin, F., Riebero, E., Rivoisy, C., Vandenhende, M.A., Barthod, L., Dauchy, F.A., Desclaux, A., Ducours, M., Dutronc, H., Duvignaud, A., Leitao, J., Lescure, M., Nguyen, D., Pistone, T., Puges, M., Wirth, G., Courtault, C., Camou, F., Greib, C., Pellegrin, J.L., Rivière, E., Viallard, J.F., Imbert, Y., Thierry-Mieg, M., Rispal, P., Caubet, O., Ferrand, H., Tchamgoué, S., Farbos, S., Wille, H., Andre, K., Caunegre, L., Gerard, Y., Osorio-Perez, F., Chossat, I., Iles, G., Labasse-Depis, M., Lacassin, F., Barret, A., Castan, B., Koffi, J., Rouanes, N., Saunier, A., Zabbe, J.B., Dumondin, G., Beraud, G., Catroux, M., Garcia, M., Giraud, V., Martellosio, J.P., Roblot, F., Pasdeloup, T., Riché, A., Grosset, M., Males, S., Bell, C. Ngo, Carpentier, C., Bellecave, Virology P., Tumiotto, C., Miremeont-Salamé, G., Arma, D., Arnou, G., Blaizeau, M.J., Camps, P., Decoin, M., Delveaux, S., Diarra, F., Gabrea, L., Lawson-Ayayi, S., Lenaud, E., Plainchamps, D., Pougetoux, A., Uwamaliya, B., Zara, K., Conte, V., Gapillout, M., Surial, Bernard, Ramírez Mena, Adrià, Roumet, Marie, Limacher, Andreas, Smit, Colette, Leleux, Olivier, Mocroft, Amanda, van der Valk, Marc, Bonnet, Fabrice, Peters, Lars, Rockstroh, Jürgen K., Günthard, Huldrych F., Berzigotti, Annalisa, Rauch, Andri, and Wandeler, Gilles
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- 2023
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8. Chronic liver enzyme elevation and use of contemporary ARVs among persons living with HIV
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Roen, Ashley O, primary, Peters, Lars, additional, Wandeler, Gilles, additional, van der Valk, Marc, additional, Zangerle, Robert, additional, Günthard, Huldrych F, additional, Wit, Ferdinand, additional, Mussini, Cristina, additional, De Wit, Stéphane, additional, d’Arminio Monforte, Antonella, additional, Vehreschild, Jörg Janne, additional, Castagna, Antonella, additional, Jaschinski, Nadine, additional, Vannappagari, Vani, additional, Chen, Linda, additional, Tallada, Joan, additional, C’mar, John, additional, Mocroft, Amanda, additional, and Ryom, Lene, additional
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- 2024
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9. Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV: a multicentre prospective study from the RESPOND cohort consortium
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Neesgaard, Bastian, Greenberg, Lauren, Miró, Jose M, Grabmeier-Pfistershammer, Katharina, Wandeler, Gilles, Smith, Colette, De Wit, Stéphane, Wit, Ferdinand, Pelchen-Matthews, Annegret, Mussini, Cristina, Castagna, Antonella, Pradier, Christian, d'Arminio Monforte, Antonella, Vehreschild, Jörg J, Sönnerborg, Anders, Anne, Alain V, Carr, Andrew, Bansi-Matharu, Loveleen, Lundgren, Jens D, Garges, Harmony, Rogatto, Felipe, Zangerle, Robert, Günthard, Huldrych F, Rasmussen, Line D, Necsoi, Coca, van der Valk, Marc, Menozzi, Marianna, Muccini, Camilla, Peters, Lars, Mocroft, Amanda, and Ryom, Lene
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- 2022
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10. Observational cohort study of rilpivirine (RPV) utilization in Europe
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Cozzi-Lepri, Alessandro, Peters, Lars, Pelchen-Matthews, Annegret, Neesgaard, Bastian, De Wit, Stephane, Johansen, Isik Somuncu, Edwards, Simon, Stephan, Christoph, Adamis, Georgios, Staub, Therese, Zagalo, Alexandra, Domingo, Pere, Elbirt, Daniel, Kusejko, Katharina, Brännström, Johanna, Paduta, Dzmitry, Trofimova, Tatyana, Szlavik, Janos, Zilmer, Kai, Losso, Marcello, Van Eygen, Veerle, Pai, Helen, Lundgren, Jens, and Mocroft, Amanda
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- 2022
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11. Contemporary antiretrovirals and body-mass index: a prospective study of the RESPOND cohort consortium
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Bansi-Matharu, Loveleen, Phillips, Andrew, Oprea, Cristiana, Grabmeier-Pfistershammer, Katharina, Günthard, Huldrych F, De Wit, Stephane, Guaraldi, Giovanni, Vehreschild, Jorg J, Wit, Ferdinand, Law, Matthew, Wasmuth, Jan-Christian, Chkhartishvili, Nikoloz, d'Arminio Monforte, Antonella, Fontas, Eric, Vesterbacka, Jan, Miro, Jose M, Castagna, Antonella, Stephan, Christoph, Llibre, Josep M, Neesgaard, Bastian, Greenberg, Lauren, Smith, Colette, Kirk, Ole, Duvivier, Claudine, Dragovic, Gordana, Lundgren, Jens, Dedes, Nikos, Knudsen, Andreas, Gallant, Joel, Vannappagari, Vani, Peters, Lars, Elbirt, Daniel, Sarcletti, Mario, Braun, Dominique L, Necsoi, Coca, Mussini, Cristina, Muccini, Camilla, Bolokadze, Natalie, Hoy, Jennifer, Mocroft, Amanda, and Ryom, Lene
- Published
- 2021
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12. No need for secondary Pneumocystis jirovecii pneumonia prophylaxis in adult people living with HIV from Europe on ART with suppressed viraemia and a CD4 cell count greater than 100 cells/[micro]L
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Atkinson, Andrew, Miro, Jose M., Mocroft, Amanda, Reiss, Peter, Kirk, Ole, Morlat, Philippe, Ghosn, Jade, Stephan, Christoph, Mussini, Cristina, Antoniadou, Anastasia, Doerholt, Katja, Girardi, Enrico, Wit, Stephane De, Kraus, David, Zwahlen, Marcel, and Furrer, Hansjakob
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Antiviral agents -- Patient outcomes ,Viremia -- Patient outcomes ,Pneumocystis carinii pneumonia -- Prevention -- Risk factors -- Statistics ,CD4 lymphocytes -- Health aspects ,HIV patients -- Drug therapy -- Statistics ,Health - Abstract
Introduction: Since the beginning of the HIV epidemic in resource-rich countries, Pneumocystis jirovecii pneumonia (PjP) is one of the most frequent opportunistic AIDS-defining infections. The Collaboration of ObservationalHIV EpidemiologicalResearch Europe (COHERE) has shown that primary Pneumocystis jirovecii Pneumonia (PjP) prophylaxis can be safely withdrawn in patients with CD4 counts of 100 to 200 cells/[micro]L if plasma HIV-RNA is suppressed on combination antiretroviraltherapy. Whether this holds true for secondary prophylaxis is not known, and this has proved difficult to determine due to the much lower population at risk. Methods: We estimated the incidence of secondary PjP by including patient data collected from 1998 to 2015 from the COHERE cohort collaboration according to time-updated CD4 counts, HIV-RNA and use of PjP prophylaxis in persons >16 years of age. We fitted a Poisson generalized additive modelin which the smoothed effect of CD4 was modelled by a restricted cubic spline, and HIV-RNA was stratified as low (10,000copies/mL). Results: There were 373 recurrences of PjP during 74,295 person-years (py) in 10,476 patients. The PjP incidence in the different plasma HIV-RNA strata differed significantly and was lowest in the low stratum. For patients off prophylaxis with CD4 counts between 100 and 200 cells/[micro]L and HIV-RNA below 400 copies/mL, the incidence of recurrent PjP was 3.9 (95% CI: 2.0 to 5.8) per 1000 py, not significantly different from patients on prophylaxis in the same stratum (1.9, 95% CI: 0.1 to 3.7). Conclusions: HIV viraemia importantly affects the risk of recurrent PjP. In virologically suppressed patients on ART with CD4 counts of 100 to 200/[micro]L, the incidence of PjP off prophylaxis is below 10/1000 py. Secondary PjP prophylaxis may be safely withheld in such patients. While European guidelines recommend discontinuing secondary PjP prophylaxis only if CD4 counts rise above 200 cells/mL, the latest US Guidelines consider secondary prophylaxis discontinuation even in patients with a CD4 count above 100 cells/[micro]L and suppressed viral load. Our results strengthen and support this US recommendation. Keywords: opportunistic infections; Pneumocystis jirovecii pneumonia; prophylaxis, 1 INTRODUCTION Since the beginning of the HIV epidemic in resource-rich countries, Pneumocystis jirovecii pneumonia (PjP) is one of the most frequent opportunistic AIDS-defining infections [1]. PjP occurs predominantly in [...]
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- 2021
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13. Comparison of Kaposi Sarcoma Risk in Human Immunodeficiency Virus-Positive Adults Across 5 Continents: A Multiregional Multicohort Study
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Judd, Ali, Zangerle, Robert, Touloumi, Giota, Warszawski, Josiane, Meyer, Laurence, Dabis, François, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Wittkop, Linda, Reiss, Peter, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Gibb, Diana, Fätkenheuer, Gerd, Julia, Del Amo, Obel, Niels, Thorne, Claire, Mocroft, Amanda, Kirk, Ole, Stephan, Christoph, Pérez-Hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, Antinori, Andrea, Monforte, Antonella d’Arminio, Brockmeyer, Norbert, Prieto, Luis, Conejo, Pablo Rojo, Soriano-Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Mussini, Cristina, Tookey, Pat, Casabona, Jordi, Miró, Jose M, Castagna, Antonella, Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Quiros-Roldan, Eugenia, Sabin, Caroline, Teira, Ramon, Garrido, Myriam, Haerry, David, de Wit, Stéphane, Costagliola, Dominique, d’Arminio-Monforte, Antonella, del Amo, Julia, Raben, Dorthe, Chêne, Geneviève, Rojo, Conejo Pablo, Barger, Diana, Schwimmer, Christine, Termote, Monique, Campbell, Maria, Frederiksen, Casper M, Friis-Møller, Nina, Kjaer, Jesper, Brandt, Rikke Salbøl, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Cozzi-Lepri, Alessandro, Davies, Mary-Anne, Dorrucci, Maria, Dunn, David, Egger, Matthias, Furrer, Hansjakob, Grabar, Sophie, Guiguet, Marguerite, Lambotte, Olivier, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Miro, Jose M, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Rohner, Eliane, and Schomaker, Michael
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Biomedical and Clinical Sciences ,Clinical Sciences ,Sexually Transmitted Infections ,Rare Diseases ,Emerging Infectious Diseases ,Infectious Diseases ,HIV/AIDS ,Infection ,Adolescent ,Adult ,Anti-Retroviral Agents ,CD4 Lymphocyte Count ,Cohort Studies ,Female ,HIV Infections ,HIV-1 ,Humans ,Male ,Middle Aged ,Risk Factors ,Sarcoma ,Kaposi ,Viral Load ,Young Adult ,AIDS-defining Cancer Project Working Group for IeDEA and COHERE in EuroCoord ,HIV ,Kaposi sarcoma ,antiretroviral therapy ,cohort study ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Clinical sciences - Abstract
BackgroundWe compared Kaposi sarcoma (KS) risk in adults who started antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America.MethodsWe included cohort data of human immunodeficiency virus (HIV)-positive adults who started ART after 1995 within the framework of 2 large collaborations of observational HIV cohorts. We present incidence rates and adjusted hazard ratios (aHRs).ResultsWe included 208140 patients from 57 countries. Over a period of 1066572 person-years, 2046 KS cases were diagnosed. KS incidence rates per 100000 person-years were 52 in the Asia-Pacific and ranged between 180 and 280 in the other regions. KS risk was 5 times higher in South African women (aHR, 4.56; 95% confidence intervals [CI], 2.73-7.62) than in their European counterparts, and 2 times higher in South African men (2.21; 1.34-3.63). In Europe, Latin, and North America KS risk was 6 times higher in men who have sex with men (aHR, 5.95; 95% CI, 5.09-6.96) than in women. Comparing patients with current CD4 cell counts ≥700 cells/µL with those whose counts were
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- 2017
14. Chronic Liver Enzyme Elevation and Use of Contemporary ARVs Among People With HIV
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Roen, Ashley, Peters, Lars, Wandeler, Gilles, Van Der Valk, Marc, Zangerle, Robert, Günthard, Hüldrych Fritz, Wit, Ferdinand, Mussini, Cristina, De Wit, Stéphane, D’Arminio Monforte, Antonella, Vehreschild, Jörg Janne, Castagna, Antonella, Jaschinski, Nadine, Vannappagari, Vani, Chen, Linda, Tallada, Joan, C’mar, John, Mocroft, Amanda, Ryom, Lene, Roen, Ashley, Peters, Lars, Wandeler, Gilles, Van Der Valk, Marc, Zangerle, Robert, Günthard, Hüldrych Fritz, Wit, Ferdinand, Mussini, Cristina, De Wit, Stéphane, D’Arminio Monforte, Antonella, Vehreschild, Jörg Janne, Castagna, Antonella, Jaschinski, Nadine, Vannappagari, Vani, Chen, Linda, Tallada, Joan, C’mar, John, Mocroft, Amanda, and Ryom, Lene
- Abstract
Background. While use of some older antiretroviral drugs (ARVs) is associated with chronic liver enzyme elevation (cLEE), the impact of newer ARVs remains unknown. Methods. People with HIV enrolled in the RESPOND cohort who started an ARV after January 1, 2012 were included (baseline). The primary outcome was first cLEE individuals were censored at first of cLEE, last visit, death, or December 31, 2021. Incidence rates (IRs; events/1000 person-years) were calculated for each ARV overall and by ARV exposure (6–12 months, 1–2 years, and 2+ years). Poisson regression was used to estimate the incidence rate ratio (IRR) of cLEE and its association with individual ARVs and ARV class. Results. Of 17 106 individuals included contributing 87 924 person-years of follow-up, 1932 (11.3%) experienced cLEE (incidence rate [IR], 22.0; 95% CI, 21.0–23.0). There was no evidence of a cumulative ARV effect on cLEE incidence, (6–12 months: IR, 45.8; 95% CI, 41.4–50.19; 1–2 years: IR, 34.3; 95% CI, 31.5–37.4; and 2+ years: IR, 18.5; 95% CI, 17.4–19.7). Any use (vs no prior use) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) as a class and tenofovir disoproxil fumarate (TDF) was independently associated with an increased IRR of cLEE, and any use of darunavir (DRV) was associated with a decreased risk of cLEE. Conclusions. cLEE is common and more frequent during the first year after initiating new ARVs. With a >5-year median follow-up, we found no short-term liver safety concerns with the use of INSTIs. Use of NNRTIs and TDF was associated with an increased cLEE risk, while DRV was associated with lower risk., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2024
15. Trends in mortality in people with HIV from 1999 to 2020: a multi-cohort collaboration
- Author
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P, Rauch, A, Rudin, C, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Wandeler, G, Yerly, S, Valk, M, Hutchinson, J, Rupasinghe, D, Han, W, Appoyer, H, Vera, J, Broster, B, Barbour, L, Carney, D, Greenland, L, Coughlan, R, Saint-Pierre, C, Stephan, C, Bucht, M, Chokoshvili, O, Borghi, V, Casabona, J, Miro, J, Lampe, F, Burns, F, Chaloner, C, Muccini, C, Lolatto, R, Sönnerborg, A, Nowak, P, Vesterbacka, J, Mattsson, L, Carrick, D, Stigsäter, K, Kusejko, K, Schulze, N, Franke, B, Rooney, J, Mcnicholl, I, Garges, H, Campo, R, Volny-Anne, A, Dedes, N, Williams, E, Bruguera, A, Volny-Anne, R, Mendão, L, Timiryasova, A, Fursa, O, Jakobsen, M, Kraef, C, Gardizi, M, Andersen, K, Kumar, L, Elsing, T, Shahi, S, Valdenmaiier, O, Bansi-Matharu, L, Byonanebye, D, Bannister, W, Roen, A, Null, N, Tusch, Erich, Ryom, Lene, Pelchen-Matthews, Annegret, Mocroft, Amanda, Elbirt, Daniel, Oprea, Cristiana, Günthard, Huldrych F, Staehelin, Cornelia, Zangerle, Robert, Suarez, Isabelle, Vehreschild, Jörg Janne, Wit, Ferdinand, Menozzi, Marianna, d'Arminio Monforte, Antonella, Spagnuolo, Vincenzo, Pradier, Christian, Carlander, Christina, Suanzes, Paula, Wasmuth, Jan-Christian, Carr, Andrew, Petoumenos, Kathy, Borgans, Frauke, Bonnet, Fabrice, De Wit, Stephane, El-Sadr, Wafaa, Neesgaard, Bastian, Jaschinski, Nadine, Greenberg, Lauren, Hosein, Sean R, Gallant, Joel, Vannappagari, Vani, Young, Lital, Sabin, Caroline, Lundgren, Jens, Peters, Lars, Reekie, Joanne, Monforte, A d’Arminio, Brandt, R Salbøl, Wit, F W N M, Marec, F Le, Laut, K Grønborg, Sabin, C A, Phillips, A N, Kamara, D A, Smith, C J, Hatleberg, C I, Brandt, R S, Grevsen, A L, Lundgren, J D, Fux, C A, Monforte, A d'Arminio, Iversen, J S, Reiss, Central P, Prins, J M, Kuijpers, T W, Scherpbier, H J, van der Meer, J T M, Godfried, M H, Nellen, F J B, Geerlings, S E, Bos, J C, Wiersinga, W J, Hovius, J W, van Hes, A M H, Nobel, H E, Pijnappel, F J J, Back, N K T, Zaaijer, H L, Cornelissen, M T E, Schinkel, C J, Thomas, X V, Ziekenhuis, Admiraal De Ruyter, de Looff, L Hage, Ziekenhuis, Catharina, Pronk, M J H, Ammerlaan, H S M, De Munnik, E S, Jansz, A R, Wegdam, M C A, Weijsenfeld, A M, van der Ende, M E, De Vries-Sluijs, T E M S, van Gorp, E C M, Schurink, C A M, Nouwen, J L, Rijnders, B J A, Bax, H I, van Beek, J E A, van Zonneveld, L M, van den Berg-Cameron, H J, Bruinsma-Broekman, F B, de Man, M de Zeeuw, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Pas, S D, MC–Sophia, Erasmus, Driessen, G J A, van Rossum, A M C, van der Knaap, L C, de Ven, C J H M Duijf-van, Ziekenhuis, Haga, Schippers, E F, van IJperen, J M, Franck, P F H, Elsenburg, L J M, Kwa, I S, Groeneveld, P H P, Bouwhuis, J W, van den Berg, J F, van Hulzen, A G W, van der Bliek, G L, Bor, P C J, Wolfhagen, M J H M, Ruijs, G J H M, Kroon, F P, de Boer, M G J, Bauer, M P, Vollaard, A M, Claas, E C J, den Hollander, J G, Smit, J V, Lowe, S H, Lashof, A M L Oude, Ackens, R P, van Loo, I H M, Havenith, T R A, Leyten, E M S, Gelinck, L B S, Wildenbeest, G S, Mutsaers, J A E M, Jansen, C L, Mulder, J W, Vrouenraets, S M E, Lauw, F N, van Broekhuizen, M C, Vlasblom, D J, Smits, P H M, Zuiderzee, M C, Bosma, A S, van Vonderen, M G A, van Houte, D P F, Kampschreur, L M, Kootstra, G J, Delsing, C E, Stuart, J W T Cohen, Diederen, B M W, van Truijen-Oud, F A, van der Reijden, W A, van den Berk, G E L, Blok, W L, Frissen, P H J, Lettinga, K D, Schouten, W E M, Brouwer, C J, Geerders, G F, Kleene, M J, van der Meché, I B, Toonen, A J M, Koopmans, P P, van der Ven, A J A M, ter Hofstede, H J M, Dofferhoff, A S M, Bosch, M E W, Grintjes-Huisman, K J T, Zomer, B J, Stelma, F F, Gisolf, E H, Hassing, R J, van Bentum, P H M, Swanink, C M A, van Lelyveld, S F L, van der Prijt, L M M, Herpers, B L, Verhagen, D W M, Ziekenhuis, St Elisabeth, van Kasteren, M E E, Brouwer, A E, de Wiel, B A F M de Kruijf-van, Santegoets, R M W J, Marcelis, J H, Buiting, A G M, Kabel, P J, Bierman, W F W, Wilting, K R, Jonge, H de Groot-de, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Hoepelman, A I M, Ellerbroek, P M, Oosterheert, J J, Arends, J E, Barth, R E, Wassenberg, M W M, Schadd, E M, van Elst-Laurijssen, D H M, van Oers-Hazelzet, E E B, Wensing, A M J, Peters, E J G, van Agtmael, M A, Laan, L M, Pettersson, A M, Vandenbroucke-Grauls, C M J E, Ang, C W, Kinderziekenhuis, Wilhelmina, Geelen, S P M, Wolfs, T F W, Bont, L J, Bezemer, D O, van Sighem, A I, Boender, T S, Rademaker, M J, Pellegrin, J L, Vareil, M O, Dauchy, F A, Receveur, M C, Vandenhende, M A, Viallard, J F, Lafon, Me, Blaizeau, M J, Boerg, Eloïse, Law, Central M, Calvo, Central G, Sambeat, M A, Gennotte, A F, Payen, M C, Neaton, Central J, El-Sadr, W M, Abrams, D I, Crane, L R, Fischer, A H, Larsen, J F, Wien, Pulmologisches Zentrum der Stadt, Mitsura, V M, Møller, N F, Nielsen, L N, Smidt, Jelena, Siseklinik, Nakkusosakond, Viard, J-P, Stellbrink, H J, Goethe, J W, Sthoeger, Z M, Monforte, A D’Arminio, Annunziata, Ospedale S Maria, Blokhina, I N, Novogrod, Nizhny, Gatell, J M, Miró, J M, Rodriguez, J M, Laporte, J M, Johnson, A M, Johnson, M A, Morfeldt, Central L, Perri, G Di, Marchetti, G C, Perno, C F, Caputo, S Lo, Capobianchi, M R, Biagio, A Di, Roldan, E Quiros, Santoro, M M, Caro, A Di, Manconi, P E, Moioli, M C, Ridolfo, A L, Martino, F Di, Cattelan, A M, Ursitti, M A, Sulekova, L Fontanelli, Plazzi, M M, Del Vecchio, R Fontana, Giuli, C Di, Orofino, G C, Roger, P M, Braun, D L, Bucher, H C, Günthard, H F, Hirsch, H H, Kouyos, R D, de Tejada, B Martinez, Metzner, K J, Scherrer, A U, Valk, Marc vd, Han, W Min, Saint-Pierre, C H U, Miro, J M, Wasmuth, J C, Vehreschild, J J, McNicholl, I, Williams, E D, Volny-Anne, R Campo Alain, Dedes, Nikos, Mendão, Luis, Jakobsen, M L, Kumar, L Ramesh, Elsing, T W, and null, null
- Abstract
Background: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020. Methods: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time. Results: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period. Conclusion: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.
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- 2024
16. Cost-effectiveness of statins for primary prevention of atherosclerotic cardiovascular disease among people living with HIV in the United States
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Boettiger, David C., Newall, Anthony T., Phillips, Andrew, Bendavid, Eran, Law, Matthew G., Ryom, Lene, Reiss, Peter, Mocroft, Amanda, Bonnet, Fabrice, Weber, Rainer, El-Sadr, Wafaa, Monforte, Antonella D'Arminio, Dewit, Stephane, Pradier, Christian, Hatleberg, Camilla I., Lundgren, Jens, Sabin, Caroline, Kahn, James G., and Kazi, Dhruv S.
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Medical care, Cost of -- Statistics ,HIV patients -- Drug therapy -- Statistics ,Pravastatin -- Usage -- Economic aspects -- Statistics ,Atherosclerosis -- Prevention ,Health - Abstract
Background: Expanding statin use may help to alleviate the excess burden of atherosclerotic cardiovascular disease in people iving with HIV (PLHIV). Pravastatin and pitavastatin are preferred agents due to their lack of substantial interaction with antiretroviral therapy. We aimed to evaluate the cost-effectiveness of pravastatin and pitavastatin for the primary prevention of atherosclerotic cardiovascular disease among PLHIV in the United States. Methods: We developed a microsimulation model that randomly selected (with replacement) individuals from the Data-collection on Adverse Effects of Anti-HIV Drugs study with follow-up between 2013 and 2016. Our study population was PLHIV aged 40 to 75 years, stable on antiretroviral therapy and not currently using lipid-lowering therapy. Direct medical costs and quality-adjusted life-years (QALYs) were assigned in annual cycles and discounted at 3% per year. We assumed a willingness-to-pay threshold of $100,000/QALY gained. The interventions assessed were as follows: (1) treating no one with statins; (2) treating everyone with generic pravastatin 40 mg/day (drug cost $236/year) and (3) treating everyone with branded pitavastatin 4 mg/day (drug cost $2,828/year). The model simulated each individual's probability of experiencing atherosclerotic cardiovascular disease over 20 years. Results: Persons receiving pravastatin accrued 0.024 additional QALYs compared with those not receiving a statin, at an incremental cost of $1338, giving an incremental cost-effectiveness ratio of $56,000/QALY gained. Individuals receiving pitavastatin accumulated 0.013 additional QALYs compared with those using pravastatin, at an additional cost of $18,251, giving an incremental cost-effectiveness ratio of $1,444,000/QALY gained. These findings were most sensitive to the pill burden associated with daily statin administration, statin costs, statin efficacy and baseline atherosclerotic cardiovascular disease risk. In probabilistic sensitivity analysis, no statin was optimal in 5.2% of simulations, pravastatin was optimal in 94.8% of simulations and pitavastatin was never optimal. Conclusions: Pravastatin was projected to be cost-effective compared with no statin. With substantial price reduction, pitavastatin may be cost-effective compared with pravastatin. These findings bode well for the expanded use of statins among PLHIV in the United States. To gain greater confidence in our conclusions it is important to generate strong, HIV-specific estimates on the efficacy of statins and the quality-of-life burden associated with taking an additional daily pill. Keywords: HIV; cardiovascular disease; statin; cost-effectiveness; United States; antiretroviral therapy Received 4 September 2020; Accepted 23 February 2021, 1 | INTRODUCTION People living with HIV (PLHIV) have an elevated risk of atherosclerotic cardiovascular disease (ASCVD) compared to people without HIV [1]. This is only partially explained by the [...]
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- 2021
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17. Chronic Liver Enzyme Elevation and Use of Contemporary ARVs Among People With HIV.
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Roen, Ashley O, Peters, Lars, Wandeler, Gilles, van der Valk, Marc, Zangerle, Robert, Günthard, Huldrych F, Wit, Ferdinand, Mussini, Cristina, Wit, Stéphane De, Monforte, Antonella d'Arminio, Vehreschild, Jörg Janne, Castagna, Antonella, Jaschinski, Nadine, Vannappagari, Vani, Chen, Linda, Tallada, Joan, C'mar, John, Mocroft, Amanda, and Ryom, Lene
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LIVER enzymes ,HIV-positive persons ,NON-nucleoside reverse transcriptase inhibitors ,POISSON regression ,ANTIRETROVIRAL agents - Abstract
Background While use of some older antiretroviral drugs (ARVs) is associated with chronic liver enzyme elevation (cLEE), the impact of newer ARVs remains unknown. Methods People with HIV enrolled in the RESPOND cohort who started an ARV after January 1, 2012 were included (baseline). The primary outcome was first cLEE individuals were censored at first of cLEE, last visit, death, or December 31, 2021. Incidence rates (IRs; events/1000 person-years) were calculated for each ARV overall and by ARV exposure (6–12 months, 1–2 years, and 2+ years). Poisson regression was used to estimate the incidence rate ratio (IRR) of cLEE and its association with individual ARVs and ARV class. Results Of 17 106 individuals included contributing 87 924 person-years of follow-up, 1932 (11.3%) experienced cLEE (incidence rate [IR], 22.0; 95% CI, 21.0–23.0). There was no evidence of a cumulative ARV effect on cLEE incidence, (6–12 months: IR, 45.8; 95% CI, 41.4–50.19; 1–2 years: IR, 34.3; 95% CI, 31.5–37.4; and 2+ years: IR, 18.5; 95% CI, 17.4–19.7). Any use (vs no prior use) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) as a class and tenofovir disoproxil fumarate (TDF) was independently associated with an increased IRR of cLEE, and any use of darunavir (DRV) was associated with a decreased risk of cLEE. Conclusions cLEE is common and more frequent during the first year after initiating new ARVs. With a >5-year median follow-up, we found no short-term liver safety concerns with the use of INSTIs. Use of NNRTIs and TDF was associated with an increased cLEE risk, while DRV was associated with lower risk. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Heavy arv exposure and exhausted/limited arv options: predictors and clinical outcomes
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Mocroft, Amanda, primary, Pelchen-Matthews, Annegret, additional, Hoy, Jennifer, additional, Llibre, Josep M., additional, Neesgaard, Bastian, additional, Jaschinski, Nadine, additional, Domingo, Pere, additional, Rasmussen, Line Dahlerup, additional, Günthard, Huldrych F., additional, Surial, Bernard, additional, Öllinger, Angela, additional, Knappik, Michael, additional, De Wit, Stephan, additional, Wit, Ferdinand, additional, Mussini, Cristina, additional, Vehreschild, Joerg, additional, Monforte, Antonella D’Arminio, additional, Sonnerborg, Anders, additional, Castagna, Antonella, additional, Anne, Alain Volny, additional, Vannappagari, Vani, additional, Cohen, Cal, additional, Greaves, Wayne, additional, Wasmuth, Jan C., additional, Spagnuolo, Vincenzo, additional, and Ryom, Lene, additional
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- 2023
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19. The hepatitis C cascade of care in HIV/HCV-coinfected individuals in Europe– regional and intra-regional differences
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Fursa, Olga, Mocroft, Amanda, Lazarus, Jeffrey V., Amele, Sarah, Lundgren, Jens, Matulionyte, Raimonda, Rasmussen, Line D., Rockstroh, Jürgen K., Parczewski, Milosz, Jilich, David, Moreno, Santiago, Vassilenko, Anna, Lacombe, Karine, Wandeler, Gilles, Borodulina, Elena, Brännström, Johanna, Wiese, Lothar, Orkin, Chloe, Behrens, Georg M.N., Mansinho, Kamal, Portu, Jose Joaquin, and Peters, Lars
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- 2021
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20. Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
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Mocroft, Amanda, Lundgren, Jens D, Ross, Michael, Law, Matthew, Reiss, Peter, Kirk, Ole, Smith, Colette, Wentworth, Deborah, Neuhaus, Jacqueline, Fux, Christoph A, Moranne, Olivier, Morlat, Phillipe, Johnson, Margaret A, Ryom, Lene, D:A:D study group, Royal Free Hospital Clinic Cohort, INSIGHT study group, SMART study group, and ESPRIT study group
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D:A:D study group ,Royal Free Hospital Clinic Cohort ,INSIGHT study group ,SMART study group ,ESPRIT study group ,Kidney ,Humans ,HIV ,HIV Infections ,HIV Seropositivity ,Anti-HIV Agents ,CD4 Lymphocyte Count ,Incidence ,Risk ,Risk Assessment ,Prospective Studies ,Age Factors ,Comorbidity ,Sex Factors ,Adult ,Middle Aged ,Female ,Male ,Renal Insufficiency ,Chronic ,Clinical Decision-Making ,Renal Insufficiency ,Chronic ,General & Internal Medicine ,Medical and Health Sciences - Abstract
BackgroundChronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice.Methods and findingsA total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with ≥3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR ≤ 60 ml/min/1.73 m2. Poisson regression was used to develop a risk score, externally validated on two independent cohorts. In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1:393 chance of developing CKD in the next 5 y in the low risk group (risk score < 0, 33 events), rising to 1:47 and 1:6 in the medium (risk score 0-4, 103 events) and high risk groups (risk score ≥ 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria.ConclusionsBoth traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.
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- 2015
21. “Risk of de novo or secondary cancer after solid organ or allogeneic haematopoietic stem cell transplantation”
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Wareham, Neval E., Li, Qiuju, Sengeløv, Henrik, Da Cunha-Bang, Caspar, Gustafsson, Finn, Heilmann, Carsten, Perch, Michael, Rasmussen, Allan, Sørensen, Søren Schwartz, Mocroft, Amanda, and Lundgren, Jens D.
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- 2019
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22. Predictors of Ischemic and Hemorrhagic Strokes Among People Living With HIV: The D:A:D International Prospective Multicohort Study
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Hatleberg, Camilla Ingrid, Ryom, Lene, Kamara, David, De Wit, Stephane, Law, Matthew, Phillips, Andrew, Reiss, Peter, D'Arminio Monforte, Antonella, Mocroft, Amanda, Pradier, Christian, Kirk, Ole, Kovari, Helen, Bonnet, Fabrice, El-Sadr, Wafaa, Lundgren, Jens D., and Sabin, Caroline
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- 2019
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23. Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral-Treated People With Human Immunodeficiency Virus.
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Chammartin, Frédérique, Mocroft, Amanda, Egle, Alexander, Zangerle, Robert, Smith, Colette, Mussini, Cristina, Wit, Ferdinand, Vehreschild, Jörg Janne, Monforte, Antonella d'Arminio, Castagna, Antonella, Bailly, Laurent, Bogner, Johannes, Wit, Stéphane de, Matulionyte, Raimonda, Law, Matthew, Svedhem, Veronica, Tallada, Joan, Garges, Harmony P, Marongiu, Andrea, and Borges, Álvaro H
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RISK assessment , *ANTIRETROVIRAL agents , *T cells , *VIRAL load , *RESEARCH funding , *CD4 lymphocyte count , *SCIENTIFIC observation , *HIV infections , *DESCRIPTIVE statistics , *PSYCHOLOGY of HIV-positive persons , *TUMORS , *CONFIDENCE intervals , *AIDS , *PROPORTIONAL hazards models , *DISEASE complications - Abstract
Background Human immunodeficiency virus (HIV) infection leads to chronic immune activation/inflammation that can persist in virally suppressed persons on fully active antiretroviral therapy (ART) and increase risk of malignancies. The prognostic role of low CD4:CD8 ratio and elevated CD8 cell counts on the risk of cancer remains unclear. Methods We investigated the association of CD4:CD8 ratio on the hazard of non-AIDS defining malignancy (NADM), AIDS-defining malignancy (ADM) and most frequent group of cancers in ART-treated people with HIV (PWH) with a CD4 and CD8 cell counts and viral load measurements at baseline. We developed Cox proportional hazard models with adjustment for known confounders of cancer risk and time-dependent cumulative and lagged exposures of CD4:CD8 ratio to account for time-evolving risk factors and avoid reverse causality. Results CD4:CD8 ratios below 0.5, compared to above 1.0, were independently associated with a 12-month time-lagged higher risk of ADM and infection-related malignancies (adjusted hazard ratio 2.61 [95% confidence interval {CI }1.10–6.19] and 2.03 [95% CI 1.24–3.33], respectively). CD4 cell counts below 350 cells/μL were associated with an increased risk of NADMs and ADMs, as did infection, smoking, and body mass index-related malignancies. Conclusions In ART-treated PWH low CD4:CD8 ratios were associated with ADM and infection-related cancers independently from CD4 and CD8 cell counts and may alert clinicians for cancer screening and prevention of NADM. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Higher Risk of Abdominal Obesity, Elevated Low-Density Lipoprotein Cholesterol, and Hypertriglyceridemia, but not of Hypertension, in People Living With Human Immunodeficiency Virus (HIV) : Results From the Copenhagen Comorbidity in HIV Infection Study
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Gelpi, Marco, Afzal, Shoaib, Lundgren, Jens, Ronit, Andreas, Roen, Ashley, Mocroft, Amanda, Gerstoft, Jan, Lebech, Anne-Mette, Lindegaard, Birgitte, Kofoed, Klaus Fuglsang, Nordestgaard, Brge G., and Nielsen, Susanne Dam
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- 2018
25. Effect of changes in body mass index on the risk of cardiovascular disease and diabetes mellitus in HIV-positive individuals: results from the D: A: D study\
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Petoumenos, Kathy, Kuwanda, Locadiah, Ryom, Lene, Mocroft, Amanda, Reiss, Peter, De Wit, Stephane, Pradier, Christian, Phillips, Andrew, Hatleberg, Camilla I, d’Arminio Monforte, Antonella, Weber, Rainer, Sabin, Caroline A, Lundgren, Jens, and Law, Matthew G
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- 2020
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26. Hepatitis delta infection among persons living with HIV in Europe
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Béguelin, Charles, Atkinson, Andrew, Boyd, Anders, Falconer, Karolin, Kirkby, Nikolai, Suter Riniker, Franziska, Günthard, Huldrych F., Rockstroh, Jürgen Kurt, Mocroft, Amanda, Rauch, Andri, Peters, Lars, Wandeler, Gilles, for EuroSIDA and SHCS, Miró Meda, José M., Infectious diseases, and AII - Infectious diseases
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PLWH ,Hepatology ,HIV (Viruses) ,prevalence ,HIV ,Virus de l'hepatitis delta ,Hepatitis B ,Càncer de fetge ,Europe ,Hepatitis vírica ,Hepatitis Delta ,VIH (Virus) ,Viral hepatitis ,HIV-positive persons ,HCC ,Persones seropositives ,Europa ,Liver cancer ,Delta-associated agent - Abstract
Background and Aims: A high prevalence of hepatitis delta virus (HDV) infection, the most severe form of viral hepatitis, has been reported among persons living with HIV (PLWH) in Europe. We analysed data from a large HIV cohort collaboration to characterize HDV epidemiological trends across Europe, as well as its impact on clinical outcomes. Methods: All PLWH with a positive hepatitis B surface antigen (HBsAg) in the Swiss HIV Cohort Study and EuroSIDA between 1988 and 2019 were tested for anti-HDV antibodies and, if positive, for HDV RNA. Demographic and clinical characteristics at initiation of antiretroviral therapy were compared between HDV-positive and HDV-negative individuals using descriptive statistics. The associations between HDV infection and overall mortality, liver-related mortality as well as hepatocellular carcinoma (HCC) were assessed using cumulative incidence plots and cause-specific multivariable Cox regression. Results: Of 2793 HBsAg-positive participants, 1556 (56%) had stored serum available and were included. The prevalence of HDV coinfection was 15.2% (237/1556, 95% confidence interval [CI]: 13.5%?17.1%) and 66% (132/200) of HDV-positive individuals had active HDV replication. Among persons who inject drugs (PWID), the prevalence of HDV coinfection was 50.5% (182/360, 95% CI: 45.3%?55.7%), with similar estimates across Europe, compared to 4.7% (52/1109, 95% CI: 3.5%?5.9%) among other participants. During a median follow-up of 10.8 years (interquartile range 5.6?17.8), 82 (34.6%) HDV-positive and 265 (20.1%) HDV-negative individuals died. 41.5% (34/82) of deaths were liver-related in HDV-positive individuals compared to 17.7% (47/265) in HDV-negative individuals. HDV infection was associated with overall mortality (adjusted hazard ratio 1.6; 95% CI 1.2?2.1), liver-related death (2.9, 1.6?5.0) and HCC (6.3, 2.5?16.0). Conclusion: We found a very high prevalence of hepatitis delta among PWID across Europe. Among PLWH who do not inject drugs, the prevalence was similar to that reported from populations without HIV. HDV coinfection was associated with liver-related mortality and HCC incidence.
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- 2023
27. Cardiovascular disease and use of contemporary protease inhibitors: the D:A:D international prospective multicohort study
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Ryom, Lene, Lundgren, Jens D, El-Sadr, Wafaa, Reiss, Peter, Kirk, Ole, Law, Matthew, Phillips, Andrew, Weber, Rainer, Fontas, Eric, d' Arminio Monforte, Antonella, De Wit, Stéphane, Dabis, Francois, Hatleberg, Camilla I, Sabin, Caroline, and Mocroft, Amanda
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- 2018
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28. Effect of Changes in Body Mass Index on the Risk of Cardiovascular Disease and Diabetes Mellitus in HIV-Positive Individuals: Results From the D: A: D Study
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Petoumenos, Kathy, Kuwanda, Locadiah, Ryom, Lene, Mocroft, Amanda, Reiss, Peter, De Wit, Stephane, Pradier, Christian, Bonnet, Fabrice, Phillips, Andrew, Hatleberg, Camilla I., dʼArminio Monforte, Antonella, Weber, Rainer, Sabin, Caroline A., Lundgren, Jens, and Law, Matthew G.
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- 2021
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29. Effectiveness and Safety of Interferon-Free Direct-Acting Antiviral Hepatitis C Virus Therapy in HIV/Hepatitis C Virus Coinfected Individuals: Results From a Pan-European Study
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Amele, Sarah, Peters, Lars, Rodger, Alison, Lundgren, Jens, Rockstroh, Jurgen, Matulionyte, Raimonda, Leen, Clifford, Jabłonowska, Elzbieta, Østergaard, Lars, Bhagani, Sanjay, Sarcletti, Mario, Clarke, Amanda, Falconer, Karolin, Wandeler, Gilles, Domingo, Pere, Maltez, Fernando, Zaccarelli, Mauro, Chkhartisvili, Nikoloz, Szlavik, Janos, Stephan, Christoph, Fonquernie, Laurent, Aho, Inka, and Mocroft, Amanda
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- 2021
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30. Antiretrovirals, Fractures, and Osteonecrosis in a Large International HIV Cohort
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EuroSIDA, Borges, Álvaro H., Hoy, Jennifer, Florence, Eric, Sedlacek, Dalibor, Stellbrink, Hans-Jürgen, Uzdaviniene, Vilma, Tomazic, Janez, Gargalianos-Kakolyris, Panagiotis, Schmid, Patrick, Orkin, Chloe, Pedersen, Court, Leen, Clifford, Pradier, Christian, Mulcahy, Fiona, Ridolfo, Anna Lisa, Staub, Therese, Maltez, Fernando, Weber, Rainer, Flamholc, Leo, Kyselyova, Galina, Lundgren, Jens D, and Mocroft, Amanda
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- 2017
31. Anemia and Survival in Human Immunodeficiency Virus
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Mocroft, Amanda
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- 2003
32. Impact of early versus deferred antiretroviral therapy on estimated glomerular filtration rate in HIV-positive individuals in the START trial
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Achhra, Amit C., Mocroft, Amanda, Ross, Michael, Ryom-Nielson, Lene, Avihingsanon, Anchalee, Bakowska, Elzbieta, Belloso, Waldo, Clarke, Amanda, Furrer, Hansjakob, Lucas, Gregory M., Ristola, Matti, Rassool, Mohammed, Ross, Jonathan, Somboonwit, Charurut, Sharma, Shweta, and Wyatt, Christina
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- 2017
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33. Influence of hepatitis C virus co-infection and hepatitis C virus treatment on risk of chronic kidney disease in HIV-positive persons
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Mocroft, Amanda, Ryom, Lene, Oprea, Cristiana, Li, Qiuju, Rauch, Andri, Boesecke, Christoph, Uzdaviniene, Vilma, Sedlacek, Dalibor, Llibre, Josep M., Lacombe, Karine, Nielsen, Lars N., Florence, Eric, Aho, Inka, Chkhartishvili, Nikoloz, Szlavik, János, Dragovic, Gordana, Leen, Clifford, Sambatakou, Helen, Staub, Therese, Laguno, Montse, Elinav, Hila, Tomažič, Janez, and Peters, Lars
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- 2020
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34. Uptake and Discontinuation of Integrase Inhibitors (INSTIs) in a Large Cohort Setting
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Greenberg, Lauren, Ryom, Lene, Wandeler, Gilles, Grabmeier-Pfistershammer, Katharina, Öllinger, Angela, Neesgaard, Bastian, Stephan, Christoph, Calmy, Alexandra, Rauch, Andri, Castagna, Antonella, Spagnuolo, Vincenzo, Johnson, Margaret, Stingone, Christof, Mussini, Cristina, De Wit, Stéphane, Necsoi, Coca, Campins, Antoni A., Pradier, Christian, Stecher, Melanie, Wasmuth, Jan-Christian, Monforte, Antonella dʼArminio, Law, Matthew, Puhr, Rainer, Chkhartishvilli, Nikoloz, Tsertsvadze, Tengiz, Garges, Harmony, Thorpe, David, Lundgren, Jens D., Peters, Lars, Bansi-Matharu, Loveleen, and Mocroft, Amanda
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- 2020
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35. Gender differences in the use of cardiovascular interventions in HIV-positive persons; the D:A:D Study
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Hatleberg, Camilla I., Ryom, Lene, Sadr, Wafaa El, Mocroft, Amanda, Reiss, Peter, De Wit, Stephane, Dabis, Francois, Pradier, Christian, Monforte, Antonella D'Arminio, Kovari, Helen, Law, Matthew, Lundgren, Jens D., and Sabin, Caroline A.
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HIV patients -- Health aspects ,Sex differences (Biology) -- Analysis ,Cardiovascular diseases -- Prevention -- Care and treatment ,Health - Abstract
Introduction: There is paucity of data related to potential gender differences in the use of interventions to prevent and treat cardiovascular disease (CVD) among HIV-positive individuals. We investigated whether such differences exist in the observational D:A:D cohort study. Methods: Participants were followed from study enrolment until the earliest of death, six months after last visit or February 1, 2015. Initiation of CVD interventions [lipid-lowering drugs (LLDs), angiotensin-converting enzyme inhibitors (ACEIs), anti-hypertensives, invasive cardiovascular procedures (ICPs) were investigated and Poisson regression models calculated whether rates were lower among women than men, adjusting for potential confounders. Results: Women (n = 12,955) were generally at lower CVD risk than men (n = 36,094). Overall, initiation rates of CVD interventions were lower in women than men; LLDs: incidence rate 1.28 [1.21, 1.35] vs. 2.40 [2.34, 2.46]; ACEIs: 0.88 [0.82, 0.93] vs. 1.43 [1.39, 1.48]; anti-hypertensives: 1.40 [1.33, 1.47] vs. 1.72 [1.68, 1.77] and ICPs: 0.08 [0.06, 0.10] vs. 0.30 [0.28, 0.32], and this was also true for most CVD interventions when exclusively considering periods of follow-up for which individuals were at high CVD risk. In fully adjusted models, women were less likely to receive CVD interventions than men (LLDs: relative rate 0.83 [0.78, 0.88]; ACEIs: 0.93 [0.86, 1.01]; ICPs: 0.54 [0.43, 0.68]), except for the receipt of anti-hypertensives (1.17 [1.10, 1.25]). Conclusion: The use of most CVD interventions was lower among women than men. Interventions are needed to ensure that all HIV-positive persons, particularly women, are appropriately monitored for CVD and, if required, receive appropriate CVD interventions. Keywords: Cardiovascular disease; gender; cardiovascular disease interventions; cohort studies; HIV; women; myocardial infarction; stroke, 1 | INTRODUCTION HIV-positive individuals are known to be at increased risk of cardiovascular disease (CVD) compared to the general population [1,2], partly due to an increased prevalence of some [...]
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- 2018
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36. Cofactors and Markers of Disease Progression in Human Immunodeficiency Virus Infection
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Sabin, Caroline A., Mocroft, Amanda, Lepri, Alessandro Cozzi, and Phillips, Andrew N.
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- 1998
37. Cascade of care and factors associated with virological suppression among HIV-positive persons linked to care in the Test and Keep in Care (TAK) project
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Kowalska, Justyna D., Ankiersztejn-Bartczak, Magdalena, Shepherd, Leah, and Mocroft, Amanda
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- 2018
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38. The value of EBV DNA in early detection of post-transplant lymphoproliferative disorders among solid organ and hematopoietic stem cell transplant recipients
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Wareham, Neval E., Mocroft, Amanda, Sengeløv, Henrik, Da Cunha-Bang, Caspar, Gustafsson, Finn, Heilmann, Carsten, Iversen, Martin, Kirkby, Nikolai S., Rasmussen, Allan, Sørensen, Søren Schwartz, Lundgren, Jens D., and MATCH in PERSIMUNE study group
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- 2018
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39. Early Antiretroviral Therapy Not Associated With Higher Cryptococcal Meningitis Mortality in People With Human Immunodeficiency Virus in High-Income Countries: An International Collaborative Cohort Study
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Ingle, Suzanne M, primary, Miro, Jose M, additional, May, Margaret T, additional, Cain, Lauren E, additional, Schwimmer, Christine, additional, Zangerle, Robert, additional, Sambatakou, Helen, additional, Cazanave, Charles, additional, Reiss, Peter, additional, Brandes, Vanessa, additional, Bucher, Heiner C, additional, Sabin, Caroline, additional, Vidal, Francesc, additional, Obel, Niels, additional, Mocroft, Amanda, additional, Wittkop, Linda, additional, d'Arminio Monforte, Antonella, additional, Torti, Carlo, additional, Mussini, Cristina, additional, Furrer, Hansjakob, additional, Konopnicki, Deborah, additional, Teira, Ramon, additional, Saag, Michael S, additional, Crane, Heidi M, additional, Moore, Richard D, additional, Jacobson, Jeffrey M, additional, Mathews, W Chris, additional, Geng, Elvin, additional, Eron, Joseph J, additional, Althoff, Keri N, additional, Kroch, Abigail, additional, Lang, Raynell, additional, Gill, M John, additional, and Sterne, Jonathan A C, additional
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- 2023
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40. Use of contraindicated antiretroviral drugs in people with HIV/HCV coinfections receiving HCV treatment with direct-acting antivirals — Results from the EuroSIDA study
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Nikolaichuk, Myroslava, Mocroft, Amanda, Wandeler, Gilles, Szlavik, János, Gottfredsson, Magnus, Reikvam, Dag Henrik, Svedhem, Veronica, Elinav, Hila, Laguno, Montserrat, Mansinho, Kamal, Devitt, Emma, Chkhartishvili, Nikoloz, Behrens, Georg, Bogner, Johannes, Viard, Jean-Paul, Winston, Alan, Benfield, Thomas, Leen, Clifford, Fursa, Olga, Rockstroh, Jürgen, Peters, Lars, Nikolaichuk, Myroslava, Mocroft, Amanda, Wandeler, Gilles, Szlavik, János, Gottfredsson, Magnus, Reikvam, Dag Henrik, Svedhem, Veronica, Elinav, Hila, Laguno, Montserrat, Mansinho, Kamal, Devitt, Emma, Chkhartishvili, Nikoloz, Behrens, Georg, Bogner, Johannes, Viard, Jean-Paul, Winston, Alan, Benfield, Thomas, Leen, Clifford, Fursa, Olga, Rockstroh, Jürgen, and Peters, Lars
- Abstract
Objectives: Our objective was to determine whether antiretroviral drugs (ARVs) were used according to the European AIDS Clinical Society (EACS) guidelines for people with HIV/hepatitis C virus (HCV) coinfection treated with direct-acting antivirals (DAAs) between 30 November 2014 and 31 December 2019 in the pan-European EuroSIDA study. Methods: At each publication date of the EACS guidelines, plus 3 and 6 months, we calculated the number of people receiving DAAs with potential and actual ARV contraindications (‘red shading’ in the EACS guidelines). We used logistic regression to investigate factors associated with using contraindicated ARVs. Results: Among 1406 people starting DAAs, the median age was 51 years, 75% were male, 57% reported injected drug use as an HIV risk, and 76% were from western Europe. Of 1624 treatment episodes, 609 (37.5%) occurred while the patient was receiving ARVs with potential contraindications; among them, 38 (6.2%; 95% confidence interval [CI] 4.3–8.2) involved a contraindicated ARV (18 non-nucleoside reverse transcriptase inhibitors), 16 involved protease inhibitors, and four involved integrase strand transfer inhibitors. The adjusted odds of receiving a contraindicated ARV were higher (3.25; 95% CI 1.40–7.57) among participants from east/central east Europe (vs. south) and lower (0.22; 95% CI 0.08–0.65) for 2015–2018 guidelines (vs. 2014). In total, 29 of the 32 (90.6%) patients receiving a contraindicated ARV and 441 of the 461 (95.7%) with potential ARV contraindications experienced a sustained virological response ≥12 weeks after stopping treatment (SVR12; p = 0.55). Conclusion: In this large heterogenous European cohort, more than one-third of people with HIV/HCV coinfection received DAAs with potential ARV contraindications, but few received a contraindicated ARV. Use of contraindicated ARVs declined over time, corresponding to the increased availability of ARV therapy regimens without interactions with DAA across Europe. Part
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- 2023
41. External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection
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Surial, Bernard; https://orcid.org/0000-0002-1402-974X, Ramírez Mena, Adrià, Roumet, Marie; https://orcid.org/0000-0001-6655-1428, Limacher, Andreas; https://orcid.org/0000-0002-9094-9476, Smit, Colette, Leleux, Olivier, Mocroft, Amanda; https://orcid.org/0000-0001-8316-1122, van der Valk, Marc, Bonnet, Fabrice, Peters, Lars, Rockstroh, Jürgen K, Günthard, Huldrych F; https://orcid.org/0000-0002-1142-6723, Berzigotti, Annalisa; https://orcid.org/0000-0003-4562-9016, Rauch, Andri; https://orcid.org/0000-0001-5297-6062, Wandeler, Gilles; https://orcid.org/0000-0002-5278-8763, Surial, Bernard; https://orcid.org/0000-0002-1402-974X, Ramírez Mena, Adrià, Roumet, Marie; https://orcid.org/0000-0001-6655-1428, Limacher, Andreas; https://orcid.org/0000-0002-9094-9476, Smit, Colette, Leleux, Olivier, Mocroft, Amanda; https://orcid.org/0000-0001-8316-1122, van der Valk, Marc, Bonnet, Fabrice, Peters, Lars, Rockstroh, Jürgen K, Günthard, Huldrych F; https://orcid.org/0000-0002-1142-6723, Berzigotti, Annalisa; https://orcid.org/0000-0003-4562-9016, Rauch, Andri; https://orcid.org/0000-0001-5297-6062, and Wandeler, Gilles; https://orcid.org/0000-0002-5278-8763
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BACKGROUND & AIMS HBV coinfection is common among people living with HIV (PLWH) and is the most important cause of hepatocellular carcinoma (HCC). While risk prediction tools for HCC have been validated in patients with HBV monoinfection, they have not been evaluated in PLWH. Thus, we performed an external validation of PAGE-B in people with HIV/HBV coinfection. METHODS We included data on PLWH from four European cohorts who were positive for HBsAg and did not have HCC before starting tenofovir. We estimated the predictive performance of PAGE-B for HCC occurrence over 15 years in patients receiving tenofovir-containing antiretroviral therapy. Model discrimination was assessed after multiple imputation using Cox regression with the prognostic index as a covariate, and by calculating Harrell's c-index. Calibration was assessed by comparing our cumulative incidence with the PAGE-B derivation study using Kaplan-Meier curves. RESULTS In total, 2,963 individuals with HIV/HBV coinfection on tenofovir-containing antiretroviral therapy were included. PAGE-B was <10 in 26.5%, 10-17 in 57.7%, and ≥18 in 15.7% of patients. Within a median follow-up of 9.6 years, HCC occurred in 68 individuals (2.58/1,000 patient-years, 95% CI 2.03-3.27). The regression slope of the prognostic index for developing HCC within 15 years was 0.93 (95% CI 0.61-1.25), and the pooled c-index was 0.77 (range 0.73-0.80), both indicating good model discrimination. The cumulative incidence of HCC was lower in our study compared to the derivation study. A PAGE-B cut-off of <10 had a negative predictive value of 99.4% for the development of HCC within 5 years. Restricting efforts to individuals with a PAGE-B of ≥10 would spare unnecessary HCC screening in 27% of individuals. CONCLUSIONS For individuals with HIV/HBV coinfection, PAGE-B is a valid tool to determine the need for HCC screening. IMPACT AND IMPLICATIONS Chronic HBV infection is the most important cause of hepatocellular carcinoma (HCC) among peopl
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- 2023
42. Hepatitis delta infection among persons living with HIV in Europe
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Béguelin, Charles; https://orcid.org/0000-0001-9346-5146, Atkinson, Andrew, Boyd, Anders; https://orcid.org/0000-0001-9512-8928, Falconer, Karolin, Kirkby, Nikolai, Suter-Riniker, Franziska, Günthard, Huldrych F, Rockstroh, Jürgen K, Mocroft, Amanda, Rauch, Andri, Peters, Lars, Wandeler, Gilles; https://orcid.org/0000-0002-5278-8763, Béguelin, Charles; https://orcid.org/0000-0001-9346-5146, Atkinson, Andrew, Boyd, Anders; https://orcid.org/0000-0001-9512-8928, Falconer, Karolin, Kirkby, Nikolai, Suter-Riniker, Franziska, Günthard, Huldrych F, Rockstroh, Jürgen K, Mocroft, Amanda, Rauch, Andri, Peters, Lars, and Wandeler, Gilles; https://orcid.org/0000-0002-5278-8763
- Abstract
BACKGROUND AND AIMS A high prevalence of hepatitis delta virus (HDV) infection, the most severe form of viral hepatitis, has been reported among persons living with HIV (PLWH) in Europe. We analysed data from a large HIV cohort collaboration to characterize HDV epidemiological trends across Europe, as well as its impact on clinical outcomes. METHODS All PLWH with a positive hepatitis B surface antigen (HBsAg) in the Swiss HIV Cohort Study and EuroSIDA between 1988 and 2019 were tested for anti-HDV antibodies and, if positive, for HDV RNA. Demographic and clinical characteristics at initiation of antiretroviral therapy were compared between HDV-positive and HDV-negative individuals using descriptive statistics. The associations between HDV infection and overall mortality, liver-related mortality as well as hepatocellular carcinoma (HCC) were assessed using cumulative incidence plots and cause-specific multivariable Cox regression. RESULTS Of 2793 HBsAg-positive participants, 1556 (56%) had stored serum available and were included. The prevalence of HDV coinfection was 15.2% (237/1556, 95% confidence interval [CI]: 13.5%-17.1%) and 66% (132/200) of HDV-positive individuals had active HDV replication. Among persons who inject drugs (PWID), the prevalence of HDV coinfection was 50.5% (182/360, 95% CI: 45.3%-55.7%), with similar estimates across Europe, compared to 4.7% (52/1109, 95% CI: 3.5%-5.9%) among other participants. During a median follow-up of 10.8 years (interquartile range 5.6-17.8), 82 (34.6%) HDV-positive and 265 (20.1%) HDV-negative individuals died. 41.5% (34/82) of deaths were liver-related in HDV-positive individuals compared to 17.7% (47/265) in HDV-negative individuals. HDV infection was associated with overall mortality (adjusted hazard ratio 1.6; 95% CI 1.2-2.1), liver-related death (2.9, 1.6-5.0) and HCC (6.3, 2.5-16.0). CONCLUSION We found a very high prevalence of hepatitis delta among PWID across Europe. Among PLWH who do not inject drugs, the pr
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- 2023
43. Recent abacavir use and incident cardiovascular disease in contemporary-treated people with HIV
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Jaschinski, Nadine, Greenberg, Lauren, Neesgaard, Bastian, Miró, Jose M., Grabmeier-Pfistershammer, Katharina, Wandeler, Gilles, Smith, Colette, De Wit, Stéphane, Wit, Ferdinand, Pelchen-Matthews, Annegret, Mussini, Cristina, Castagna, Antonella, Pradier, Christian, D'Arminio Monforte, Antonella, Vehreschild, Jörg, Sönnerborg, Anders, Anne, Alain V., Carr, Andrew, Bansi-Matharu, Loveleen, Lundgren, Jens, Garges, Harmony, Rogatto, Felipe, Zangerle, Robert, Günthard, Huldrych F., Rasmussen, Line D., Nescoi, Coca, Van Der Valk, Marc, Menozzi, Marianna, Muccini, Camilla, Mocroft, Amanda, Peters, Lars, Ryom, Lene, Jaschinski, Nadine, Greenberg, Lauren, Neesgaard, Bastian, Miró, Jose M., Grabmeier-Pfistershammer, Katharina, Wandeler, Gilles, Smith, Colette, De Wit, Stéphane, Wit, Ferdinand, Pelchen-Matthews, Annegret, Mussini, Cristina, Castagna, Antonella, Pradier, Christian, D'Arminio Monforte, Antonella, Vehreschild, Jörg, Sönnerborg, Anders, Anne, Alain V., Carr, Andrew, Bansi-Matharu, Loveleen, Lundgren, Jens, Garges, Harmony, Rogatto, Felipe, Zangerle, Robert, Günthard, Huldrych F., Rasmussen, Line D., Nescoi, Coca, Van Der Valk, Marc, Menozzi, Marianna, Muccini, Camilla, Mocroft, Amanda, Peters, Lars, and Ryom, Lene
- Abstract
Objective:Assessing whether the previously reported association between abacavir (ABC) and cardiovascular disease (CVD) remained amongst contemporarily treated people with HIV.Design:Multinational cohort collaboration.Methods:RESPOND participants were followed from the latest of 1 January 2012 or cohort enrolment until the first of a CVD event (myocardial infarction, stroke, invasive cardiovascular procedure), last follow-up or 31 December 2019. Logistic regression examined the odds of starting ABC by 5-year CVD or chronic kidney disease (CKD) D:A:D risk score. We assessed associations between recent ABC use (use within the past 6 months) and risk of CVD with negative binomial regression models, adjusted for potential confounders.Results:Of 29 340 individuals, 34% recently used ABC. Compared with those at low estimated CVD and CKD risks, the odds of starting ABC were significantly higher among individuals at high CKD risk [odds ratio 1.12 (95% confidence interval = 1.04-1.21)] and significantly lower for individuals at moderate, high or very high CVD risk [0.80 (0.72-0.88), 0.75 (0.64-0.87), 0.71 (0.56-0.90), respectively]. During 6.2 years of median follow-up (interquartile range; 3.87-7.52), there were 748 CVD events (incidence rate 4.7 of 1000 persons-years of follow up (4.3-5.0)]. The adjusted CVD incidence rate ratio was higher for individuals with recent ABC use [1.40 (1.20-1.64)] compared with individuals without, consistent across sensitivity analyses. The association did not differ according to estimated CVD (interaction P = 0.56) or CKD (P = 0.98) risk strata.Conclusion:Within RESPOND's contemporarily treated population, a significant association between CVD incidence and recent ABC use was confirmed and not explained by preferential ABC use in individuals at increased CVD or CKD risk.
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- 2023
44. Tuberculosis-related mortality in people living with HIV in Europe and Latin America: an international cohort study
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Podlekareva, Daria N, Efsen, Anne Marie W, Schultze, Anna, Post, Frank A, Skrahina, Alena M, Panteleev, Alexander, Furrer, Hansjakob, Miller, Robert F, Losso, Marcelo H, Toibaro, Javier, Miro, Jose M, Vassilenko, Anna, Girardi, Enrico, Bruyand, Mathias, Obel, Niels, Lundgren, Jens D, Mocroft, Amanda, and Kirk, Ole
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- 2016
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45. Cumulative and current exposure to potentially nephrotoxic antiretrovirals and development of chronic kidney disease in HIV-positive individuals with a normal baseline estimated glomerular filtration rate: a prospective international cohort study
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Mocroft, Amanda, Lundgren, Jens D, Ross, Michael, Fux, Christoph A, Reiss, Peter, Moranne, Olivier, Morlat, Philippe, Monforte, Antonella d'Arminio, Kirk, Ole, and Ryom, Lene
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- 2016
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46. Studies on the prognosis of patients with the Acquired Immunodeficiency Syndrome (AIDS)
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Mocroft, Amanda Jayne
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610 ,AIDS - Abstract
This thesis presents the epidemiological results of the follow-up of almost nine thousand patients with AIDS diagnosed between 1979 and July 1995 from three groups; the AIDS in Europe Study Group, the Royal Free Hospital cohort and the Chelsea and Westminster Hospital cohort. There is known to be considerable heterogeneity in survival after an AIDS defining diagnosis, such differences may be caused by a variety of factors and it is these factors which are explored in this thesis. AIDS defining events have been ranked in terms of survival. Median survival ranged from 2 to 19 months depending on the diagnosis but the ranking of diseases was consistent after stratification for year of diagnosis, whether the event was an initial or subsequent diagnosis, and whether zidovudine treatment had been initiated. Median survival after an initial AIDS diagnosis in a large group of UK AIDS patients was 20 months, somewhat longer than previously estimated. Patients diagnosed with AIDS after 1987 were significantly more likely to survive their initial AIDS defining event than patients diagnosed before this date. The CD4 lymphocyte count, which drops throughout infection with HIV, and age were found to be strongly related to survival. The median CD4 lymphocyte count at which AIDS defining events occur varied quite widely, similarly, the incidence of AIDS defining events was highly dependent on the CD4 count. Each successive diagnosis of an AIDS defining illness was found to increase the risk of death significantly independently of the latest CD4 lymphocyte count; categorising the events as mild, severe and very severe led to a staging system which also utilised the CD4 lymphocyte count. This staging system was validated on two further cohorts of patients with remarkable agreement. Following the recent identification of a herpes virus thought to play a role in the development of Kaposi's sarcoma, patients who were treated with foscarnet and ganciclovir were found to be at a reduced risk of Kaposi's sarcoma during subsequent follow-up.
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- 1997
47. Renal Impairment and Cardiovascular Disease in HIV-Positive Individuals: The D:A:D Study
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Ryom, Lene, Lundgren, Jens D., Ross, Mike, Kirk, Ole, Law, Matthew, Morlat, Philippe, Fontas, Eric, Smit, Colette, Fux, Christoph A., Hatleberg, Camilla I., de Wit, Stéphane, Sabin, Caroline A., and Mocroft, Amanda
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- 2016
48. Trends in Incidences and Risk Factors for Hepatocellular Carcinoma and Other Liver Events in HIV and Hepatitis C Virus-coinfected Individuals From 2001 to 2014: A Multicohort Study
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Gjærde, Lars I., Shepherd, Leah, Jablonowska, Elzbieta, Lazzarin, Adriano, Rougemont, Mathieu, Darling, Katharine, Battegay, Manuel, Braun, Dominique, Martel-Laferriere, Valerie, Lundgren, Jens D., Rockstroh, Jürgen K., Gill, John, Rauch, Andri, Mocroft, Amanda, Klein, Marina B., and Peters, Lars
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- 2016
49. Immunological and virological response to antiretroviral treatment in migrant and native men and women in Western Europe; is benefit equal for all?
- Author
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Monge, S, Mocroft, A, Sabin, A, Touloumi, G, Sighem, A, Abgrall, S, Dray‐Spira, R, Spire, B, Castagna, A, Mussini, C, Zangerle, R, Hessamfar, M, Anderson, J, Hamouda, O, Ehren, K, Obel, N, Kirk, O, Antinori, A, Girardi, E, Saracino, A, Calmy, A, Wit, S, Wittkop, L, Bucher, C, Montoliu, A, Raben, D, Prins, M, Meyer, L, Chene, G, Burns, F, Amo, J, Judd, Ali, Zangerle, Robert, Touloumi, Giota, Warszawski, Josiane, Meyer, Laurence, Dabis, François, Krause, Murielle, Ghosn, Jade, Leport, Catherine, Wittkop, Linda, Reiss, Peter, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Gibb, Diana, Fätkenheuer, Gerd, Amo, Julia, Obel, Niels, Thorne, Claire, Mocroft, Amanda, Kirk, Ole, Stephan, Christoph, Pérez‐Hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera‐Julian, Antoni, Antinori, Andrea, Monforte, Antonella, Brockmeyer, Norbert, Prieto, Luis, Conejo, Pablo, Soriano‐Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Mussini, Cristina, Tookey, Pat, Casabona, Jordi, Miró, JoseM, Castagna, Antonella, Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Torti, Carlo, Sabin, Caroline, Teira, Ramon, Garrido, Myriam, Haerry, David, Wit, Stéphane, Miró, Mª, Costagliola, Dominique, dʼArminio‐Monforte, Antonella, Castagna, Antonella, Amo, Julia, Mocroft, Amanda, Raben, Dorthe, Chêne, Geneviève, Judd, Ali, Conejo, Pablo, Barger, Diana, Schwimmer, Christine, Termote, Monique, Wittkop, Linda, Campbell, Maria, Frederiksen, Casper M, Friis‐Møller, Nina, Kjaer, Jesper, Raben, Dorthe, Brandt, Rikke, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Bucher, Heiner, Cozzi‐Lepri, Alessandro, Dabis, François, Monforte, Antonella, Davies, Mary‐Anne, Amo, Julia, Dorrucci, Maria, Dunn, David, Egger, Matthias, Furrer, Hansjakob, Guiguet, Marguerite, Grabar, Sophie, Judd, Ali, Kirk, Ole, Lambotte, Olivier, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Meyer, Laurence, Miró, Jose, Mocroft, Amanda, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Rohner, Eliane, Schomaker, Michael, Smit, Colette, Sterne, Jonathan, Thiebaut, Rodolphe, Thorne, Claire, Torti, Carlo, Valk, Marc, and Wittkop, Linda
- Published
- 2018
- Full Text
- View/download PDF
50. Uptake of HCV treatment in HIV/HCV coinfected patients across europe in the era of direct-acting antivirals
- Author
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Peters, Lars, Laut, Kamilla, Resnati, Chiara, Del Campo, Santos, Leen, Clifford, Falconer, Karolin, Trofimova, Tatyana, Paduta, Dzmitry, Gatell, Jose, Rauch, Andri, Lacombe, Karine, Domingo, Pere, Chkhartishvili, Nikoloz, Zangerle, Robert, Matulionyte, Raimonda, Mitsura, Viktar, Benfield, Thomas, Zilmer, Kai, Khromova, Irina, Lundgren, Jens, Rockstroh, Jürgen, and Mocroft, Amanda
- Published
- 2018
- Full Text
- View/download PDF
Catalog
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