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6. Determinants of Erectile Dysfunction Risk in a Large Series of Italian Men Attending Andrology Clinics

Author

Mirone V., Ricci E., Gentile V., Basile Fasolo C., Parazzini F., Calabrese M., Di Cicco G., Goldoni S., Pento C., Scipioni G., Iantorno R., Nicolai M., Tenaglia R. L., Vaggi L., Annese P., Fiorentino V. A. V., Ielapi V., Morrone G., Cozza P. P., Nigro G., Pariano D., Sidari V., Ventrice G. A., Zumbo G., Carrino M., Fedelini P., Cicalese V., Cirillo A., D' Agostino D., FUSCO, FERDINANDO, Di Rienzo A., Izzo P., Varriale O., Maffucci A., Mazzarella F., Palmiera A., Pecoraro S., Russo A., Sorrentino M., Tripodi V., Zito A., Nobile C., Bianchi M., Mofferdin A., Fiordelise S., Granata A. R. M., Irianni G. N., Lusenti C., Maretti C., Maver A., Pescatori E., Barbieri A., Modenini F., Poletti F., Vitali G., Zoli M., Severini G., Scarano P., Basunti G., Bertaccini A., Soli M., Zaganelli S., Tellarini V., Ughi G., Vaccari E., Zenico T., Liguori G., Savoca G., Belgrano E., Capone M., Ciampalini S., Ciciliato S., Bettin A., Bucci S., Buttazzi L., Trombetta C., Alei G., Franco G., Bitelli M., Bulzomì R., Ferro F., Cardella A., Carlomagno G., Casini A., Catarinella M., Corvese F., De Pasquale F., Di Luigi L., Di Trapano M. C., Marchionni L., D'Ottavio G., Travaglia S., Guerani A., La Pera G., Lauretii S., Mazzoni G., Michetti P. M., Nucci G., IMBIMBO, CIRO, Mirone, V., Ricci, E., Gentile, V., Basile Fasolo, C., Parazzini, F., Calabrese, M., Di Cicco, G., Goldoni, S., Pento, C., Scipioni, G., Iantorno, R., Nicolai, M., Tenaglia, R. L., Vaggi, L., Annese, P., Fiorentino, V. A. V., Ielapi, V., Morrone, G., Cozza, P. P., Nigro, G., Pariano, D., Sidari, V., Ventrice, G. A., Zumbo, G., Carrino, M., Fedelini, P., Cicalese, V., Cirillo, A., D' Agostino, D., Fusco, Ferdinando, Di Rienzo, A., Izzo, P., Varriale, O., Maffucci, A., Mazzarella, F., Imbimbo, Ciro, Palmiera, A., Pecoraro, S., Russo, A., Sorrentino, M., Tripodi, V., Zito, A., Nobile, C., Bianchi, M., Mofferdin, A., Fiordelise, S., Granata, A. R. M., Irianni, G. N., Lusenti, C., Maretti, C., Maver, A., Pescatori, E., Barbieri, A., Modenini, F., Poletti, F., Vitali, G., Zoli, M., Severini, G., Scarano, P., Basunti, G., Bertaccini, A., Soli, M., Zaganelli, S., Tellarini, V., Ughi, G., Vaccari, E., Zenico, T., Liguori, G., Savoca, G., Belgrano, E., Capone, M., Ciampalini, S., Ciciliato, S., Bettin, A., Bucci, S., Buttazzi, L., Trombetta, C., Alei, G., Franco, G., Bitelli, M., Bulzomì, R., Ferro, F., Cardella, A., Carlomagno, G., Casini, A., Catarinella, M., Corvese, F., De Pasquale, F., Di Luigi, L., Di Trapano, M. C., Marchionni, L., D'Ottavio, G., Travaglia, S., Guerani, A., La Pera, G., Lauretii, S., Mazzoni, G., Michetti, P. M., and Nucci, G.

Published
2004

9. Open preliminary randomized prospective clinical trial of efficacy and safety of three different verapamil dilutions for intraplaque therapy of Peyronie's disease.

Author

Cavallini G, Modenini F, and Vitali G

Subjects
Adult, Dose-Response Relationship, Drug, Drug Administration Schedule, Follow-Up Studies, Humans, Injections, Intralesional, Male, Middle Aged, Penile Induration diagnosis, Probability, Prospective Studies, Reference Values, Risk Assessment, Severity of Illness Index, Single-Blind Method, Treatment Outcome, Penile Induration drug therapy, Vasodilator Agents administration & dosage, Verapamil administration & dosage
Abstract

Objectives: To investigate the efficacy and safety of three different dilutions of verapamil used in intraplaque injections in an attempt to reduce Peyronie's disease symptoms., Methods: A total of 77 patients (age 48 +/- 9 years) with chronic Peyronie's disease were randomized into three groups, each receiving 12 intraplaque injections (1 injection every 2 weeks) of 10 mg verapamil in different dilutions. Group 1 (27 patients) received verapamil 10 mg/4 mL, group 2 (24 patients) received verapamil 10 mg/10 mL, and group 3 (26 patients) received verapamil 10 mg/20 mL. The variables, assessed before and 8 months after therapy, were erectile function (assessed by semistructured interview), plaque size, peak systolic velocity, end-diastolic velocity, left and right cavernosal arteries (assessed with dynamic Duplex ultrasonography), pain (assessed with a pain scale), penile curvature (measured using a photograph of a pharmacologically induced full erection), and side effects. Analysis of variance and the chi-square test were used to analyze the differences among the groups., Results: No significant differences were found in the baseline values among the groups. The peak systolic velocity of the left and right cavernosal arteries was never significantly modified. The plaque area, penile curvature, erectile function, end-diastolic velocity of the left and right cavernosal arteries, and pain improved more significantly in group 3 than in groups 1 and 2. The side effects were ecchymosis, with no significant differences among the groups., Conclusions: The dilution of verapamil significantly improved its efficacy in improving Peyronie's disease symptoms.

Published
2007
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10. Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy.

Author

Cavallini G, Modenini F, Vitali G, and Koverech A

Subjects
Carnitine therapeutic use, Drug Therapy, Combination, Humans, Male, Middle Aged, Prospective Studies, Prostate innervation, Prostate surgery, Prostatectomy methods, Purines, Sildenafil Citrate, Sulfones, Acetylcarnitine therapeutic use, Carnitine analogs & derivatives, Erectile Dysfunction drug therapy, Erectile Dysfunction etiology, Piperazines therapeutic use, Prostatectomy adverse effects
Abstract

Objectives: To determine whether propionyl-L-carnitine (PLC) plus acetyl-L-carnitine (ALC) improves the effectiveness of sildenafil in restoring sexual potency after bilateral nerve-sparing radical retropubic prostatectomy., Methods: We analyzed the data from 96 patients who had undergone bilateral nerve-sparing radical retropubic prostatectomy: 33 were given placebo (group 1), 32 used PLC 2 g/day plus ALC 2 g/day plus sildenafil 100 mg when needed (group 2), and 35 used sildenafil alone (group 3). The studied variables were sexual function (assessed through sexual behavior interviews and the International Index of Erectile Function), peak systolic velocity and end-diastolic velocity of cavernosal arteries (assayed by dynamic echo-color Doppler), the percentage of patients able to achieve a positive intracavernous injection test, and side effects., Results: Placebo proved ineffective and sildenafil and sildenafil plus ALC and PLC proved effective. The International Index of Erectile Function-15 scores of the group 2 patients were significantly greater than those of group 3 in the following domains: erectile function, sexual intercourse satisfaction, orgasm, and general sexual well-being. The drugs did not significantly modify the score in the sexual desire domain or in the peak systolic velocity or end-diastolic velocity of the cavernosal arteries. Sexual behavior interviews revealed that 2 of 29 in group 1, 28 of 32 in group 2, and 20 of 39 in group 3 attained satisfactory sexual intercourse (P <0.01). Only group 2 had a significantly increased percentage of patients with a positive intracavernous injection test after therapy (36.4% versus 63.6%; P <0.01). ALC plus PLC did not significantly improve the side effects of sildenafil., Conclusions: PLC and ALC proved to be safe and reliable in improving the efficacy of sildenafil in restoring sexual potency after bilateral nerve-sparing radical retropubic prostatectomy.

Published
2005
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