Search

Your search keyword '"Modugno, Francesca"' showing total 623 results
Start Over Author "Modugno, Francesca"
623 results on '"Modugno, Francesca"'

2. Upregulated expression of miR-4443 and miR-4488 in drug resistant melanomas promotes migratory and invasive phenotypes through downregulation of intermediate filament nestin

Author

Castaldo, Vittorio, Minopoli, Michele, Di Modugno, Francesca, Sacconi, Andrea, Liguoro, Domenico, Frigerio, Rachele, Ortolano, Arianna, Di Martile, Marta, Gesualdi, Luisa, Madonna, Gabriele, Capone, Mariaelena, Cirombella, Roberto, Catizone, Angiolina, Del Bufalo, Donatella, Vecchione, Andrea, Carriero, Maria Vincenza, Ascierto, Paolo Antonio, Mancini, Rita, Fattore, Luigi, and Ciliberto, Gennaro

Published
2023
Full Text
View/download PDF

8. Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancer

Author

Di Modugno, Francesca, Di Carlo, Anna, Spada, Sheila, Palermo, Belinda, D'Ambrosio, Lorenzo, D'Andrea, Daniel, Morello, Gaia, Belmonte, Beatrice, Sperduti, Isabella, Balzano, Vittoria, Gallo, Enzo, Melchionna, Roberta, Panetta, Mariangela, Campo, Giulia, De Nicola, Francesca, Goeman, Frauke, Antoniani, Barbara, Carpano, Silvia, Frigè, Gianmaria, Warren, Sarah, Gallina, Filippo, Lambrechts, Diether, Xiong, Jieyi, Vincent, Benjamin G., Wheeler, Nathan, Bortone, Dante S., Cappuzzo, Federico, Facciolo, Francesco, Tripodo, Claudio, Visca, Paolo, and Nisticò, Paola

Published
2024
Full Text
View/download PDF

10. Stability of Microplastics: Detection of Potentially Harmful Compounds Produced by Microplastics During Accelerated Aging Studies

Author

La Nasa, Jacopo, Biale, Greta, Mattonai, Marco, Degano, Ilaria, Corti, Andrea, Castelvetro, Valter, Modugno, Francesca, Carpenter, Angela, Editorial Board Member, Kostianoy, Andrey, Series Editor, Younos, Tamim, Editorial Board Member, Scozzari, Andrea, Editorial Board Member, Vignudelli, Stefano, Editorial Board Member, Kouraev, Alexei, Editorial Board Member, Cocca, Mariacristina, editor, Ambrogi, Veronica, editor, Avolio, Roberto, editor, Castaldo, Rachele, editor, Errico, Maria Emanuela, editor, and Gentile, Gennaro, editor

Published
2023
Full Text
View/download PDF

11. Analytical Pyrolysis: A Useful Tool to Analyze and Evaluate Consolidated Archaeological Wood

Author

Lucejko, Jeannette J., Bargagli, Irene, Mattonai, Marco, Ribechini, Erika, Colombini, Maria Perla, Chaumat, Gilles, Braovac, Susan, Zborowska, Magdalena, Modugno, Francesca, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Haddar, Mohamed, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Furferi, Rocco, editor, Governi, Lapo, editor, Volpe, Yary, editor, and Seymour, Kate, editor

Published
2023
Full Text
View/download PDF

17. Step-By-Step Evaluation of Matrix Effect and Sample Recovery During Pretreatment of Wastewater Samples for the Quali-Quantitation of Microplastics by Py-GC-MS

Author

Lykkemark, Jeanette, Mattonai, Marco, Vianello, Alvise, Vollertsen, Jes, Modugno, Francesca, Carpenter, Angela, Editorial Board Member, Kostianoy, Andrey, Series Editor, Younos, Tamim, Editorial Board Member, Scozzari, Andrea, Editorial Board Member, Vignudelli, Stefano, Editorial Board Member, Kouraev, Alexei, Editorial Board Member, Cocca, Mariacristina, editor, Ambrogi, Veronica, editor, Avolio, Roberto, editor, Castaldo, Rachele, editor, Errico, Maria Emanuela, editor, and Gentile, Gennaro, editor

Published
2023
Full Text
View/download PDF

20. hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis.

Author

Di Modugno, Francesca, Spada, Sheila, Palermo, Belinda, Visca, Paolo, Iapicca, Pierluigi, Di Carlo, Anna, Antoniani, Barbara, Sperduti, Isabella, Di Benedetto, Anna, Terrenato, Irene, Mottolese, Marcella, Gandolfi, Francesco, Facciolo, Francesco, Chen, Emily I, Schwartz, Martin A, Santoni, Angela, Bissell, Mina J, and Nisticò, Paola

Subjects
Extracellular Matrix, Humans, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Microfilament Proteins, Fibronectins, Protein Isoforms, Signal Transduction, Gene Expression Regulation, Neoplastic, Tumor Microenvironment, Integrin beta1, Oncology & Carcinogenesis, Oncology and Carcinogenesis, Clinical Sciences
Abstract

We demonstrated previously that the splicing of the actin regulator, hMENA, generates two alternatively expressed isoforms, hMENA11a and hMENAΔv6, which have opposite functions in cell invasiveness. Their mechanisms of action have remained unclear. Here we report two major findings: (i) hMENA regulates β1 integrin expression. This was shown by depleting total hMENA, which led to loss of nuclear expression of serum response factor (SRF)-coactivator myocardin-related transcription factor 1 (MRTF-A), leading to an increase in the G-actin/F-actin ratio crucial for MRTF-A localization. This in turn inhibited SRF activity and the expression of its target gene β1 integrin. (ii) hMENA11a reduces and hMENAΔv6 increases β1 integrin activation and signaling. Moreover, exogenous expression of hMENA11a in hMENAΔv6-positive cancer cells dramatically reduces secretion of extracellular matrix (ECM) components, including β1 integrin ligands and metalloproteinases. On the other hand, overexpression of the pro-invasive hMENAΔv6 increases fibronectin production. In primary tumors high hMENA11a correlates with low stromal fibronectin and a favorable clinical outcome of early node-negative non-small-cell lung cancer patients. These data provide new insights into the roles of hMENA11a and hMENAΔv6 in the druggable β1 integrin-ECM signaling axis and allow stratification of patient risk, guiding their clinical management.

Published
2018

25. Understanding the Source, Distribution, and Fate of Micro- and Nanoplastics in Natural Water Bodies

Author

Castelvetro, Valter, Corti, Andrea, Ceccarini, Alessio, La Nasa, Jacopo, Lomonaco, Tommaso, Manariti, Antonella, Manco, Enrico, Modugno, Francesca, Vinciguerra, Virginia, Förstner, Ulrich, Series Editor, Rulkens, Wim H., Series Editor, Salomons, Wim, Series Editor, Ksibi, Mohamed, editor, Ghorbal, Achraf, editor, Chakraborty, Sudip, editor, Chaminé, Helder I., editor, Barbieri, Maurizio, editor, Guerriero, Giulia, editor, Hentati, Olfa, editor, Negm, Abdelazim, editor, Lehmann, Anthony, editor, Römbke, Jörg, editor, Costa Duarte, Armando, editor, Xoplaki, Elena, editor, Khélifi, Nabil, editor, Colinet, Gilles, editor, Miguel Dias, João, editor, Gargouri, Imed, editor, Van Hullebusch, Eric D., editor, Sánchez Cabrero, Benigno, editor, Ferlisi, Settimio, editor, Tizaoui, Chedly, editor, Kallel, Amjad, editor, Rtimi, Sami, editor, Panda, Sandeep, editor, Michaud, Philippe, editor, Sahu, Jaya Narayana, editor, Seffen, Mongi, editor, and Naddeo, Vincenzo, editor

Published
2021
Full Text
View/download PDF

30. The Influence of Metal Stearates on the Water Sensitivity of Modern Oil Paints

Author

Banti, Donatella, Burnstock, Aviva, Bonaduce, Ilaria, La Nasa, Jacopo, Lee, Judith, Lluveras-Tenorio, Anna, Modugno, Francesca, Ormsby, Bronwyn, van den Berg, Klaas Jan, van den Berg, Klaas Jan, editor, Bonaduce, Ilaria, editor, Burnstock, Aviva, editor, Ormsby, Bronwyn, editor, Scharff, Mikkel, editor, Carlyle, Leslie, editor, Heydenreich, Gunnar, editor, and Keune, Katrien, editor

Published
2019
Full Text
View/download PDF

36. hMENA isoforms regulate cancer intrinsic type I IFN signaling and extrinsic mechanisms of resistance to immune checkpoint blockade in NSCLC

Author

Trono, Paola, primary, Tocci, Annalisa, additional, Palermo, Belinda, additional, Di Carlo, Anna, additional, D'Ambrosio, Lorenzo, additional, D'Andrea, Daniel, additional, Di Modugno, Francesca, additional, De Nicola, Francesca, additional, Goeman, Frauke, additional, Corleone, Giacomo, additional, Warren, Sarah, additional, Paolini, Francesca, additional, Panetta, Mariangela, additional, Sperduti, Isabella, additional, Baldari, Silvia, additional, Visca, Paolo, additional, Carpano, Silvia, additional, Cappuzzo, Federico, additional, Russo, Vincenzo, additional, Tripodo, Claudio, additional, Zucali, Paolo, additional, Gregorc, Vanesa, additional, Marchesi, Federica, additional, and Nistico, Paola, additional

Published
2023
Full Text
View/download PDF

43. Analytical Approaches Based on Gas Chromatography Mass Spectrometry (GC/MS) to Study Organic Materials in Artworks and Archaeological Objects

Author

Bonaduce, Ilaria, Ribechini, Erika, Modugno, Francesca, Colombini, Maria Perla, Bayley, Hagan, Editorial board, Houk, Kendall N., Editorial board, Hughes, Greg, Editorial board, Hunter, Christopher A., Editorial board, Ishihara, Kazuaki, Series editor, Krische, Michael J, Editorial board, Lehn, Jean-Marie, Series editor, Lehn, J.-M., Editorial board, Luque, Rafael, Editorial board, Olivucci, Massimo, Editorial board, Siegel, Jay S., Editorial board, Thiem, Joachim, Series editor, Venturi, Margherita, Series editor, Wong, Chi-Huey, Editorial board, Wong, Henry N.C., Editorial board, Wong, Wai-Yeung, Series editor, Wing-Wah Yam, Vivian, Editorial board, Yam, Vivian Wing-Wah, Series editor, Yan, Chunhua, Series editor, You, Shu-Li, Editorial board, Hwang, Seong-Ju, Series editor, Larsen, Delmar, Series editor, and Mazzeo, Rocco, editor

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results