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2. 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial

Author

Halliday, A, Harrison, M, Hayter, E, Kong, X, Mansfield, A, Marro, J, Pan, H, Peto, R, Potter, J, Rahimi, K, Rau, A, Robertson, S, Streifler, J, Thomas, D, Fraedrich G, Asymptomatic Carotid Surgery Trial Collaborative G. r. o. u. p., Schmidauer, C, Hölzenbein, Th, Huk, I, Haumer, M, Kretschmer, G, Metz, V, Polterauer, P, Teufelsbauer, H, Cras, P, Hendriks, J, Lauwers, P, Van Schil, P, de Souza EB, Dourado, Me, Gurgel, G, Rocha, Gm, Petrov, V, Slabakov, G, Cooper, Me, Gubitz, G, Holness, R, Howes, W, Langille, R, Legg, K, Nearing, S, Mackean, G, Mackay, M, Phillips, Sj, Sullivan, J, Wood, J, Erdelez, L, Sosa, T, Angelides, Ns, Christopoulos, G, Malikidou, A, Pesta, A, Ambler, Z, Mracek, J, Polivka, J, Rohan, V, Sevcik, P, Simaná, J, Benes, V, Kramár, F, Kaste, M, Lepäntalo, M, Soinne, L, Cardon, Jm, Legalou, A, Gengenbach, B, Pfadenhauer, K, Wölfl, Kd, Flessenkämper, I, Klumpp, Bf, Marsch, J, Kolvenbach, R, Pfeiff, T, Sandmann, W, Beyersdorf, F, Hetzel, A, Sarai, K, Schöllhorn, J, Spillner, G, Lutz, Hj, Böckler, D, Maeder, N, Busse, O, Grönniger, J, Haukamp, F, Balzer, K, Knoob, Hg, Roedig, G, Virreira, L, Franke, S, Moll, R, Schneider, J, Dayantas, J, Sechas, Mn, Tsiaza, S, Kiskinis, D, Apor, A, Dzinich, C, Entz, L, Hüttl, K, Jàrànyi, Z, Mogan, I, Nagy, Z, Szabo, A, Varga, D, Juhász, G, Mátyás, L, Hutchinson, M, Mehigan, D, Aladjem, Z, Harah, E, Elmakias, S, Gurvich, D, Yoffe, B, Ben Meir, H, Dagan, L, Karmeli, R, Keren, G, Shimony, A, Weller, B, Avrahami, R, Koren, R, Streifler, Jy, Tabachnik, S, Zelikovski, A, Angiletta, D, Federico, F, Impedovo, G, Marotta, V, Pascazio, L, Regina, G, Andreoli, A, Pozzati, E, Bonardelli, S, Giulini, Sm, Guarneri, B, Caiazzo, P, Mascoli, F, Becchi, G, Masini, R, Santoro, E, Simoni, G, Ventura, M, Scarpelli, P, Spartera, C, Arena, O, Collice, M, Puttini, M, Romani, F, Santilli, I, Segramora, V, Sterzi, R, Deriu, G, Verlato, F, Cao, Pg, Cieri, Enrico, De Rango, P, Moggi, L, Ricci, S, Antico, A, Spigonardo, F, Malferrari, G, Tusini, N, Vecchiati, E, Cavallaro, A, Kasemi, H, Marino, M, Sbarigia, E, Speziale, F, Zinicola, N, Alò, Fp, Bartolini, M, Carbonari, L, Caporelli, S, Grili Cicilioni, C, Lagalla, G, Ioannidis, G, Pagliariccio, G, Silvestrini, M, Palombo, D, Peinetti, F, Adovasio, R, Chiodo Grandi, F, Mase, G, Zamolo, F, Fregonese, V, Gonano, N, Mozzon, L, Blair, R, Chuen, J, Ferrar, D, Garbowski, M, Hamilton, Mj, Holdaway, C, Muthu, S, Shakibaie, F, Vasudevan, Tm, Kroese, A, Slagsvold, Ce, Dahl, T, Johnsen, Hj, Lange, C, Myhre, Ho, Gniadek, J, Andziak, P, Elwertowski, M, Leszczynski, J, Malek, Ak, Mieszkowski, J, Noszczyk, W, Szostek, M, Toutounchi, S, Correia, C, Pereira, Mc, Akchurin, Rs, Flis, V, Miksic, K, Stirn, B, Tetickovic, E, Cairols, M, Capdevila, Jm, Iborra Ortega, E, Obach, V, Riambau, V, Vidal Barraquer, F, Vila Coll, R, Diaz Vidal, E, Iglesias Negreia JI, Tovar Pardo, A, Iglesias, Rj, Alfageme, Af, Barba Velez, A, Estallo Laliena, L, Garcia Monco JC, Gonzalez, Lr, Corominas, C, Julia, J, Lozano, P, Marti Masso JF, Porta, Rm, Carrera, Ar, Gomez, J, Blomstrand, C, Gelin, J, Holm, J, Karlström, L, Mattsson, E, Bornhov, S, Dahlstrom, J, De Pedis, G, Jensen, Sm, Pärsson, H, Plate, G, Qvarfordt, P, Arvidsson, B, Brattström, L, Forssell, C, Potemkowski, A, Skiöldebrand, C, Stoor, P, Blomqvist, M, Calander, M, Lundgren, F, Almqvist, H, Norgren, L, Norrving, B, Ribbe, E, Thörne, J, Gottsäter, A, Mätzsch, T, Nilsson, Me, Lonsson, M, Stahre, B, Stenberg, B, Konrad, P, Jarl, L, Lundqvist, L, Olofsson, P, Rosfors, S, Swedenborg, J, Takolander, R, Bergqvist, D, Ljungman, C, Kniemeyer, Hw, Widmer, Mk, Kuster, R, Kaiser, R, Nagel, W, Sege, D, Weder, B, De Nie, J, Doelman, J, Yilmaz, N, Buth, J, Stultiens, G, Boiten, J, Boon, A, van der Linden, F, Busman, Dc, Sinnige, Ha, Yo, Ti, de Borst GJ, Eikelboom, Bc, Kappelle, Lj, Moll, F, Dortland, Rw, Westra, Te, Jaber, H, Manaa, J, Meftah, Rb, Nabil, Br, Sraieb, T, Bateman, D, Budd, J, Horrocks, M, Kivela, M, Shaw, L, Walker, R, D'Sa, Aa, Fullerton, K, Hannon, R, Hood, Jm, Lee, B, Mcguigan, K, Morrow, J, Reid, J, Soong, Cv, Simms, M, Baird, R, Campbell, M, Cole, S, Ferguson, It, Lamont, P, Mitchell, D, Sassano, A, Smith, Fc, Blake, K, Kirkpatrick, Pj, Martin, P, Turner, C, Clegg, Jf, Crosley, M, Hall, J, De Cossart, L, Edwards, P, Fletcher, D, Rosser, S, Mccollum, Pt, Davidson, D, Levison, R, Bradbury, Aw, Chalmers, Rt, Dennis, M, Murie, J, Ruckley, Cv, Sandercock, P, Campbell, Wb, Frankel, T, Gardner Thorpe, C, Gutowski, N, Hardie, R, Honan, W, Niblett, P, Peters, A, Ridler, B, Thompson, Jf, Bone, I, Welch, G, Grocott, Ec, Overstall, P, Aldoori, Mi, Dafalla, Be, Bryce, J, Clarke, C, Ming, A, Wilkinson, Ar, Bamford, J, Berridge, D, Scott, J, Abbott, Rj, Naylor, R, Harris, P, Humphrey, P, Adiseshiah, M, Aukett, M, Baker, D, Bishop, Cc, Boutin, A, Brown, M, Burke, P, Burnand, Kg, Colchester, A, Coward, L, Davies, Ah, Espasandin, M, Giddings, Ae, Hamilton, G, Judge, C, Kakkos, S, Mcguiness, C, Morris Vincent, P, Nicolaides, A, Padayachee, Ts, Riordan, H, Sullivan, E, Taylor, P, Thompson, M, Wolfe, Jh, Mccollum, Cn, O'Neill, Pa, Welsh, S, Barnes, J, Cleland, P, Davis, M, Gholkar, A, Jones, R, Jaykishnam, V, Mendelow, Ad, O'Connell, Je, Siddique, Ms, Stansby, G, Vivar, R, Ashley, S, Cosgrove, C, Gibson, J, Wilkins, Dc, Chant, Ad, Frankel, J, Shearman, Cp, Williams, J, Hall, G, Holdsworth, R, Davies, Jn, Mclean, B, Woodburn, Kr, Brown, G, Curley, P, Loizou, L, Chaturvedi, S, Diaz, F, Radak, D, Todorovic, Pr, Kamugasha, D, Baxter, A, Berry, C, Burrett, J, Collins, R, Crowther, J, Davies, C, Farrell, B, Godwin, J, Gray, R, Harwood, C, Hirt, L, Hope, C, Knight, S, Lay, M, Munday, A, Murawska, A, Peto, Cg, Radley, A, Richards, S., Cras, Patrick, van Schil, Paul, et al., Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group, Halliday, A, Harrison, M, Hayter, E, Kong, X, Mansfield, A, Marro, J, Pan, H, Peto, R, Potter, J, Rahimi, K, Rau, A, Robertson, S, Streifler, J, Thomas, D, Adovasio, Roberto, and Asymptomatic Carotid Surgery Trial Collaborative, Group

Subjects
Male, Time Factors, medicine.medical_treatment, Kaplan-Meier Estimate, Carotid endarterectomy, Aged, 80 and over, Carotid Stenosis, Endarterectomy, Carotid, Female, Humans, Incidence, Middle Aged, Primary Prevention, Stroke, Treatment Outcome, Stroke/epidemiology, law.invention, Randomized controlled trial, law, Aged, 80 and over, Endarterectomy, Carotid, endarterectomy, Carotid Stenosis/mortality, Incidence (epidemiology), Carotid*/mortality, General Medicine, Carotid Stenosis | Internal Carotid Artery | Endarterectomy, medicine.symptom, medicine.medical_specialty, Asymptomatic, Internal medicine, asymptomatic carotid artery stenosi, medicine, asymptomatic carotid artery stenosis, business.industry, Carotid Stenosis/complications, Stroke/prevention & control, Perioperative, medicine.disease, Surgery, Stenosis, Human medicine, business
Abstract

SummaryBackgroundIf carotid artery narrowing remains asymptomatic (ie, has caused no recent stroke or other neurological symptoms), successful carotid endarterectomy (CEA) reduces stroke incidence for some years. We assessed the long-term effects of successful CEA.MethodsBetween 1993 and 2003, 3120 asymptomatic patients from 126 centres in 30 countries were allocated equally, by blinded minimised randomisation, to immediate CEA (median delay 1 month, IQR 0·3–2·5) or to indefinite deferral of any carotid procedure, and were followed up until death or for a median among survivors of 9 years (IQR 6–11). The primary outcomes were perioperative mortality and morbidity (death or stroke within 30 days) and non-perioperative stroke. Kaplan-Meier percentages and logrank p values are from intention-to-treat analyses. This study is registered, number ISRCTN26156392.Findings1560 patients were allocated immediate CEA versus 1560 allocated deferral of any carotid procedure. The proportions operated on while still asymptomatic were 89·7% versus 4·8% at 1 year (and 92·1% vs 16·5% at 5 years). Perioperative risk of stroke or death within 30 days was 3·0% (95% CI 2·4–3·9; 26 non-disabling strokes plus 34 disabling or fatal perioperative events in 1979 CEAs). Excluding perioperative events and non-stroke mortality, stroke risks (immediate vs deferred CEA) were 4·1% versus 10·0% at 5 years (gain 5·9%, 95% CI 4·0–7·8) and 10·8% versus 16·9% at 10 years (gain 6·1%, 2·7–9·4); ratio of stroke incidence rates 0·54, 95% CI 0·43–0·68, p

Published
2010
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3. Vascular access

Author

Coentrao, L., primary, Ribeiro, C., additional, Santos-Araujo, C., additional, Neto, R., additional, Pestana, M., additional, Rahman, E., additional, Rahman, H., additional, Ahmed, D., additional, Mousa, D., additional, El Bishlawi, M., additional, Shibahara, H., additional, Shibahara, N., additional, Takahashi, S., additional, Dupuis, E., additional, Duval, X., additional, Dornic, Q., additional, Bonnal, C., additional, Lucet, J.-C., additional, Cerceau, O., additional, Randoux, C., additional, Balde, C., additional, Besson, F., additional, Mentre, F., additional, Vrtovsnik, F., additional, Koutroubas, G., additional, Malindretos, P., additional, Zagotsis, G., additional, Makri, P., additional, Syrganis, C., additional, Mambelli, E., additional, Mancini, E., additional, Elia, C., additional, Guadagno, V., additional, Facchini, M. G., additional, Zucchelli, A., additional, Grazia, M., additional, Patregnani, L., additional, Santoro, A., additional, Stefan, G., additional, Stancu, S., additional, Capusa, C., additional, Ailioaiei, O. R., additional, Mircescu, G., additional, Anwar, S., additional, Little, C., additional, Kingston, R., additional, Diwakar, P., additional, Kaikini, R., additional, Nikolaou, E., additional, Loukas, G., additional, Sabry, A., additional, Alsaran, K., additional, Al Sherbeiny, S., additional, Abdulkader, M., additional, Kwak, I., additional, Song, S., additional, Seong, E., additional, Lee, S., additional, Lee, D., additional, Kim, I., additional, Rhee, H., additional, Silva, F., additional, Queiros, J., additional, Malheiro, J., additional, Cabrita, A., additional, Rocha, A., additional, Bamidis, P., additional, Liaskos, C., additional, Chryssogonidis, I., additional, Frantzidis, C., additional, Papagiannis, A., additional, Vrochides, D., additional, Lasaridis, A., additional, Nikolaidis, P., additional, Kotwal, S., additional, Muir, C., additional, Hawley, C., additional, Snelling, P., additional, Gallagher, M., additional, Jardine, M., additional, Shibata, K., additional, Toya, Y., additional, Umemura, S., additional, Iwamoto, T., additional, Ono, S., additional, Ikeda, E., additional, Kitazawa, A., additional, Kuji, T., additional, Koguchi, N., additional, Satta, H., additional, Nishihara, M., additional, Kawata, S., additional, Kaneda, T., additional, Yamada, Y., additional, Murakami, T., additional, Yanagi, M., additional, Yasuda, G., additional, Mathieu, S., additional, Yves, D., additional, Jean-Michel, T., additional, Nicolas, Q., additional, Jean-Francois, C., additional, Ibrahim, M., additional, Abdel Salam, M., additional, Awadalla, A., additional, Bichari, W., additional, Zaki, S., additional, Roca-Tey, R., additional, Samon, R., additional, Ibrik, O., additional, Roda, A., additional, Gonzalez-Oliva, J. C., additional, Martinez-Cercos, R., additional, Viladoms, J., additional, Lin, C.-C., additional, Yang, W.-C., additional, Kim, Y.-O., additional, Yoon, S.-A., additional, Yun, Y.-S., additional, Song, H.-C., additional, Kim, B.-S., additional, Cheong, M.-A., additional, Ogawa, T., additional, Kiba, T., additional, Okazaki, S., additional, Hatano, M., additional, Iwanaga, M., additional, Noiri, C., additional, Matsuda, A., additional, Hasegawa, H., additional, Mitarai, T., additional, DI Napoli, A., additional, DI Lallo, D., additional, Tazza, L., additional, De Cicco, C., additional, Salvatori, M. F., additional, Chicca, S., additional, Guasticchi, G., additional, Gelev, S., additional, Trajceska, L., additional, Srbinovska, E., additional, Pavleska, S., additional, Oncevski, A., additional, Dejanov, P., additional, Gerasomovska, V., additional, Selim, G., additional, Sikole, A., additional, Wilson, S., additional, Mayne, T., additional, Krishnan, M., additional, Holland, J., additional, Volz, A., additional, Good, L., additional, Nissenson, A., additional, Stavroulopoulos, A., additional, Aresti, V., additional, Maragkakis, G., additional, Kyriakides, S., additional, Rikker, C., additional, Juhasz, E., additional, Tornoci, L., additional, Tovarosi, S., additional, Greguschik, J., additional, Mag, O., additional, Rosivall, L., additional, Golebiowski, T., additional, Watorek, E., additional, Kusztal, M., additional, Letachowicz, K., additional, Letachowicz, W., additional, Madziarska, K., additional, Augustyniak Bartosik, H., additional, Krajewska, M., additional, Weyde, W., additional, Klinger, M., additional, Capitanini, A., additional, Lange, S., additional, Cupisti, A., additional, Schier, T., additional, Gobel, G., additional, Bosmuller, C., additional, Gruber, I., additional, Tiefenthaler, M., additional, Shipley, T., additional, Adam, J., additional, Sweeney, D., additional, Fenwick, S., additional, Mansy, H., additional, Ahmed, S., additional, Moore, I., additional, Vigeral, P., additional, Saksi, S., additional, Flamant, M., additional, Boulanger, H., additional, Park, W.-D., additional, Cheong, M. A., additional, Nikam, M., additional, Tavakoli, A., additional, Chemla, E., additional, Evans, J., additional, Malete, H., additional, Matyas, L., additional, Mogan, I., additional, Lazarides, M., additional, Ebner, A., additional, Shi, Y., additional, Zhang, J., additional, Cheng, J., additional, Frank, L. R., additional, Melanie, H., additional, Dominique, B., additional, Michel, G., additional, Ikeda, K., additional, Yasuda, T., additional, Yotueda, H., additional, Ebah, L., additional, Jayanti, A., additional, Kanigicherla, D., additional, Summers, A., additional, Manley, G., additional, Dutton, G., additional, Chalmers, N., additional, Mitra, S., additional, Checherita, I.-A., additional, Niculae, A., additional, Radulescu, D., additional, David, C., additional, Turcu, F. L., additional, Ciocalteu, A., additional, Persic, V., additional, Buturovic-Ponikvar, J., additional, Ponikvar, R., additional, Touam, M., additional, Menoyo, V., additional, Drueke, T., additional, Rifaat, M., additional, Muresan, C., additional, Abtahi, M., additional, Koochakipour, Z., additional, Joly, D., additional, Baharani, J., additional, Rizvi, S., additional, Ng, K. P., additional, Buzzi, L., additional, Sarcina, C., additional, Alberghini, E., additional, Ferrario, F., additional, Baragetti, I., additional, Santagostino, G., additional, Furiani, S., additional, Corghi, E., additional, Terraneo, V., additional, Rastelli, F., additional, Bacchini, G., additional, Pozzi, C., additional, Adorati Menegato, M., additional, Mortellaro, R., additional, Locicero, A., additional, Romano, A., additional, Manzini, P. P., additional, Steckiph, D., additional, Shintaku, S., additional, Kawanishi, H., additional, Moriishi, M., additional, Bansyodani, M., additional, Nakamura, S., additional, Saito, M., additional, Tsuchiya, S., additional, Barros, F., additional, Vaz, R., additional, Carvalho, B., additional, Martins, P., additional, Likaj, E., additional, Seferi, S., additional, Rroji, M., additional, Idrizi, A., additional, Duraku, A., additional, Barbullushi, M., additional, and Thereska, N., additional

Published
2012
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7. [Preocclusive stenosis syndrome of the internal carotid artery].

Author

Van de Berg L and Mogan I

Subjects
Aged, Arteriosclerosis diagnosis, Arteriosclerosis pathology, Carotid Artery, Internal, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Syndrome, Ultrasonography, Carotid Artery Diseases diagnosis, Carotid Artery Thrombosis diagnosis
Published
1983

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