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2. Doppler ultrasound, a noninvasive tool for the study of mesenteric arterial flow in systemic sclerosis: a cross-sectional study of a patient cohort with review and meta-analysis of the literature

Author

Bandini, Giulia, Monami, Matteo, Ciuti, Gabriele, Mercatelli, Paolo, Lo Cricchio, Anna, De Santis, Maria Cristina, Bonomi, Francesco, Bellando Randone, Silvia, Campochiaro, Corrado, El Aoufy, Khadija, Ruaro, Barbara, Giuggioli, Dilia, Hughes, Michael, McMahan, Zsuzsanna H., Benfaremo, Devis, Moroncini, Gianluca, Maconi, Giovanni, Accogli, Esterita, Dagna, Lorenzo, Matucci Cerinic, Marco, and Moggi Pignone, Alberto

Published
2024
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8. The Potential Role of Butyrate in the Pathogenesis and Treatment of Autoimmune Rheumatic Diseases.

Author

Coccia, Carmela, Bonomi, Francesco, Lo Cricchio, Anna, Russo, Edda, Peretti, Silvia, Bandini, Giulia, Lepri, Gemma, Bartoli, Francesca, Moggi-Pignone, Alberto, Guiducci, Serena, Del Galdo, Francesco, Furst, Daniel E., Matucci Cerinic, Marco, and Bellando-Randone, Silvia

Subjects
SYSTEMIC lupus erythematosus, BEHCET'S disease, SJOGREN'S syndrome, SHORT-chain fatty acids, AUTOIMMUNE diseases
Abstract

The gut microbiota is a complex ecosystem of microorganisms residing in the human gastrointestinal tract, playing a crucial role in various biological processes and overall health maintenance. Dysbiosis, an imbalance in the composition and function of the gut microbiota, is linked to systemic autoimmune diseases (SAD). Short-chain fatty acids (SCFAs), especially butyrate, produced by the gut microbiota through the fermentation of dietary fibers, play a significant role in immunomodulation and maintaining intestinal homeostasis. Butyrate is essential for colonocyte energy, anti-inflammatory responses, and maintaining intestinal barrier integrity. Studies show reduced butyrate-producing bacteria in SAD patients, suggesting that increasing butyrate levels could have therapeutic benefits. Butyrate's anti-inflammatory effects and its potential therapeutic role have been studied in rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, systemic sclerosis, and Behçet's disease. Despite promising in vitro and animal model results, human studies are limited, and the optimal strategies for modulating dysbiosis in SADs remain elusive. This review explores the current evidence on the immunoregulatory role of butyrate and its potential therapeutic effects in SAD. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Patients’ unmet needs and treatment preferences concerning digital ulcers in systemic sclerosis

Author

Bandini, Giulia, primary, Alunno, Alessia, additional, Alcacer-Pitarch, Begonya, additional, Ruaro, Barbara, additional, Galetti, Ilaria, additional, El-Aoufy, Khadija, additional, Pinheiro, Filipe, additional, Campanaro, Giulia, additional, Jade, Judith, additional, Donato, StefanoDi, additional, Muir, Lindsay, additional, Moggi Pignone, Alberto, additional, Bellando Randone, Silvia, additional, Del Galdo, Francesco, additional, McMahan, Zsuzsanna H, additional, Matucci-Cerinic, Marco, additional, and Hughes, Michael, additional

Published
2024
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12. Digital Ulcers and Ventricular Arrhythmias as Red Flags to Predict Replacement Myocardial Fibrosis in Systemic Sclerosis

Author

Gargani, Luna, primary, Bruni, Cosimo, additional, Todiere, Giancarlo, additional, Pugliese, Nicola Riccardo, additional, Bandini, Giulia, additional, Bellando-Randone, Silvia, additional, Guiducci, Serena, additional, D’Angelo, Gennaro, additional, Campochiaro, Corrado, additional, De Luca, Giacomo, additional, Stagnaro, Chiara, additional, Lombardi, Massimo, additional, Dagna, Lorenzo, additional, Pepe, Alessia, additional, Allanore, Yannick, additional, Moggi-Pignone, Alberto, additional, and Matucci-Cerinic, Marco, additional

Published
2023
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13. Exercise Stress Echocardiography of the Right Ventricle and Pulmonary Circulation

Author

Gargani, Luna, primary, Pugliese, Nicola Riccardo, additional, De Biase, Nicolò, additional, Mazzola, Matteo, additional, Agoston, Gergely, additional, Arcopinto, Michele, additional, Argiento, Paola, additional, Armstrong, William F., additional, Bandera, Francesco, additional, Cademartiri, Filippo, additional, Carbone, Andreina, additional, Castaldo, Rossana, additional, Citro, Rodolfo, additional, Cocchia, Rosangela, additional, Codullo, Veronica, additional, D’Alto, Michele, additional, D'Andrea, Antonello, additional, Douschan, Philipp, additional, Fabiani, Iacopo, additional, Ferrara, Francesco, additional, Franzese, Monica, additional, Frumento, Paolo, additional, Ghio, Stefano, additional, Grünig, Ekkehard, additional, Guazzi, Marco, additional, Kasprzak, Jaroslaw D., additional, Kolias, Theodore, additional, Kovacs, Gabor, additional, La Gerche, André, additional, Limogelli, Giuseppe, additional, Marra, Alberto Maria, additional, Matucci-Cerinic, Marco, additional, Mauro, Ciro, additional, Moreo, Antonella, additional, Pratali, Lorenza, additional, Ranieri, Brigida, additional, Rega, Salvatore, additional, Rudski, Lawrence, additional, Saggar, Rajan, additional, Salzano, Andrea, additional, Serra, Walter, additional, Stanziola, Anna A., additional, Vannan, Mani A., additional, Voilliot, Damien, additional, Vriz, Olga, additional, Wierzbowska-Drabik, Karina, additional, Cittadini, Antonio, additional, Naeije, Robert, additional, Bossone, Eduardo, additional, Gargani, Luna, additional, Kolias, Theodore John, additional, Capone, Valentina, additional, Sepe, Chiara, additional, Capuano, Francesco, additional, Benvenga, Rossella, additional, Bellino, Michele, additional, Iuliano, Giuseppe, additional, Migliarino, Serena, additional, Radano, Ilaria, additional, Marra, Alberto, additional, Crisci, Giulia, additional, D’Assante, Roberta, additional, De Luca, Mariarosaria, additional, Giardino, Federica, additional, Rainone, Carmen, additional, Valente, Valeria, additional, D’Andrea, Antonello, additional, Russo, Valentina, additional, Dellegrottaglie, Santo, additional, Di Salvo, Giovanni, additional, Guida, Stefania, additional, Grunig, Ekkerard, additional, Eichstaedt, Christina A., additional, Labate, Valentina, additional, La Gerch, André, additional, Limongelli, Giuseppe, additional, Pacileo, Giuseppe, additional, Verrengia, Marina, additional, Casadei, Francesca, additional, De Chiara, Benedetta, additional, Ostenfeld, Ellen, additional, Pedrizzetti, Gianni, additional, Pieri, Francesco, additional, Mori, Fabio, additional, Moggi-Pignone, Alberto, additional, Raciti, Mauro, additional, Pugliese, Nicola, additional, D’Angelo, Gennaro, additional, Stanziola, Anna Agnese, additional, Rossella, D’Angelo, additional, Gallotta, Lorena, additional, Szabó, István, additional, Varga, Albert, additional, Galzerano, Domenico, additional, Vannan, Mani, additional, Mobasseri, Sara, additional, Flueckiger, Peter, additional, and Liu, Shizhen, additional

Published
2023
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16. The Performance of Pulmonary Function Tests in Predicting Systemic Sclerosis—Interstitial Lung Disease in the European Scleroderma Trial and Research Database.

Author

Lepri, Gemma, Bruni, Cosimo, Tofani, Lorenzo, Moggi-Pignone, Alberto, Orlandi, Martina, Tomassetti, Sara, Hughes, Michael, Del Galdo, Francesco, Irace, Rosaria, Distler, Oliver, Riccieri, Valeria, Allanore, Yannick, Gheorghiu, Ana Maria, Siegert, Elise, De Vries-Bouwstra, Jeska, Hachulla, Eric, Tikly, Mohammed, Damjanov, Nemanja, Spertini, Francois, and Mouthon, Luc

Subjects
INTERSTITIAL lung diseases, PULMONARY function tests, SYSTEMIC scleroderma, SCLERODERMA (Disease), DATABASES, LUNG volume measurements
Abstract

Background and Objectives: In SSc, ILD is a major cause of morbidity and mortality. We aimed to investigate the performance of DLCO (diffusing capacity of lung carbon monoxide) and FVC (forced vital capacity) delta change (Δ) and baseline values in predicting the development of SSc-ILD. Methods: Longitudinal data of DLCO, FVC, and ILD on the HRCT of SSc patients from the EUSTAR database were evaluated at baseline (t0) and after 12 (±4) (t1) and 24 (±4) (t2) months. Results: 474/17805 patients were eligible for the study (403 females); 46 (9.7%) developed ILD at t2. Positivity for anti-topoisomerase antibodies (117 patients) showed an association with ILD development at t2 (p = 0.0031). Neither the mean t0 to t1 change (Δ) of DLCO nor the mean t0 to t1 FVCΔ predicted the appearance of ILD at t2. Investigating the possible role of baseline DLCO and FVC values in predicting ILD appearance after 24 (±4) months, we observed a moderate predictive capability of t0 DLCO < 80%, stronger than that of FVC < 80%. Conclusions: We suggest that an impaired baseline DLCO may be predictive of the appearance of ILD after 2 years of follow-up. This result advances the hypothesis that a reduction in gas exchange may be considered an early sign of lung involvement. However, further rigorous studies are warranted to understand the predictive role of DLCO evaluation in the course of SSc. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Digital Ulcers and Ventricular Arrhythmias as Red Flags to Predict Replacement Myocardial Fibrosis in Systemic Sclerosis.

Author

Gargani, Luna, Bruni, Cosimo, Todiere, Giancarlo, Pugliese, Nicola Riccardo, Bandini, Giulia, Bellando-Randone, Silvia, Guiducci, Serena, D'Angelo, Gennaro, Campochiaro, Corrado, De Luca, Giacomo, Stagnaro, Chiara, Lombardi, Massimo, Dagna, Lorenzo, Pepe, Alessia, Allanore, Yannick, Moggi-Pignone, Alberto, and Matucci-Cerinic, Marco

Subjects
SYSTEMIC scleroderma, VENTRICULAR arrhythmia, PATIENT selection, FIBROSIS, ULCERS, CAPILLAROSCOPY, PROGNOSIS, LIVER histology
Abstract

Background: Cardiac involvement in systemic sclerosis (SSc) affects the prognosis of the disease. Echocardiography is the first line imaging tool to detect cardiac involvement, but it is not able to routinely detect myocardial fibrosis. Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is the gold standard for replacement myocardial fibrosis assessment, but its availability is currently limited. Aim: We aimed to assess the clinical and instrumental parameters that would be useful for predicting the presence of LGE-CMR, to achieve a better selection of patients with SSc that could benefit from third-level CMR imaging. Methods: 344 SSc patients underwent a comprehensive echocardiogram and LGE-CMR on the same day; for 189 patients, a 24 h ECG Holter monitoring was available. Results: CMR showed non-junctional replacement myocardial fibrosis via LGE in 25.1% patients. A history of digital ulcers (OR 2.188; 95% C.I. 1.069–4.481) and ventricular arrhythmias at ECG Holter monitoring (OR 3.086; 95% C.I. 1.191–7.998) were independent predictors of replacement myocardial fibrosis. Conclusions: CMR can detect patterns of clinical and subclinical cardiac involvement, which are frequent in SSc. A history of digital ulcers and evidence of ventricular arrhythmias at ECG Holter monitoring are red flags for the presence of replacement myocardial fibrosis in CMR. The association between digital ulcers and myocardial fibrosis suggests that a similar pathological substrate of abnormal vascular function may underlie peripheral vascular and cardiac complications. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Prognostic Role of Sonographic Decongestion in Patients with Acute Heart Failure with Reduced and Preserved Ejection Fraction: A Multicentre Study

Author

Pugliese, Nicola R., primary, Mazzola, Matteo, additional, Bandini, Giulia, additional, Barbieri, Greta, additional, Spinelli, Stefano, additional, De Biase, Nicolò, additional, Masi, Stefano, additional, Moggi-Pignone, Alberto, additional, Ghiadoni, Lorenzo, additional, Taddei, Stefano, additional, Sicari, Rosa, additional, Pang, Peter S., additional, De Carlo, Marco, additional, and Gargani, Luna, additional

Published
2023
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19. Corrigendum to “Intravenous immunoglobulins reduce skin thickness in systemic sclerosis: evidence from Systematic Literature Review and from real life experience” [Autoimmunity Reviews, Volume 20, Issue 12, December 2021, 102981]

Author

Agostini, Elena, primary, De Luca, Giacomo, additional, Bruni, Cosimo, additional, Bartoli, Francesca, additional, Tofani, Lorenzo, additional, Campochiaro, Corrado, additional, Pacini, Giovanni, additional, Moggi-Pignone, Alberto, additional, Guiducci, Serena, additional, Bellando-Randone, Silvia, additional, Shoenfeld, Yehuda, additional, Dagna, Lorenzo, additional, and Matucci-Cerinic, Marco, additional

Published
2023
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23. The role of chest CT in deciphering interstitial lung involvement: systemic sclerosis versus COVID-19

Author

Orlandi, M, Landini, N, Sambataro, G, Nardi, C, Tofani, L, Bruni, C, Bellando-Randone, S, Blagojevic, J, Melchiorre, D, Hughes, M, Denton, C, Luppi, F, Ruaro, B, Della Casa, F, Rossi, F, De Luca, G, Campochiaro, C, Spinicci, M, Zammarchi, L, Tomassetti, S, Caminati, A, Cavigli, E, Albanesi, M, Melchiorre, F, Palmucci, S, Vegni, V, Guiducci, S, Moggi-Pignone, A, Allanore, Y, Bartoloni, A, Confalonieri, M, Dagna, L, De Cobelli, F, De Paulis, A, Harari, S, Khanna, D, Kuwana, M, Taliani, G, Lavorini, F, Miele, V, Morana, G, Pesci, A, Vancheri, C, Colagrande, S, Matucci-Cerinic, M, Orlandi, Martina, Landini, Nicholas, Sambataro, Gianluca, Nardi, Cosimo, Tofani, Lorenzo, Bruni, Cosimo, Bellando-Randone, Silvia, Blagojevic, Jelena, Melchiorre, Daniela, Hughes, Michael, Denton, Christopher P, Luppi, Fabrizio, Ruaro, Barbara, Della Casa, Francesca, Rossi, Francesca W, De Luca, Giacomo, Campochiaro, Corrado, Spinicci, Michele, Zammarchi, Lorenzo, Tomassetti, Sara, Caminati, Antonella, Cavigli, Edoardo, Albanesi, Marco, Melchiorre, Fabio, Palmucci, Stefano, Vegni, Virginia, Guiducci, Serena, Moggi-Pignone, Alberto, Allanore, Yannick, Bartoloni, Alessandro, Confalonieri, Marco, Dagna, Lorenzo, De Cobelli, Francesco, De Paulis, Amato, Harari, Sergio, Khanna, Dinesh, Kuwana, Masataka, Taliani, Gloria, Lavorini, Federico, Miele, Vittorio, Morana, Giovanni, Pesci, Alberto, Vancheri, Carlo, Colagrande, Stefano, Matucci-Cerinic, Marco, Orlandi, M, Landini, N, Sambataro, G, Nardi, C, Tofani, L, Bruni, C, Bellando-Randone, S, Blagojevic, J, Melchiorre, D, Hughes, M, Denton, C, Luppi, F, Ruaro, B, Della Casa, F, Rossi, F, De Luca, G, Campochiaro, C, Spinicci, M, Zammarchi, L, Tomassetti, S, Caminati, A, Cavigli, E, Albanesi, M, Melchiorre, F, Palmucci, S, Vegni, V, Guiducci, S, Moggi-Pignone, A, Allanore, Y, Bartoloni, A, Confalonieri, M, Dagna, L, De Cobelli, F, De Paulis, A, Harari, S, Khanna, D, Kuwana, M, Taliani, G, Lavorini, F, Miele, V, Morana, G, Pesci, A, Vancheri, C, Colagrande, S, Matucci-Cerinic, M, Orlandi, Martina, Landini, Nicholas, Sambataro, Gianluca, Nardi, Cosimo, Tofani, Lorenzo, Bruni, Cosimo, Bellando-Randone, Silvia, Blagojevic, Jelena, Melchiorre, Daniela, Hughes, Michael, Denton, Christopher P, Luppi, Fabrizio, Ruaro, Barbara, Della Casa, Francesca, Rossi, Francesca W, De Luca, Giacomo, Campochiaro, Corrado, Spinicci, Michele, Zammarchi, Lorenzo, Tomassetti, Sara, Caminati, Antonella, Cavigli, Edoardo, Albanesi, Marco, Melchiorre, Fabio, Palmucci, Stefano, Vegni, Virginia, Guiducci, Serena, Moggi-Pignone, Alberto, Allanore, Yannick, Bartoloni, Alessandro, Confalonieri, Marco, Dagna, Lorenzo, De Cobelli, Francesco, De Paulis, Amato, Harari, Sergio, Khanna, Dinesh, Kuwana, Masataka, Taliani, Gloria, Lavorini, Federico, Miele, Vittorio, Morana, Giovanni, Pesci, Alberto, Vancheri, Carlo, Colagrande, Stefano, and Matucci-Cerinic, Marco

Abstract

Objective: The aim of this study was to identify the main CT features that may help in distinguishing a progression of interstitial lung disease (ILD) secondary to SSc from COVID-19 pneumonia. Methods: This multicentric study included 22 international readers grouped into a radiologist group (RADs) and a non-radiologist group (nRADs). A total of 99 patients, 52 with COVID-19 and 47 with SSc-ILD, were included in the study. Results: Fibrosis inside focal ground-glass opacities (GGOs) in the upper lobes; fibrosis in the lower lobe GGOs; reticulations in lower lobes (especially if bilateral and symmetrical or associated with signs of fibrosis) were the CT features most frequently associated with SSc-ILD. The CT features most frequently associated with COVID- 19 pneumonia were: consolidation (CONS) in the lower lobes, CONS with peripheral (both central/peripheral or patchy distributions), anterior and posterior CONS and rounded-shaped GGOs in the lower lobes. After multivariate analysis, the presence of CONs in the lower lobes (P < 0.0001) and signs of fibrosis in GGOs in the lower lobes (P < 0.0001) remained independently associated with COVID-19 pneumonia and SSc-ILD, respectively. A predictive score was created that was positively associated with COVID-19 diagnosis (96.1% sensitivity and 83.3% specificity). Conclusion: CT diagnosis differentiating between COVID-19 pneumonia and SSc-ILD is possible through a combination of the proposed score and radiologic expertise. The presence of consolidation in the lower lobes may suggest COVID-19 pneumonia, while the presence of fibrosis inside GGOs may indicate SSc-ILD.

Published
2022

25. Ultrashort Echo-Time Magnetic Resonance Imaging Sequence in the Assessment of Systemic Sclerosis-Interstitial Lung Disease

Author

Landini, Nicholas, primary, Orlandi, Martina, additional, Occhipinti, Mariaelena, additional, Nardi, Cosimo, additional, Tofani, Lorenzo, additional, Bellando-Randone, Silvia, additional, Ciet, Pierluigi, additional, Wielopolski, Piotr, additional, Benkert, Thomas, additional, Bruni, Cosimo, additional, Bertolo, Silvia, additional, Moggi-Pignone, Alberto, additional, Matucci-Cerinic, Marco, additional, Morana, Giovanni, additional, and Colagrande, Stefano, additional

Published
2022
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28. Intravenous immunoglobulins reduce skin thickness in systemic sclerosis: evidence from Systematic Literature Review and from real life experience

Author

Agostini, Elana, primary, De Luca, Giacomo, additional, Bruni, Cosimo, additional, Bartoli, Francesca, additional, Tofani, Lorenzo, additional, Campochiaro, Corrado, additional, Pacini, Giovanni, additional, Moggi-Pignone, Alberto, additional, Guiducci, Serena, additional, Bellando-Randone, Silvia, additional, Shoenfeld, Yehuda, additional, Dagna, Lorenzo, additional, and Matucci-Cerinic, Marco, additional

Published
2021
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29. Hookworm infection presenting as recurrent severe anaemia requiring blood transfusion in a Pakistani migrant to Italy

Author

Barbarisi, Giorgia, primary, Piccica, Matteo, additional, Zavagli, Martina, additional, Bandini, Giulia, additional, Di Lauria, Nicoletta, additional, Antonelli, Alberto, additional, Spinicci, Michele, additional, Rossolini, Gian Maria, additional, Bartoloni, Alessandro, additional, Moggi Pignone, Alberto, additional, and Zammarchi, Lorenzo, additional

Published
2021
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30. Serum Organ-Specific Anti-Heart and Anti-Intercalated Disk Autoantibodies as New Autoimmune Markers of Cardiac Involvement in Systemic Sclerosis: Frequency, Clinical and Prognostic Correlates

Author

Caforio, Alida Linda Patrizia, primary, De Luca, Giacomo, additional, Baritussio, Anna, additional, Seguso, Mara, additional, Gallo, Nicoletta, additional, Bison, Elisa, additional, Cattini, Maria Grazia, additional, Pontara, Elena, additional, Gargani, Luna, additional, Pepe, Alessia, additional, Campochiaro, Corrado, additional, Plebani, Mario, additional, Iliceto, Sabino, additional, Peretto, Giovanni, additional, Esposito, Antonio, additional, Tofani, Lorenzo, additional, Moggi-Pignone, Alberto, additional, Dagna, Lorenzo, additional, Marcolongo, Renzo, additional, Matucci-Cerinic, Marco, additional, and Bruni, Cosimo, additional

Published
2021
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31. The positive side of the coin: Sars-Cov-2 pandemic has taught us how much Telemedicine is useful as standard of care procedure in real life

Author

El Aoufy, Khadija, primary, Melis, Maria Ramona, additional, Bellando Randone, Silvia, additional, Blagojevic, Jelena, additional, Bartoli, Francesca, additional, Fiori, Ginevra, additional, Nacci, Francesca, additional, Conforti, Maria Letizia, additional, Cometi, Laura, additional, Bruni, Cosimo, additional, Orlandi, Martina, additional, Moggi-Pignone, Alberto, additional, Rasero, Laura, additional, Guiducci, Serena, additional, and Matucci-Cerinic, Marco, additional

Published
2021
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32. Lung ultrasound B-lines in systemic sclerosis: cut-off values and methodological indications for interstitial lung disease screening

Author

Gargani, Luna, primary, Romei, Chiara, additional, Bruni, Cosimo, additional, Lepri, Gemma, additional, El-Aoufy, Khadija, additional, Orlandi, Martina, additional, D’Errico, Luigia, additional, Bandini, Giulia, additional, D’Angelo, Gennaro, additional, Guiducci, Serena, additional, Dagna, Lorenzo, additional, Falaschi, Fabio, additional, Matucci-Cerinic, Marco, additional, and Moggi-Pignone, Alberto, additional

Published
2021
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34. Diagnostic and Prognostic Value of Lung Ultrasound B-Lines in Acute Heart Failure With Concomitant Pneumonia

Author

Mazzola, Matteo, primary, Pugliese, Nicola Riccardo, additional, Zavagli, Martina, additional, De Biase, Nicolò, additional, Bandini, Giulia, additional, Barbarisi, Giorgia, additional, D'Angelo, Gennaro, additional, Sollazzo, Michela, additional, Piazzai, Chiara, additional, David, Simon, additional, Masi, Stefano, additional, Moggi-Pignone, Alberto, additional, and Gargani, Luna, additional

Published
2021
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35. The role of chest CT in deciphering interstitial lung involvement: systemic sclerosis versus COVID-19

Author

Orlandi, Martina, primary, Landini, Nicholas, additional, Sambataro, Gianluca, additional, Nardi, Cosimo, additional, Tofani, Lorenzo, additional, Bruni, Cosimo, additional, Bellando-Randone, Silvia, additional, Blagojevic, Jelena, additional, Melchiorre, Daniela, additional, Hughes, Michael, additional, Denton, Christopher P, additional, Luppi, Fabrizio, additional, Ruaro, Barbara, additional, della Casa, Francesca, additional, Rossi, Francesca W, additional, De Luca, Giacomo, additional, Campochiaro, Corrado, additional, Spinicci, Michele, additional, Zammarchi, Lorenzo, additional, Tomassetti, Sara, additional, Caminati, Antonella, additional, Cavigli, Edoardo, additional, Albanesi, Marco, additional, Melchiorre, Fabio, additional, Palmucci, Stefano, additional, Vegni, Virginia, additional, Guiducci, Serena, additional, Moggi-Pignone, Alberto, additional, Allanore, Yannick, additional, Bartoloni, Alessandro, additional, Confalonieri, Marco, additional, Dagna, Lorenzo, additional, DeCobelli, Francesco, additional, dePaulis, Amato, additional, Harari, Sergio, additional, Khanna, Dinesh, additional, Kuwana, Masataka, additional, Taliani, Gloria, additional, Lavorini, Federico, additional, Miele, Vittorio, additional, Morana, Giovanni, additional, Pesci, Alberto, additional, Vancheri, Carlo, additional, Colagrande, Stefano, additional, and Matucci-Cerinic, Marco, additional

Published
2021
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36. sj-docx-1-tab-10.1177_1759720X211033679 – Supplemental material for Switching from originator adalimumab to biosimilar SB5 in a rheumatology cohort: persistence on treatment, predictors of drug interruption and safety analysis

Author

Bruni, Cosimo, Gentileschi, Stefano, Pacini, Giovanni, Bardelli, Marco, Tofani, Lorenzo, Bartoli, Francesca, Baldi, Caterina, Cometi, Laura, Fiori, Ginevra, Nacci, Francesca, Cantarini, Luca, Guiducci, Serena, Moggi-Pignone, Alberto, Frediani, Bruno, and Matucci-Cerinic, Marco

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-docx-1-tab-10.1177_1759720X211033679 for Switching from originator adalimumab to biosimilar SB5 in a rheumatology cohort: persistence on treatment, predictors of drug interruption and safety analysis by Cosimo Bruni, Stefano Gentileschi, Giovanni Pacini, Marco Bardelli, Lorenzo Tofani, Francesca Bartoli, Caterina Baldi, Laura Cometi, Ginevra Fiori, Francesca Nacci, Luca Cantarini, Serena Guiducci, Alberto Moggi-Pignone, Bruno Frediani and Marco Matucci-Cerinic in Therapeutic Advances in Musculoskeletal Disease

Published
2021
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37. Oral Lactobacillus Species in Systemic Sclerosis

Author

Melchiorre, Daniela, primary, Ceccherini, Maria Teresa, additional, Romano, Eloisa, additional, Cometi, Laura, additional, El-Aoufy, Khadija, additional, Bellando-Randone, Silvia, additional, Roccotelli, Angela, additional, Bruni, Cosimo, additional, Moggi-Pignone, Alberto, additional, Carboni, Davide, additional, Guiducci, Serena, additional, Lepri, Gemma, additional, Tofani, Lorenzo, additional, Pietramellara, Giacomo, additional, and Matucci-Cerinic, Marco, additional

Published
2021
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38. The emerging challenge of pain in systemic sclerosis: Similarity to the pain experience reported by Sjőgren’s syndrome patients

Author

De Luca, Rossella, primary, Maresca, Marco, additional, Orlandi, Martina, additional, Bruni, Cosimo, additional, Solanki, Kamal, additional, Wang, Yukai, additional, Lepri, Gemma, additional, Guiducci, Serena, additional, Melchiorre, Daniela, additional, Moggi-Pignone, Alberto, additional, Rossi, Wanda, additional, De Paulis, Amato, additional, Dzhus, Marta, additional, Matucci-Cerinic, Marco, additional, and Bellando-Randone, Silvia, additional

Published
2021
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40. Cardiac magnetic resonance predicts ventricular arrhythmias in scleroderma: the Scleroderma Arrhythmia Clinical Utility Study (SAnCtUS)

Author

Mavrogeni, Sophie Gargani, Luna Pepe, Alessia Monti, Lorenzo and Markousis-Mavrogenis, George De Santis, Maria De Marchi, Daniele Koutsogeorgopoulou, Loukia Karabela, Georgia and Stavropoulos, Efthymios Katsifis, Gikas Bratis, Konstantinos and Bellando-Randone, Silvia Guiducci, Serena Bruni, Cosimo and Moggi-Pignone, Alberto Dimitroulas, Theodoros Kolovou, Genovefa and Bournia, Vasiliki-Kalliopi Sfikakis, Petros P. and Matucci-Cerinic, Marco

Subjects
cardiovascular system, cardiovascular diseases
Abstract

Objectives: Cardiac rhythm disturbances constitute the most frequent cardiovascular cause of death in SSc. However, electrocardiographic findings are not a part of risk stratification in SSc. We aimed to translate 24 h Holter findings into a tangible risk prediction score using cardiovascular magnetic resonance. Methods: The Scleroderma Arrhythmia Clinical Utility Study (SAnCtUS) was a prospective multicentre study including 150 consecutive SSc patients from eight European centres, assessed with 24 h Holter and cardiovascular magnetic resonance, including ventricular function, oedema (T2 ratio) and late gadolinium enhancement (%LGE). Laboratory/clinical parameters were included in multivariable corrections. A combined endpoint of sustained ventricular tachycardia requiring hospitalization and sudden cardiac death at a median (interquartile range) follow-up of 1 (1.0-1.4) year was generated. Results: Only T2 ratio and %LGE were significant predictors of ventricular rhythm disturbances, but not of supraventricular rhythm disturbances, after multivariable correction and adjustment for multiple comparisons. Using decision-tree analysis, we created the SAnCtUS score, a four-category scoring system based on T2 ratio and %LGE, for identifying SSc patients at high risk of experiencing ventricular rhythm disturbance at baseline. Increasing SAnCtUS scores were associated with a greater disease and arrhythmic burden. All cases of non-sustained ventricular tachycardia (n = 7) occurred in patients with the highest SAnCtUS score (=4). Having a score of 4 conveyed a higher risk of reaching the combined endpoint in multivariable Cox regression compared with scores 1/2/3 [hazard ratio (95% CI): 3.86 (1.14, 13.04), P = 0.029] independently of left ventricular ejection fraction and baseline ventricular tachycardia occurrence. Conclusion: T2 ratio and %LGE had the greatest utility as independent predictors of rhythm disturbances in SSc patients.

Published
2020

41. Use of vasoactive/vasodilating drugs for systemic sclerosis (SSc)-related digital ulcers (DUs) in expert tertiary centres: results from the analysis of the observational real-life DeSScipher study

Author

Blagojevic, Jelena, Abignano, Giuseppina, Avouac, Jérôme, Cometi, L, Frerix, Marc, Bellando-Randone, Silvia, Guiducci, Serena, Bruni, Cosimo, Huscher, Dörte, Jaeger, V K, Lóránd, Veronika, Maurer, Britta, Nihtyanova, Svetlana, Riemekasten, Gabriela, Siegert, Elise, Tarner, I H, Vettori, Serena, Walker, U A, Czirják, László, Denton, C P, Distler, Oliver, Allanore, Yannick, Müller-Ladner, Ulf, Moggi-Pignone, Alberto, Matucci-Cerinic, Marco, Del Galdo, Francesco, EUSTAR co-workers, University of Zurich, and Blagojevic, Jelena

Subjects
2745 Rheumatology, 10051 Rheumatology Clinic and Institute of Physical Medicine, 610 Medicine & health
Published
2020
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42. Switching from originator adalimumab to biosimilar SB5 in a rheumatology cohort: persistence on treatment, predictors of drug interruption and safety analysis

Author

Bruni, Cosimo, primary, Gentileschi, Stefano, additional, Pacini, Giovanni, additional, Bardelli, Marco, additional, Tofani, Lorenzo, additional, Bartoli, Francesca, additional, Baldi, Caterina, additional, Cometi, Laura, additional, Fiori, Ginevra, additional, Nacci, Francesca, additional, Cantarini, Luca, additional, Guiducci, Serena, additional, Moggi-Pignone, Alberto, additional, Frediani, Bruno, additional, and Matucci-Cerinic, Marco, additional

Published
2021
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44. Lung ultrasound B-lines in systemic sclerosis: cut-off values and methodological indications for interstitial lung disease screening.

Author

Gargani, Luna, Romei, Chiara, Bruni, Cosimo, Lepri, Gemma, El-Aoufy, Khadija, Orlandi, Martina, D'Errico, Luigia, Bandini, Giulia, D'Angelo, Gennaro, Guiducci, Serena, Dagna, Lorenzo, Falaschi, Fabio, Matucci-Cerinic, Marco, and Moggi-Pignone, Alberto

Subjects
REFERENCE values, CYTOKINES, AUTOANTIBODIES, PREDICTIVE tests, INTERSTITIAL lung diseases, MEDICAL screening, SYSTEMIC scleroderma, DESCRIPTIVE statistics, COMPUTED tomography, SENSITIVITY & specificity (Statistics)
Abstract

Objectives Lung ultrasound (LUS), through assessment of B-lines and pleural line alterations, is able to evaluate interstitial lung disease (ILD), a frequent complication of SSc. Different scanning schemes and counting methods have been proposed but no clear cut-off values have been indicated for screening. We aimed to evaluate the accuracy of different LUS methodological approaches to detect ILD compared with high-resolution CT (HRCT) as the gold standard. Methods Sixty-nine SSc patients underwent LUS and chest HRCT on the same day. Both exams were scored by expert readers. The accuracy of different scanning schemes and counting methods was assessed and clinical and functional data were compared with imaging findings. Results B-lines were more numerous in patients with the diffuse skin subset and Scl70 autoantibody positivity. The number of B-lines correlated with the Scleroderma Lung Study (SLS) I HRCT score (R  = 0.754, P  < 0.0001). A total of >10 B-lines on the whole chest or >1 B-line on the postero-basal chest showed 97% sensitivity for detecting even very early ILD signs (corresponding to an SLS I score of 1). Sensitivity increased to 100% when pleural line alterations were included in the analysis. Conclusions LUS has a very high sensitivity in detecting SSc-related ILD. A cut-off value of >10 B-lines on the whole chest or >1 B-line on the postero-basal chest can be used for the screening of SSc-ILD. Assessing only the postero-basal chest seems to be mostly effective, combining high sensitivity with a less time-consuming approach. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Risk of malignancy and biologic therapy in rheumatic inflammatory diseases: A single-center experience

Author

Cometi, Laura, primary, Bruni, Cosimo, additional, Passavanti, Saverio, additional, Tofani, Lorenzo, additional, Bartoli, Francesca, additional, Fiori, Ginevra, additional, Nacci, Francesca, additional, Lepri, Gemma, additional, Orlandi, Martina, additional, Melchiorre, Daniela, additional, Antonuzzo, Lorenzo, additional, Matucci-Cerinic, Marco, additional, and Moggi-Pignone, Alberto, additional

Published
2020
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48. Lung magnetic resonance imaging in systemic sclerosis: a new promising approach to evaluate pulmonary involvement and progression

Author

Gargani, Luna, primary, Bruni, Cosimo, additional, De Marchi, Daniele, additional, Romei, Chiara, additional, Guiducci, Serena, additional, Bellando-Randone, Silvia, additional, Aquaro, Giovanni Donato, additional, Pepe, Alessia, additional, Neri, Emanuele, additional, Colagrande, Stefano, additional, Falaschi, Fabio, additional, Moggi-Pignone, Alberto, additional, Pingitore, Alessandro, additional, and Matucci-Cerinic, Marco, additional

Published
2020
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